Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F.

abstract：:Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress granules to limit the use of energy and nutrients. Because this threatens viral gene expression,...

journal_title：PLoS pathogens

authors： Brocard M,Iadevaia V,Klein P,Hall B,Lewis G,Lu J,Burke J,Willcocks MM,Parker R,Goodfellow IG,Ruggieri A,Locker N

更新日期：2020-01-06 00:00:00

abstract：:A recently characterized calmodulin-like protein is an endogenous RNA silencing suppressor that suppresses sense-RNA induced post-transcriptional gene silencing (S-PTGS) and enhances virus infection, but the mechanism underlying calmodulin-like protein-mediated S-PTGS suppression is obscure. Here, we show that a calmo...

journal_title：PLoS pathogens

authors： Li F,Zhao N,Li Z,Xu X,Wang Y,Yang X,Liu SS,Wang A,Zhou X

更新日期：2017-02-17 00:00:00

abstract：:Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To eluc...

journal_title：PLoS pathogens

authors： Hagiwara D,Miura D,Shimizu K,Paul S,Ohba A,Gonoi T,Watanabe A,Kamei K,Shintani T,Moye-Rowley WS,Kawamoto S,Gomi K

更新日期：2017-01-04 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:Poxviruses subvert the host immune response by producing immunomodulatory proteins, including a complement regulatory protein. Ectromelia virus provides a mouse model for smallpox where the virus and the host's immune response have co-evolved. Using this model, our study investigated the role of the complement system ...

journal_title：PLoS pathogens

authors： Moulton EA,Atkinson JP,Buller RM

更新日期：2008-12-01 00:00:00

abstract：:The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported that vaccination with ex vivo-generated dendritic-cells (DC) loaded with HIV-lipopeptides (LIPO-5-DC vaccine) in HIV-infected patients was well tolerated and highly immunogenic. These responses and their relation to vi...

journal_title：PLoS pathogens

authors： Brezar V,Ruffin N,Richert L,Surenaud M,Lacabaratz C,Palucka K,Thiébaut R,Banchereau J,Levy Y,Seddiki N

更新日期：2015-03-27 00:00:00

abstract：:We have identified from the mutualistic grass endophyte Epichloë festucae a non-ribosomal peptide synthetase gene (sidN) encoding a siderophore synthetase. The enzymatic product of SidN is shown to be a novel extracellular siderophore designated as epichloënin A, related to ferrirubin from the ferrichrome family. Targ...

journal_title：PLoS pathogens

authors： Johnson LJ,Koulman A,Christensen M,Lane GA,Fraser K,Forester N,Johnson RD,Bryan GT,Rasmussen S

更新日期：2013-01-01 00:00:00

abstract：:EBV transforms B cells in vitro and causes human B-cell lymphomas including classical Hodgkin lymphoma (CHL), Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). The EBV latency protein, EBNA2, transcriptionally activates the promoters of all latent viral protein-coding genes expressed in type III EBV lat...

journal_title：PLoS pathogens

authors： Li C,Romero-Masters JC,Huebner S,Ohashi M,Hayes M,Bristol JA,Nelson SE,Eichelberg MR,Van Sciver N,Ranheim EA,Scott RS,Johannsen EC,Kenney SC

更新日期：2020-06-15 00:00:00

abstract：:T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms regulating HIV-1 transcription in lymph nodes (LNs) remain unclear. In...

journal_title：PLoS pathogens

authors： Banga R,Rebecchini C,Procopio FA,Noto A,Munoz O,Ioannidou K,Fenwick C,Ohmiti K,Cavassini M,Corpataux JM,de Leval L,Pantaleo G,Perreau M

更新日期：2019-07-22 00:00:00

abstract：:Herpes simplex virus (HSV)--and herpesviruses in general--encode for a multipartite entry/fusion apparatus. In HSV it consists of the HSV-specific glycoprotein D (gD), and three additional glycoproteins, gH/gL and gB, conserved across the Herpesviridae family and responsible for the execution of fusion. According to t...

journal_title：PLoS pathogens

authors： Gianni T,Salvioli S,Chesnokova LS,Hutt-Fletcher LM,Campadelli-Fiume G

更新日期：2013-01-01 00:00:00

abstract：:Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon pr...

