Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.

abstract：:Candida bloodstream infection, i.e. candidemia, is the most frequently encountered life-threatening fungal infection worldwide, with mortality rates up to almost 50%. In the majority of candidemia cases, Candida albicans is responsible. Worryingly, a global increase in the number of patients who are susceptible to inf...

journal_title：PLoS pathogens

authors： de Vries DH,Matzaraki V,Bakker OB,Brugge H,Westra HJ,Netea MG,Franke L,Kumar V,van der Wijst MGP

更新日期：2020-04-06 00:00:00

abstract：:Elucidating virus-host interactions responsible for HIV-1 transmission is important for advancing HIV-1 prevention strategies. To this end, single genome amplification (SGA) and sequencing of HIV-1 within the context of a model of random virus evolution has made possible for the first time an unambiguous identificatio...

journal_title：PLoS pathogens

authors： Li H,Bar KJ,Wang S,Decker JM,Chen Y,Sun C,Salazar-Gonzalez JF,Salazar MG,Learn GH,Morgan CJ,Schumacher JE,Hraber P,Giorgi EE,Bhattacharya T,Korber BT,Perelson AS,Eron JJ,Cohen MS,Hicks CB,Haynes BF,Markowitz M,K

更新日期：2010-05-13 00:00:00

abstract：:Plants have evolved pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) to protect themselves from infection by diverse pathogens. Avirulence (Avr) effectors that trigger plant ETI as a result of recognition by plant resistance (R) gene products have been identif...

journal_title：PLoS pathogens

authors： Dong S,Yin W,Kong G,Yang X,Qutob D,Chen Q,Kale SD,Sui Y,Zhang Z,Dou D,Zheng X,Gijzen M,Tyler BM,Wang Y

更新日期：2011-11-01 00:00:00

abstract：:The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

journal_title：PLoS pathogens

authors： Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

更新日期：2013-01-01 00:00:00

abstract：:HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T lymphocytes or enter into endosomes resulting in degradation. HIV-1 binding and fusion with the DC membrane results in low level de novo infection that can also be tra...

journal_title：PLoS pathogens

authors： Mercier SK,Donaghy H,Botting RA,Turville SG,Harman AN,Nasr N,Ji H,Kusebauch U,Mendoza L,Shteynberg D,Sandgren K,Simpson RJ,Moritz RL,Cunningham AL

更新日期：2013-10-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. And the bacterial su...

journal_title：PLoS pathogens

authors： Tyler JS,Beeri K,Reynolds JL,Alteri CJ,Skinner KG,Friedman JH,Eaton KA,Friedman DI

更新日期：2013-03-01 00:00:00

abstract：:RNA helicases and chaperones are the two major classes of RNA remodeling proteins, which function to remodel RNA structures and/or RNA-protein interactions, and are required for all aspects of RNA metabolism. Although some virus-encoded RNA helicases/chaperones have been predicted or identified, their RNA remodeling a...

journal_title：PLoS pathogens

authors： Xia H,Wang P,Wang GC,Yang J,Sun X,Wu W,Qiu Y,Shu T,Zhao X,Yin L,Qin CF,Hu Y,Zhou X

更新日期：2015-07-28 00:00:00

abstract：:Hepatitis C virus (HCV) core protein is directed to the surface of lipid droplets (LD), a step that is essential for infectious virus production. However, the process by which core is recruited from LD into nascent virus particles is not well understood. To investigate the kinetics of core trafficking, we developed me...

journal_title：PLoS pathogens

authors： Counihan NA,Rawlinson SM,Lindenbach BD

更新日期：2011-10-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the activities performed by the RSV polymerase when it encounters the viral antigenomic promoter were examined. RSV RNA synthesis was reconstituted in vitro using recombinant, isolated polymerase and an RNA oligonucleotide template ...

journal_title：PLoS pathogens

authors： Noton SL,Deflubé LR,Tremaglio CZ,Fearns R

更新日期：2012-01-01 00:00:00

abstract：:Idiopathic chronic diarrhea (ICD) is a leading cause of morbidity amongst rhesus monkeys kept in captivity. Here, we show that exposure of affected animals to the whipworm Trichuris trichiura led to clinical improvement in fecal consistency, accompanied by weight gain, in four out of the five treated monkeys. By flow ...

