Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.

abstract：:Genetic exchange by recombination, or reassortment of genomic segments, has been shown to be an important process in RNA virus evolution, resulting often in important phenotypic changes affecting host range and virulence. However, data from numerous systems indicate that reassortant or recombinant genotypes could be s...

journal_title：PLoS pathogens

authors： Escriu F,Fraile A,García-Arenal F

更新日期：2007-01-01 00:00:00

abstract：:Trypanosoma cruzi is the most important parasitic infection in Latin America and is also genetically highly diverse, with at least six discrete typing units (DTUs) reported: Tc I, IIa, IIb, IIc, IId, and IIe. However, the current six-genotype classification is likely to be a poor reflection of the total genetic divers...

journal_title：PLoS pathogens

authors： Llewellyn MS,Miles MA,Carrasco HJ,Lewis MD,Yeo M,Vargas J,Torrico F,Diosque P,Valente V,Valente SA,Gaunt MW

更新日期：2009-05-01 00:00:00

abstract：:Whereas the majority of pathogenic Salmonella serovars are capable of infecting many different animal species, typically producing a self-limited gastroenteritis, serovars with narrow host-specificity exhibit increased virulence and their infections frequently result in fatal systemic diseases. In our study, a genetic...

journal_title：PLoS pathogens

authors： Kisiela DI,Chattopadhyay S,Libby SJ,Karlinsey JE,Fang FC,Tchesnokova V,Kramer JJ,Beskhlebnaya V,Samadpour M,Grzymajlo K,Ugorski M,Lankau EW,Mackie RI,Clegg S,Sokurenko EV

更新日期：2012-01-01 00:00:00

abstract：:Exposure to Plasmodium falciparum is associated with circulating "atypical" memory B cells (atMBCs), which appear similar to dysfunctional B cells found in HIV-infected individuals. Functional analysis of atMBCs has been limited, with one report suggesting these cells are not dysfunctional but produce protective antib...

journal_title：PLoS pathogens

authors： Sullivan RT,Kim CC,Fontana MF,Feeney ME,Jagannathan P,Boyle MJ,Drakeley CJ,Ssewanyana I,Nankya F,Mayanja-Kizza H,Dorsey G,Greenhouse B

更新日期：2015-05-19 00:00:00

abstract：:The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inoculated mice....

journal_title：PLoS pathogens

authors： Sorce S,Nuvolone M,Russo G,Chincisan A,Heinzer D,Avar M,Pfammatter M,Schwarz P,Delic M,Müller M,Hornemann S,Sanoudou D,Scheckel C,Aguzzi A

更新日期：2020-06-29 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. And the bacterial su...

journal_title：PLoS pathogens

authors： Tyler JS,Beeri K,Reynolds JL,Alteri CJ,Skinner KG,Friedman JH,Eaton KA,Friedman DI

更新日期：2013-03-01 00:00:00

abstract：:Poxviruses subvert the host immune response by producing immunomodulatory proteins, including a complement regulatory protein. Ectromelia virus provides a mouse model for smallpox where the virus and the host's immune response have co-evolved. Using this model, our study investigated the role of the complement system ...

journal_title：PLoS pathogens

authors： Moulton EA,Atkinson JP,Buller RM

更新日期：2008-12-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) arise from retroviruses chromosomally integrated in the host germline. ERVs are common in vertebrate genomes and provide a valuable fossil record of past retroviral infections to investigate the biology and evolution of retroviruses over a deep time scale, including cross-species transmi...

journal_title：PLoS pathogens

authors： Zhuo X,Feschotte C

更新日期：2015-11-12 00:00:00

abstract：:Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutio...

journal_title：PLoS pathogens

authors： Deeg CM,Zimmer MM,George EE,Husnik F,Keeling PJ,Suttle CA

更新日期：2019-05-31 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) vGPCR is a constitutively active G protein-coupled receptor that subverts proliferative and inflammatory signaling pathways to induce cell transformation in Kaposi's sarcoma. Cyclooxygenase-2 (COX-2) is an inflammatory mediator that plays a key regulatory role in the acti...

journal_title：PLoS pathogens

authors： Medina MV,D Agostino A,Ma Q,Eroles P,Cavallin L,Chiozzini C,Sapochnik D,Cymeryng C,Hyjek E,Cesarman E,Naipauer J,Mesri EA,Coso OA

更新日期：2020-10-15 00:00:00

abstract：:The ~9.5 kilobase HIV-1 genome contains RNA sequences and structures that control many aspects of viral replication, including transcription, splicing, nuclear export, translation, packaging and reverse transcription. Nonetheless, chemical probing and other approaches suggest that the HIV-1 genome may contain many mor...

