Structural analysis of HIV-1 maturation using cryo-electron tomography.

abstract：:Glycolysis is a metabolic pathway that is central to the assimilation of carbon for either respiration or fermentation and therefore is critical for the growth of all organisms. Consequently, glycolytic transcriptional regulation is important for the metabolic flexibility of pathogens in their attempts to colonize div...

journal_title：PLoS pathogens

authors： Askew C,Sellam A,Epp E,Hogues H,Mullick A,Nantel A,Whiteway M

更新日期：2009-10-01 00:00:00

abstract：:The shape and form of the flagellated eukaryotic parasite Leishmania is sculpted to its ecological niches and needs to be transmitted to each generation with great fidelity. The shape of the Leishmania cell is defined by the sub-pellicular microtubule array and the positioning of the nucleus, kinetoplast and the flage...

journal_title：PLoS pathogens

authors： Halliday C,Yanase R,Catta-Preta CMC,Moreira-Leite F,Myskova J,Pruzinova K,Volf P,Mottram JC,Sunter JD

更新日期：2020-10-22 00:00:00

abstract：:Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [P...

journal_title：PLoS pathogens

authors： Sáez-Cirión A,Bacchus C,Hocqueloux L,Avettand-Fenoel V,Girault I,Lecuroux C,Potard V,Versmisse P,Melard A,Prazuck T,Descours B,Guergnon J,Viard JP,Boufassa F,Lambotte O,Goujard C,Meyer L,Costagliola D,Venet A,Pancin

更新日期：2013-03-01 00:00:00

abstract：:Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Given that RTA is a transcri...

journal_title：PLoS pathogens

authors： Wei X,Bai L,Dong L,Liu H,Xing P,Zhou Z,Wu S,Lan K

更新日期：2019-11-21 00:00:00

abstract：:Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon pr...

journal_title：PLoS pathogens

authors： Assil S,Futsch N,Décembre E,Alais S,Gessain A,Cosset FL,Mahieux R,Dreux M,Dutartre H

更新日期：2019-02-28 00:00:00

abstract：:The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-time as the infection progresses within an organ of a live host. Here w...

journal_title：PLoS pathogens

authors： Melican K,Sandoval RM,Kader A,Josefsson L,Tanner GA,Molitoris BA,Richter-Dahlfors A

更新日期：2011-02-01 00:00:00

abstract：:The matrix (M) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. We have solved the structures of M from the vesicular stomatitis virus serotype New Jersey (genus: Vesiculovirus) and from Lagos bat virus (genu...

journal_title：PLoS pathogens

authors： Graham SC,Assenberg R,Delmas O,Verma A,Gholami A,Talbi C,Owens RJ,Stuart DI,Grimes JM,Bourhy H

更新日期：2008-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use. Alternative antiviral strategies may include inhibition of entry. We show that soluble derivatives of th...

journal_title：PLoS pathogens

authors： Stegmann C,Hochdorfer D,Lieber D,Subramanian N,Stöhr D,Laib Sampaio K,Sinzger C

更新日期：2017-04-12 00:00:00

abstract：:Kaposi's sarcoma (KS) lesions are complex mixtures of KS-associated herpesvirus (KSHV)-infected spindle and inflammatory cells. In order to survive the host immune responses, KSHV encodes a number of immunomodulatory proteins, including the E3 ubiquitin ligase K5. In exploring the role of this viral protein in monocyt...

journal_title：PLoS pathogens

authors： Karki R,Lang SM,Means RE

更新日期：2011-04-01 00:00:00

abstract：:Poliomyelitis has nearly been eradicated through the efforts of the World Health Organization's Global Eradication Initiative raising questions on containment of the virus after it has been eliminated in the wild. Most manufacture of inactivated polio vaccines currently requires the growth of large amounts of highly v...

journal_title：PLoS pathogens

authors： Knowlson S,Burlison J,Giles E,Fox H,Macadam AJ,Minor PD

更新日期：2015-12-31 00:00:00

abstract：:Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding. Curiously, the matrix proteins of a few paramyxoviruses have been found in the nucleus, although the biological function associat...

journal_title：PLoS pathogens

authors： Wang YE,Park A,Lake M,Pentecost M,Torres B,Yun TE,Wolf MC,Holbrook MR,Freiberg AN,Lee B

