Prophage induction is enhanced and required for renal disease and lethality in an EHEC mouse model.

abstract：:Phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation of bacterial populations to changing environments and is frequently important in bacterial virulence. Here we elucidate a novel phase variable mechanism for NadA, an adhesin and inv...

journal_title：PLoS pathogens

authors： Metruccio MM,Pigozzi E,Roncarati D,Berlanda Scorza F,Norais N,Hill SA,Scarlato V,Delany I

更新日期：2009-12-01 00:00:00

abstract：:Eradication of tuberculosis (TB), the world's leading cause of death due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to pe...

journal_title：PLoS pathogens

authors： Rodo MJ,Rozot V,Nemes E,Dintwe O,Hatherill M,Little F,Scriba TJ

更新日期：2019-03-04 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing relationship to disease onset is unknown. We developed two novel mo...

journal_title：PLoS pathogens

authors： Small CL,Xing L,McPhee JB,Law HT,Coombes BK

更新日期：2016-10-06 00:00:00

abstract：:HIV-1 assembly and release are believed to occur at the plasma membrane in most host cells with the exception of primary macrophages, for which exclusive budding at late endosomes has been reported. Here, we applied a novel ultrastructural approach to assess HIV-1 budding in primary macrophages in an immunomarker-inde...

journal_title：PLoS pathogens

authors： Welsch S,Keppler OT,Habermann A,Allespach I,Krijnse-Locker J,Kräusslich HG

更新日期：2007-03-01 00:00:00

abstract：:Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode...

journal_title：PLoS pathogens

authors： Luallen RJ,Reinke AW,Tong L,Botts MR,Félix MA,Troemel ER

更新日期：2016-06-30 00:00:00

abstract：:Tissue samples from Australian carpet pythons (Morelia spilota) with neurological disease were screened for viruses using next-generation sequencing. Coding complete genomes of two bornaviruses were identified with the gene order 3'-N-X-P-G-M-L, representing a transposition of the G and M genes compared to other borna...

journal_title：PLoS pathogens

authors： Hyndman TH,Shilton CM,Stenglein MD,Wellehan JFX Jr

更新日期：2018-02-20 00:00:00

abstract：:We have previously shown that the Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth and may be required for the establishment of tuberculous persistence. Here, yeast two-hybrid and affinity chromatography experiments have demonstrated that Rv2623 interacts with one of the two fo...

journal_title：PLoS pathogens

authors： Glass LN,Swapna G,Chavadi SS,Tufariello JM,Mi K,Drumm JE,Lam TT,Zhu G,Zhan C,Vilchéze C,Arcos J,Chen Y,Bi L,Mehta S,Porcelli SA,Almo SC,Yeh SR,Jacobs WR Jr,Torrelles JB,Chan J

更新日期：2017-07-28 00:00:00

abstract：:The host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae ("inflammation-inflicted bloo...

journal_title：PLoS pathogens

authors： Nedialkova LP,Denzler R,Koeppel MB,Diehl M,Ring D,Wille T,Gerlach RG,Stecher B

更新日期：2014-01-01 00:00:00

abstract：:The Pneumococcal serine-rich repeat protein (PsrP) is a pathogenicity island encoded adhesin that has been positively correlated with the ability of Streptococcus pneumoniae to cause invasive disease. Previous studies have shown that PsrP mediates bacterial attachment to Keratin 10 (K10) on the surface of lung cells t...

journal_title：PLoS pathogens

authors： Sanchez CJ,Shivshankar P,Stol K,Trakhtenbroit S,Sullam PM,Sauer K,Hermans PW,Orihuela CJ

更新日期：2010-08-12 00:00:00

abstract：:In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability modulates virulence factor production and biofilm formation by other ba...

journal_title：PLoS pathogens

authors： Szelestey BR,Heimlich DR,Raffel FK,Justice SS,Mason KM

更新日期：2013-01-01 00:00:00

abstract：:Neisseria gonorrhoeae causes the sexually-transmitted infection gonorrhea, a global disease that is difficult to treat and for which there is no vaccine. This pathogen employs an arsenal of conserved outer membrane proteins called TonB-dependent transporters (TdTs) that allow the gonococcus to overcome nutritional imm...