journal_title：PLoS pathogens

authors： Broadhurst MJ,Ardeshir A,Kanwar B,Mirpuri J,Gundra UM,Leung JM,Wiens KE,Vujkovic-Cvijin I,Kim CC,Yarovinsky F,Lerche NW,McCune JM,Loke P

更新日期：2012-01-01 00:00:00

abstract：:Legionella pneumophila translocates multiple bacterial effector proteins into host cells to direct formation of a replication vacuole for the bacterium. The emerging consensus is that formation of this compartment involves recruitment of membrane material that traffics between the endoplasmic reticulum (ER) and Golgi....

journal_title：PLoS pathogens

authors： Dorer MS,Kirton D,Bader JS,Isberg RR

更新日期：2006-04-01 00:00:00

abstract：:The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation...

journal_title：PLoS pathogens

authors： Khurana S,Frasca D,Blomberg B,Golding H

更新日期：2012-09-01 00:00:00

abstract：:Highly pathogenic avian H5N1 influenza A viruses have spread throughout Asia, Europe, and Africa, raising serious worldwide concern about their pandemic potential. Although more than 250 people have been infected with these viruses, with a consequent high rate of mortality, the molecular mechanisms responsible for the...

journal_title：PLoS pathogens

authors： Hatta M,Hatta Y,Kim JH,Watanabe S,Shinya K,Nguyen T,Lien PS,Le QM,Kawaoka Y

更新日期：2007-10-05 00:00:00

abstract：:Regulated protein secretion is required for malaria parasite life cycle progression and transmission between the mammalian host and mosquito vector. During transmission from the host to the vector, exocytosis of highly specialised secretory vesicles, such as osmiophilic bodies, is key to the dissolution of the red blo...

journal_title：PLoS pathogens

authors： Kehrer J,Singer M,Lemgruber L,Silva PA,Frischknecht F,Mair GR

更新日期：2016-07-18 00:00:00

abstract：:Magnaporthe oryzae is the causal agent of rice blast disease, a devastating problem worldwide. This fungus has caused breakdown of resistance conferred by newly developed commercial cultivars. To address how the rice blast fungus adapts itself to new resistance genes so quickly, we examined chromosomal locations of AV...

journal_title：PLoS pathogens

authors： Chuma I,Isobe C,Hotta Y,Ibaragi K,Futamata N,Kusaba M,Yoshida K,Terauchi R,Fujita Y,Nakayashiki H,Valent B,Tosa Y

更新日期：2011-07-01 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase activity that reduces cellular dNTP to a level where reverse transcriptase cannot function, although alternative mechanisms have been proposed recently. Here, w...

journal_title：PLoS pathogens

authors： Arnold LH,Groom HC,Kunzelmann S,Schwefel D,Caswell SJ,Ordonez P,Mann MC,Rueschenbaum S,Goldstone DC,Pennell S,Howell SA,Stoye JP,Webb M,Taylor IA,Bishop KN

更新日期：2015-10-02 00:00:00

abstract：:Accurate calculation of mutation rates for viruses and viroids is necessary for evolutionary studies and to evaluate adaptation potential. However, estimation of in vivo mutation rates is complicated by selection, which leads to loss or proliferation of certain mutations. To minimize this concern, lethal mutations, in...

journal_title：PLoS pathogens

authors： Wu J,Bisaro DM

更新日期：2020-12-22 00:00:00

abstract：:Cellular immune responses require the generation and recruitment of diverse blood cell types that recognize and kill pathogens. In Drosophila melanogaster larvae, immune-inducible lamellocytes participate in recognizing and killing parasitoid wasp eggs. However, the sequence of events required for lamellocyte generati...

journal_title：PLoS pathogens

authors： Anderl I,Vesala L,Ihalainen TO,Vanha-Aho LM,Andó I,Rämet M,Hultmark D

更新日期：2016-07-14 00:00:00

abstract：:The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression. These viruses have evolved countermeasures to disperse PML-NBs,...

journal_title：PLoS pathogens

authors： Reichelt M,Wang L,Sommer M,Perrino J,Nour AM,Sen N,Baiker A,Zerboni L,Arvin AM