journal_title：PLoS pathogens

authors： Takata MA,Soll SJ,Emery A,Blanco-Melo D,Swanstrom R,Bieniasz PD

更新日期：2018-01-29 00:00:00

abstract：:Modern agriculture favours the selection and spread of novel plant diseases. Furthermore, crop genetic resistance against pathogens is often rendered ineffective within a few years of its commercial deployment. Leptosphaeria maculans, the cause of phoma stem canker of oilseed rape, develops gene-for-gene interactions ...

journal_title：PLoS pathogens

authors： Daverdin G,Rouxel T,Gout L,Aubertot JN,Fudal I,Meyer M,Parlange F,Carpezat J,Balesdent MH

更新日期：2012-01-01 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:Sensing of viral RNA by RIG-I-like receptors initiates innate antiviral response, which is mediated by the central adaptor VISA. How the RIG-I-VISA-mediated antiviral response is terminated at the late phase of infection is enigmatic. Here we identified the protein kinase A catalytic (PKAC) subunits α and β as negativ...

journal_title：PLoS pathogens

authors： Yan BR,Zhou L,Hu MM,Li M,Lin H,Yang Y,Wang YY,Shu HB

更新日期：2017-09-21 00:00:00

abstract：:Influenza A virus (IAV) infection can be severe or even lethal in toddlers, the elderly and patients with certain medical conditions. Infection of apparently healthy individuals nonetheless accounts for many severe disease cases and deaths, suggesting that viruses with increased pathogenicity co-circulate with pandemi...

journal_title：PLoS pathogens

authors： Vasilijevic J,Zamarreño N,Oliveros JC,Rodriguez-Frandsen A,Gómez G,Rodriguez G,Pérez-Ruiz M,Rey S,Barba I,Pozo F,Casas I,Nieto A,Falcón A

更新日期：2017-10-12 00:00:00

abstract：:We have previously shown that the Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth and may be required for the establishment of tuberculous persistence. Here, yeast two-hybrid and affinity chromatography experiments have demonstrated that Rv2623 interacts with one of the two fo...

journal_title：PLoS pathogens

authors： Glass LN,Swapna G,Chavadi SS,Tufariello JM,Mi K,Drumm JE,Lam TT,Zhu G,Zhan C,Vilchéze C,Arcos J,Chen Y,Bi L,Mehta S,Porcelli SA,Almo SC,Yeh SR,Jacobs WR Jr,Torrelles JB,Chan J

更新日期：2017-07-28 00:00:00

abstract：:The picornaviruses coxsackievirus A24 variant (CVA24v) and enterovirus 70 (EV70) cause continued outbreaks and pandemics of acute hemorrhagic conjunctivitis (AHC), a highly contagious eye disease against which neither vaccines nor antiviral drugs are currently available. Moreover, these viruses can cause symptoms in t...

journal_title：PLoS pathogens

authors： Zocher G,Mistry N,Frank M,Hähnlein-Schick I,Ekström JO,Arnberg N,Stehle T

更新日期：2014-10-16 00:00:00

abstract：:Yersinia utilizes a sophisticated type III secretion system to enhance its chances of survival and to overcome the host immune system. SmpB (small protein B) and SsrA (small stable RNA A) are components of a unique bacterial translational control system that help maintain the bacterial translational machinery in a ful...

journal_title：PLoS pathogens

authors： Okan NA,Bliska JB,Karzai AW

更新日期：2006-01-01 00:00:00

abstract：:The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A major cause for this lack in effectiveness has been attributed to the egg-based vaccine production process. Substitutions on the hemagglutinin glycoprotein (HA...

journal_title：PLoS pathogens

authors： Wu NC,Zost SJ,Thompson AJ,Oyen D,Nycholat CM,McBride R,Paulson JC,Hensley SE,Wilson IA

更新日期：2017-10-23 00:00:00

abstract：:Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and th...

journal_title：PLoS pathogens

authors： Denic M,Turlin E,Michel V,Fischer F,Khorasani-Motlagh M,Zamble D,Vinella D,de Reuse H

更新日期：2021-01-14 00:00:00

abstract：:HIV-1 uses a number of means to manipulate the immune system, to avoid recognition and to highjack signaling pathways. HIV-1 infected cells show limited Toll-Like Receptor (TLR) responsiveness via as yet unknown mechanisms. Using biochemical and biophysical approaches, we demonstrate that the trans-membrane domain (TM...

journal_title：PLoS pathogens

authors： Reuven EM,Ali M,Rotem E,Schwarzer R,Gramatica A,Futerman AH,Shai Y

更新日期：2014-08-14 00:00:00

abstract：:HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection in blood and SIV i...

