14-3-3 scaffold proteins mediate the inactivation of trim25 and inhibition of the type I interferon response by herpesvirus deconjugases.

abstract：:Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense mechanism against the human pathogens Group A Streptococcus (GAS) and Group B Stre...

journal_title：PLoS pathogens

authors： van Hensbergen VP,Movert E,de Maat V,Lüchtenborg C,Le Breton Y,Lambeau G,Payré C,Henningham A,Nizet V,van Strijp JAG,Brügger B,Carlsson F,McIver KS,van Sorge NM

更新日期：2018-10-15 00:00:00

abstract：:Clostridium difficile is a global health burden and the leading cause of antibiotic-associated diarrhoea worldwide, causing severe gastrointestinal disease and death. Three well characterised toxins are encoded by this bacterium in two genetic loci, specifically, TcdB (toxin B) and TcdA (toxin A) in the Pathogenicity ...

journal_title：PLoS pathogens

authors： Lyon SA,Hutton ML,Rood JI,Cheung JK,Lyras D

更新日期：2016-07-14 00:00:00

abstract：:RNA interference (RNAi) pathways are widespread in metaozoans but the genes required show variable occurrence or activity in eukaryotic microbes, including many pathogens. While some Leishmania lack RNAi activity and Argonaute or Dicer genes, we show that Leishmania braziliensis and other species within the Leishmania...

journal_title：PLoS pathogens

authors： Lye LF,Owens K,Shi H,Murta SM,Vieira AC,Turco SJ,Tschudi C,Ullu E,Beverley SM

更新日期：2010-10-28 00:00:00

abstract：:Type VI secretion systems (T6SS) are trans-envelope machines dedicated to the secretion of virulence factors into eukaryotic or prokaryotic cells, therefore required for pathogenesis and/or for competition towards neighboring bacteria. The T6SS apparatus resembles the injection device of bacteriophage T4, and is ancho...

journal_title：PLoS pathogens

authors： Felisberto-Rodrigues C,Durand E,Aschtgen MS,Blangy S,Ortiz-Lombardia M,Douzi B,Cambillau C,Cascales E

更新日期：2011-11-01 00:00:00

abstract：:The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature is switched from 29°C at 37°...

journal_title：PLoS pathogens

authors： Lim XN,Shan C,Marzinek JK,Dong H,Ng TS,Ooi JSG,Fibriansah G,Wang J,Verma CS,Bond PJ,Shi PY,Lok SM

更新日期：2019-09-19 00:00:00

abstract：:Infectious complications are a common cause of morbidity and mortality in cancer patients undergoing chemotherapy due to increased risk of oral and gastrointestinal candidiasis, candidemia and septicemia. Interactions between C. albicans and endogenous mucosal bacteria are important in understanding the mechanisms of ...

journal_title：PLoS pathogens

authors： Bertolini M,Ranjan A,Thompson A,Diaz PI,Sobue T,Maas K,Dongari-Bagtzoglou A

更新日期：2019-04-22 00:00:00

abstract：:In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g. beta lactams) are incompletely understood, but the activities of enzymes that degrade the cell wall ('autolysins') are thought to be c...

journal_title：PLoS pathogens

authors： Dörr T,Davis BM,Waldor MK

更新日期：2015-04-17 00:00:00

abstract：:Staphylococcus aureus USA300 strains cause a highly inflammatory necrotizing pneumonia. The virulence of this strain has been attributed to its expression of multiple toxins that have diverse targets including ADAM10, NLRP3 and CD11b. We demonstrate that induction of necroptosis through RIP1/RIP3/MLKL signaling is a m...

journal_title：PLoS pathogens

authors： Kitur K,Parker D,Nieto P,Ahn DS,Cohen TS,Chung S,Wachtel S,Bueno S,Prince A

