Phosphoenolpyruvate carboxylase identified as a key enzyme in erythrocytic Plasmodium falciparum carbon metabolism.

abstract：:Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral DNA, resulting in inh...

journal_title：PLoS pathogens

authors： Liang G,Liu G,Kitamura K,Wang Z,Chowdhury S,Monjurul AM,Wakae K,Koura M,Shimadu M,Kinoshita K,Muramatsu M

更新日期：2015-04-02 00:00:00

abstract：:There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown. By using the rice-rice dwarf virus (RDV) model system, here we report that...

journal_title：PLoS pathogens

authors： Qin Q,Li G,Jin L,Huang Y,Wang Y,Wei C,Xu Z,Yang Z,Wang H,Li Y

更新日期：2020-12-02 00:00:00

abstract：:The macrophage is the primary host cell for the fungal pathogen Histoplasma capsulatum during mammalian infections, yet little is known about fungal genes required for intracellular replication in the host. Since the ability to scavenge iron from the host is important for the virulence of most pathogens, we investigat...

journal_title：PLoS pathogens

authors： Hwang LH,Mayfield JA,Rine J,Sil A

更新日期：2008-04-11 00:00:00

abstract：:Phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation of bacterial populations to changing environments and is frequently important in bacterial virulence. Here we elucidate a novel phase variable mechanism for NadA, an adhesin and inv...

journal_title：PLoS pathogens

authors： Metruccio MM,Pigozzi E,Roncarati D,Berlanda Scorza F,Norais N,Hill SA,Scarlato V,Delany I

更新日期：2009-12-01 00:00:00

abstract：:Pathogens often follow more than one transmission route during outbreaks-from needle sharing plus sexual transmission of HIV to small droplet aerosol plus fomite transmission of influenza. Thus, controlling an infectious disease outbreak often requires characterizing the risk associated with multiple mechanisms of tra...

journal_title：PLoS pathogens

authors： Allard A,Althouse BM,Hébert-Dufresne L,Scarpino SV

更新日期：2017-09-21 00:00:00

abstract：:Unlike the pandemic form of HIV-1 (group M), group O viruses are endemic in west central Africa, especially in Cameroon. However, little is known about group O's genetic evolution, and why this highly divergent lineage has not become pandemic. Using a unique and large set of group O sequences from samples collected fr...

journal_title：PLoS pathogens

authors： Leoz M,Feyertag F,Kfutwah A,Mauclère P,Lachenal G,Damond F,De Oliveira F,Lemée V,Simon F,Robertson DL,Plantier JC

更新日期：2015-08-04 00:00:00

abstract：:Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacterial invasion mechanism. Its ectopic expression in eukaryotic cells inh...

journal_title：PLoS pathogens

authors： Patot S,Imbert PR,Baude J,Martins Simões P,Campergue JB,Louche A,Nijland R,Bès M,Tristan A,Laurent F,Fischer A,Schrenzel J,Vandenesch F,Salcedo SP,François P,Lina G

更新日期：2017-01-06 00:00:00

abstract：:Ingested Vibrio cholerae pass through the stomach and colonize the small intestines of its host. Here, we show that V. cholerae requires at least two types of DNA repair systems to efficiently compete for colonization of the infant mouse intestine. These results show that V. cholerae experiences increased DNA damage i...

journal_title：PLoS pathogens

authors： Davies BW,Bogard RW,Dupes NM,Gerstenfeld TA,Simmons LA,Mekalanos JJ

更新日期：2011-02-01 00:00:00

abstract：:RNA viruses typically occur in genetically diverse populations due to their error-prone genome replication. Genetic diversity is thought to be important in allowing RNA viruses to explore sequence space, facilitating adaptation to changing environments and hosts. Some arboviruses that infect both a mosquito vector and...

journal_title：PLoS pathogens

authors： Forrester NL,Guerbois M,Seymour RL,Spratt H,Weaver SC

更新日期：2012-09-01 00:00:00

abstract：:Many thousands of endoparasitic wasp species are known to inject polydnavirus (PDV) particles into their caterpillar host during oviposition, causing immune and developmental dysfunctions that benefit the wasp larva. PDVs associated with braconid and ichneumonid wasps, bracoviruses and ichnoviruses respectively, both ...

