Identification of cellular genes targeted by KSHV-encoded microRNAs.

abstract：:The host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae ("inflammation-inflicted bloo...

journal_title：PLoS pathogens

authors： Nedialkova LP,Denzler R,Koeppel MB,Diehl M,Ring D,Wille T,Gerlach RG,Stecher B

更新日期：2014-01-01 00:00:00

abstract：:In addition to modulating the function and stability of cellular mRNAs, microRNAs can profoundly affect the life cycles of viruses bearing sequence complementary targets, a finding recently exploited to ameliorate toxicities of vaccines and oncolytic viruses. To elucidate the mechanisms underlying microRNA-mediated an...

journal_title：PLoS pathogens

authors： Kelly EJ,Hadac EM,Cullen BR,Russell SJ

更新日期：2010-03-19 00:00:00

abstract：:Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens. Colonization by Streptococcus pneumoniae, which is central to the organism's transmission and therefore evolution, is limited by two arms of the immune system: antibody- and T cell- mediated i...

journal_title：PLoS pathogens

authors： Li Y,Gierahn T,Thompson CM,Trzciński K,Ford CB,Croucher N,Gouveia P,Flechtner JB,Malley R,Lipsitch M

更新日期：2012-01-01 00:00:00

abstract：:Vertical transmission (VT) and horizontal transmission (HT) of pathogens refer to parental and non-parental chains of host-to-host transmission. Combining HT with VT enlarges considerably the range of ecological conditions in which a pathogen can persist, but the factors governing the relative frequency of each transm...

journal_title：PLoS pathogens

authors： Lequime S,Paul RE,Lambrechts L

更新日期：2016-05-12 00:00:00

abstract：:Certain cutaneous human papillomaviruses (HPVs), which are ubiquitous and acquired early during childhood, can cause a variety of skin tumors and are likely involved in the development of non-melanoma skin cancer, especially in immunosuppressed patients. Hence, the burden of these clinical manifestations demands for a...

journal_title：PLoS pathogens

authors： Vinzón SE,Braspenning-Wesch I,Müller M,Geissler EK,Nindl I,Gröne HJ,Schäfer K,Rösl F

更新日期：2014-02-20 00:00:00

abstract：:Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by relapsing enteritis and severe autoimmune disorders. To establish a persistent infection, the bacteria have to cope with hostile surroundings when they transmigrate through the intestinal epithelium and colonize underlying...

journal_title：PLoS pathogens

authors： Heine W,Beckstette M,Heroven AK,Thiemann S,Heise U,Nuss AM,Pisano F,Strowig T,Dersch P

更新日期：2018-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) infects about 50% of the US population, is the leading infectious cause of birth defects, and is considered the most important infectious agent in transplant recipients. The virus infects many cell types in vivo and in vitro. While previous studies have identified several cellular proteins...

journal_title：PLoS pathogens

authors： Li Q,Wilkie AR,Weller M,Liu X,Cohen JI

更新日期：2015-07-06 00:00:00

abstract：:Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathoge...

journal_title：PLoS pathogens

authors： Liu F,He CX,Luo LJ,Zou QL,Zhao YX,Saini R,Han SF,Knölker HJ,Wang LS,Ge BX

更新日期：2013-01-01 00:00:00

abstract：:Magnaporthe oryzae, the fungus causing rice blast disease, should contend with host innate immunity to develop invasive hyphae (IH) within living host cells. However, molecular strategies to establish the biotrophic interactions are largely unknown. Here, we report the biological function of a M. oryzae-specific gene,...

journal_title：PLoS pathogens

authors： Nishimura T,Mochizuki S,Ishii-Minami N,Fujisawa Y,Kawahara Y,Yoshida Y,Okada K,Ando S,Matsumura H,Terauchi R,Minami E,Nishizawa Y

更新日期：2016-10-06 00:00:00

abstract：:Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and th...

journal_title：PLoS pathogens

authors： Denic M,Turlin E,Michel V,Fischer F,Khorasani-Motlagh M,Zamble D,Vinella D,de Reuse H

更新日期：2021-01-14 00:00:00

abstract：:Entry of Staphylococcus aureus into the bloodstream can lead to metastatic abscess formation and infective endocarditis. Crucial to the development of both these conditions is the interaction of S. aureus with endothelial cells. In vivo and in vitro studies have shown that the staphylococcal invasin FnBPA triggers bac...