更新日期：2010-11-11 00:00:00

abstract：:Interferon Regulatory Factor 8 (IRF8) is required for development, maturation and expression of anti-microbial defenses of myeloid cells. BXH2 mice harbor a severely hypomorphic allele at Irf8 (Irf8(R294C)) that causes susceptibility to infection with intracellular pathogens including Mycobacterium tuberculosis. We re...

journal_title：PLoS pathogens

authors： Berghout J,Langlais D,Radovanovic I,Tam M,MacMicking JD,Stevenson MM,Gros P

更新日期：2013-01-01 00:00:00

abstract：:The wide utilization of biocides poses a concern on the impact of these compounds on natural bacterial populations. Furthermore, it has been demonstrated that biocides can select, at least in laboratory experiments, antibiotic resistant bacteria. This situation has raised concerns, not just on scientists and clinician...

journal_title：PLoS pathogens

authors： Hernández A,Ruiz FM,Romero A,Martínez JL

更新日期：2011-06-01 00:00:00

abstract：:Since mucosal surfaces may be simultaneously colonized by multiple species, the success of an organism may be determined by its ability to compete with co-inhabitants of its niche. To explore the contribution of host factors to polymicrobial competition, a murine model was used to study the initiation of colonization ...

journal_title：PLoS pathogens

authors： Lysenko ES,Ratner AJ,Nelson AL,Weiser JN

更新日期：2005-09-01 00:00:00

abstract：:Kaposi's sarcoma (KS), caused by Kaposi's sarcoma herpesvirus (KSHV), is a highly vascularised tumour of endothelial origin. KSHV infected endothelial cells show increased invasiveness and angiogenesis. Here, we report that the KSHV K15 protein, which we showed previously to contribute to KSHV-induced angiogenesis, is...

journal_title：PLoS pathogens

authors： Gramolelli S,Weidner-Glunde M,Abere B,Viejo-Borbolla A,Bala K,Rückert J,Kremmer E,Schulz TF

更新日期：2015-08-21 00:00:00

abstract：:Viral infections of central nervous system (CNS) often trigger inflammatory responses that give rise to a wide range of pathological outcomes. The CNS is equipped with an elaborate network of innate immune sentinels (e.g. microglia, macrophages, dendritic cells) that routinely serve as first responders to these infect...

journal_title：PLoS pathogens

authors： Nayak D,Johnson KR,Heydari S,Roth TL,Zinselmeyer BH,McGavern DB

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005822.]. ...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-30 00:00:00

abstract：:Exosomes can transfer genetic materials between cells. Their roles in viral infections are beginning to be appreciated. Researches have shown that exosomes released from virus-infected cells contain a variety of viral and host cellular factors that are able to modulate recipient's cellular response and result in produ...

journal_title：PLoS pathogens

authors： Fu Y,Zhang L,Zhang F,Tang T,Zhou Q,Feng C,Jin Y,Wu Z

更新日期：2017-09-14 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1004331.]. ...

journal_title：PLoS pathogens

authors： PLOS Pathogens Staff.

更新日期：2015-02-19 00:00:00

abstract：:IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response DNA sensor and induces the IL-1β and antiviral type-1 interferon-β (IFN-β) cytokines. We have shown that IFI16, in association with BRCA1, functions as a se...

journal_title：PLoS pathogens

authors： Iqbal J,Ansari MA,Kumar B,Dutta D,Roy A,Chikoti L,Pisano G,Dutta S,Vahedi S,Veettil MV,Chandran B

更新日期：2016-10-20 00:00:00

abstract：:Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses, particularly of the herpesvirus family, have been shown to express their own miRNAs to control both viral a...

journal_title：PLoS pathogens

authors： Dölken L,Krmpotic A,Kothe S,Tuddenham L,Tanguy M,Marcinowski L,Ruzsics Z,Elefant N,Altuvia Y,Margalit H,Koszinowski UH,Jonjic S,Pfeffer S

更新日期：2010-10-14 00:00:00

abstract：:Intracellular bacteria have evolved mechanisms that promote survival within hostile host environments, often resulting in functional dysregulation and disease. Using the Anaplasma phagocytophilum-infected granulocyte model, we establish a link between host chromatin modifications, defense gene transcription and intrac...

