A Role for the SmpB-SsrA system in Yersinia pseudotuberculosis pathogenesis.

abstract：:T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms regulating HIV-1 transcription in lymph nodes (LNs) remain unclear. In...

journal_title：PLoS pathogens

authors： Banga R,Rebecchini C,Procopio FA,Noto A,Munoz O,Ioannidou K,Fenwick C,Ohmiti K,Cavassini M,Corpataux JM,de Leval L,Pantaleo G,Perreau M

更新日期：2019-07-22 00:00:00

abstract：:Plant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a...

journal_title：PLoS pathogens

authors： Warnock ND,Wilson L,Patten C,Fleming CC,Maule AG,Dalzell JJ

更新日期：2017-02-27 00:00:00

abstract：:The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify the ancestry of titan c...

journal_title：PLoS pathogens

authors： Hommel B,Mukaremera L,Cordero RJB,Coelho C,Desjardins CA,Sturny-Leclère A,Janbon G,Perfect JR,Fraser JA,Casadevall A,Cuomo CA,Dromer F,Nielsen K,Alanio A

更新日期：2018-05-18 00:00:00

abstract：:In order to complete their life cycle, papillomaviruses have evolved to manipulate a plethora of cellular pathways. The products of the human Alphapapillomavirus E6 proteins specifically interact with and target PDZ containing proteins for degradation. This viral phenotype has been suggested to play a role in viral on...

journal_title：PLoS pathogens

authors： Van Doorslaer K,DeSalle R,Einstein MH,Burk RD

更新日期：2015-06-18 00:00:00

abstract：:We performed a quantitative analysis of the HLA restriction, antigen and epitope specificity of human pathogen specific responses in healthy individuals infected with M. tuberculosis (Mtb), in a South African cohort as a test case. The results estimate the breadth of T cell responses for the first time in the context ...

journal_title：PLoS pathogens

authors： Lindestam Arlehamn CS,McKinney DM,Carpenter C,Paul S,Rozot V,Makgotlho E,Gregg Y,van Rooyen M,Ernst JD,Hatherill M,Hanekom WA,Peters B,Scriba TJ,Sette A

更新日期：2016-07-13 00:00:00

abstract：:Hepatitis B virus infection (HBV) is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA) that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein HBx ...

journal_title：PLoS pathogens

authors： Ducroux A,Benhenda S,Rivière L,Semmes OJ,Benkirane M,Neuveut C

更新日期：2014-09-11 00:00:00

abstract：:My father was diagnosed with stomach cancer recently. Luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. My father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. In ...

journal_title：PLoS pathogens

authors： Shinohara ML

更新日期：2017-08-10 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety. Analysis of the genetic tree suggests that SARS-CoV-2 belongs to the same Betacoronavirus group a...

journal_title：PLoS pathogens

authors： Tang D,Comish P,Kang R

更新日期：2020-05-22 00:00:00

abstract：:Interferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis; however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate the antiviral effect. A prominent family of ISGs is the interferon-induced with tetratricopeptide repeats (Ifit) genes comprising three mem...

journal_title：PLoS pathogens

authors： Fensterl V,Wetzel JL,Ramachandran S,Ogino T,Stohlman SA,Bergmann CC,Diamond MS,Virgin HW,Sen GC

更新日期：2012-01-01 00:00:00

abstract：:Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk and severe constraints to livestock health and economic development. The complete genome sequence was undertaken to facilitate vaccine antigen discovery, and to allow for comparative analysis with the related apicomplexan hemop...

journal_title：PLoS pathogens

authors： Brayton KA,Lau AO,Herndon DR,Hannick L,Kappmeyer LS,Berens SJ,Bidwell SL,Brown WC,Crabtree J,Fadrosh D,Feldblum T,Forberger HA,Haas BJ,Howell JM,Khouri H,Koo H,Mann DJ,Norimine J,Paulsen IT,Radune D,Ren Q,Smith

更新日期：2007-10-19 00:00:00

abstract：:CD4(+) T cell loss is central to HIV pathogenesis. In the initial weeks post-infection, the great majority of dying cells are uninfected CD4(+) T cells. We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD...