journal_title：PLoS pathogens

authors： Edwards AM,Potts JR,Josefsson E,Massey RC

更新日期：2010-06-24 00:00:00

abstract：:Anthrax poses a community health risk due to accidental or intentional aerosol release. Reliable quantitative dose-response analyses are required to estimate the magnitude and timeline of potential consequences and the effect of public health intervention strategies under specific scenarios. Analyses of available data...

journal_title：PLoS pathogens

authors： Toth DJ,Gundlapalli AV,Schell WA,Bulmahn K,Walton TE,Woods CW,Coghill C,Gallegos F,Samore MH,Adler FR

更新日期：2013-08-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1008639.]. ...

journal_title：PLoS pathogens

authors： Bonhomme D,Santecchia I,Vernel-Pauillac F,Caroff M,Germon P,Murray G,Adler B,Boneca IG,Werts C

更新日期：2020-12-23 00:00:00

abstract：:As targets of adaptive immunity, influenza viruses are characterized by the fluidity with which they respond to the selective pressure applied by neutralizing antibodies. This mutability of structural determinants of protective immunity is the obstacle in developing universal influenza vaccines. Towards the developmen...

journal_title：PLoS pathogens

authors： Wang TT,Tan GS,Hai R,Pica N,Petersen E,Moran TM,Palese P

更新日期：2010-02-26 00:00:00

abstract：:Trichodysplasia spinulosa-associated Polyomavirus (TSPyV) was isolated from a patient suffering from trichodysplasia spinulosa, a skin disease that can appear in severely immunocompromised patients. While TSPyV is one of the five members of the polyomavirus family that are directly linked to a human disease, details a...

journal_title：PLoS pathogens

authors： Ströh LJ,Gee GV,Blaum BS,Dugan AS,Feltkamp MC,Atwood WJ,Stehle T

更新日期：2015-08-24 00:00:00

abstract：:Pseudomonas aeruginosa is one of the leading causes of nosocomial pneumonia and its associated mortality. Moreover, extensively drug-resistant high-risk clones are globally widespread, presenting a major challenge to the healthcare systems. Despite this, no vaccine is available against this high-concerning pathogen. H...

journal_title：PLoS pathogens

authors： Cabral MP,Correia A,Vilanova M,Gärtner F,Moscoso M,García P,Vallejo JA,Pérez A,Francisco-Tomé M,Fuentes-Valverde V,Bou G

更新日期：2020-02-10 00:00:00

abstract：:Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasite Ascaris lumbricoides, estimated to infect approximately 1.4 billion...

journal_title：PLoS pathogens

authors： Williamson SM,Robertson AP,Brown L,Williams T,Woods DJ,Martin RJ,Sattelle DB,Wolstenholme AJ

更新日期：2009-07-01 00:00:00

abstract：:Mokola virus (MOKV) belongs to the lyssavirus genus. As other genus members-including rabies virus (RABV)-it causes deadly encephalitis in mammals. MOKV entry into host cells is mediated by its transmembrane glycoprotein G. First, G binds cellular receptors, triggering virion endocytosis. Then, in the acidic endosomal...

journal_title：PLoS pathogens

authors： Belot L,Ouldali M,Roche S,Legrand P,Gaudin Y,Albertini AA

更新日期：2020-03-09 00:00:00

abstract：:Infection of host tissues by Staphylococcus aureus and S. epidermidis requires an unusual family of staphylococcal adhesive proteins that contain long stretches of serine-aspartate dipeptide-repeats (SDR). The prototype member of this family is clumping factor A (ClfA), a key virulence factor that mediates adhesion to...

journal_title：PLoS pathogens

authors： Hazenbos WL,Kajihara KK,Vandlen R,Morisaki JH,Lehar SM,Kwakkenbos MJ,Beaumont T,Bakker AQ,Phung Q,Swem LR,Ramakrishnan S,Kim J,Xu M,Shah IM,Diep BA,Sai T,Sebrell A,Khalfin Y,Oh A,Koth C,Lin SJ,Lee BC,Strandh M

更新日期：2013-01-01 00:00:00

abstract：:The envelope glycoprotein (Env) of the Human Immunodeficiency Virus Type-1 (HIV-1) is a critical determinant of viral infectivity, tropism and is the main target for humoral immunity; however, little is known about the cellular machinery that directs Env trafficking and its incorporation into nascent virions. Here we ...

