Monomeric nucleoprotein of influenza A virus.

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:The two-component system (TCS) KdpD/KdpE, extensively studied for its regulatory role in potassium (K(+)) transport, has more recently been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria, including Staphylococcus aureus, entero-haemorrhagic Escherichia c...

journal_title：PLoS pathogens

authors： Freeman ZN,Dorus S,Waterfield NR

更新日期：2013-03-01 00:00:00

abstract：:The type VI secretion system (T6SS) is a widespread protein secretion apparatus used by Gram-negative bacteria to deliver toxic effector proteins into adjacent bacterial or host cells. Here, we uncovered a role in interbacterial competition for the two T6SSs encoded by the marine pathogen Vibrio alginolyticus. Using c...

journal_title：PLoS pathogens

authors： Salomon D,Klimko JA,Trudgian DC,Kinch LN,Grishin NV,Mirzaei H,Orth K

更新日期：2015-08-25 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing relationship to disease onset is unknown. We developed two novel mo...

journal_title：PLoS pathogens

authors： Small CL,Xing L,McPhee JB,Law HT,Coombes BK

更新日期：2016-10-06 00:00:00

abstract：:SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV mutants, we longitud...

journal_title：PLoS pathogens

authors： Vanderford TH,Bleckwehl C,Engram JC,Dunham RM,Klatt NR,Feinberg MB,Garber DA,Betts MR,Silvestri G

更新日期：2011-05-01 00:00:00

abstract：:The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature is switched from 29°C at 37°...

journal_title：PLoS pathogens

authors： Lim XN,Shan C,Marzinek JK,Dong H,Ng TS,Ooi JSG,Fibriansah G,Wang J,Verma CS,Bond PJ,Shi PY,Lok SM

更新日期：2019-09-19 00:00:00

abstract：:It is poorly understood how progressive brain swelling in experimental cerebral malaria (ECM) evolves in space and over time, and whether mechanisms of inflammation or microvascular sequestration/obstruction dominate the underlying pathophysiology. We therefore monitored in the Plasmodium berghei ANKA-C57BL/6 murine E...

journal_title：PLoS pathogens

authors： Hoffmann A,Pfeil J,Alfonso J,Kurz FT,Sahm F,Heiland S,Monyer H,Bendszus M,Mueller AK,Helluy X,Pham M

更新日期：2016-03-10 00:00:00

abstract：:The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the...

journal_title：PLoS pathogens

authors： Chen CY,Huang D,Wang RC,Shen L,Zeng G,Yao S,Shen Y,Halliday L,Fortman J,McAllister M,Estep J,Hunt R,Vasconcelos D,Du G,Porcelli SA,Larsen MH,Jacobs WR Jr,Haynes BF,Letvin NL,Chen ZW

更新日期：2009-04-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005698.]. ...

journal_title：PLoS pathogens

authors： Ersching J,Basso AS,Calich VL,Bortoluci KR,Rodrigues MM

更新日期：2016-07-11 00:00:00

abstract：:Negative-sense RNA viruses assemble large ribonucleoprotein (RNP) complexes that direct replication and transcription of the viral genome. Influenza virus RNPs contain the polymerase, genomic RNA and multiple copies of nucleoprotein (NP). During RNP assembly, monomeric NP oligomerizes along the length of the genomic R...

journal_title：PLoS pathogens

authors： Mondal A,Potts GK,Dawson AR,Coon JJ,Mehle A

更新日期：2015-04-13 00:00:00

abstract：:Human rhinovirus (RV) infections are the principle cause of common colds and precipitate asthma and COPD exacerbations. There is currently no RV vaccine, largely due to the existence of ∼150 strains. We aimed to define highly conserved areas of the RV proteome and test their usefulness as candidate antigens for a broa...

journal_title：PLoS pathogens

authors： Glanville N,McLean GR,Guy B,Lecouturier V,Berry C,Girerd Y,Gregoire C,Walton RP,Pearson RM,Kebadze T,Burdin N,Bartlett NW,Almond JW,Johnston SL

更新日期：2013-01-01 00:00:00

abstract：:Over 200 million people have, and another 600 million are at risk of contracting, schistosomiasis, one of the major neglected tropical diseases. Transmission of this infection, which is caused by helminth parasites of the genus Schistosoma, depends upon the release of parasite eggs from the human host. However, approx...

journal_title：PLoS pathogens

authors： Freitas TC,Jung E,Pearce EJ

更新日期：2007-04-01 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease in humans, is exposed to reactive oxygen and nitrogen species (ROS and RNS) in both the tick vector and vertebrate reservoir hosts. B. burgdorferi contains a limited repertoire of canonical oxidative stress response genes, suggesting that novel gene functions m...

