RNAi screening identifies a new Toll from shrimp Litopenaeus vannamei that restricts WSSV infection through activating Dorsal to induce antimicrobial peptides.

abstract：:Accurate calculation of mutation rates for viruses and viroids is necessary for evolutionary studies and to evaluate adaptation potential. However, estimation of in vivo mutation rates is complicated by selection, which leads to loss or proliferation of certain mutations. To minimize this concern, lethal mutations, in...

journal_title：PLoS pathogens

authors： Wu J,Bisaro DM

更新日期：2020-12-22 00:00:00

abstract：:Amebiasis is caused by the protozoan parasite Entamoeba histolytica (Eh), a potentially fatal disease occurring mainly in developing countries. How Eh interacts with innate host factors in the gut is poorly understood. Eh resides and feed in/on the outer colonic mucus layer and thus share an ecological niche with indi...

journal_title：PLoS pathogens

authors： Leon-Coria A,Kumar M,Moreau F,Chadee K

更新日期：2018-11-30 00:00:00

abstract：:Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate...

journal_title：PLoS pathogens

authors： Liang J,Sagum CA,Bedford MT,Sidhu SS,Sudol M,Han Z,Harty RN

更新日期：2017-01-11 00:00:00

abstract：:Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange fact...

journal_title：PLoS pathogens

authors： Fukazawa A,Alonso C,Kurachi K,Gupta S,Lesser CF,McCormick BA,Reinecker HC

更新日期：2008-11-01 00:00:00

abstract：:In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory neurons. In humans, local opioids and opioid peptides significantly...

journal_title：PLoS pathogens

authors： Rittner HL,Hackel D,Voigt P,Mousa S,Stolz A,Labuz D,Schäfer M,Schaefer M,Stein C,Brack A

更新日期：2009-04-01 00:00:00

abstract：:Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense mechanisms. The cellular transcriptional repressor Daxx prevents ...

journal_title：PLoS pathogens

authors： Schreiner S,Martinez R,Groitl P,Rayne F,Vaillant R,Wimmer P,Bossis G,Sternsdorf T,Marcinowski L,Ruzsics Z,Dobner T,Wodrich H

更新日期：2012-02-01 00:00:00

abstract：:Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Given that RTA is a transcri...

journal_title：PLoS pathogens

authors： Wei X,Bai L,Dong L,Liu H,Xing P,Zhou Z,Wu S,Lan K

更新日期：2019-11-21 00:00:00

abstract：:Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and liver disease. The characterization of viral populations that successfully initiate infection, and also those that drive progression to chronicity is instrumental for understanding pathogenesis and vaccine design. A comprehensive an...

journal_title：PLoS pathogens

authors： Bull RA,Luciani F,McElroy K,Gaudieri S,Pham ST,Chopra A,Cameron B,Maher L,Dore GJ,White PA,Lloyd AR

更新日期：2011-09-01 00:00:00

abstract：:Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient pteropine orthoreov...

journal_title：PLoS pathogens

authors： Kanai Y,Kawagishi T,Sakai Y,Nouda R,Shimojima M,Saijo M,Matsuura Y,Kobayashi T

更新日期：2019-04-25 00:00:00

abstract：:The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade and replicate within mammalian cells. Remarkably, of the 15 serovars within the genus, strains belonging to serovar 4b cause the majority of listeriosis clinical cases and outbreaks. The Listeria O-antigens are defined by subtl...

journal_title：PLoS pathogens

authors： Sumrall ET,Shen Y,Keller AP,Rismondo J,Pavlou M,Eugster MR,Boulos S,Disson O,Thouvenot P,Kilcher S,Wollscheid B,Cabanes D,Lecuit M,Gründling A,Loessner MJ

更新日期：2019-10-07 00:00:00

abstract：:Malaria, caused by the apicomplexan parasite Plasmodium, still represents a major threat to human health and welfare and leads to about one million human deaths annually. Plasmodium is a rapidly multiplying unicellular organism undergoing a complex developmental cycle in man and mosquito - a life style that requires r...

