Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans.

abstract：:The intestine is a common site for invasion by intracellular pathogens, but little is known about how pathogens restructure and exit intestinal cells in vivo. The natural microsporidian parasite N. parisii invades intestinal cells of the nematode C. elegans, progresses through its life cycle, and then exits cells in a...

journal_title：PLoS pathogens

authors： Estes KA,Szumowski SC,Troemel ER

更新日期：2011-09-01 00:00:00

abstract：:Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are bat-borne viruses that cause fatal disease in humans and a range of other mammalian species. Gaining a deeper understanding of host pathways exploited by henipaviruses for infection may identify targets for new anti-viral therapies. Here we have ...

journal_title：PLoS pathogens

authors： Foo CH,Rootes CL,Cowley K,Marsh GA,Gould CM,Deffrasnes C,Cowled CJ,Klein R,Riddell SJ,Middleton D,Simpson KJ,Wang LF,Bean AG,Stewart CR

更新日期：2016-10-26 00:00:00

abstract：:Pathogenic hantaviruses, genus Orthohantaviridae, are maintained in rodent reservoirs with zoonotic transmission to humans occurring through inhalation of rodent excreta. Hantavirus disease in humans is characterized by localized vascular leakage and elevated levels of circulating proinflammatory cytokines. Despite th...

journal_title：PLoS pathogens

authors： Kell AM,Hemann EA,Turnbull JB,Gale M Jr

更新日期：2020-04-24 00:00:00

abstract：:Pathogens hide immunogenic epitopes from the host to evade immunity, persist and cause infection. The opportunistic human fungal pathogen Candida albicans, which can cause fatal disease in immunocompromised patient populations, offers a good example as it masks the inflammatory epitope β-glucan in its cell wall from h...

journal_title：PLoS pathogens

authors： Hopke A,Nicke N,Hidu EE,Degani G,Popolo L,Wheeler RT

更新日期：2016-05-25 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005698.]. ...

journal_title：PLoS pathogens

authors： Ersching J,Basso AS,Calich VL,Bortoluci KR,Rodrigues MM

更新日期：2016-07-11 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) cassette of the cell wall integrity (CWI) pathway is primarily responsible for orchestrating changes of cell wall. However, functions of this cassette in other cellular processes are not well understood. Here, we found that the Botrytis cinerea mutant of MAPK kinase (BcMkk1)...

journal_title：PLoS pathogens

authors： Yin Y,Wu S,Chui C,Ma T,Jiang H,Hahn M,Ma Z

更新日期：2018-09-13 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading causes of nosocomial pneumonia and its associated mortality. Moreover, extensively drug-resistant high-risk clones are globally widespread, presenting a major challenge to the healthcare systems. Despite this, no vaccine is available against this high-concerning pathogen. H...

journal_title：PLoS pathogens

authors： Cabral MP,Correia A,Vilanova M,Gärtner F,Moscoso M,García P,Vallejo JA,Pérez A,Francisco-Tomé M,Fuentes-Valverde V,Bou G

更新日期：2020-02-10 00:00:00

abstract：:Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysb...

journal_title：PLoS pathogens

authors： Jones TA,Hernandez DZ,Wong ZC,Wandler AM,Guillemin K

更新日期：2017-10-19 00:00:00

abstract：:Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and represents a recent, independent origin of plant parasitism in nematodes, ecologically and taxonomically distinct from other nematodes for which genomic data is available. As well as being an ...

journal_title：PLoS pathogens

authors： Kikuchi T,Cotton JA,Dalzell JJ,Hasegawa K,Kanzaki N,McVeigh P,Takanashi T,Tsai IJ,Assefa SA,Cock PJ,Otto TD,Hunt M,Reid AJ,Sanchez-Flores A,Tsuchihara K,Yokoi T,Larsson MC,Miwa J,Maule AG,Sahashi N,Jones JT,Berr

更新日期：2011-09-01 00:00:00

abstract：:Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood. Here we investigated the molecular mechanism by which apoptosis induced vi...

