Tubular structure induced by a plant virus facilitates viral spread in its vector insect.

abstract：:Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed structural and functional studies using the human neutralizing antibod...

journal_title：PLoS pathogens

authors： Harshbarger W,Tian S,Wahome N,Balsaraf A,Bhattacharya D,Jiang D,Pandey R,Tungare K,Friedrich K,Mehzabeen N,Biancucci M,Chinchilla-Olszar D,Mallett CP,Huang Y,Wang Z,Bottomley MJ,Malito E,Chandramouli S

更新日期：2020-11-02 00:00:00

abstract：:Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Nikolayevskyy V,Elkington PT,Hanifa Y,Islam K,Timms PM,Bothamley GH,Claxton AP,Packe GE,Darmalingam M,Davidson RN,Milburn HJ,Baker LV,Barker RD,Drobniewski FA,Mein CA,Bhaw-Rosun L,Nuamah RA,

更新日期：2013-01-01 00:00:00

abstract：:Highly pathogenic avian H5N1 influenza A viruses have spread throughout Asia, Europe, and Africa, raising serious worldwide concern about their pandemic potential. Although more than 250 people have been infected with these viruses, with a consequent high rate of mortality, the molecular mechanisms responsible for the...

journal_title：PLoS pathogens

authors： Hatta M,Hatta Y,Kim JH,Watanabe S,Shinya K,Nguyen T,Lien PS,Le QM,Kawaoka Y

更新日期：2007-10-05 00:00:00

abstract：:The neuraminidase (NA) inhibitor (NAI) oseltamivir (OST) is the most widely used influenza antiviral drug. Several NA amino acid substitutions are reported to reduce viral susceptibility to OST in in vitro assays. However, whether there is a correlation between the level of reduction in susceptibility in vitro and the...

journal_title：PLoS pathogens

authors： Farrukee R,Tai CM,Oh DY,Anderson DE,Gunalan V,Hibberd M,Lau GY,Barr IG,Messling VV,Maurer-Stroh S,Hurt AC

更新日期：2020-06-18 00:00:00

abstract：:Intracellular pathogens must withstand nitric oxide (NO.) generated by host phagocytes. Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify NO.. Consequently, the level of NO. stress encountered by S. Typ...

journal_title：PLoS pathogens

authors： Richardson AR,Soliven KC,Castor ME,Barnes PD,Libby SJ,Fang FC

更新日期：2009-05-01 00:00:00

abstract：:Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapid emergence of resistant viruses. Here we show that soft-randomizatio...

journal_title：PLoS pathogens

authors： Otsuka Y,Schmitt K,Quinlan BD,Gardner MR,Alfant B,Reich A,Farzan M,Choe H

更新日期：2018-08-20 00:00:00

abstract：:Tsetse flies are vectors of the protozoan parasite African trypanosomes, which cause sleeping sickness disease in humans and nagana in livestock. Although there are no effective vaccines and efficacious drugs against this parasite, vector reduction methods have been successful in curbing the disease, especially for na...

journal_title：PLoS pathogens

authors： Alam U,Medlock J,Brelsfoard C,Pais R,Lohs C,Balmand S,Carnogursky J,Heddi A,Takac P,Galvani A,Aksoy S

更新日期：2011-12-01 00:00:00

abstract：:Endogenous retroviruses (ERVs), remnants of ancient germline infections, comprise 8% of the human genome. The most recently integrated includes human ERV-K (HERV-K) where several envelope (env) sequences remain intact. Viral pseudotypes decorated with one of those Envs are infectious. Using a recombinant vesicular sto...

journal_title：PLoS pathogens

authors： Robinson-McCarthy LR,McCarthy KR,Raaben M,Piccinotti S,Nieuwenhuis J,Stubbs SH,Bakkers MJG,Whelan SPJ

更新日期：2018-08-06 00:00:00

abstract：:Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing and killing parasitoid wasp eggs. However, the sequence of events required for lamellocyte generati...

journal_title：PLoS pathogens

authors： Anderl I,Vesala L,Ihalainen TO,Vanha-Aho LM,Andó I,Rämet M,Hultmark D

更新日期：2016-07-14 00:00:00

abstract：:HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T lymphocytes or enter into endosomes resulting in degradation. HIV-1 binding and fusion with the DC membrane results in low level de novo infection that can also be tra...