journal_title：PLoS pathogens

authors： Volkoff AN,Jouan V,Urbach S,Samain S,Bergoin M,Wincker P,Demettre E,Cousserans F,Provost B,Coulibaly F,Legeai F,Béliveau C,Cusson M,Gyapay G,Drezen JM

更新日期：2010-05-27 00:00:00

abstract：:Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that release their content upon host cell recognition. Dense granules are secreted in...

journal_title：PLoS pathogens

authors： Venugopal K,Chehade S,Werkmeister E,Barois N,Periz J,Lafont F,Tardieux I,Khalife J,Langsley G,Meissner M,Marion S

更新日期：2020-05-28 00:00:00

abstract：:The wide utilization of biocides poses a concern on the impact of these compounds on natural bacterial populations. Furthermore, it has been demonstrated that biocides can select, at least in laboratory experiments, antibiotic resistant bacteria. This situation has raised concerns, not just on scientists and clinician...

journal_title：PLoS pathogens

authors： Hernández A,Ruiz FM,Romero A,Martínez JL

更新日期：2011-06-01 00:00:00

abstract：:G3BP-1 and -2 (hereafter referred to as G3BP) are multifunctional RNA-binding proteins involved in stress granule (SG) assembly. Viruses from diverse families target G3BP for recruitment to replication or transcription complexes in order to block SG assembly but also to acquire pro-viral effects via other unknown func...

journal_title：PLoS pathogens

authors： Götte B,Panas MD,Hellström K,Liu L,Samreen B,Larsson O,Ahola T,McInerney GM

更新日期：2019-06-14 00:00:00

abstract：:The function of Toll pathway defense against bacterial infection has been well established in shrimp, however how this pathway responds to viral infection is still largely unknown. In this study, we report the Toll4-Dorsal-AMPs cascade restricts the white spot syndrome virus (WSSV) infection of shrimp. A total of nine...

journal_title：PLoS pathogens

authors： Li H,Yin B,Wang S,Fu Q,Xiao B,Lǚ K,He J,Li C

更新日期：2018-09-26 00:00:00

abstract：:Accurate calculation of mutation rates for viruses and viroids is necessary for evolutionary studies and to evaluate adaptation potential. However, estimation of in vivo mutation rates is complicated by selection, which leads to loss or proliferation of certain mutations. To minimize this concern, lethal mutations, in...

journal_title：PLoS pathogens

authors： Wu J,Bisaro DM

更新日期：2020-12-22 00:00:00

abstract：:To guide control policies, it is important that the determinants of influenza transmission are fully characterized. Such assessment is complex because the risk of influenza infection is multifaceted and depends both on immunity acquired naturally or via vaccination and on the individual level of exposure to influenza ...

journal_title：PLoS pathogens

authors： Cauchemez S,Ferguson NM,Fox A,Mai le Q,Thanh le T,Thai PQ,Thoang DD,Duong TN,Minh Hoa le N,Tran Hien N,Horby P

更新日期：2014-08-21 00:00:00

abstract：:Mosquito-borne flaviviruses are among the most significant arboviral pathogens worldwide. Vaccinations and mosquito population control programs remain the most reliable means for flavivirus disease prevention, and live attenuated viruses remain one of the most attractive flavivirus vaccine platforms. Some live attenua...

journal_title：PLoS pathogens

authors： Tsetsarkin KA,Liu G,Kenney H,Bustos-Arriaga J,Hanson CT,Whitehead SS,Pletnev AG

更新日期：2015-04-23 00:00:00

abstract：:Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation characterized by the influx of myeloid cells and production of proinflammatory cytokines including interferons (IFNs). It is unclear, however, how the immune system clears the virus without causing lethal immunopathology. Here,...

journal_title：PLoS pathogens

authors： Stifter SA,Bhattacharyya N,Pillay R,Flórido M,Triccas JA,Britton WJ,Feng CG