journal_title：PLoS pathogens

authors： Assil S,Futsch N,Décembre E,Alais S,Gessain A,Cosset FL,Mahieux R,Dreux M,Dutartre H

更新日期：2019-02-28 00:00:00

abstract：:The hemolytic phospholipase C (PlcHR) expressed by Pseudomonas aeruginosa is the original member of a Phosphoesterase Superfamily, which includes phosphorylcholine-specific phospholipases C (PC-PLC) produced by frank and opportunistic pathogens. PlcHR, but not all its family members, is also a potent sphingomyelinase ...

journal_title：PLoS pathogens

authors： Vasil ML,Stonehouse MJ,Vasil AI,Wadsworth SJ,Goldfine H,Bolcome RE 3rd,Chan J

更新日期：2009-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are 19 to 23 nucleotide-long RNAs that post-transcriptionally regulate gene expression. Human cells express several hundred miRNAs which regulate important biological pathways such as development, proliferation, and apoptosis. Recently, 12 miRNA genes have been identified within the genome of Kaposi...

journal_title：PLoS pathogens

authors： Samols MA,Skalsky RL,Maldonado AM,Riva A,Lopez MC,Baker HV,Renne R

更新日期：2007-05-11 00:00:00

abstract：:The recent emergence of a novel H7N9 influenza A virus (IAV) causing severe human infections in China raises concerns about a possible pandemic. The lack of pre-existing neutralizing antibodies in the broader population highlights the potential protective role of IAV-specific CD8(+) cytotoxic T lymphocyte (CTL) memory...

journal_title：PLoS pathogens

authors： Duan S,Meliopoulos VA,McClaren JL,Guo XZ,Sanders CJ,Smallwood HS,Webby RJ,Schultz-Cherry SL,Doherty PC,Thomas PG

更新日期：2015-02-10 00:00:00

abstract：:Expression of genes of the locus of enterocyte effacement (LEE) is essential for adherence of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells. Gut factors that may modulate LEE gene expression may therefore influence the outcome of the infection. Because nitric oxide (NO) is a critical effecto...

journal_title：PLoS pathogens

authors： Branchu P,Matrat S,Vareille M,Garrivier A,Durand A,Crépin S,Harel J,Jubelin G,Gobert AP

更新日期：2014-01-01 00:00:00

abstract：:Beyond their canonical roles in hemostasis and thrombosis, platelets function in the innate immune response by interacting directly with pathogens and by regulating the recruitment and activation of immune effector cells. Thrombocytopenia often coincides with neutropenia in patients with hematologic malignancies and i...

journal_title：PLoS pathogens

authors： Tischler BY,Tosini NL,Cramer RA,Hohl TM

更新日期：2020-05-14 00:00:00

abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

journal_title：PLoS pathogens

authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

更新日期：2020-04-30 00:00:00

abstract：:Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As a result, cargo proteins such as cadherins fail to reach inter-cellu...

journal_title：PLoS pathogens

authors： Guichard A,Jain P,Moayeri M,Schwartz R,Chin S,Zhu L,Cruz-Moreno B,Liu JZ,Aguilar B,Hollands A,Leppla SH,Nizet V,Bier E

更新日期：2017-09-25 00:00:00

abstract：:Type I interferons (IFNs) play a critical role in host defense against influenza virus infection, and the mechanism of influenza virus to evade type I IFNs responses remains to be fully understood. Here, we found that progranulin (PGRN) was significantly increased both in vitro and in vivo during influenza virus infec...

journal_title：PLoS pathogens

authors： Wei F,Jiang Z,Sun H,Pu J,Sun Y,Wang M,Tong Q,Bi Y,Ma X,Gao GF,Liu J

更新日期：2019-10-04 00:00:00

abstract：:The agr quorum-sensing system of Staphylococcus aureus modulates the expression of virulence factors in response to autoinducing peptides (AIPs). Recent studies have suggested a role for the agr system in S. aureus biofilm development, as agr mutants exhibit a high propensity to form biofilms, and cells dispersing fro...

