Discovery of a Natural Microsporidian Pathogen with a Broad Tissue Tropism in Caenorhabditis elegans.

abstract：:The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH. Vaccines containing recombinant fHbp or native outer membrane vesicles (NOMV...

journal_title：PLoS pathogens

authors： Beernink PT,Shaughnessy J,Pajon R,Braga EM,Ram S,Granoff DM

更新日期：2012-01-01 00:00:00

abstract：:HIV Nef acts as an anti-autophagic maturation factor through interaction with beclin-1 (BECN1). We report that exposure of macrophages to infectious or non-infectious purified HIV induces toll-like receptor 8 (TLR8) and BECN1 dependent dephosphorylation and nuclear translocation of TFEB and that this correlates with a...

journal_title：PLoS pathogens

authors： Campbell GR,Rawat P,Bruckman RS,Spector SA

更新日期：2015-06-26 00:00:00

abstract：:The microbiome and the phage meta-genome within the human gut are influenced by antibiotic treatments. Identifying a novel mechanism, here we demonstrate that bacteria use the universal communication molecule AI-2 to induce virulence genes and transfer them via phage release. High concentrations (i.e. 100 μM) of AI-2 ...

journal_title：PLoS pathogens

authors： Rossmann FS,Racek T,Wobser D,Puchalka J,Rabener EM,Reiger M,Hendrickx AP,Diederich AK,Jung K,Klein C,Huebner J

更新日期：2015-02-23 00:00:00

abstract：:Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have identified MV-infected keratinocytes and mononuclear cells in the ...

journal_title：PLoS pathogens

authors： Laksono BM,Fortugno P,Nijmeijer BM,de Vries RD,Cordisco S,Kuiken T,Geijtenbeek TBH,Duprex WP,Brancati F,de Swart RL

更新日期：2020-10-08 00:00:00

abstract：:Influenza A virus (IAV) infection can be severe or even lethal in toddlers, the elderly and patients with certain medical conditions. Infection of apparently healthy individuals nonetheless accounts for many severe disease cases and deaths, suggesting that viruses with increased pathogenicity co-circulate with pandemi...

journal_title：PLoS pathogens

authors： Vasilijevic J,Zamarreño N,Oliveros JC,Rodriguez-Frandsen A,Gómez G,Rodriguez G,Pérez-Ruiz M,Rey S,Barba I,Pozo F,Casas I,Nieto A,Falcón A

更新日期：2017-10-12 00:00:00

abstract：:Bovine tuberculosis (bTB) is a chronic disease of cattle caused by Mycobacterium bovis, a member of the Mycobacterium tuberculosis complex group of bacteria. Vaccination of cattle might offer a long-term solution for controlling the disease and priority has been given to the development of a cattle vaccine against bTB...

journal_title：PLoS pathogens

authors： Bhuju S,Aranday-Cortes E,Villarreal-Ramos B,Xing Z,Singh M,Vordermeier HM

更新日期：2012-12-01 00:00:00

abstract：:The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrPSc replicates by converting the non-infectious, cellular prion protei...

journal_title：PLoS pathogens

authors： Vázquez-Fernández E,Vos MR,Afanasyev P,Cebey L,Sevillano AM,Vidal E,Rosa I,Renault L,Ramos A,Peters PJ,Fernández JJ,van Heel M,Young HS,Requena JR,Wille H

更新日期：2016-09-08 00:00:00

abstract：:It is poorly understood how progressive brain swelling in experimental cerebral malaria (ECM) evolves in space and over time, and whether mechanisms of inflammation or microvascular sequestration/obstruction dominate the underlying pathophysiology. We therefore monitored in the Plasmodium berghei ANKA-C57BL/6 murine E...

journal_title：PLoS pathogens

authors： Hoffmann A,Pfeil J,Alfonso J,Kurz FT,Sahm F,Heiland S,Monyer H,Bendszus M,Mueller AK,Helluy X,Pham M

更新日期：2016-03-10 00:00:00

abstract：:Anthrax poses a community health risk due to accidental or intentional aerosol release. Reliable quantitative dose-response analyses are required to estimate the magnitude and timeline of potential consequences and the effect of public health intervention strategies under specific scenarios. Analyses of available data...

