Abstract:
:The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that serotonin, synthesized in Caenorhabditis elegans chemosensory neurons, modulates the immune response. Serotonin released from these cells acts, directly or indirectly, to regulate G-protein signaling in epithelial cells. Signaling in these cells is required for the immune response to infection by the natural pathogen Microbacterium nematophilum. Here we show that serotonin signaling suppresses the innate immune response and limits the rate of pathogen clearance. We show that C. elegans uses classical neurotransmitters to alter the immune response. Serotonin released from sensory neurons may function to modify the immune system in response to changes in the animal's external environment such as the availability, or quality, of food.
journal_name
PLoS Pathogjournal_title
PLoS pathogensauthors
Anderson A,Laurenson-Schafer H,Partridge FA,Hodgkin J,McMullan Rdoi
10.1371/journal.ppat.1003787subject
Has Abstractpub_date
2013-01-01 00:00:00pages
e1003787issue
12eissn
1553-7366issn
1553-7374pii
PPATHOGENS-D-13-01791journal_volume
9pub_type
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