An extracellular siderophore is required to maintain the mutualistic interaction of Epichloë festucae with Lolium perenne.

abstract：:The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from peo...

journal_title：PLoS pathogens

authors： Olival KJ,Cryan PM,Amman BR,Baric RS,Blehert DS,Brook CE,Calisher CH,Castle KT,Coleman JTH,Daszak P,Epstein JH,Field H,Frick WF,Gilbert AT,Hayman DTS,Ip HS,Karesh WB,Johnson CK,Kading RC,Kingston T,Lorch JM,Mend

更新日期：2020-09-03 00:00:00

abstract：:The N-terminal domains of the herpesvirus large tegument proteins encode a conserved cysteine protease with ubiquitin- and NEDD8-specific deconjugase activity. The proteins are expressed during the productive virus cycle and are incorporated into infectious virus particles, being delivered to the target cells upon pri...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Callegari S,Tsai MH,Delecluse HJ,Masucci MG

更新日期：2018-01-22 00:00:00

abstract：:The sedentary plant-parasitic nematodes are considered among the most economically damaging pathogens of plants. Following infection and the establishment of a feeding site, sedentary nematodes become immobile. Loss of mobility is reversed in adult males while females never regain mobility. The structural basis for th...

journal_title：PLoS pathogens

authors： Han Z,Thapa S,Reuter-Carlson U,Reed H,Gates M,Lambert KN,Schroeder NE

更新日期：2018-08-16 00:00:00

abstract：:Influenza A virus (IAV) infection can be severe or even lethal in toddlers, the elderly and patients with certain medical conditions. Infection of apparently healthy individuals nonetheless accounts for many severe disease cases and deaths, suggesting that viruses with increased pathogenicity co-circulate with pandemi...

journal_title：PLoS pathogens

authors： Vasilijevic J,Zamarreño N,Oliveros JC,Rodriguez-Frandsen A,Gómez G,Rodriguez G,Pérez-Ruiz M,Rey S,Barba I,Pozo F,Casas I,Nieto A,Falcón A

更新日期：2017-10-12 00:00:00

abstract：:Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env)...

journal_title：PLoS pathogens

authors： Del Prete GQ,Keele BF,Fode J,Thummar K,Swanstrom AE,Rodriguez A,Raymond A,Estes JD,LaBranche CC,Montefiori DC,KewalRamani VN,Lifson JD,Bieniasz PD,Hatziioannou T

更新日期：2017-09-25 00:00:00

abstract：:Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense mechanism against the human pathogens Group A Streptococcus (GAS) and Group B Stre...

journal_title：PLoS pathogens

authors： van Hensbergen VP,Movert E,de Maat V,Lüchtenborg C,Le Breton Y,Lambeau G,Payré C,Henningham A,Nizet V,van Strijp JAG,Brügger B,Carlsson F,McIver KS,van Sorge NM

更新日期：2018-10-15 00:00:00

abstract：:B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatmen...

journal_title：PLoS pathogens

authors： Watson DC,Moysi E,Valentin A,Bergamaschi C,Devasundaram S,Fortis SP,Bear J,Chertova E,Bess J Jr,Sowder R,Venzon DJ,Deleage C,Estes JD,Lifson JD,Petrovas C,Felber BK,Pavlakis GN

更新日期：2018-02-23 00:00:00

abstract：:Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV infection of CD4+ T cells-by up to 37-fold...

journal_title：PLoS pathogens

authors： Neidleman JA,Chen JC,Kohgadai N,Müller JA,Laustsen A,Thavachelvam K,Jang KS,Stürzel CM,Jones JJ,Ochsenbauer C,Chitre A,Somsouk M,Garcia MM,Smith JF,Greenblatt RM,Münch J,Jakobsen MR,Giudice LC,Greene WC,Roan NR

更新日期：2017-02-16 00:00:00

abstract：:As well as their importance to nutrition, fatty acids (FA) represent a unique group of quorum sensing chemicals that modulate the behavior of bacterial population in virulence. However, the way in which full-length, membrane-bound receptors biochemically detect FA remains unclear. Here, we provide genetic, enzymologic...