journal_title：PLoS pathogens

authors： Toth DJ,Gundlapalli AV,Schell WA,Bulmahn K,Walton TE,Woods CW,Coghill C,Gallegos F,Samore MH,Adler FR

更新日期：2013-08-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed structural and functional studies using the human neutralizing antibod...

journal_title：PLoS pathogens

authors： Harshbarger W,Tian S,Wahome N,Balsaraf A,Bhattacharya D,Jiang D,Pandey R,Tungare K,Friedrich K,Mehzabeen N,Biancucci M,Chinchilla-Olszar D,Mallett CP,Huang Y,Wang Z,Bottomley MJ,Malito E,Chandramouli S

更新日期：2020-11-02 00:00:00

abstract：:This Pearl article recounts the story of a US corporation, Lennar, the nation's leading homebuilder, an essential function in the US (not allowed to lock down), when faced with the coronavirus disease 2019 (COVID-19) pandemic at the end of February 2020. The culture of the company, which allowed it to proceed safely, ...

journal_title：PLoS pathogens

authors： Goldschmidt-Clermont PJ

更新日期：2020-08-27 00:00:00

abstract：:Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-bo...

journal_title：PLoS pathogens

authors： Schmidt ME,Knudson CJ,Hartwig SM,Pewe LL,Meyerholz DK,Langlois RA,Harty JT,Varga SM

更新日期：2018-01-02 00:00:00

abstract：:Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both innate and adaptive immune responses. In the present study, we demonstrate that nucleotide-binding oligomerization domain 2 (NOD2)...

journal_title：PLoS pathogens

authors： Ferwerda G,Girardin SE,Kullberg BJ,Le Bourhis L,de Jong DJ,Langenberg DM,van Crevel R,Adema GJ,Ottenhoff TH,Van der Meer JW,Netea MG

更新日期：2005-11-01 00:00:00

abstract：:Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. However, reduced susceptibility to antibiotics-even below this breakpoint-is associated with poor treatment outcomes in the clinic, including in tub...

journal_title：PLoS pathogens

authors： Hicks ND,Giffen SR,Culviner PH,Chao MC,Dulberger CL,Liu Q,Stanley S,Brown J,Sixsmith J,Wolf ID,Fortune SM

更新日期：2020-11-30 00:00:00

abstract：:Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed with a variety of functions, including the uptake and clearance of blood and lymph-borne pathogens, little is known about the effector mechanisms they employ aft...

journal_title：PLoS pathogens

authors： Phillips R,Svensson M,Aziz N,Maroof A,Brown N,Beattie L,Signoret N,Kaye PM

更新日期：2010-03-12 00:00:00

abstract：:The intestine is a common site for invasion by intracellular pathogens, but little is known about how pathogens restructure and exit intestinal cells in vivo. The natural microsporidian parasite N. parisii invades intestinal cells of the nematode C. elegans, progresses through its life cycle, and then exits cells in a...

journal_title：PLoS pathogens

authors： Estes KA,Szumowski SC,Troemel ER

更新日期：2011-09-01 00:00:00

abstract：:Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates. Postmortem samples from the characteristic purpuric rashes of the infection show bacterial aggreg...

journal_title：PLoS pathogens

authors： Melican K,Michea Veloso P,Martin T,Bruneval P,Duménil G

更新日期：2013-01-01 00:00:00

abstract：:To ensure their survival, microbial pathogens have evolved diverse strategies to subvert host immune defenses. The human retrovirus HIV-1 has been proposed to hijack the natural endocytic function of dendritic cells (DCs) to infect interacting CD4 T cells in a process termed trans-infection. Although DCs can be direct...

journal_title：PLoS pathogens

authors： Cavrois M,Neidleman J,Greene WC

更新日期：2008-06-27 00:00:00

abstract：:The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in ...

journal_title：PLoS pathogens

authors： Gullberg E,Cao S,Berg OG,Ilbäck C,Sandegren L,Hughes D,Andersson DI

更新日期：2011-07-01 00:00:00

abstract：:Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HE...

journal_title：PLoS pathogens

authors： Uchil PD,Quinlan BD,Chan WT,Luna JM,Mothes W

更新日期：2008-02-08 00:00:00

abstract：:In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital infection. The guinea pig is the only small animal model for congenit...