journal_title：PLoS pathogens

authors： Groppelli E,Len AC,Granger LA,Jolly C

更新日期：2014-11-13 00:00:00

abstract：:Viral infections of central nervous system (CNS) often trigger inflammatory responses that give rise to a wide range of pathological outcomes. The CNS is equipped with an elaborate network of innate immune sentinels (e.g. microglia, macrophages, dendritic cells) that routinely serve as first responders to these infect...

journal_title：PLoS pathogens

authors： Nayak D,Johnson KR,Heydari S,Roth TL,Zinselmeyer BH,McGavern DB

更新日期：2013-01-01 00:00:00

abstract：:CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV) express the regulatory cytokine interleukin (IL)-10. IL-10+CD4+ T...

journal_title：PLoS pathogens

authors： Clement M,Marsden M,Stacey MA,Abdul-Karim J,Gimeno Brias S,Costa Bento D,Scurr MJ,Ghazal P,Weaver CT,Carlesso G,Clare S,Jones SA,Godkin A,Jones GW,Humphreys IR

更新日期：2016-12-07 00:00:00

abstract：:HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti...

journal_title：PLoS pathogens

authors： Leslie GJ,Wang J,Richardson MW,Haggarty BS,Hua KL,Duong J,Secreto AJ,Jordon AP,Romano J,Kumar KE,DeClercq JJ,Gregory PD,June CH,Root MJ,Riley JL,Holmes MC,Hoxie JA

更新日期：2016-11-17 00:00:00

abstract：:Biofilm formation is an important virulence trait of the pathogenic yeast Candida albicans. We have combined gene overexpression, strain barcoding and microarray profiling to screen a library of 531 C. albicans conditional overexpression strains (∼10% of the genome) for genes affecting biofilm development in mixed-pop...

journal_title：PLoS pathogens

authors： Cabral V,Znaidi S,Walker LA,Martin-Yken H,Dague E,Legrand M,Lee K,Chauvel M,Firon A,Rossignol T,Richard ML,Munro CA,Bachellier-Bassi S,d'Enfert C

更新日期：2014-12-11 00:00:00

abstract：:Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of muscle disorders. Whilst neurotoxin expression by the spore-formin...

journal_title：PLoS pathogens

authors： Zhang Z,Korkeala H,Dahlsten E,Sahala E,Heap JT,Minton NP,Lindström M

更新日期：2013-03-01 00:00:00

abstract：:Mycobacterium abscessus is considered the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. Infections with M. abscessus are increasingly found in patients with chronic lung diseases, especially cystic fibrosis, and are often refractory to antibiotic therapy. M. abscessus has two...

journal_title：PLoS pathogens

authors： Bernut A,Nguyen-Chi M,Halloum I,Herrmann JL,Lutfalla G,Kremer L

更新日期：2016-11-02 00:00:00

abstract：:Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates. Postmortem samples from the characteristic purpuric rashes of the infection show bacterial aggreg...

journal_title：PLoS pathogens

authors： Melican K,Michea Veloso P,Martin T,Bruneval P,Duménil G

更新日期：2013-01-01 00:00:00

abstract：:Targeting of permissive entry sites is crucial for bacterial infection. The targeting mechanisms are incompletely understood. We have analyzed target-site selection by S. Typhimurium. This enteropathogenic bacterium employs adhesins (e.g. fim) and the type III secretion system 1 (TTSS-1) for host cell binding, the tri...

journal_title：PLoS pathogens

authors： Misselwitz B,Barrett N,Kreibich S,Vonaesch P,Andritschke D,Rout S,Weidner K,Sormaz M,Songhet P,Horvath P,Chabria M,Vogel V,Spori DM,Jenny P,Hardt WD

更新日期：2012-01-01 00:00:00

abstract：:Plant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a...

journal_title：PLoS pathogens

authors： Warnock ND,Wilson L,Patten C,Fleming CC,Maule AG,Dalzell JJ

更新日期：2017-02-27 00:00:00

abstract：:Isolated influenza A virus nucleoprotein exists in an equilibrium between monomers and trimers. Samples containing only monomers or only trimers can be stabilized by respectively low and high salt. The trimers bind RNA with high affinity but remain trimmers, whereas the monomers polymerise onto RNA forming nucleoprote...

journal_title：PLoS pathogens

authors： Chenavas S,Estrozi LF,Slama-Schwok A,Delmas B,Di Primo C,Baudin F,Li X,Crépin T,Ruigrok RW

更新日期：2013-03-01 00:00:00