Iron acquisition in Bacillus cereus: the roles of IlsA and bacillibactin in exogenous ferritin iron mobilization.

abstract：:Respiratory virus infections, such as influenza, typically induce a robust type I (pro-inflammatory cytokine) immune response, however, the production of type 2 cytokines has been observed. Type 2 cytokine production during respiratory virus infection is linked to asthma exacerbation; however, type 2 cytokines may als...

journal_title：PLoS pathogens

authors： Gorski SA,Hahn YS,Braciale TJ

更新日期：2013-09-01 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed structural and functional studies using the human neutralizing antibod...

journal_title：PLoS pathogens

authors： Harshbarger W,Tian S,Wahome N,Balsaraf A,Bhattacharya D,Jiang D,Pandey R,Tungare K,Friedrich K,Mehzabeen N,Biancucci M,Chinchilla-Olszar D,Mallett CP,Huang Y,Wang Z,Bottomley MJ,Malito E,Chandramouli S

更新日期：2020-11-02 00:00:00

abstract：:Host heterogeneity in disease transmission is widespread but precisely how different host traits drive this heterogeneity remains poorly understood. Part of the difficulty in linking individual variation to population-scale outcomes is that individual hosts can differ on multiple behavioral, physiological and immunolo...

journal_title：PLoS pathogens

authors： Siva-Jothy JA,Vale PF

更新日期：2021-01-19 00:00:00

abstract：:The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that s...

journal_title：PLoS pathogens

authors： Anderson A,Laurenson-Schafer H,Partridge FA,Hodgkin J,McMullan R

更新日期：2013-01-01 00:00:00

abstract：:The heterosexual risk group has become the largest HIV infected group in the United Kingdom during the last 10 years, but little is known of the network structure and dynamics of viral transmission in this group. The overwhelming majority of UK heterosexual infections are of non-B HIV subtypes, indicating viruses orig...

journal_title：PLoS pathogens

authors： Hughes GJ,Fearnhill E,Dunn D,Lycett SJ,Rambaut A,Leigh Brown AJ,UK HIV Drug Resistance Collaboration.

更新日期：2009-09-01 00:00:00

abstract：:Enterococci are robust gram-positive bacteria that are found in a variety of surroundings and that cause a significant number of healthcare-associated infections. The genus possesses a high-efficiency pheromone-responsive plasmid (PRP) transfer system for genetic exchange that allows antimicrobial-resistance determina...

journal_title：PLoS pathogens

authors： Sterling AJ,Snelling WJ,Naughton PJ,Ternan NG,Dooley JSG

更新日期：2020-04-02 00:00:00

abstract：:Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycl...

journal_title：PLoS pathogens

authors： Zurnic I,Hütter S,Rzeha U,Stanke N,Reh J,Müllers E,Hamann MV,Kern T,Gerresheim GK,Lindel F,Serrao E,Lesbats P,Engelman AN,Cherepanov P,Lindemann D

更新日期：2016-08-31 00:00:00

abstract：:DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis showed an altered leuk...

journal_title：PLoS pathogens

authors： Szappanos D,Tschismarov R,Perlot T,Westermayer S,Fischer K,Platanitis E,Kallinger F,Novatchkova M,Lassnig C,Müller M,Sexl V,Bennett KL,Foong-Sobis M,Penninger JM,Decker T

更新日期：2018-11-26 00:00:00

abstract：:Trypanosoma cruzi is the most important parasitic infection in Latin America and is also genetically highly diverse, with at least six discrete typing units (DTUs) reported: Tc I, IIa, IIb, IIc, IId, and IIe. However, the current six-genotype classification is likely to be a poor reflection of the total genetic divers...

journal_title：PLoS pathogens

authors： Llewellyn MS,Miles MA,Carrasco HJ,Lewis MD,Yeo M,Vargas J,Torrico F,Diosque P,Valente V,Valente SA,Gaunt MW

更新日期：2009-05-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IκB kinases (IKKs) and NF-κB and promote cell survival; however, the key ubiquitinated factors downstream of Tax involved in cell transformation are unknown. Using mass spectrometry, we undertook an unbiased pr...

journal_title：PLoS pathogens

authors： Choi YB,Harhaj EW

更新日期：2014-10-23 00:00:00

abstract：:Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion during P. chabaudi infection is...

journal_title：PLoS pathogens

authors： Fontana MF,de Melo GL,Anidi C,Hamburger R,Kim CY,Lee SY,Pham J,Kim CC

更新日期：2016-12-06 00:00:00

abstract：:Clinical strains of HCMV encode 20 putative ORFs within a region of the genome termed ULb' that are postulated to encode functions related to persistence or immune evasion. We have previously identified ULb'-encoded pUL138 as necessary, but not sufficient, for HCMV latency in CD34+ hematopoietic progenitor cells (HPCs...

journal_title：PLoS pathogens

authors： Umashankar M,Petrucelli A,Cicchini L,Caposio P,Kreklywich CN,Rak M,Bughio F,Goldman DC,Hamlin KL,Nelson JA,Fleming WH,Streblow DN,Goodrum F

更新日期：2011-12-01 00:00:00

abstract：:Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was...

journal_title：PLoS pathogens

authors： Poppe M,Wittig S,Jurida L,Bartkuhn M,Wilhelm J,Müller H,Beuerlein K,Karl N,Bhuju S,Ziebuhr J,Schmitz ML,Kracht M

更新日期：2017-03-29 00:00:00

abstract：:Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have identified MV-infected keratinocytes and mononuclear cells in the ...

journal_title：PLoS pathogens

authors： Laksono BM,Fortugno P,Nijmeijer BM,de Vries RD,Cordisco S,Kuiken T,Geijtenbeek TBH,Duprex WP,Brancati F,de Swart RL