journal_title：PLoS pathogens

authors： Cai Z,Yuan ZH,Zhang H,Pan Y,Wu Y,Tian XQ,Wang FF,Wang L,Qian W

更新日期：2017-04-03 00:00:00

abstract：:We performed a quantitative analysis of the HLA restriction, antigen and epitope specificity of human pathogen specific responses in healthy individuals infected with M. tuberculosis (Mtb), in a South African cohort as a test case. The results estimate the breadth of T cell responses for the first time in the context ...

journal_title：PLoS pathogens

authors： Lindestam Arlehamn CS,McKinney DM,Carpenter C,Paul S,Rozot V,Makgotlho E,Gregg Y,van Rooyen M,Ernst JD,Hatherill M,Hanekom WA,Peters B,Scriba TJ,Sette A

更新日期：2016-07-13 00:00:00

abstract：:Competence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated receptor kinase ComD, a cascade of signaling events is initiated, leading to activation of the competence regulon by the response regulator ComE. Genes encoding...

journal_title：PLoS pathogens

authors： Zhu L,Lau GW

更新日期：2011-09-01 00:00:00

abstract：:Two billion people are latently infected with Mycobacterium tuberculosis (Mtb). Mtb-infected macrophages are likely to be sequestered inside the hypoxic environments of the granuloma and differentiate into lipid-loaded macrophages that contain triacylglycerol (TAG)-filled lipid droplets which may provide a fatty acid-...

journal_title：PLoS pathogens

authors： Daniel J,Maamar H,Deb C,Sirakova TD,Kolattukudy PE

更新日期：2011-06-01 00:00:00

abstract：:Mitochondrial antiviral-signaling protein (MAVS) transmits signals from RIG-I-like receptors after RNA virus infections. However, the mechanism by which MAVS activates downstream components, such as TBK1 and IKKα/β, is unclear, although previous work suggests the involvement of NEMO or TBK1-binding proteins TANK, NAP1...

journal_title：PLoS pathogens

authors： Fang R,Jiang Q,Zhou X,Wang C,Guan Y,Tao J,Xi J,Feng JM,Jiang Z

更新日期：2017-11-10 00:00:00

abstract：:Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone marrow. HSCs become activated in response to stress, such as acute infections, which adapt the bone marrow output to the needs of the immune response. However, the impact of infection-adapted HSC activation and differentia...

journal_title：PLoS pathogens

authors： Abidin BM,Hammami A,Stäger S,Heinonen KM

更新日期：2017-08-07 00:00:00

abstract：:The herpesvirus life cycle has two distinct phases: latency and lytic replication. The balance between these two phases is critical for viral pathogenesis. It is believed that cellular signals regulate the switch from latency to lytic replication. To systematically evaluate the cellular signals regulating this reactiv...

journal_title：PLoS pathogens

authors： Yu F,Harada JN,Brown HJ,Deng H,Song MJ,Wu TT,Kato-Stankiewicz J,Nelson CG,Vieira J,Tamanoi F,Chanda SK,Sun R

更新日期：2007-03-01 00:00:00

abstract：:Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease...

journal_title：PLoS pathogens

authors： Cui Y,Yu H,Zheng X,Peng R,Wang Q,Zhou Y,Wang R,Wang J,Qu B,Shen N,Guo Q,Liu X,Wang C

更新日期：2017-01-17 00:00:00

abstract：:Bdellovibrio bacteriovorus is a Delta-proteobacterium that oscillates between free-living growth and predation on Gram-negative bacteria including important pathogens of man, animals and plants. After entering the prey periplasm, killing the prey and replicating inside the prey bdelloplast, several motile B. bacteriov...

journal_title：PLoS pathogens

authors： Hobley L,Fung RK,Lambert C,Harris MA,Dabhi JM,King SS,Basford SM,Uchida K,Till R,Ahmad R,Aizawa S,Gomelsky M,Sockett RE

更新日期：2012-02-01 00:00:00

abstract：:Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient pteropine orthoreov...

journal_title：PLoS pathogens

authors： Kanai Y,Kawagishi T,Sakai Y,Nouda R,Shimojima M,Saijo M,Matsuura Y,Kobayashi T

更新日期：2019-04-25 00:00:00

abstract：:Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of...

