Serotonergic chemosensory neurons modify the C. elegans immune response by regulating G-protein signaling in epithelial cells.

Abstract:

:The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that serotonin, synthesized in Caenorhabditis elegans chemosensory neurons, modulates the immune response. Serotonin released from these cells acts, directly or indirectly, to regulate G-protein signaling in epithelial cells. Signaling in these cells is required for the immune response to infection by the natural pathogen Microbacterium nematophilum. Here we show that serotonin signaling suppresses the innate immune response and limits the rate of pathogen clearance. We show that C. elegans uses classical neurotransmitters to alter the immune response. Serotonin released from sensory neurons may function to modify the immune system in response to changes in the animal's external environment such as the availability, or quality, of food.

journal_name

PLoS Pathog

journal_title

PLoS pathogens

authors

Anderson A,Laurenson-Schafer H,Partridge FA,Hodgkin J,McMullan R

doi

10.1371/journal.ppat.1003787

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

e1003787

issue

12

eissn

1553-7366

issn

1553-7374

pii

PPATHOGENS-D-13-01791

journal_volume

9

pub_type

杂志文章
  • Tissue maintenance of CMV-specific inflationary memory T cells by IL-15.

    abstract::Cytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary, that is characterised by accumulation and maintenance of high numbers of effector memory like cells in circulation and peripheral tissues-a feature being successfully harnessed for vaccine purposes. Although stability of this...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006993

    authors: Baumann NS,Torti N,Welten SPM,Barnstorf I,Borsa M,Pallmer K,Oduro JD,Cicin-Sain L,Ikuta K,Ludewig B,Oxenius A

    更新日期:2018-04-13 00:00:00

  • Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity.

    abstract::Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leishmania and related trypanosomatids, which lack catalase and selenium-glutathione peroxidases, the discovery of this family of enzymes provided the molecular basis for peroxide removal in these organisms. In this report ...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1002325

    authors: Castro H,Teixeira F,Romao S,Santos M,Cruz T,Flórido M,Appelberg R,Oliveira P,Ferreira-da-Silva F,Tomás AM

    更新日期:2011-10-01 00:00:00

  • AIG1 affects in vitro and in vivo virulence in clinical isolates of Entamoeba histolytica.

    abstract::The disease state of amebiasis, caused by Entamoeba histolytica, varies from asymptomatic to severe manifestations that include dysentery and extraintestinal abscesses. The virulence factors of the pathogen, and host defense mechanisms, contribute to the outcomes of infection; however, the underlying genetic factors, ...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006882

    authors: Nakada-Tsukui K,Sekizuka T,Sato-Ebine E,Escueta-de Cadiz A,Ji DD,Tomii K,Kuroda M,Nozaki T

    更新日期:2018-03-19 00:00:00

  • Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (ABC) transporter Rv1747 to regulate mycobacterial growth.

    abstract::We have previously shown that the Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth and may be required for the establishment of tuberculous persistence. Here, yeast two-hybrid and affinity chromatography experiments have demonstrated that Rv2623 interacts with one of the two fo...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006515

    authors: Glass LN,Swapna G,Chavadi SS,Tufariello JM,Mi K,Drumm JE,Lam TT,Zhu G,Zhan C,Vilchéze C,Arcos J,Chen Y,Bi L,Mehta S,Porcelli SA,Almo SC,Yeh SR,Jacobs WR Jr,Torrelles JB,Chan J

    更新日期:2017-07-28 00:00:00

  • NFAT5 regulates HIV-1 in primary monocytes via a highly conserved long terminal repeat site.

    abstract::To replicate, HIV-1 capitalizes on endogenous cellular activation pathways resulting in recruitment of key host transcription factors to its viral enhancer. RNA interference has been a powerful tool for blocking key checkpoints in HIV-1 entry into cells. Here we apply RNA interference to HIV-1 transcription in primary...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.0020130

    authors: Ranjbar S,Tsytsykova AV,Lee SK,Rajsbaum R,Falvo JV,Lieberman J,Shankar P,Goldfeld AE

    更新日期:2006-12-01 00:00:00

  • The HSV-1 exonuclease, UL12, stimulates recombination by a single strand annealing mechanism.

    abstract::Production of concatemeric DNA is an essential step during HSV infection, as the packaging machinery must recognize longer-than-unit-length concatemers; however, the mechanism by which they are formed is poorly understood. Although it has been proposed that the viral genome circularizes and rolling circle replication ...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1002862

    authors: Schumacher AJ,Mohni KN,Kan Y,Hendrickson EA,Stark JM,Weller SK

    更新日期:2012-01-01 00:00:00

  • The hallmarks of COVID-19 disease.

    abstract::Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety. Analysis of the genetic tree suggests that SARS-CoV-2 belongs to the same Betacoronavirus group a...

