Equine rhinitis A virus and its low pH empty particle: clues towards an aphthovirus entry mechanism?

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today. In past years, studies on the entry of the virus into its host cell have led to the identification of a number of essential virus...

journal_title：PLoS pathogens

authors： Van Breedam W,Van Gorp H,Zhang JQ,Crocker PR,Delputte PL,Nauwynck HJ

更新日期：2010-01-15 00:00:00

abstract：:A facile and efficient method for the precise editing of large viral genomes is required for the selection of attenuated vaccine strains and the construction of gene therapy vectors. The type II prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)) RNA-guided nucl...

journal_title：PLoS pathogens

authors： Bi Y,Sun L,Gao D,Ding C,Li Z,Li Y,Cun W,Li Q

更新日期：2014-05-01 00:00:00

abstract：:Immunocompromised individuals tend to suffer from influenza longer with more serious complications than otherwise healthy patients. Little is known about the impact of prolonged infection and the efficacy of antiviral therapy in these patients. Among all 189 influenza A virus infected immunocompromised patients admitt...

journal_title：PLoS pathogens

authors： van der Vries E,Stittelaar KJ,van Amerongen G,Veldhuis Kroeze EJ,de Waal L,Fraaij PL,Meesters RJ,Luider TM,van der Nagel B,Koch B,Vulto AG,Schutten M,Osterhaus AD

更新日期：2013-01-01 00:00:00

abstract：:Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis. The bona fide receptor for HNoV is unknown. Recently, we identified CD300lf as a proteinaceous receptor for ...

journal_title：PLoS pathogens

authors： Graziano VR,Walker FC,Kennedy EA,Wei J,Ettayebi K,Strine MS,Filler RB,Hassan E,Hsieh LL,Kim AS,Kolawole AO,Wobus CE,Lindesmith LC,Baric RS,Estes MK,Orchard RC,Baldridge MT,Wilen CB

更新日期：2020-04-06 00:00:00

abstract：:Ebolavirus (EBOV), the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This is achieved through RNA editing, during which non-template adeno...

journal_title：PLoS pathogens

authors： Mehedi M,Hoenen T,Robertson S,Ricklefs S,Dolan MA,Taylor T,Falzarano D,Ebihara H,Porcella SF,Feldmann H

更新日期：2013-01-01 00:00:00

abstract：:The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this process, we asked whether adaptation also required interference with the metabolic machinery of the host cell. Temporal profiling of the metabolic flux, in cells ...

journal_title：PLoS pathogens

authors： Mehrotra P,Jamwal SV,Saquib N,Sinha N,Siddiqui Z,Manivel V,Chatterjee S,Rao KV

更新日期：2014-07-24 00:00:00

abstract：:The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflammatory response elicited by the parasite while tunnelling through intes...

journal_title：PLoS pathogens

authors： Duque-Correa MA,Karp NA,McCarthy C,Forman S,Goulding D,Sankaranarayanan G,Jenkins TP,Reid AJ,Cambridge EL,Ballesteros Reviriego C,Sanger Mouse Genetics Project.,3i consortium.,Müller W,Cantacessi C,Dougan G,Grencis RK,Ber

更新日期：2019-01-14 00:00:00

abstract：:Information on the growth rate and metabolism of microbial pathogens that cause long-term chronic infections is limited, reflecting the absence of suitable tools for measuring these parameters in vivo. Here, we have measured the replication and physiological state of Leishmania mexicana parasites in murine inflammator...

journal_title：PLoS pathogens

authors： Kloehn J,Saunders EC,O'Callaghan S,Dagley MJ,McConville MJ

更新日期：2015-02-25 00:00:00

abstract：:Necrotrophic plant pathogens acquire nutrients from dead plant cells, which requires the disintegration of the plant cell wall and tissue structures by the pathogen. Infected plants lose tissue integrity and functional immunity as a result, exposing the nutrient rich, decayed tissues to the environment. One challenge ...

journal_title：PLoS pathogens

authors： Cui Z,Yang CH,Kharadi RR,Yuan X,Sundin GW,Triplett LR,Wang J,Zeng Q

更新日期：2019-08-05 00:00:00

abstract：:The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that s...