journal_title：PLoS pathogens

authors： Mercier SK,Donaghy H,Botting RA,Turville SG,Harman AN,Nasr N,Ji H,Kusebauch U,Mendoza L,Shteynberg D,Sandgren K,Simpson RJ,Moritz RL,Cunningham AL

更新日期：2013-10-01 00:00:00

abstract：:Schistosomiasis is a tropical parasitic disease afflicting ~200 million people worldwide and current therapy depends on a single drug (praziquantel) which exhibits several non-optimal features. These shortcomings underpin the need for next generation anthelmintics, but the process of validating physiologically relevan...

journal_title：PLoS pathogens

authors： Chan JD,McCorvy JD,Acharya S,Johns ME,Day TA,Roth BL,Marchant JS

更新日期：2016-05-17 00:00:00

abstract：:Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed with a variety of functions, including the uptake and clearance of blood and lymph-borne pathogens, little is known about the effector mechanisms they employ aft...

journal_title：PLoS pathogens

authors： Phillips R,Svensson M,Aziz N,Maroof A,Brown N,Beattie L,Signoret N,Kaye PM

更新日期：2010-03-12 00:00:00

abstract：:The NLRP3 inflammasome has emerged as a central immune regulator that senses virulence factors expressed by microbial pathogens for triggering inflammation. Inflammation can be harmful and therefore this response must be tightly controlled. The mechanisms by which immune cells, such as macrophages, discriminate benign...

journal_title：PLoS pathogens

authors： Tucey TM,Verma J,Olivier FAB,Lo TL,Robertson AAB,Naderer T,Traven A

更新日期：2020-08-04 00:00:00

abstract：:Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism...

journal_title：PLoS pathogens

authors： De Majumdar S,Yu J,Fookes M,McAteer SP,Llobet E,Finn S,Spence S,Monahan A,Monaghan A,Kissenpfennig A,Ingram RJ,Bengoechea J,Gally DL,Fanning S,Elborn JS,Schneiders T

更新日期：2015-01-29 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:Plant microRNAs (miRNA) guide cleavage of target mRNAs by DICER-like proteins, thereby reducing mRNA abundance. Native precursor miRNAs can be redesigned to target RNAs of interest, and one application of such artificial microRNA (amiRNA) technology is to generate plants resistant to pathogenic viruses. Transgenic Ara...

journal_title：PLoS pathogens

authors： Lin SS,Wu HW,Elena SF,Chen KC,Niu QW,Yeh SD,Chen CC,Chua NH

更新日期：2009-02-01 00:00:00

abstract：:The Spumaretrovirinae, or foamy viruses (FVs) are complex retroviruses that infect many species of monkey and ape. Despite little sequence homology, FV and orthoretroviral Gag proteins perform equivalent functions, including genome packaging, virion assembly, trafficking and membrane targeting. However, there is a pau...

journal_title：PLoS pathogens

authors： Ball NJ,Nicastro G,Dutta M,Pollard DJ,Goldstone DC,Sanz-Ramos M,Ramos A,Müllers E,Stirnnagel K,Stanke N,Lindemann D,Stoye JP,Taylor WR,Rosenthal PB,Taylor IA

更新日期：2016-11-09 00:00:00

abstract：:Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycl...

journal_title：PLoS pathogens

authors： Zurnic I,Hütter S,Rzeha U,Stanke N,Reh J,Müllers E,Hamann MV,Kern T,Gerresheim GK,Lindel F,Serrao E,Lesbats P,Engelman AN,Cherepanov P,Lindemann D

更新日期：2016-08-31 00:00:00

abstract：:Surface recognition and penetration are critical steps in the infection cycle of many plant pathogenic fungi. In Magnaporthe oryzae, cAMP signaling is involved in surface recognition and pathogenesis. Deletion of the MAC1 adenylate cyclase gene affected appressorium formation and plant infection. In this study, we use...

journal_title：PLoS pathogens

authors： Zhou X,Zhang H,Li G,Shaw B,Xu JR

更新日期：2012-09-01 00:00:00

abstract：:Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including human herpesviruses. Human N-myc interactor (Nmi) protein, which has been shown to interact with signal transducer and activator of transcription (STAT) proteins including ...

journal_title：PLoS pathogens

authors： Feng L,Sheng J,Vu GP,Liu Y,Foo C,Wu S,Trang P,Paliza-Carre M,Ran Y,Yang X,Sun X,Deng Z,Zhou T,Lu S,Li H,Liu F