更新日期：2020-10-08 00:00:00

abstract：:Genetic exchange by recombination, or reassortment of genomic segments, has been shown to be an important process in RNA virus evolution, resulting often in important phenotypic changes affecting host range and virulence. However, data from numerous systems indicate that reassortant or recombinant genotypes could be s...

journal_title：PLoS pathogens

authors： Escriu F,Fraile A,García-Arenal F

更新日期：2007-01-01 00:00:00

abstract：:Phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation of bacterial populations to changing environments and is frequently important in bacterial virulence. Here we elucidate a novel phase variable mechanism for NadA, an adhesin and inv...

journal_title：PLoS pathogens

authors： Metruccio MM,Pigozzi E,Roncarati D,Berlanda Scorza F,Norais N,Hill SA,Scarlato V,Delany I

更新日期：2009-12-01 00:00:00

abstract：:Entamoeba histolytica transmembrane kinases (EhTMKs) can be grouped into six distinct families on the basis of motifs and sequences. Analysis of the E. histolytica genome revealed the presence of 35 EhTMKB1 members on the basis of sequence identity (>or=95%). Only six homologs were full length containing an extracellu...

journal_title：PLoS pathogens

authors： Shrimal S,Bhattacharya S,Bhattacharya A

更新日期：2010-06-03 00:00:00

abstract：:Populations of honey bees are declining throughout the world, with US beekeepers losing 30% of their colonies each winter. Though multiple factors are driving these colony losses, it is increasingly clear that viruses play a major role. However, information about the molecular mechanisms mediating antiviral immunity i...

journal_title：PLoS pathogens

authors： Galbraith DA,Yang X,Niño EL,Yi S,Grozinger C

更新日期：2015-03-26 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:The actions of the RIG-I like receptor (RLR) and type I interferon (IFN) signaling pathways are essential for a protective innate immune response against the emerging flavivirus West Nile virus (WNV). In mice lacking RLR or IFN signaling pathways, WNV exhibits enhanced tissue tropism, indicating that specific host fac...

journal_title：PLoS pathogens

authors： Suthar MS,Brassil MM,Blahnik G,McMillan A,Ramos HJ,Proll SC,Belisle SE,Katze MG,Gale M Jr

更新日期：2013-02-01 00:00:00

abstract：:Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of...

journal_title：PLoS pathogens

authors： Pont S,Fraikin N,Caspar Y,Van Melderen L,Attrée I,Cretin F

更新日期：2020-12-16 00:00:00

abstract：:The opportunistic human fungal pathogen, Candida albicans, undergoes morphological and transcriptional adaptation in the switch from commensalism to pathogenicity. Although previous gene-knockout studies have identified many factors involved in this transformation, it remains unclear how these factors are regulated to...

journal_title：PLoS pathogens

authors： Greig JA,Sudbery IM,Richardson JP,Naglik JR,Wang Y,Sudbery PE

更新日期：2015-01-24 00:00:00

abstract：:A key difference that distinguishes viral infections from protein immunizations is the recognition of viral nucleic acids by cytosolic pattern recognition receptors (PRRs). Insights into the functions of cytosolic PRRs such as the RNA-sensing Rig-I-like receptors (RLRs) in the instruction of adaptive immunity are ther...

journal_title：PLoS pathogens

authors： O'Ketch M,Williams S,Larson C,Uhrlaub JL,Wong R,Hall B,Deshpande NR,Schenten D

更新日期：2020-10-26 00:00:00

abstract：:As well as their importance to nutrition, fatty acids (FA) represent a unique group of quorum sensing chemicals that modulate the behavior of bacterial population in virulence. However, the way in which full-length, membrane-bound receptors biochemically detect FA remains unclear. Here, we provide genetic, enzymologic...

journal_title：PLoS pathogens

authors： Cai Z,Yuan ZH,Zhang H,Pan Y,Wu Y,Tian XQ,Wang FF,Wang L,Qian W

更新日期：2017-04-03 00:00:00

abstract：:Type I interferons (IFN) are important for antiviral responses. Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and mediate IFN production. Cytosolic 5'-ppp RNA and dsRNA are generated duri...

journal_title：PLoS pathogens

authors： Nikonov A,Mölder T,Sikut R,Kiiver K,Männik A,Toots U,Lulla A,Lulla V,Utt A,Merits A,Ustav M

更新日期：2013-01-01 00:00:00

abstract：:Exosomes are secreted cellular vesicles that can induce specific CD4(+) T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic a...

journal_title：PLoS pathogens

authors： Izquierdo-Useros N,Naranjo-Gómez M,Erkizia I,Puertas MC,Borràs FE,Blanco J,Martinez-Picado J

更新日期：2010-03-26 00:00:00

abstract：:Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (α/β hydrolase domain containing pro...

journal_title：PLoS pathogens

authors： Vieyres G,Welsch K,Gerold G,Gentzsch J,Kahl S,Vondran FW,Kaderali L,Pietschmann T

更新日期：2016-04-28 00:00:00

abstract：:Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to such obstacles, many viruses have developed the ability of establishing actin rich-membrane bridges to aid in future infections. Herein through dynamic imaging of...

journal_title：PLoS pathogens

authors： Aggarwal A,Iemma TL,Shih I,Newsome TP,McAllery S,Cunningham AL,Turville SG

更新日期：2012-01-01 00:00:00

abstract：:Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum. In this study, we have examined the effect of sub-inhibitory concentrations of human α-defen...

journal_title：PLoS pathogens

authors： Demirkhanyan L,Marin M,Lu W,Melikyan GB

更新日期：2013-01-01 00:00:00