journal_title：PLoS pathogens

authors： Pont S,Fraikin N,Caspar Y,Van Melderen L,Attrée I,Cretin F

更新日期：2020-12-16 00:00:00

abstract：:Clonorchis sinensis is a carcinogenic human liver fluke, prolonged infection which provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma (CCA). These effects are driven by direct physical damage caused by the worms, as well as chemical irritation from their excretory-s...

journal_title：PLoS pathogens

authors： Won J,Cho Y,Lee D,Jeon BY,Ju JW,Chung S,Pak JH

更新日期：2019-05-23 00:00:00

abstract：:Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HE...

journal_title：PLoS pathogens

authors： Uchil PD,Quinlan BD,Chan WT,Luna JM,Mothes W

更新日期：2008-02-08 00:00:00

abstract：:A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial phenotypes controlled by complex regulatory networks that sense and respond to the host environm...

journal_title：PLoS pathogens

authors： Kesarwani M,Hazan R,He J,Que YA,Apidianakis Y,Lesic B,Xiao G,Dekimpe V,Milot S,Deziel E,Lépine F,Rahme LG

更新日期：2011-08-01 00:00:00

abstract：:The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity a...

journal_title：PLoS pathogens

authors： Refsland EW,Hultquist JF,Harris RS

更新日期：2012-01-01 00:00:00

abstract：:Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapid emergence of resistant viruses. Here we show that soft-randomizatio...

journal_title：PLoS pathogens

authors： Otsuka Y,Schmitt K,Quinlan BD,Gardner MR,Alfant B,Reich A,Farzan M,Choe H

更新日期：2018-08-20 00:00:00

abstract：:Pathogens hide immunogenic epitopes from the host to evade immunity, persist and cause infection. The opportunistic human fungal pathogen Candida albicans, which can cause fatal disease in immunocompromised patient populations, offers a good example as it masks the inflammatory epitope β-glucan in its cell wall from h...

journal_title：PLoS pathogens

authors： Hopke A,Nicke N,Hidu EE,Degani G,Popolo L,Wheeler RT

更新日期：2016-05-25 00:00:00

abstract：:The two-component system (TCS) KdpD/KdpE, extensively studied for its regulatory role in potassium (K(+)) transport, has more recently been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria, including Staphylococcus aureus, entero-haemorrhagic Escherichia c...

journal_title：PLoS pathogens

authors： Freeman ZN,Dorus S,Waterfield NR

更新日期：2013-03-01 00:00:00

abstract：:Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis. The bona fide receptor for HNoV is unknown. Recently, we identified CD300lf as a proteinaceous receptor for ...

journal_title：PLoS pathogens

authors： Graziano VR,Walker FC,Kennedy EA,Wei J,Ettayebi K,Strine MS,Filler RB,Hassan E,Hsieh LL,Kim AS,Kolawole AO,Wobus CE,Lindesmith LC,Baric RS,Estes MK,Orchard RC,Baldridge MT,Wilen CB

更新日期：2020-04-06 00:00:00

abstract：:Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Nikolayevskyy V,Elkington PT,Hanifa Y,Islam K,Timms PM,Bothamley GH,Claxton AP,Packe GE,Darmalingam M,Davidson RN,Milburn HJ,Baker LV,Barker RD,Drobniewski FA,Mein CA,Bhaw-Rosun L,Nuamah RA,

更新日期：2013-01-01 00:00:00

abstract：:Accurate calculation of mutation rates for viruses and viroids is necessary for evolutionary studies and to evaluate adaptation potential. However, estimation of in vivo mutation rates is complicated by selection, which leads to loss or proliferation of certain mutations. To minimize this concern, lethal mutations, in...

journal_title：PLoS pathogens

authors： Wu J,Bisaro DM

更新日期：2020-12-22 00:00:00

abstract：:Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species through recognition of the common polysaccharide antigen (CPA) of...

journal_title：PLoS pathogens

authors： McCaughey LC,Grinter R,Josts I,Roszak AW,Waløen KI,Cogdell RJ,Milner J,Evans T,Kelly S,Tucker NP,Byron O,Smith B,Walker D

更新日期：2014-02-06 00:00:00