journal_title：PLoS pathogens

authors： Rajalingam K,Sharma M,Paland N,Hurwitz R,Thieck O,Oswald M,Machuy N,Rudel T

更新日期：2006-10-01 00:00:00

abstract：:Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract. Colonization of these different niches involves an N-acetylglucosamine binding protein (GbpA) that has been reported to mediate bacterial attachment to both marine chitin and mam...

journal_title：PLoS pathogens

authors： Wong E,Vaaje-Kolstad G,Ghosh A,Hurtado-Guerrero R,Konarev PV,Ibrahim AF,Svergun DI,Eijsink VG,Chatterjee NS,van Aalten DM

更新日期：2012-01-01 00:00:00

abstract：:Innate immune cells shape the host response to microbial pathogens. Here we elucidate critical differences in the molecular response of macrophages vs. dendritic cells (DCs) to Histoplasma capsulatum, an intracellular fungal pathogen of humans. It has long been known that macrophages are permissive for Histoplasma gro...

journal_title：PLoS pathogens

authors： Van Prooyen N,Henderson CA,Hocking Murray D,Sil A

更新日期：2016-07-26 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:In host-pathogen interactions, the struggle for iron may have major consequences on the outcome of the disease. To overcome the low solubility and bio-availability of iron, bacteria have evolved multiple systems to acquire iron from various sources such as heme, hemoglobin and ferritin. The molecular basis of iron acq...

journal_title：PLoS pathogens

authors： Segond D,Abi Khalil E,Buisson C,Daou N,Kallassy M,Lereclus D,Arosio P,Bou-Abdallah F,Nielsen Le Roux C

更新日期：2014-02-13 00:00:00

abstract：:Transformation is an important mechanism of microbial evolution through which bacteria have been observed to rapidly adapt in response to clinical interventions; examples include facilitating vaccine evasion and the development of penicillin resistance in the major respiratory pathogen Streptococcus pneumoniae. To cha...

journal_title：PLoS pathogens

authors： Croucher NJ,Harris SR,Barquist L,Parkhill J,Bentley SD

更新日期：2012-01-01 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chick embryo fibroblast...

journal_title：PLoS pathogens

authors： Peng C,Wyatt LS,Glushakow-Smith SG,Lal-Nag M,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence i...

journal_title：PLoS pathogens

authors： Chung D,Barker BM,Carey CC,Merriman B,Werner ER,Lechner BE,Dhingra S,Cheng C,Xu W,Blosser SJ,Morohashi K,Mazurie A,Mitchell TK,Haas H,Mitchell AP,Cramer RA

更新日期：2014-11-06 00:00:00

abstract：:The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle. Although many proteins involved in kDNA replication and segregation are now known, several key steps in the replication...

journal_title：PLoS pathogens

authors： Peña-Diaz P,Vancová M,Resl C,Field MC,Lukeš J

更新日期：2017-04-07 00:00:00

abstract：:Herpesviruses persist indefinitely in their host through complex and poorly defined interactions that mediate latent, chronic or productive states of infection. Human cytomegalovirus (CMV or HCMV), a ubiquitous β-herpesvirus, coordinates the expression of two viral genes, UL135 and UL138, which have opposing roles in ...

journal_title：PLoS pathogens

authors： Buehler J,Zeltzer S,Reitsma J,Petrucelli A,Umashankar M,Rak M,Zagallo P,Schroeder J,Terhune S,Goodrum F

更新日期：2016-05-24 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, invades and replicates within macrophages and protozoan cells inside a vacuole. The type IVB Icm/Dot secretion system is necessary for the translocation of effector proteins that modulate vesicle trafficking pathways in the host cell, thus avoiding ...

journal_title：PLoS pathogens

authors： Franco IS,Shohdy N,Shuman HA

更新日期：2012-02-01 00:00:00

abstract：:My father was diagnosed with stomach cancer recently. Luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. My father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. In ...