更新日期：2016-01-05 00:00:00

abstract：:Intracellular pathogens must withstand nitric oxide (NO.) generated by host phagocytes. Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify NO.. Consequently, the level of NO. stress encountered by S. Typ...

journal_title：PLoS pathogens

authors： Richardson AR,Soliven KC,Castor ME,Barnes PD,Libby SJ,Fang FC

更新日期：2009-05-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection is a chronic condition, where viral DNA integrates into the genome. Latently infected cells form a persistent, heterogeneous reservoir that at any time can reactivate the integrated HIV-1. Here we confirmed that latently infected cells from HIV-1 positive study par...

journal_title：PLoS pathogens

authors： Lindqvist B,Svensson Akusjärvi S,Sönnerborg A,Dimitriou M,Svensson JP

更新日期：2020-01-30 00:00:00

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Among the several new antimalarials discovered over the past decade are at least three clinical candidate drugs, each with a distinct chemical structure, that disrupt Na+ homeostasis resulting in a rapid increase in intracellular Na+ concentration ([Na+]i) within the erythrocytic stages of Plasmodium falciparum. At pr...

journal_title：PLoS pathogens

authors： Das S,Bhatanagar S,Morrisey JM,Daly TM,Burns JM Jr,Coppens I,Vaidya AB

更新日期：2016-05-26 00:00:00

abstract：:Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HE...

journal_title：PLoS pathogens

authors： Uchil PD,Quinlan BD,Chan WT,Luna JM,Mothes W

更新日期：2008-02-08 00:00:00

abstract：:The human T cell leukemia virus HTLV-1 establishes a persistent infection in vivo in which the viral sense-strand transcription is usually silent at a given time in each cell. However, cellular stress responses trigger the reactivation of HTLV-1, enabling the virus to transmit to a new host cell. Using single-molecule...

journal_title：PLoS pathogens

authors： Miura M,Dey S,Ramanayake S,Singh A,Rueda DS,Bangham CRM

更新日期：2019-11-18 00:00:00

abstract：:Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env)...

journal_title：PLoS pathogens

authors： Del Prete GQ,Keele BF,Fode J,Thummar K,Swanstrom AE,Rodriguez A,Raymond A,Estes JD,LaBranche CC,Montefiori DC,KewalRamani VN,Lifson JD,Bieniasz PD,Hatziioannou T

更新日期：2017-09-25 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs. The aptitude of ba...

journal_title：PLoS pathogens

authors： Felden B,Vandenesch F,Bouloc P,Romby P

更新日期：2011-03-01 00:00:00

abstract：:Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wi...

journal_title：PLoS pathogens

authors： Zhu K,Yang J,Luo K,Yang C,Zhang N,Xu R,Chen J,Jin M,Xu B,Guo N,Wang J,Chen Z,Cui Y,Zhao H,Wang Y,Deng C,Bai L,Ge B,Qin CF,Shen H,Yang CF,Leng Q

更新日期：2015-01-23 00:00:00

abstract：:The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little is known about this interaction. We used isothermal titration calorimetry, X-ray crystallography and mutagenesis-validated modeling to...

journal_title：PLoS pathogens

authors： Fisher CR,Sutton HJ,Kaczmarski JA,McNamara HA,Clifton B,Mitchell J,Cai Y,Dups JN,D'Arcy NJ,Singh M,Chuah A,Peat TS,Jackson CJ,Cockburn IA

更新日期：2017-07-31 00:00:00

abstract：:The matrix (M) proteins of rhabdoviruses are multifunctional proteins essential for virus maturation and budding that also regulate the expression of viral and host proteins. We have solved the structures of M from the vesicular stomatitis virus serotype New Jersey (genus: Vesiculovirus) and from Lagos bat virus (genu...

journal_title：PLoS pathogens

authors： Graham SC,Assenberg R,Delmas O,Verma A,Gholami A,Talbi C,Owens RJ,Stuart DI,Grimes JM,Bourhy H

更新日期：2008-12-01 00:00:00