journal_title：PLoS pathogens

authors： Kehr S,Sturm N,Rahlfs S,Przyborski JM,Becker K

更新日期：2010-12-23 00:00:00

abstract：:Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV infection of CD4+ T cells-by up to 37-fold...

journal_title：PLoS pathogens

authors： Neidleman JA,Chen JC,Kohgadai N,Müller JA,Laustsen A,Thavachelvam K,Jang KS,Stürzel CM,Jones JJ,Ochsenbauer C,Chitre A,Somsouk M,Garcia MM,Smith JF,Greenblatt RM,Münch J,Jakobsen MR,Giudice LC,Greene WC,Roan NR

更新日期：2017-02-16 00:00:00

abstract：:Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, and fever and high rates of abortions in livestock. A nonstructural RVFV NSs protein inhibit...

journal_title：PLoS pathogens

authors： Ikegami T,Narayanan K,Won S,Kamitani W,Peters CJ,Makino S

更新日期：2009-02-01 00:00:00

abstract：:We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes involved in detoxification processes, including oxidative stress response and metal ion homeostasis,...

journal_title：PLoS pathogens

authors： Soutourina O,Dubrac S,Poupel O,Msadek T,Martin-Verstraete I

更新日期：2010-05-13 00:00:00

abstract：:Whereas the majority of pathogenic Salmonella serovars are capable of infecting many different animal species, typically producing a self-limited gastroenteritis, serovars with narrow host-specificity exhibit increased virulence and their infections frequently result in fatal systemic diseases. In our study, a genetic...

journal_title：PLoS pathogens

authors： Kisiela DI,Chattopadhyay S,Libby SJ,Karlinsey JE,Fang FC,Tchesnokova V,Kramer JJ,Beskhlebnaya V,Samadpour M,Grzymajlo K,Ugorski M,Lankau EW,Mackie RI,Clegg S,Sokurenko EV

更新日期：2012-01-01 00:00:00

abstract：:Rabbit hemorrhagic disease, first described in China in 1984, causes hemorrhagic necrosis of the liver. Its etiological agent, rabbit hemorrhagic disease virus (RHDV), belongs to the Lagovirus genus in the family Caliciviridae. The detailed molecular structure of any lagovirus capsid has yet to be determined. Here, we...

journal_title：PLoS pathogens

authors： Wang X,Xu F,Liu J,Gao B,Liu Y,Zhai Y,Ma J,Zhang K,Baker TS,Schulten K,Zheng D,Pang H,Sun F

更新日期：2013-01-01 00:00:00

abstract：:Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As a result, cargo proteins such as cadherins fail to reach inter-cellu...

journal_title：PLoS pathogens

authors： Guichard A,Jain P,Moayeri M,Schwartz R,Chin S,Zhu L,Cruz-Moreno B,Liu JZ,Aguilar B,Hollands A,Leppla SH,Nizet V,Bier E

更新日期：2017-09-25 00:00:00

abstract：:The bank vole is a rodent susceptible to different prion strains from humans and various animal species. We analyzed the transmission features of different prions in a panel of seven rodent species which showed various degrees of phylogenetic affinity and specific prion protein (PrP) sequence divergences in order to i...

journal_title：PLoS pathogens

authors： Agrimi U,Nonno R,Dell'Omo G,Di Bari MA,Conte M,Chiappini B,Esposito E,Di Guardo G,Windl O,Vaccari G,Lipp HP

更新日期：2008-07-25 00:00:00

abstract：:Hepatitis B virus infection (HBV) is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA) that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein HBx ...

journal_title：PLoS pathogens

authors： Ducroux A,Benhenda S,Rivière L,Semmes OJ,Benkirane M,Neuveut C

更新日期：2014-09-11 00:00:00

abstract：:Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [P...