journal_title：PLoS pathogens

authors： Shinohara ML

更新日期：2017-08-10 00:00:00

abstract：:Hepatitis B virus (HBV) capsid or core protein (HBc) contains an N-terminal domain (NTD) and a C-terminal domain (CTD) connected by a short linker peptide. HBc plays a critical role in virtually every step of viral replication, which is further modulated by dynamic phosphorylation and dephosphorylation of its CTD. Whi...

journal_title：PLoS pathogens

authors： Xi J,Luckenbaugh L,Hu J

更新日期：2021-01-25 00:00:00

abstract：:In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neuritogenesis, to prion d...

journal_title：PLoS pathogens

authors： Alleaume-Butaux A,Nicot S,Pietri M,Baudry A,Dakowski C,Tixador P,Ardila-Osorio H,Haeberlé AM,Bailly Y,Peyrin JM,Launay JM,Kellermann O,Schneider B

更新日期：2015-08-04 00:00:00

abstract：:A striking feature of human visceral leishmaniasis (VL) is chronic inflammation in the spleen and liver, and VL patients present increased production levels of multiple inflammatory mediators, which contribute to tissue damage and disease severity. Here, we combined an experimental model with the transcriptional profi...

journal_title：PLoS pathogens

authors： Sacramento LA,Benevides L,Maruyama SR,Tavares L,Fukutani KF,Francozo M,Sparwasser T,Cunha FQ,Almeida RP,da Silva JS,Carregaro V

更新日期：2020-03-25 00:00:00

abstract：:Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome formation. Nascent autophagosomes were found commonly associated w...

journal_title：PLoS pathogens

authors： Williams RA,Smith TK,Cull B,Mottram JC,Coombs GH

更新日期：2012-01-01 00:00:00

abstract：:Candida albicans, a clinically important dimorphic fungal pathogen that can evade immune attack by masking its cell wall beta-glucan from immune recognition, mutes protective host responses mediated by the Dectin-1 beta-glucan receptor on innate immune cells. Although the ability of C. albicans to switch between a yea...

journal_title：PLoS pathogens

authors： Wheeler RT,Kombe D,Agarwala SD,Fink GR

更新日期：2008-12-01 00:00:00

abstract：:The envelope glycoprotein (Env) complexes of the human and simian immunodeficiency viruses (HIV and SIV, respectively) mediate viral entry and are a target for neutralizing antibodies. The receptor binding surfaces of Env are in large part sterically occluded or conformationally masked prior to receptor binding. Knowl...

journal_title：PLoS pathogens

authors： Zanetti G,Briggs JA,Grünewald K,Sattentau QJ,Fuller SD

更新日期：2006-08-01 00:00:00

abstract：:Promyelocytic leukemia protein (PML) has antiviral functions and many viruses encode gene products that disrupt PML nuclear bodies (PML NBs). However, evidence of the relevance of PML NB modification for viral pathogenesis is limited and little is known about viral gene functions required for PML NB disruption in infe...

journal_title：PLoS pathogens

authors： Wang L,Oliver SL,Sommer M,Rajamani J,Reichelt M,Arvin AM

更新日期：2011-08-01 00:00:00

abstract：:Influenza is a major cause of mortality and morbidity worldwide. Despite numerous studies of the pathogenesis of influenza in humans and animal models the dynamics of infection and transmission in individual hosts remain poorly characterized. In this study, we experimentally modelled transmission using the H1N1pdm09 i...

journal_title：PLoS pathogens

authors： Canini L,Holzer B,Morgan S,Dinie Hemmink J,Clark B,sLoLa Dynamics Consortium.,Woolhouse MEJ,Tchilian E,Charleston B

更新日期：2020-07-24 00:00:00

abstract：:The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolut...

journal_title：PLoS pathogens

authors： Sabin C,Corti D,Buzon V,Seaman MS,Lutje Hulsik D,Hinz A,Vanzetta F,Agatic G,Silacci C,Mainetti L,Scarlatti G,Sallusto F,Weiss R,Lanzavecchia A,Weissenhorn W

更新日期：2010-11-18 00:00:00