journal_title：PLoS pathogens

authors： Anderson A,Laurenson-Schafer H,Partridge FA,Hodgkin J,McMullan R

更新日期：2013-01-01 00:00:00

abstract：:Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, and fever and high rates of abortions in livestock. A nonstructural RVFV NSs protein inhibit...

journal_title：PLoS pathogens

authors： Ikegami T,Narayanan K,Won S,Kamitani W,Peters CJ,Makino S

更新日期：2009-02-01 00:00:00

abstract：:Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism...

journal_title：PLoS pathogens

authors： De Majumdar S,Yu J,Fookes M,McAteer SP,Llobet E,Finn S,Spence S,Monahan A,Monaghan A,Kissenpfennig A,Ingram RJ,Bengoechea J,Gally DL,Fanning S,Elborn JS,Schneiders T

更新日期：2015-01-29 00:00:00

abstract：:Monepantel is a member of the recently identified class of anthelmintics known as the amino-acetonitrile derivatives (AADs). Monepantel controls all major gastro-intestinal nematodes in sheep including those that are resistant to the classical anthelmintics. Previous studies have shown that the Caenorhabditis elegans ...

journal_title：PLoS pathogens

authors： Rufener L,Bedoni N,Baur R,Rey S,Glauser DA,Bouvier J,Beech R,Sigel E,Puoti A

更新日期：2013-01-01 00:00:00

abstract：:The opportunistic human fungal pathogen, Candida albicans, undergoes morphological and transcriptional adaptation in the switch from commensalism to pathogenicity. Although previous gene-knockout studies have identified many factors involved in this transformation, it remains unclear how these factors are regulated to...

journal_title：PLoS pathogens

authors： Greig JA,Sudbery IM,Richardson JP,Naglik JR,Wang Y,Sudbery PE

更新日期：2015-01-24 00:00:00

abstract：:Pomalidomide (Pom) is an immunomodulatory drug that has efficacy against Kaposi's sarcoma, a tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Pom also induces direct cytotoxicity in primary effusion lymphoma (PEL), a B-cell malignancy caused by KSHV, in part through downregulation of IRF4, cMyc, and CK1...

journal_title：PLoS pathogens

authors： Shrestha P,Davis DA,Jaeger HK,Stream A,Aisabor AI,Yarchoan R

更新日期：2021-01-07 00:00:00

abstract：:Many Gram-negative bacteria use Type Three Secretion Systems (T3SS) to deliver effector proteins into host cells. These protein delivery machines are composed of cytosolic components that recognize substrates and generate the force needed for translocation, the secretion conduit, formed by a needle complex and associa...

journal_title：PLoS pathogens

authors： Archuleta TL,Spiller BW

更新日期：2014-11-06 00:00:00

abstract：:The envelope glycoprotein (Env) complexes of the human and simian immunodeficiency viruses (HIV and SIV, respectively) mediate viral entry and are a target for neutralizing antibodies. The receptor binding surfaces of Env are in large part sterically occluded or conformationally masked prior to receptor binding. Knowl...

journal_title：PLoS pathogens

authors： Zanetti G,Briggs JA,Grünewald K,Sattentau QJ,Fuller SD

更新日期：2006-08-01 00:00:00

abstract：:Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and represents a recent, independent origin of plant parasitism in nematodes, ecologically and taxonomically distinct from other nematodes for which genomic data is available. As well as being an ...

journal_title：PLoS pathogens

authors： Kikuchi T,Cotton JA,Dalzell JJ,Hasegawa K,Kanzaki N,McVeigh P,Takanashi T,Tsai IJ,Assefa SA,Cock PJ,Otto TD,Hunt M,Reid AJ,Sanchez-Flores A,Tsuchihara K,Yokoi T,Larsson MC,Miwa J,Maule AG,Sahashi N,Jones JT,Berr

更新日期：2011-09-01 00:00:00

abstract：:The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a major barrier to the design of vaccines and therapeutic approaches to prevent infection or limit disease. This deficit...

journal_title：PLoS pathogens

authors： Graham JB,Swarts JL,Leist SR,Schäfer A,Menachery VD,Gralinski LE,Jeng S,Miller DR,Mooney MA,McWeeney SK,Ferris MT,Pardo-Manuel de Villena F,Heise MT,Baric RS,Lund JM