journal_title：PLoS pathogens

authors： Fausther-Bovendo H,Vieillard V,Sagan S,Bismuth G,Debré P

更新日期：2010-07-01 00:00:00

abstract：:Pathogenic hantaviruses, genus Orthohantaviridae, are maintained in rodent reservoirs with zoonotic transmission to humans occurring through inhalation of rodent excreta. Hantavirus disease in humans is characterized by localized vascular leakage and elevated levels of circulating proinflammatory cytokines. Despite th...

journal_title：PLoS pathogens

authors： Kell AM,Hemann EA,Turnbull JB,Gale M Jr

更新日期：2020-04-24 00:00:00

abstract：:The unfolded protein response (UPR) in the endoplasmic reticulum (ER) constitutes a critical component of host innate immunity against microbial infections. In this report, we show that porcine reproductive and respiratory syndrome virus (PRRSV) utilizes the UPR machinery for its own benefit. We provide evidence that ...

journal_title：PLoS pathogens

authors： Gao P,Chai Y,Song J,Liu T,Chen P,Zhou L,Ge X,Guo X,Han J,Yang H

更新日期：2019-11-18 00:00:00

abstract：:Ebolaviruses, highly lethal zoonotic pathogens, possess longer genomes than most other non-segmented negative-strand RNA viruses due in part to long 5' and 3' untranslated regions (UTRs) present in the seven viral transcriptional units. To date, specific functions have not been assigned to these UTRs. With reporter as...

journal_title：PLoS pathogens

authors： Shabman RS,Hoenen T,Groseth A,Jabado O,Binning JM,Amarasinghe GK,Feldmann H,Basler CF

更新日期：2013-01-01 00:00:00

abstract：:Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone marrow. HSCs become activated in response to stress, such as acute infections, which adapt the bone marrow output to the needs of the immune response. However, the impact of infection-adapted HSC activation and differentia...

journal_title：PLoS pathogens

authors： Abidin BM,Hammami A,Stäger S,Heinonen KM

更新日期：2017-08-07 00:00:00

abstract：:The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence i...

journal_title：PLoS pathogens

authors： Chung D,Barker BM,Carey CC,Merriman B,Werner ER,Lechner BE,Dhingra S,Cheng C,Xu W,Blosser SJ,Morohashi K,Mazurie A,Mitchell TK,Haas H,Mitchell AP,Cramer RA

更新日期：2014-11-06 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong in the host. In ∼4% of infected people, HTLV-1 causes a chronic disabling neuroinflammatory disease known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is unknown and treatment remain...

journal_title：PLoS pathogens

authors： Tattermusch S,Skinner JA,Chaussabel D,Banchereau J,Berry MP,McNab FW,O'Garra A,Taylor GP,Bangham CR

更新日期：2012-01-01 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) causes lifelong infection affecting between 50 and 90% of the global population. In addition to causing dermal lesions, HSV-1 is a leading cause of blindness resulting from recurrent corneal infection. Corneal disease is characterized by loss of corneal immunologic privilege and extensiv...

journal_title：PLoS pathogens

authors： Wuest T,Zheng M,Efstathiou S,Halford WP,Carr DJ

更新日期：2011-10-01 00:00:00

abstract：:In plants, innate immune responses are initiated by plasma membrane-located pattern recognition receptors (PRRs) upon recognition of elicitors, including exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs). Arabidopsis thaliana produces more than 1000 se...

journal_title：PLoS pathogens

authors： Hou S,Wang X,Chen D,Yang X,Wang M,Turrà D,Di Pietro A,Zhang W

更新日期：2014-09-04 00:00:00

abstract：:The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however, little is known about its relationship to early disease progression. To better understand the relationship between the lung microbiome and early respiratory disease, we characterized the lower airways microbiome using bronchoalv...

journal_title：PLoS pathogens

authors： Muhlebach MS,Zorn BT,Esther CR,Hatch JE,Murray CP,Turkovic L,Ranganathan SC,Boucher RC,Stick SM,Wolfgang MC

更新日期：2018-01-18 00:00:00

abstract：:A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the expression of surf...

journal_title：PLoS pathogens

authors： Ogbechi J,Ruf MT,Hall BS,Bodman-Smith K,Vogel M,Wu HL,Stainer A,Esmon CT,Ahnström J,Pluschke G,Simmonds RE

