Abstract:
:The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this process, we asked whether adaptation also required interference with the metabolic machinery of the host cell. Temporal profiling of the metabolic flux, in cells infected with differently virulent mycobacterial strains, confirmed that this was indeed the case. Subsequent analysis identified the core subset of host reactions that were targeted. It also elucidated that the goal of regulation was to integrate pathways facilitating macrophage survival, with those promoting mycobacterial sustenance. Intriguingly, this synthesis then provided an axis where both host- and pathogen-derived factors converged to define determinants of pathogenicity. Consequently, whereas the requirement for macrophage survival sensitized TB susceptibility to the glycemic status of the individual, mediation by pathogen ensured that the virulence properties of the infecting strain also contributed towards the resulting pathology.
journal_name
PLoS Pathogjournal_title
PLoS pathogensauthors
Mehrotra P,Jamwal SV,Saquib N,Sinha N,Siddiqui Z,Manivel V,Chatterjee S,Rao KVdoi
10.1371/journal.ppat.1004265subject
Has Abstractpub_date
2014-07-24 00:00:00pages
e1004265issue
7eissn
1553-7366issn
1553-7374pii
PPATHOGENS-D-14-00637journal_volume
10pub_type
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