journal_title：PLoS pathogens

authors： Garcia-Garcia JC,Barat NC,Trembley SJ,Dumler JS

更新日期：2009-06-01 00:00:00

abstract：:The microbiome and the phage meta-genome within the human gut are influenced by antibiotic treatments. Identifying a novel mechanism, here we demonstrate that bacteria use the universal communication molecule AI-2 to induce virulence genes and transfer them via phage release. High concentrations (i.e. 100 μM) of AI-2 ...

journal_title：PLoS pathogens

authors： Rossmann FS,Racek T,Wobser D,Puchalka J,Rabener EM,Reiger M,Hendrickx AP,Diederich AK,Jung K,Klein C,Huebner J

更新日期：2015-02-23 00:00:00

abstract：:The recent emergence of a novel H7N9 influenza A virus (IAV) causing severe human infections in China raises concerns about a possible pandemic. The lack of pre-existing neutralizing antibodies in the broader population highlights the potential protective role of IAV-specific CD8(+) cytotoxic T lymphocyte (CTL) memory...

journal_title：PLoS pathogens

authors： Duan S,Meliopoulos VA,McClaren JL,Guo XZ,Sanders CJ,Smallwood HS,Webby RJ,Schultz-Cherry SL,Doherty PC,Thomas PG

更新日期：2015-02-10 00:00:00

abstract：:Infection of the vascular system by Pseudomonas aeruginosa (Pa) occurs during bacterial dissemination in the body or in blood-borne infections. Type 3 secretion system (T3SS) toxins from Pa induce a massive retraction when injected into endothelial cells. Here, we addressed the role of type 2 secretion system (T2SS) e...

journal_title：PLoS pathogens

authors： Golovkine G,Faudry E,Bouillot S,Voulhoux R,Attrée I,Huber P

更新日期：2014-03-13 00:00:00

abstract：:Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env)...

journal_title：PLoS pathogens

authors： Del Prete GQ,Keele BF,Fode J,Thummar K,Swanstrom AE,Rodriguez A,Raymond A,Estes JD,LaBranche CC,Montefiori DC,KewalRamani VN,Lifson JD,Bieniasz PD,Hatziioannou T

更新日期：2017-09-25 00:00:00

abstract：:Mycobacterium leprae, an obligate intracellular bacillus, infects Schwann cells (SCs), leading to peripheral nerve damage, the most severe leprosy symptom. In the present study, we revisited the involvement of phenolic glycolipid I (PGL I), an abundant, private, surface M. leprae molecule, in M. leprae-SC interaction ...

journal_title：PLoS pathogens

authors： Díaz Acosta CC,Dias AA,Rosa TLSA,Batista-Silva LR,Rosa PS,Toledo-Pinto TG,Costa FDMR,Lara FA,Rodrigues LS,Mattos KA,Sarno EN,Bozza PT,Guilhot C,de Berrêdo-Pinho M,Pessolani MCV

更新日期：2018-07-06 00:00:00

abstract：:The disease state of amebiasis, caused by Entamoeba histolytica, varies from asymptomatic to severe manifestations that include dysentery and extraintestinal abscesses. The virulence factors of the pathogen, and host defense mechanisms, contribute to the outcomes of infection; however, the underlying genetic factors, ...

journal_title：PLoS pathogens

authors： Nakada-Tsukui K,Sekizuka T,Sato-Ebine E,Escueta-de Cadiz A,Ji DD,Tomii K,Kuroda M,Nozaki T

更新日期：2018-03-19 00:00:00

abstract：:Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobino...

journal_title：PLoS pathogens

authors： Taylor SM,Cerami C,Fairhurst RM

更新日期：2013-01-01 00:00:00

abstract：:Kaposi's sarcoma (KS), an enigmatic endothelial cell vascular neoplasm, is characterized by the proliferation of spindle shaped endothelial cells, inflammatory cytokines (ICs), growth factors (GFs) and angiogenic factors. KSHV is etiologically linked to KS and expresses its latent genes in KS lesion endothelial cells....

journal_title：PLoS pathogens

authors： Sharma-Walia N,Paul AG,Bottero V,Sadagopan S,Veettil MV,Kerur N,Chandran B

更新日期：2010-02-12 00:00:00