journal_title：PLoS pathogens

authors： Chew GM,Fujita T,Webb GM,Burwitz BJ,Wu HL,Reed JS,Hammond KB,Clayton KL,Ishii N,Abdel-Mohsen M,Liegler T,Mitchell BI,Hecht FM,Ostrowski M,Shikuma CM,Hansen SG,Maurer M,Korman AJ,Deeks SG,Sacha JB,Ndhlovu LC

更新日期：2016-01-07 00:00:00

abstract：:Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 and MASP-2, the two key activator proteases of the complement lec...

journal_title：PLoS pathogens

authors： Nagy ZA,Szakács D,Boros E,Héja D,Vígh E,Sándor N,Józsi M,Oroszlán G,Dobó J,Gál P,Pál G

更新日期：2019-12-20 00:00:00

abstract：:Respiratory virus infections, such as influenza, typically induce a robust type I (pro-inflammatory cytokine) immune response, however, the production of type 2 cytokines has been observed. Type 2 cytokine production during respiratory virus infection is linked to asthma exacerbation; however, type 2 cytokines may als...

journal_title：PLoS pathogens

authors： Gorski SA,Hahn YS,Braciale TJ

更新日期：2013-09-01 00:00:00

abstract：:The emergence of ceftriaxone-resistant strains of Neisseria gonorrhoeae may herald an era of untreatable gonorrhea. Vaccines against this infection are urgently needed. The 2C7 epitope is a conserved oligosaccharide (OS) structure, a part of lipooligosaccharide (LOS) on N gonorrhoeae. The epitope is expressed by 94% o...

journal_title：PLoS pathogens

authors： Gulati S,Zheng B,Reed GW,Su X,Cox AD,St Michael F,Stupak J,Lewis LA,Ram S,Rice PA

更新日期：2013-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most virulent enteroviruses, but the specific molecular features that enhance its ability to disseminate in humans remain unknown. We analyzed the genomic features of EV71 in an immunocompromised host with disseminated disease according to the different sites of infection. Compariso...

journal_title：PLoS pathogens

authors： Cordey S,Petty TJ,Schibler M,Martinez Y,Gerlach D,van Belle S,Turin L,Zdobnov E,Kaiser L,Tapparel C

更新日期：2012-01-01 00:00:00

abstract：:The human parvovirus Adeno-Associated Virus (AAV) type 2 can only replicate in cells co-infected with a helper virus, such as Adenovirus or Herpes Simplex Virus type 1 (HSV-1); whereas, in the absence of a helper virus, it establishes a latent infection. Previous studies demonstrated that the ternary HSV-1 helicase/pr...

journal_title：PLoS pathogens

authors： Alazard-Dany N,Nicolas A,Ploquin A,Strasser R,Greco A,Epstein AL,Fraefel C,Salvetti A

更新日期：2009-03-01 00:00:00

abstract：:The bank vole is a rodent susceptible to different prion strains from humans and various animal species. We analyzed the transmission features of different prions in a panel of seven rodent species which showed various degrees of phylogenetic affinity and specific prion protein (PrP) sequence divergences in order to i...

journal_title：PLoS pathogens

authors： Agrimi U,Nonno R,Dell'Omo G,Di Bari MA,Conte M,Chiappini B,Esposito E,Di Guardo G,Windl O,Vaccari G,Lipp HP

更新日期：2008-07-25 00:00:00

abstract：:The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypic cell-based assay enabling individual sub-cellular analysis of over ...

journal_title：PLoS pathogens

authors： Brodin P,Poquet Y,Levillain F,Peguillet I,Larrouy-Maumus G,Gilleron M,Ewann F,Christophe T,Fenistein D,Jang J,Jang MS,Park SJ,Rauzier J,Carralot JP,Shrimpton R,Genovesio A,Gonzalo-Asensio JA,Puzo G,Martin C,Brosch R

更新日期：2010-09-09 00:00:00

abstract：:Trichothecenes are a family of terpenoid toxins produced by multiple genera of fungi, including plant and insect pathogens. Some trichothecenes produced by the fungus Fusarium are among the mycotoxins of greatest concern to food and feed safety because of their toxicity and frequent occurrence in cereal crops, and tri...

journal_title：PLoS pathogens

authors： Proctor RH,McCormick SP,Kim HS,Cardoza RE,Stanley AM,Lindo L,Kelly A,Brown DW,Lee T,Vaughan MM,Alexander NJ,Busman M,Gutiérrez S

更新日期：2018-04-12 00:00:00