journal_title：PLoS pathogens

authors： Sáez-Cirión A,Bacchus C,Hocqueloux L,Avettand-Fenoel V,Girault I,Lecuroux C,Potard V,Versmisse P,Melard A,Prazuck T,Descours B,Guergnon J,Viard JP,Boufassa F,Lambotte O,Goujard C,Meyer L,Costagliola D,Venet A,Pancin

更新日期：2013-03-01 00:00:00

abstract：:RNA viruses typically occur in genetically diverse populations due to their error-prone genome replication. Genetic diversity is thought to be important in allowing RNA viruses to explore sequence space, facilitating adaptation to changing environments and hosts. Some arboviruses that infect both a mosquito vector and...

journal_title：PLoS pathogens

authors： Forrester NL,Guerbois M,Seymour RL,Spratt H,Weaver SC

更新日期：2012-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1008639.]. ...

journal_title：PLoS pathogens

authors： Bonhomme D,Santecchia I,Vernel-Pauillac F,Caroff M,Germon P,Murray G,Adler B,Boneca IG,Werts C

更新日期：2020-12-23 00:00:00

abstract：:CD4(+) T cell loss is central to HIV pathogenesis. In the initial weeks post-infection, the great majority of dying cells are uninfected CD4(+) T cells. We previously showed that the 3S motif of HIV-1 gp41 induces surface expression of NKp44L, a cellular ligand for an activating NK receptor, on uninfected bystander CD...

journal_title：PLoS pathogens

authors： Fausther-Bovendo H,Vieillard V,Sagan S,Bismuth G,Debré P

更新日期：2010-07-01 00:00:00

abstract：:IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response DNA sensor and induces the IL-1β and antiviral type-1 interferon-β (IFN-β) cytokines. We have shown that IFI16, in association with BRCA1, functions as a se...

journal_title：PLoS pathogens

authors： Iqbal J,Ansari MA,Kumar B,Dutta D,Roy A,Chikoti L,Pisano G,Dutta S,Vahedi S,Veettil MV,Chandran B

更新日期：2016-10-20 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety. Analysis of the genetic tree suggests that SARS-CoV-2 belongs to the same Betacoronavirus group a...

journal_title：PLoS pathogens

authors： Tang D,Comish P,Kang R

更新日期：2020-05-22 00:00:00

abstract：:Helicobacter pylori (Hp) injects the CagA effector protein into host epithelial cells and induces growth factor-like signaling, perturbs cell-cell junctions, and alters host cell polarity. This enables Hp to grow as microcolonies adhered to the host cell surface even in conditions that do not support growth of free-sw...

journal_title：PLoS pathogens

authors： Tan S,Noto JM,Romero-Gallo J,Peek RM Jr,Amieva MR

更新日期：2011-05-01 00:00:00

abstract：:The opportunistic human fungal pathogen, Candida albicans, undergoes morphological and transcriptional adaptation in the switch from commensalism to pathogenicity. Although previous gene-knockout studies have identified many factors involved in this transformation, it remains unclear how these factors are regulated to...

journal_title：PLoS pathogens

authors： Greig JA,Sudbery IM,Richardson JP,Naglik JR,Wang Y,Sudbery PE

更新日期：2015-01-24 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:RsaE is a conserved small regulatory RNA (sRNA) which was previously reported to represent a riboregulator of central carbon flow and other metabolic pathways in Staphylococcus aureus and Bacillus subtilis. Here we show that RsaE contributes to extracellular (e)DNA release and biofilm-matrix switching towards polysacc...

journal_title：PLoS pathogens

authors： Schoenfelder SMK,Lange C,Prakash SA,Marincola G,Lerch MF,Wencker FDR,Förstner KU,Sharma CM,Ziebuhr W

更新日期：2019-03-14 00:00:00

abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

journal_title：PLoS pathogens

authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

更新日期：2020-04-30 00:00:00