    journal_title:PLoS pathogens

    pub_type: 杂志文章,评审

    doi:10.1371/journal.ppat.1008536

    authors: Tang D,Comish P,Kang R

    更新日期:2020-05-22 00:00:00

  • Plant NLR immune receptor Tm-22 activation requires NB-ARC domain-mediated self-association of CC domain.

    abstract::The nucleotide-binding, leucine-rich repeat-containing (NLR) class of immune receptors of plants and animals recognize pathogen-encoded proteins and trigger host defenses. Although animal NLRs form oligomers upon pathogen recognition to activate downstream signaling, the mechanisms of plant NLR activation remain large...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1008475

    authors: Wang J,Chen T,Han M,Qian L,Li J,Wu M,Han T,Cao J,Nagalakshmi U,Rathjen JP,Hong Y,Liu Y

    更新日期:2020-04-27 00:00:00

  • Attaching and effacing (A/E) lesion formation by enteropathogenic E. coli on human intestinal mucosa is dependent on non-LEE effectors.

    abstract::Enteropathogenic E. coli (EPEC) is a human pathogen that causes acute and chronic pediatric diarrhea. The hallmark of EPEC infection is the formation of attaching and effacing (A/E) lesions in the intestinal epithelium. Formation of A/E lesions is mediated by genes located on the pathogenicity island locus of enterocy...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006706

    authors: Cepeda-Molero M,Berger CN,Walsham ADS,Ellis SJ,Wemyss-Holden S,Schüller S,Frankel G,Fernández LÁ

    更新日期:2017-10-30 00:00:00

  • Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).

    abstract::The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.We examine interactions between two critical modi...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1002184

    authors: Sakane N,Kwon HS,Pagans S,Kaehlcke K,Mizusawa Y,Kamada M,Lassen KG,Chan J,Greene WC,Schnoelzer M,Ott M

    更新日期:2011-08-01 00:00:00

  • Epigenetic silencing of host cell defense genes enhances intracellular survival of the rickettsial pathogen Anaplasma phagocytophilum.

    abstract::Intracellular bacteria have evolved mechanisms that promote survival within hostile host environments, often resulting in functional dysregulation and disease. Using the Anaplasma phagocytophilum-infected granulocyte model, we establish a link between host chromatin modifications, defense gene transcription and intrac...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1000488

    authors: Garcia-Garcia JC,Barat NC,Trembley SJ,Dumler JS

    更新日期:2009-06-01 00:00:00

  • Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure.

    abstract::Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and secreted as stable vir...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1007488

    authors: Heger-Stevic J,Zimmermann P,Lecoq L,Böttcher B,Nassal M

    更新日期:2018-12-19 00:00:00

  • RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication.

    abstract::Type I interferons (IFN) are important for antiviral responses. Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and mediate IFN production. Cytosolic 5'-ppp RNA and dsRNA are generated duri...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1003610

    authors: Nikonov A,Mölder T,Sikut R,Kiiver K,Männik A,Toots U,Lulla A,Lulla V,Utt A,Merits A,Ustav M

    更新日期:2013-01-01 00:00:00

  • Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.

    abstract::Interferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis; however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate the antiviral effect. A prominent family of ISGs is the interferon-induced with tetratricopeptide repeats (Ifit) genes comprising three mem...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1002712

    authors: Fensterl V,Wetzel JL,Ramachandran S,Ogino T,Stohlman SA,Bergmann CC,Diamond MS,Virgin HW,Sen GC

    更新日期:2012-01-01 00:00:00

  • Decreased HIV-specific T-regulatory responses are associated with effective DC-vaccine induced immunity.

    abstract::The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported that vaccination with ex vivo-generated dendritic-cells (DC) loaded with HIV-lipopeptides (LIPO-5-DC vaccine) in HIV-infected patients was well tolerated and highly immunogenic. These responses and their relation to vi...

    journal_title:PLoS pathogens

    pub_type: 杂志文章,多中心研究

    doi:10.1371/journal.ppat.1004752

    authors: Brezar V,Ruffin N,Richert L,Surenaud M,Lacabaratz C,Palucka K,Thiébaut R,Banchereau J,Levy Y,Seddiki N

    更新日期:2015-03-27 00:00:00

  • Autophagy pathway induced by a plant virus facilitates viral spread and transmission by its insect vector.

    abstract::Many viral pathogens are persistently transmitted by insect vectors and cause agricultural or health problems. Generally, an insect vector can use autophagy as an intrinsic antiviral defense mechanism against viral infection. Whether viruses can evolve to exploit autophagy to promote their transmission by insect vecto...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006727

    authors: Chen Y,Chen Q,Li M,Mao Q,Chen H,Wu W,Jia D,Wei T

    更新日期:2017-11-10 00:00:00

  • MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner.

    abstract::Mitochondrial antiviral-signaling protein (MAVS) transmits signals from RIG-I-like receptors after RNA virus infections. However, the mechanism by which MAVS activates downstream components, such as TBK1 and IKKα/β, is unclear, although previous work suggests the involvement of NEMO or TBK1-binding proteins TANK, NAP1...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006720

    authors: Fang R,Jiang Q,Zhou X,Wang C,Guan Y,Tao J,Xi J,Feng JM,Jiang Z

    更新日期:2017-11-10 00:00:00

  • Gene expression profiles of Chlamydophila pneumoniae during the developmental cycle and iron depletion-mediated persistence.

    abstract::The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. The latter stage has been linked to chronic diseases. To analyze Cpn C...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.0030083

    authors: Mäurer AP,Mehlitz A,Mollenkopf HJ,Meyer TF

    更新日期:2007-06-01 00:00:00

  • Genome-wide transcriptomics identifies an early preclinical signature of prion infection.

    abstract::The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inoculated mice....