journal_title：PLoS pathogens

authors： Maurakis S,Keller K,Maxwell CN,Pereira K,Chazin WJ,Criss AK,Cornelissen CN

更新日期：2019-08-01 00:00:00

abstract：:Hepatitis B virus (HBV) capsids are found in many forms: immature single-stranded RNA-filled cores, single-stranded DNA-filled replication intermediates, mature cores with relaxed circular double-stranded DNA, and empty capsids. A capsid, the protein shell of the core, is a complex of 240 copies of core protein. Matur...

journal_title：PLoS pathogens

authors： Chen C,Wang JC,Pierson EE,Keifer DZ,Delaleau M,Gallucci L,Cazenave C,Kann M,Jarrold MF,Zlotnick A

更新日期：2016-08-12 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:The survival and persistence of Mycobacterium tuberculosis depends on its capacity to manipulate multiple host defense pathways, including the ability to actively inhibit the death by apoptosis of infected host cells. The genetic basis for this anti-apoptotic activity and its implication for mycobacterial virulence ha...

journal_title：PLoS pathogens

authors： Velmurugan K,Chen B,Miller JL,Azogue S,Gurses S,Hsu T,Glickman M,Jacobs WR Jr,Porcelli SA,Briken V

更新日期：2007-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) suppress the transcriptional and post-transcriptional expression of genes in plants. Several miRNA families target genes encoding nucleotide-binding site-leucine-rich repeat (NB-LRR) plant innate immune receptors. The fungus Fusarium oxysporum f. sp. lycopersici causes vascular wilt disease in tomat...

journal_title：PLoS pathogens

authors： Ouyang S,Park G,Atamian HS,Han CS,Stajich JE,Kaloshian I,Borkovich KA

更新日期：2014-10-16 00:00:00

abstract：:Many thousands of endoparasitic wasp species are known to inject polydnavirus (PDV) particles into their caterpillar host during oviposition, causing immune and developmental dysfunctions that benefit the wasp larva. PDVs associated with braconid and ichneumonid wasps, bracoviruses and ichnoviruses respectively, both ...

journal_title：PLoS pathogens

authors： Volkoff AN,Jouan V,Urbach S,Samain S,Bergoin M,Wincker P,Demettre E,Cousserans F,Provost B,Coulibaly F,Legeai F,Béliveau C,Cusson M,Gyapay G,Drezen JM

更新日期：2010-05-27 00:00:00

abstract：:The ability of pathogens to escape the host's immune response is crucial for the establishment of persistent infections and can influence virulence. Recombination has been observed to contribute to this process by generating novel genetic variants. Although distinctive recombination patterns have been described in man...

journal_title：PLoS pathogens

authors： Simon-Loriere E,Galetto R,Hamoudi M,Archer J,Lefeuvre P,Martin DP,Robertson DL,Negroni M

更新日期：2009-05-01 00:00:00

abstract：:The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5), sense cytoplasmic viral RNA and initiate innate antiviral responses. How RIG-I and MDA5 are differentially regulated remains enigmatic. In this study, we identified the guanylate-bin...

journal_title：PLoS pathogens

authors： Zhong X,Feng L,Zang R,Lei CQ,Yang Q,Shu HB

更新日期：2020-04-06 00:00:00

abstract：:DNA methylation is a fundamental epigenetic modification that regulates gene expression and represses endogenous transposons and invading DNA viruses. As a counter-defense, the geminiviruses encode proteins that inhibit methylation and transcriptional gene silencing (TGS). Some geminiviruses have acquired a betasatell...

journal_title：PLoS pathogens

authors： Yang X,Xie Y,Raja P,Li S,Wolf JN,Shen Q,Bisaro DM,Zhou X

更新日期：2011-10-01 00:00:00

abstract：:Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infecte...

journal_title：PLoS pathogens

authors： Favre D,Lederer S,Kanwar B,Ma ZM,Proll S,Kasakow Z,Mold J,Swainson L,Barbour JD,Baskin CR,Palermo R,Pandrea I,Miller CJ,Katze MG,McCune JM