更新日期：2015-07-16 00:00:00

abstract：:To further its pathogenesis, S. Typhimurium delivers effector proteins into host cells, including the novel E3 ubiquitin ligase (NEL) effector SspH2. Using model systems in a cross-kingdom approach we gained further insight into the molecular function of this effector. Here, we show that SspH2 modulates innate immunit...

journal_title：PLoS pathogens

authors： Bhavsar AP,Brown NF,Stoepel J,Wiermer M,Martin DD,Hsu KJ,Imami K,Ross CJ,Hayden MR,Foster LJ,Li X,Hieter P,Finlay BB

更新日期：2013-01-01 00:00:00

abstract：:DNA methylation is a fundamental epigenetic modification that regulates gene expression and represses endogenous transposons and invading DNA viruses. As a counter-defense, the geminiviruses encode proteins that inhibit methylation and transcriptional gene silencing (TGS). Some geminiviruses have acquired a betasatell...

journal_title：PLoS pathogens

authors： Yang X,Xie Y,Raja P,Li S,Wolf JN,Shen Q,Bisaro DM,Zhou X

更新日期：2011-10-01 00:00:00

abstract：:The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature is switched from 29°C at 37°...

journal_title：PLoS pathogens

authors： Lim XN,Shan C,Marzinek JK,Dong H,Ng TS,Ooi JSG,Fibriansah G,Wang J,Verma CS,Bond PJ,Shi PY,Lok SM

更新日期：2019-09-19 00:00:00

abstract：:The process by which drug-resistant HIV-1 arises and spreads spatially within an infected individual is poorly understood. Studies have found variable results relating how HIV-1 in the blood differs from virus sampled in tissues, offering conflicting findings about whether HIV-1 throughout the body is homogeneously di...

journal_title：PLoS pathogens

authors： Feder AF,Kline C,Polacino P,Cottrell M,Kashuba ADM,Keele BF,Hu SL,Petrov DA,Pennings PS,Ambrose Z

更新日期：2017-05-25 00:00:00

abstract：:Equine rhinitis A virus (ERAV) is closely related to foot-and-mouth disease virus (FMDV), belonging to the genus Aphthovirus of the Picornaviridae. How picornaviruses introduce their RNA genome into the cytoplasm of the host cell to initiate replication is unclear since they have no lipid envelope to facilitate fusion...

journal_title：PLoS pathogens

authors： Tuthill TJ,Harlos K,Walter TS,Knowles NJ,Groppelli E,Rowlands DJ,Stuart DI,Fry EE

更新日期：2009-10-01 00:00:00

abstract：:Plants have evolved pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) to protect themselves from infection by diverse pathogens. Avirulence (Avr) effectors that trigger plant ETI as a result of recognition by plant resistance (R) gene products have been identif...

journal_title：PLoS pathogens

authors： Dong S,Yin W,Kong G,Yang X,Qutob D,Chen Q,Kale SD,Sui Y,Zhang Z,Dou D,Zheng X,Gijzen M,Tyler BM,Wang Y

更新日期：2011-11-01 00:00:00

abstract：:African trypanosomes of the Trypanosoma brucei species are extra-cellular parasites that cause human African trypanosomiasis (HAT) as well as infections in game animals and livestock. Trypanosomes are known to evade the immune response of their mammalian host by continuous antigenic variation of their surface coat. He...

journal_title：PLoS pathogens

authors： Radwanska M,Guirnalda P,De Trez C,Ryffel B,Black S,Magez S

更新日期：2008-05-30 00:00:00

abstract：:The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflammatory response elicited by the parasite while tunnelling through intes...

journal_title：PLoS pathogens

authors： Duque-Correa MA,Karp NA,McCarthy C,Forman S,Goulding D,Sankaranarayanan G,Jenkins TP,Reid AJ,Cambridge EL,Ballesteros Reviriego C,Sanger Mouse Genetics Project.,3i consortium.,Müller W,Cantacessi C,Dougan G,Grencis RK,Ber

更新日期：2019-01-14 00:00:00

abstract：:Information on the growth rate and metabolism of microbial pathogens that cause long-term chronic infections is limited, reflecting the absence of suitable tools for measuring these parameters in vivo. Here, we have measured the replication and physiological state of Leishmania mexicana parasites in murine inflammator...

journal_title：PLoS pathogens

authors： Kloehn J,Saunders EC,O'Callaghan S,Dagley MJ,McConville MJ

更新日期：2015-02-25 00:00:00