journal_title：PLoS pathogens

authors： Boles BR,Horswill AR

更新日期：2008-04-25 00:00:00

abstract：:Adenoviral vectors have shown significant promise as vaccine delivery vectors due to their ability to elicit both innate and adaptive immune responses. α-defensins are effector molecules of the innate immune response and have been shown to modulate natural infection with adenoviruses, but the majority of α-defensin-ad...

journal_title：PLoS pathogens

authors： Tartaglia LJ,Badamchi-Zadeh A,Abbink P,Blass E,Aid M,Gebre MS,Li Z,Pastores KC,Trott S,Gupte S,Larocca RA,Barouch DH

更新日期：2019-12-16 00:00:00

abstract：:The innate immune system is the first line of host defense against invading organisms. Thus, pathogens have developed virulence mechanisms to evade the innate immune system. Here, we report a novel means for inhibition of neutrophil recruitment by Group A Streptococcus (GAS). Deletion of the secreted esterase gene (de...

journal_title：PLoS pathogens

authors： Liu M,Zhu H,Li J,Garcia CC,Feng W,Kirpotina LN,Hilmer J,Tavares LP,Layton AW,Quinn MT,Bothner B,Teixeira MM,Lei B

更新日期：2012-01-01 00:00:00

abstract：:Marek's Disease Virus (MDV) is an alphaherpesvirus that infects chickens, transforms CD4+ T cells and causes deadly lymphomas. In addition, MDV induces immunosuppression early during infection by inducing cell death of the infected lymphocytes, and potentially due to activation of regulatory T (Treg)-cells. Furthermor...

journal_title：PLoS pathogens

authors： Gurung A,Kamble N,Kaufer BB,Pathan A,Behboudi S

更新日期：2017-12-21 00:00:00

abstract：:Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle. The extracellular infectious elementary body (EB) is an infectious, electron-dense structure that, following host cell infection, diffe...

journal_title：PLoS pathogens

authors： Wang Y,Kahane S,Cutcliffe LT,Skilton RJ,Lambden PR,Clarke IN

更新日期：2011-09-01 00:00:00

abstract：:Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons (IFNs). It is unclear, however, how the immune system clears the virus without causing lethal immunopathology. Here,...

journal_title：PLoS pathogens

authors： Stifter SA,Bhattacharyya N,Pillay R,Flórido M,Triccas JA,Britton WJ,Feng CG

更新日期：2016-01-05 00:00:00

abstract：:Many viruses express factors that reduce host gene expression through widespread degradation of cellular mRNA. An example of this class of proteins is the mRNA-targeting endoribonuclease SOX from the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV). Previous studies indicated that cleavage of messenger...

journal_title：PLoS pathogens

authors： Gaglia MM,Rycroft CH,Glaunsinger BA

更新日期：2015-12-08 00:00:00

abstract：:In nature, larvae of the fruitfly Drosophila melanogaster are commonly infected by parasitoid wasps, and so have evolved a robust immune response to counter wasp infection. In this response, fly immune cells form a multilayered capsule surrounding the wasp egg, leading to death of the parasite. Many of the molecular m...

journal_title：PLoS pathogens

authors： Mortimer NT,Kacsoh BZ,Keebaugh ES,Schlenke TA

更新日期：2012-01-01 00:00:00

abstract：:The AraC Negative Regulators (ANR) comprise a large family of virulence regulators distributed among diverse clinically important Gram-negative pathogens, including Vibrio spp., Salmonella spp., Shigella spp., Yersinia spp., Citrobacter spp., and pathogenic E. coli strains. We have previously reported broad effects of...

journal_title：PLoS pathogens

authors： Santiago AE,Yan MB,Hazen TH,Sauder B,Meza-Segura M,Rasko DA,Kendall MM,Ruiz-Perez F,Nataro JP

更新日期：2017-08-14 00:00:00

abstract：:Infection of the vascular system by Pseudomonas aeruginosa (Pa) occurs during bacterial dissemination in the body or in blood-borne infections. Type 3 secretion system (T3SS) toxins from Pa induce a massive retraction when injected into endothelial cells. Here, we addressed the role of type 2 secretion system (T2SS) e...

journal_title：PLoS pathogens

authors： Golovkine G,Faudry E,Bouillot S,Voulhoux R,Attrée I,Huber P

更新日期：2014-03-13 00:00:00