更新日期：2009-02-01 00:00:00

abstract：:Monepantel is a member of the recently identified class of anthelmintics known as the amino-acetonitrile derivatives (AADs). Monepantel controls all major gastro-intestinal nematodes in sheep including those that are resistant to the classical anthelmintics. Previous studies have shown that the Caenorhabditis elegans ...

journal_title：PLoS pathogens

authors： Rufener L,Bedoni N,Baur R,Rey S,Glauser DA,Bouvier J,Beech R,Sigel E,Puoti A

更新日期：2013-01-01 00:00:00

abstract：:The Ras-GAP SH3 domain-binding proteins (G3BP) are essential regulators of the formation of stress granules (SG), cytosolic aggregates of proteins and RNA that are induced upon cellular stress, such as virus infection. Many viruses, including Semliki Forest virus (SFV), block SG induction by targeting G3BP. In this wo...

journal_title：PLoS pathogens

authors： Panas MD,Schulte T,Thaa B,Sandalova T,Kedersha N,Achour A,McInerney GM

更新日期：2015-02-06 00:00:00

abstract：:Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense mechanism against the human pathogens Group A Streptococcus (GAS) and Group B Stre...

journal_title：PLoS pathogens

authors： van Hensbergen VP,Movert E,de Maat V,Lüchtenborg C,Le Breton Y,Lambeau G,Payré C,Henningham A,Nizet V,van Strijp JAG,Brügger B,Carlsson F,McIver KS,van Sorge NM

更新日期：2018-10-15 00:00:00

abstract：:Salmonella spp. are Gram-negative enteropathogenic bacteria that infect a variety of vertebrate hosts. Like any other living organism, protein secretion is a fundamental process essential for various aspects of Salmonella biology. Herein we report the identification and characterization of a horizontally acquired, aut...

journal_title：PLoS pathogens

authors： Gal-Mor O,Gibson DL,Baluta D,Vallance BA,Finlay BB

更新日期：2008-04-04 00:00:00

abstract：:Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new effective vaccines and in the appropriate use of antimalarial drugs. By performing a full-genome s...

journal_title：PLoS pathogens

authors： Kidgell C,Volkman SK,Daily J,Borevitz JO,Plouffe D,Zhou Y,Johnson JR,Le Roch K,Sarr O,Ndir O,Mboup S,Batalov S,Wirth DF,Winzeler EA

更新日期：2006-06-01 00:00:00

abstract：:Our appreciation for the extent of Epstein Barr virus (EBV) transcriptome complexity continues to grow through findings of EBV encoded microRNAs, new long non-coding RNAs as well as the more recent discovery of over a hundred new polyadenylated lytic transcripts. Here we report an additional layer to the EBV transcrip...

journal_title：PLoS pathogens

authors： Ungerleider N,Concha M,Lin Z,Roberts C,Wang X,Cao S,Baddoo M,Moss WN,Yu Y,Seddon M,Lehman T,Tibbetts S,Renne R,Dong Y,Flemington EK

更新日期：2018-08-06 00:00:00

abstract：:There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown. By using the rice-rice dwarf virus (RDV) model system, here we report that...

journal_title：PLoS pathogens

authors： Qin Q,Li G,Jin L,Huang Y,Wang Y,Wei C,Xu Z,Yang Z,Wang H,Li Y

更新日期：2020-12-02 00:00:00

abstract：:Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome formation. Nascent autophagosomes were found commonly associated w...

journal_title：PLoS pathogens

authors： Williams RA,Smith TK,Cull B,Mottram JC,Coombs GH

更新日期：2012-01-01 00:00:00

abstract：:Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HE...

journal_title：PLoS pathogens

authors： Uchil PD,Quinlan BD,Chan WT,Luna JM,Mothes W

更新日期：2008-02-08 00:00:00

abstract：:Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange fact...

journal_title：PLoS pathogens

authors： Fukazawa A,Alonso C,Kurachi K,Gupta S,Lesser CF,McCormick BA,Reinecker HC

更新日期：2008-11-01 00:00:00