更新日期：2018-01-29 00:00:00

abstract：:In bacteria, transformation and restriction-modification (R-M) systems play potentially antagonistic roles. While the former, proposed as a form of sexuality, relies on internalized foreign DNA to create genetic diversity, the latter degrade foreign DNA to protect from bacteriophage attack. The human pathogen Streptoc...

journal_title：PLoS pathogens

authors： Johnston C,Martin B,Granadel C,Polard P,Claverys JP

更新日期：2013-02-01 00:00:00

abstract：:The human T cell leukemia virus HTLV-1 establishes a persistent infection in vivo in which the viral sense-strand transcription is usually silent at a given time in each cell. However, cellular stress responses trigger the reactivation of HTLV-1, enabling the virus to transmit to a new host cell. Using single-molecule...

journal_title：PLoS pathogens

authors： Miura M,Dey S,Ramanayake S,Singh A,Rueda DS,Bangham CRM

更新日期：2019-11-18 00:00:00

abstract：:Rabbit hemorrhagic disease, first described in China in 1984, causes hemorrhagic necrosis of the liver. Its etiological agent, rabbit hemorrhagic disease virus (RHDV), belongs to the Lagovirus genus in the family Caliciviridae. The detailed molecular structure of any lagovirus capsid has yet to be determined. Here, we...

journal_title：PLoS pathogens

authors： Wang X,Xu F,Liu J,Gao B,Liu Y,Zhai Y,Ma J,Zhang K,Baker TS,Schulten K,Zheng D,Pang H,Sun F

更新日期：2013-01-01 00:00:00

abstract：:The fungal pathogen Candida albicans is frequently associated with catheter-based infections because of its ability to form resilient biofilms. Prior studies have shown that the transcription factor Bcr1 governs biofilm formation in an in vitro catheter model. However, the mechanistic role of the Bcr1 pathway and its ...

journal_title：PLoS pathogens

authors： Nobile CJ,Andes DR,Nett JE,Smith FJ,Yue F,Phan QT,Edwards JE,Filler SG,Mitchell AP

更新日期：2006-07-01 00:00:00

abstract：:Although the intracellular bacterium Listeria monocytogenes has an established predilection for disseminated infection during pregnancy that often results in spontaneous abortion or stillbirth, the specific host-pathogen interaction that dictates these disastrous complications remain incompletely defined. Herein, we d...

journal_title：PLoS pathogens

authors： Rowe JH,Ertelt JM,Xin L,Way SS

更新日期：2012-01-01 00:00:00

abstract：:The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals regulate the switch from latency to lytic replication. To systematically evaluate the cellular signals regulating this reactiv...

journal_title：PLoS pathogens

authors： Yu F,Harada JN,Brown HJ,Deng H,Song MJ,Wu TT,Kato-Stankiewicz J,Nelson CG,Vieira J,Tamanoi F,Chanda SK,Sun R

更新日期：2007-03-01 00:00:00

abstract：:The recent origin and great evolutionary potential of HIV imply that the virulence of the virus might still be changing, which could greatly affect the future of the pandemic. However, previous studies of time trends of HIV virulence have yielded conflicting results. Here we used an established methodology to assess t...

journal_title：PLoS pathogens

authors： Müller V,Maggiolo F,Suter F,Ladisa N,De Luca A,Antinori A,Sighinolfi L,Quiros-Roldan E,Carosi G,Torti C

更新日期：2009-05-01 00:00:00

abstract：:Toxoplasma gondii and Hammondia hammondi are closely-related coccidian intracellular parasites that differ in their ability to cause disease in animal and (likely) humans. The role of the host response in these phenotypic differences is not known and to address this we performed a transcriptomic analysis of a monocyte...

journal_title：PLoS pathogens

authors： Wong ZS,Sokol-Borrelli SL,Olias P,Dubey JP,Boyle JP

更新日期：2020-06-23 00:00:00

abstract：:Shoot apical meristems (SAM) are resistant to most plant viruses due to RNA silencing, which is restrained by viral suppressors of RNA silencing (VSRs) to facilitate transient viral invasion of the SAM. In many cases chronic symptoms and long-term virus recovery occur, but the underlying mechanisms are poorly understo...

journal_title：PLoS pathogens

authors： Zhang XP,Liu DS,Yan T,Fang XD,Dong K,Xu J,Wang Y,Yu JL,Wang XB

更新日期：2017-07-20 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005822.]. ...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-30 00:00:00