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1008653

    authors: Sorce S,Nuvolone M,Russo G,Chincisan A,Heinzer D,Avar M,Pfammatter M,Schwarz P,Delic M,Müller M,Hornemann S,Sanoudou D,Scheckel C,Aguzzi A

    更新日期:2020-06-29 00:00:00

  • A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.

    abstract::The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A major cause for this lack in effectiveness has been attributed to the egg-based vaccine production process. Substitutions on the hemagglutinin glycoprotein (HA...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006682

    authors: Wu NC,Zost SJ,Thompson AJ,Oyen D,Nycholat CM,McBride R,Paulson JC,Hensley SE,Wilson IA

    更新日期:2017-10-23 00:00:00

  • Bidirectional introgressive hybridization between a cattle and human schistosome species.

    abstract::Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1000571

    authors: Huyse T,Webster BL,Geldof S,Stothard JR,Diaw OT,Polman K,Rollinson D

    更新日期:2009-09-01 00:00:00

  • RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides.

    abstract::The function of Toll pathway defense against bacterial infection has been well established in shrimp, however how this pathway responds to viral infection is still largely unknown. In this study, we report the Toll4-Dorsal-AMPs cascade restricts the white spot syndrome virus (WSSV) infection of shrimp. A total of nine...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1007109

    authors: Li H,Yin B,Wang S,Fu Q,Xiao B,Lǚ K,He J,Li C

    更新日期:2018-09-26 00:00:00

  • The novel Candida albicans transporter Dur31 Is a multi-stage pathogenicity factor.

    abstract::Candida albicans is the most frequent cause of oral fungal infections. However, the exact pathogenicity mechanisms that this fungus employs are largely unknown and many of the genes expressed during oral infection are uncharacterized. In this study we sought to functionally characterize 12 previously unknown function ...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1002592

    authors: Mayer FL,Wilson D,Jacobsen ID,Miramón P,Große K,Hube B

    更新日期:2012-01-01 00:00:00

  • Brucella modulates secretory trafficking via multiple type IV secretion effector proteins.

    abstract::The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1003556

    authors: Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

    更新日期:2013-01-01 00:00:00

  • The membrane fusion step of vaccinia virus entry is cooperatively mediated by multiple viral proteins and host cell components.

    abstract::For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate cell attachment and twelve that are associated in a membrane compl...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1002446

    authors: Laliberte JP,Weisberg AS,Moss B

    更新日期:2011-12-01 00:00:00

  • Pathogenicity of Mycobacterium tuberculosis is expressed by regulating metabolic thresholds of the host macrophage.

    abstract::The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this process, we asked whether adaptation also required interference with the metabolic machinery of the host cell. Temporal profiling of the metabolic flux, in cells ...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1004265

    authors: Mehrotra P,Jamwal SV,Saquib N,Sinha N,Siddiqui Z,Manivel V,Chatterjee S,Rao KV

    更新日期:2014-07-24 00:00:00

  • A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis.

    abstract::The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at residue 198 (T198F...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006178

    authors: Goo L,VanBlargan LA,Dowd KA,Diamond MS,Pierson TC

    更新日期:2017-02-16 00:00:00

  • The effect of immune selection on the structure of the meningococcal opa protein repertoire.

    abstract::The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles....

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1000020

    authors: Callaghan MJ,Buckee CO,Jolley KA,Kriz P,Maiden MC,Gupta S

    更新日期:2008-03-14 00:00:00

  • Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication.

    abstract::The ~9.5 kilobase HIV-1 genome contains RNA sequences and structures that control many aspects of viral replication, including transcription, splicing, nuclear export, translation, packaging and reverse transcription. Nonetheless, chemical probing and other approaches suggest that the HIV-1 genome may contain many mor...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006824

    authors: Takata MA,Soll SJ,Emery A,Blanco-Melo D,Swanstrom R,Bieniasz PD

    更新日期:2018-01-29 00:00:00

  • Yes, research matters.

    abstract::My father was diagnosed with stomach cancer recently. Luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. My father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. In ...

    journal_title:PLoS pathogens

    pub_type: 杂志文章

    doi:10.1371/journal.ppat.1006420

    authors: Shinohara ML

    更新日期:2017-08-10 00:00:00