journal_title：PLoS pathogens

authors： Coleman S,Choi KY,Root M,McGregor A

更新日期：2016-07-07 00:00:00

abstract：:RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism. Although some virus-encoded RNA helicases/chaperones have been predicted or identified, their RNA remodeling a...

journal_title：PLoS pathogens

authors： Xia H,Wang P,Wang GC,Yang J,Sun X,Wu W,Qiu Y,Shu T,Zhao X,Yin L,Qin CF,Hu Y,Zhou X

更新日期：2015-07-28 00:00:00

abstract：:The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A major cause for this lack in effectiveness has been attributed to the egg-based vaccine production process. Substitutions on the hemagglutinin glycoprotein (HA...

journal_title：PLoS pathogens

authors： Wu NC,Zost SJ,Thompson AJ,Oyen D,Nycholat CM,McBride R,Paulson JC,Hensley SE,Wilson IA

更新日期：2017-10-23 00:00:00

abstract：:Giardia intestinalis is a major cause of diarrheal disease worldwide and two major Giardia genotypes, assemblages A and B, infect humans. The genome of assemblage A parasite WB was recently sequenced, and the structurally compact 11.7 Mbp genome contains simplified basic cellular machineries and metabolism. We here pe...

journal_title：PLoS pathogens

authors： Franzén O,Jerlström-Hultqvist J,Castro E,Sherwood E,Ankarklev J,Reiner DS,Palm D,Andersson JO,Andersson B,Svärd SG

更新日期：2009-08-01 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease in humans, is exposed to reactive oxygen and nitrogen species (ROS and RNS) in both the tick vector and vertebrate reservoir hosts. B. burgdorferi contains a limited repertoire of canonical oxidative stress response genes, suggesting that novel gene functions m...

journal_title：PLoS pathogens

authors： Ramsey ME,Hyde JA,Medina-Perez DN,Lin T,Gao L,Lundt ME,Li X,Norris SJ,Skare JT,Hu LT

更新日期：2017-02-17 00:00:00

abstract：:Populations of honey bees are declining throughout the world, with US beekeepers losing 30% of their colonies each winter. Though multiple factors are driving these colony losses, it is increasingly clear that viruses play a major role. However, information about the molecular mechanisms mediating antiviral immunity i...

journal_title：PLoS pathogens

authors： Galbraith DA,Yang X,Niño EL,Yi S,Grozinger C

更新日期：2015-03-26 00:00:00

abstract：:The opportunistic human fungal pathogen, Candida albicans, undergoes morphological and transcriptional adaptation in the switch from commensalism to pathogenicity. Although previous gene-knockout studies have identified many factors involved in this transformation, it remains unclear how these factors are regulated to...

journal_title：PLoS pathogens

authors： Greig JA,Sudbery IM,Richardson JP,Naglik JR,Wang Y,Sudbery PE

更新日期：2015-01-24 00:00:00

abstract：:Ingested Vibrio cholerae pass through the stomach and colonize the small intestines of its host. Here, we show that V. cholerae requires at least two types of DNA repair systems to efficiently compete for colonization of the infant mouse intestine. These results show that V. cholerae experiences increased DNA damage i...

journal_title：PLoS pathogens

authors： Davies BW,Bogard RW,Dupes NM,Gerstenfeld TA,Simmons LA,Mekalanos JJ

更新日期：2011-02-01 00:00:00

abstract：:The factors determining the functional avidity and its relationship with the broad heterogeneity of antiviral T cell responses remain partially understood. We investigated HIV-specific CD8 T cell responses in 85 patients with primary HIV infection (PHI) or chronic (progressive and non-progressive) infection. The funct...

journal_title：PLoS pathogens

authors： Viganò S,Bellutti Enders F,Miconnet I,Cellerai C,Savoye AL,Rozot V,Perreau M,Faouzi M,Ohmiti K,Cavassini M,Bart PA,Pantaleo G,Harari A

更新日期：2013-01-01 00:00:00

abstract：:The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify the ancestry of titan c...

journal_title：PLoS pathogens

authors： Hommel B,Mukaremera L,Cordero RJB,Coelho C,Desjardins CA,Sturny-Leclère A,Janbon G,Perfect JR,Fraser JA,Casadevall A,Cuomo CA,Dromer F,Nielsen K,Alanio A

更新日期：2018-05-18 00:00:00