更新日期：2015-04-16 00:00:00

abstract：:Vaginal HIV transmission accounts for the majority of new infections worldwide. Currently, multiple efforts to prevent HIV transmission are based on pre-exposure prophylaxis with various antiretroviral drugs. Here, we describe two novel nanoformulations of the reverse transcriptase inhibitor rilpivirine for pericoital...

journal_title：PLoS pathogens

authors： Kovarova M,Council OD,Date AA,Long JM,Nochi T,Belshan M,Shibata A,Vincent H,Baker CE,Thayer WO,Kraus G,Lachaud-Durand S,Williams P,Destache CJ,Garcia JV

更新日期：2015-08-13 00:00:00

abstract：:Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, the relationships bet...

journal_title：PLoS pathogens

authors： Barber BE,William T,Grigg MJ,Parameswaran U,Piera KA,Price RN,Yeo TW,Anstey NM

更新日期：2015-01-08 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006750.]. ...

journal_title：PLoS pathogens

authors： Patterson Ross Z,Klunk J,Fornaciari G,Giuffra V,Duchêne S,Duggan AT,Poinar D,Douglas MW,Eden JS,Holmes EC,Poinar HN

更新日期：2018-02-09 00:00:00

abstract：:Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-micro...

journal_title：PLoS pathogens

authors： Tay HL,Kaiko GE,Plank M,Li J,Maltby S,Essilfie AT,Jarnicki A,Yang M,Mattes J,Hansbro PM,Foster PS

更新日期：2015-04-20 00:00:00

abstract：:Transcriptional regulatory networks are fundamental to how microbes alter gene expression in response to environmental stimuli, thereby playing a critical role in bacterial pathogenesis. However, understanding how bacterial transcriptional regulatory networks function during host-pathogen interaction is limited. Recen...

journal_title：PLoS pathogens

authors： Shelburne SA,Olsen RJ,Suber B,Sahasrabhojane P,Sumby P,Brennan RG,Musser JM

更新日期：2010-03-19 00:00:00

abstract：:Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity to interfere with th...

journal_title：PLoS pathogens

authors： Fleming P,Kvansakul M,Voigt V,Kile BT,Kluck RM,Huang DC,Degli-Esposti MA,Andoniou CE

更新日期：2013-02-01 00:00:00

abstract：:Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the cellular basis for this is poorly understood. Here, we investigated the effects of maternal Schistosoma mansoni infection on steady-state offspring immunity, as ...

journal_title：PLoS pathogens

authors： Cortés-Selva D,Gibbs L,Ready A,Ekiz HA,O'Connell R,Rajwa B,Fairfax KC

更新日期：2021-02-01 00:00:00

abstract：:Host heterogeneity in disease transmission is widespread but precisely how different host traits drive this heterogeneity remains poorly understood. Part of the difficulty in linking individual variation to population-scale outcomes is that individual hosts can differ on multiple behavioral, physiological and immunolo...

journal_title：PLoS pathogens

authors： Siva-Jothy JA,Vale PF

更新日期：2021-01-19 00:00:00

abstract：:Astroviruses (AstVs) are positive sense, single-stranded RNA viruses transmitted to a wide range of hosts via the fecal-oral route. The number of AstV-infected animal hosts has rapidly expanded in recent years with many more likely to be discovered because of the advances in viral surveillance and next generation sequ...

journal_title：PLoS pathogens

authors： Karlsson EA,Small CT,Freiden P,Feeroz MM,Matsen FA 4th,San S,Hasan MK,Wang D,Jones-Engel L,Schultz-Cherry S

更新日期：2015-11-16 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange fact...

journal_title：PLoS pathogens

authors： Fukazawa A,Alonso C,Kurachi K,Gupta S,Lesser CF,McCormick BA,Reinecker HC

更新日期：2008-11-01 00:00:00

abstract：:The shape and form of the flagellated eukaryotic parasite Leishmania is sculpted to its ecological niches and needs to be transmitted to each generation with great fidelity. The shape of the Leishmania cell is defined by the sub-pellicular microtubule array and the positioning of the nucleus, kinetoplast and the flage...