更新日期：2011-02-03 00:00:00

abstract：:CD8+ T cell responses to Epstein-Barr virus (EBV) lytic cycle expressed antigens display a hierarchy of immunodominance, in which responses to epitopes of immediate-early (IE) and some early (E) antigens are more frequently observed than responses to epitopes of late (L) expressed antigens. It has been proposed that t...

journal_title：PLoS pathogens

authors： Quinn LL,Zuo J,Abbott RJ,Shannon-Lowe C,Tierney RJ,Hislop AD,Rowe M

更新日期：2014-08-21 00:00:00

abstract：:The sedentary plant-parasitic nematodes are considered among the most economically damaging pathogens of plants. Following infection and the establishment of a feeding site, sedentary nematodes become immobile. Loss of mobility is reversed in adult males while females never regain mobility. The structural basis for th...

journal_title：PLoS pathogens

authors： Han Z,Thapa S,Reuter-Carlson U,Reed H,Gates M,Lambert KN,Schroeder NE

更新日期：2018-08-16 00:00:00

abstract：:The intrinsic oncotropism and oncosuppressive activities of rodent protoparvoviruses (PVs) are opening new prospects for cancer virotherapy. Virus propagation, cytolytic activity, and spread are tightly connected to activation of the PDK1 signaling cascade, which delays stress-induced cell death and sustains functioni...

journal_title：PLoS pathogens

authors： Bär S,Rommelaere J,Nüesch JP

更新日期：2015-03-05 00:00:00

abstract：:Extracellular vesicles (EV) mediate intercellular communication events and alterations in normal vesicle content contribute to function and disease initiation or progression. The ability to package a variety of cargo and transmit molecular information between cells renders EVs important mediators of cell-to-cell cross...

journal_title：PLoS pathogens

authors： Nkosi D,Sun L,Duke LC,Meckes DG Jr

更新日期：2020-12-31 00:00:00

abstract：:Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange fact...

journal_title：PLoS pathogens

authors： Fukazawa A,Alonso C,Kurachi K,Gupta S,Lesser CF,McCormick BA,Reinecker HC

更新日期：2008-11-01 00:00:00

abstract：:RNA polyadenylation (pA) is one of the major steps in regulation of gene expression at the posttranscriptional level. In this report, a genome landscape of pA sites of viral transcripts in B lymphocytes with Kaposi sarcoma-associated herpesvirus (KSHV) infection was constructed using a modified PA-seq strategy. We ide...

journal_title：PLoS pathogens

authors： Majerciak V,Ni T,Yang W,Meng B,Zhu J,Zheng ZM

更新日期：2013-01-01 00:00:00

abstract：:The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrPSc replicates by converting the non-infectious, cellular prion protei...

journal_title：PLoS pathogens

authors： Vázquez-Fernández E,Vos MR,Afanasyev P,Cebey L,Sevillano AM,Vidal E,Rosa I,Renault L,Ramos A,Peters PJ,Fernández JJ,van Heel M,Young HS,Requena JR,Wille H

更新日期：2016-09-08 00:00:00

abstract：:A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence attributes, the M1T1 clone secretes NAD+-glycohydrolase (NADase). When GAS binds to epithelial...

journal_title：PLoS pathogens

authors： Sharma O,O'Seaghdha M,Velarde JJ,Wessels MR

更新日期：2016-03-03 00:00:00

abstract：:Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense mechanisms. The cellular transcriptional repressor Daxx prevents ...

journal_title：PLoS pathogens

authors： Schreiner S,Martinez R,Groitl P,Rayne F,Vaillant R,Wimmer P,Bossis G,Sternsdorf T,Marcinowski L,Ruzsics Z,Dobner T,Wodrich H

更新日期：2012-02-01 00:00:00

abstract：:Phospoenolpyruvate carboxylase (PEPC) is absent from humans but encoded in the Plasmodium falciparum genome, suggesting that PEPC has a parasite-specific function. To investigate its importance in P. falciparum, we generated a pepc null mutant (D10(Δpepc) ), which was only achievable when malate, a reduction product o...

journal_title：PLoS pathogens

authors： Storm J,Sethia S,Blackburn GJ,Chokkathukalam A,Watson DG,Breitling R,Coombs GH,Müller S

更新日期：2014-01-01 00:00:00