更新日期：2021-01-29 00:00:00

abstract：:Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies. While natural killer (NK) cells can directly contribute to the control of viral replication, whet...

journal_title：PLoS pathogens

authors： Robbins SH,Bessou G,Cornillon A,Zucchini N,Rupp B,Ruzsics Z,Sacher T,Tomasello E,Vivier E,Koszinowski UH,Dalod M

更新日期：2007-08-24 00:00:00

abstract：:The Ras-GAP SH3 domain-binding proteins (G3BP) are essential regulators of the formation of stress granules (SG), cytosolic aggregates of proteins and RNA that are induced upon cellular stress, such as virus infection. Many viruses, including Semliki Forest virus (SFV), block SG induction by targeting G3BP. In this wo...

journal_title：PLoS pathogens

authors： Panas MD,Schulte T,Thaa B,Sandalova T,Kedersha N,Achour A,McInerney GM

更新日期：2015-02-06 00:00:00

abstract：:Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wi...

journal_title：PLoS pathogens

authors： Zhu K,Yang J,Luo K,Yang C,Zhang N,Xu R,Chen J,Jin M,Xu B,Guo N,Wang J,Chen Z,Cui Y,Zhao H,Wang Y,Deng C,Bai L,Ge B,Qin CF,Shen H,Yang CF,Leng Q

更新日期：2015-01-23 00:00:00

abstract：:Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process. Pili have been observed on the surface of several gram-positive bacteria including S. agalactiae. We previously characterized ...

journal_title：PLoS pathogens

authors： Konto-Ghiorghi Y,Mairey E,Mallet A,Duménil G,Caliot E,Trieu-Cuot P,Dramsi S

更新日期：2009-05-01 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:Cholera, the pandemic diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, continues to be a major public health challenge in the developing world. Cholera toxin, which is responsible for the voluminous stools of cholera, causes constitutive activation of adenylyl cyclase, resulting in the export o...

journal_title：PLoS pathogens

authors： Blow NS,Salomon RN,Garrity K,Reveillaud I,Kopin A,Jackson FR,Watnick PI

更新日期：2005-09-01 00:00:00

abstract：:Prions are pathogens formed from abnormal conformers (PrPSc) of the host-encoded cellular prion protein (PrPC). PrPSc conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-dependent tropism for lymphoid tissues. Prions can be composed of several su...

journal_title：PLoS pathogens

authors： Béringue V,Tixador P,Andréoletti O,Reine F,Castille J,Laï TL,Le Dur A,Laisné A,Herzog L,Passet B,Rezaei H,Vilotte JL,Laude H

更新日期：2020-07-23 00:00:00

abstract：:Next to the two-component and quorum sensing systems, cell-surface signaling (CSS) has been recently identified as an important regulatory system in Pseudomonas aeruginosa. CSS systems sense signals from outside the cell and transmit them into the cytoplasm. They generally consist of a TonB-dependent outer membrane re...

journal_title：PLoS pathogens

authors： Llamas MA,van der Sar A,Chu BC,Sparrius M,Vogel HJ,Bitter W

更新日期：2009-09-01 00:00:00

abstract：:The Haemophilus influenzae HMW1 adhesin is a high-molecular weight protein that is secreted by the bacterial two-partner secretion pathway and mediates adherence to respiratory epithelium, an essential early step in the pathogenesis of H. influenzae disease. In recent work, we discovered that HMW1 is a glycoprotein an...

journal_title：PLoS pathogens

authors： Grass S,Lichti CF,Townsend RR,Gross J,St Geme JW 3rd

更新日期：2010-05-27 00:00:00

abstract：:Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion during P. chabaudi infection is...

journal_title：PLoS pathogens

authors： Fontana MF,de Melo GL,Anidi C,Hamburger R,Kim CY,Lee SY,Pham J,Kim CC

更新日期：2016-12-06 00:00:00

abstract：:The flagellum organelle is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g., for Salmonella enterica, Campylobacter jejuni, Pseudomon...

journal_title：PLoS pathogens

authors： Rossez Y,Wolfson EB,Holmes A,Gally DL,Holden NJ

更新日期：2015-01-15 00:00:00