journal_title：PLoS pathogens

authors： Halliday C,Yanase R,Catta-Preta CMC,Moreira-Leite F,Myskova J,Pruzinova K,Volf P,Mottram JC,Sunter JD

更新日期：2020-10-22 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

journal_title：PLoS pathogens

authors： Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

更新日期：2013-01-01 00:00:00

abstract：:Our skin is our first line of defense against environmental and pathogenic challenges. It is densely populated by a flora of bacteria, fungi, and viruses that normally interact with each other and with our immune system to promote skin health and homeostasis. Staphylococcus epidermidis is one of the most abundant bact...

journal_title：PLoS pathogens

authors： Brown MM,Horswill AR

更新日期：2020-11-12 00:00:00

abstract：:The intestine is a common site for invasion by intracellular pathogens, but little is known about how pathogens restructure and exit intestinal cells in vivo. The natural microsporidian parasite N. parisii invades intestinal cells of the nematode C. elegans, progresses through its life cycle, and then exits cells in a...

journal_title：PLoS pathogens

authors： Estes KA,Szumowski SC,Troemel ER

更新日期：2011-09-01 00:00:00

abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

journal_title：PLoS pathogens

authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

更新日期：2020-04-30 00:00:00

abstract：:Hendra and Nipah viruses (family Paramyxoviridae, genus Henipavirus) are bat-borne viruses that cause fatal disease in humans and a range of other mammalian species. Gaining a deeper understanding of host pathways exploited by henipaviruses for infection may identify targets for new anti-viral therapies. Here we have ...

journal_title：PLoS pathogens

authors： Foo CH,Rootes CL,Cowley K,Marsh GA,Gould CM,Deffrasnes C,Cowled CJ,Klein R,Riddell SJ,Middleton D,Simpson KJ,Wang LF,Bean AG,Stewart CR

更新日期：2016-10-26 00:00:00

abstract：:One of the hallmarks of adaptive immunity is the development of a long-term pathogen specific memory response. While persistent memory T cells certainly impact the immune response during a secondary challenge, their role in unrelated infections is less clear. To address this issue, we utilized lymphocytic choriomening...

journal_title：PLoS pathogens

authors： Crosby EJ,Goldschmidt MH,Wherry EJ,Scott P

更新日期：2014-02-27 00:00:00

abstract：:Exposure to Plasmodium falciparum is associated with circulating "atypical" memory B cells (atMBCs), which appear similar to dysfunctional B cells found in HIV-infected individuals. Functional analysis of atMBCs has been limited, with one report suggesting these cells are not dysfunctional but produce protective antib...

journal_title：PLoS pathogens

authors： Sullivan RT,Kim CC,Fontana MF,Feeney ME,Jagannathan P,Boyle MJ,Drakeley CJ,Ssewanyana I,Nankya F,Mayanja-Kizza H,Dorsey G,Greenhouse B

更新日期：2015-05-19 00:00:00

abstract：:RNA polyadenylation (pA) is one of the major steps in regulation of gene expression at the posttranscriptional level. In this report, a genome landscape of pA sites of viral transcripts in B lymphocytes with Kaposi sarcoma-associated herpesvirus (KSHV) infection was constructed using a modified PA-seq strategy. We ide...

journal_title：PLoS pathogens

authors： Majerciak V,Ni T,Yang W,Meng B,Zhu J,Zheng ZM

更新日期：2013-01-01 00:00:00

abstract：:Bovine tuberculosis (bTB) is a chronic disease of cattle caused by Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex group of bacteria. Vaccination of cattle might offer a long-term solution for controlling the disease and priority has been given to the development of a cattle vaccine against bTB...

journal_title：PLoS pathogens

authors： Bhuju S,Aranday-Cortes E,Villarreal-Ramos B,Xing Z,Singh M,Vordermeier HM

更新日期：2012-12-01 00:00:00