journal_title：PLoS pathogens

authors： Ramsey ME,Hyde JA,Medina-Perez DN,Lin T,Gao L,Lundt ME,Li X,Norris SJ,Skare JT,Hu LT

更新日期：2017-02-17 00:00:00

abstract：:Dengue virus (DENV) is the leading cause of mosquito-borne viral illness and death in humans. Like many viruses, DENV has evolved potent mechanisms that abolish the antiviral response within infected cells. Nevertheless, several in vivo studies have demonstrated a key role of the innate immune response in controlling ...

journal_title：PLoS pathogens

authors： Décembre E,Assil S,Hillaire ML,Dejnirattisai W,Mongkolsapaya J,Screaton GR,Davidson AD,Dreux M

更新日期：2014-10-23 00:00:00

abstract：:The heterosexual risk group has become the largest HIV infected group in the United Kingdom during the last 10 years, but little is known of the network structure and dynamics of viral transmission in this group. The overwhelming majority of UK heterosexual infections are of non-B HIV subtypes, indicating viruses orig...

journal_title：PLoS pathogens

authors： Hughes GJ,Fearnhill E,Dunn D,Lycett SJ,Rambaut A,Leigh Brown AJ,UK HIV Drug Resistance Collaboration.

更新日期：2009-09-01 00:00:00

abstract：:Pathogenic hantaviruses, genus Orthohantaviridae, are maintained in rodent reservoirs with zoonotic transmission to humans occurring through inhalation of rodent excreta. Hantavirus disease in humans is characterized by localized vascular leakage and elevated levels of circulating proinflammatory cytokines. Despite th...

journal_title：PLoS pathogens

authors： Kell AM,Hemann EA,Turnbull JB,Gale M Jr

更新日期：2020-04-24 00:00:00

abstract：:Plant pathogens secrete an arsenal of effector proteins to impair host immunity. Some effectors possess enzymatic activities that can modify their host targets. Previously, we demonstrated that a Phytophthora sojae RXLR effector Avr3b acts as a Nudix hydrolase when expressed in planta; and this enzymatic activity is r...

journal_title：PLoS pathogens

authors： Kong G,Zhao Y,Jing M,Huang J,Yang J,Xia Y,Kong L,Ye W,Xiong Q,Qiao Y,Dong S,Ma W,Wang Y

更新日期：2015-08-28 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1002924.]. ...

journal_title：PLoS pathogens

authors： Grard G,Fair JN,Lee D,Slikas E,Steffen I,Muyembe JJ,Sittler T,Veeraraghavan N,Ruby JG,Wang C,Makuwa M,Mulembakani P,Tesh RB,Mazet J,Rimoin AW,Taylor T,Schneider BS,Simmons G,Delwart E,Wolfe ND,Chiu CY,Leroy EM

更新日期：2017-09-07 00:00:00

abstract：:Environments such as light condition influence the spread of infectious diseases by affecting insect vector behavior. However, whether and how light affects the host defense which further affects insect preference and performance, remains unclear, nor has been demonstrated how pathogens co-adapt light condition to fac...

journal_title：PLoS pathogens

authors： Zhao P,Zhang X,Gong Y,Wang D,Xu D,Wang N,Sun Y,Gao L,Liu SS,Deng XW,Kliebenstein DJ,Zhou X,Fang RX,Ye J

更新日期：2021-01-11 00:00:00

abstract：:Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection has remained uncertain. Here we report that, following low dose aerosol infection with Mtb, mice lacking TLR2 (TLR2KO), in comparison wit...

journal_title：PLoS pathogens

authors： McBride A,Konowich J,Salgame P

更新日期：2013-01-01 00:00:00

abstract：:The agr quorum-sensing system of Staphylococcus aureus modulates the expression of virulence factors in response to autoinducing peptides (AIPs). Recent studies have suggested a role for the agr system in S. aureus biofilm development, as agr mutants exhibit a high propensity to form biofilms, and cells dispersing fro...

journal_title：PLoS pathogens

authors： Boles BR,Horswill AR

更新日期：2008-04-25 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chick embryo fibroblast...

journal_title：PLoS pathogens

authors： Peng C,Wyatt LS,Glushakow-Smith SG,Lal-Nag M,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:The host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae ("inflammation-inflicted bloo...

journal_title：PLoS pathogens

authors： Nedialkova LP,Denzler R,Koeppel MB,Diehl M,Ring D,Wille T,Gerlach RG,Stecher B

更新日期：2014-01-01 00:00:00

abstract：:The control of mosquito populations with insecticide treated bed nets and indoor residual sprays remains the cornerstone of malaria reduction and elimination programs. In light of widespread insecticide resistance in mosquitoes, however, alternative strategies for reducing transmission by the mosquito vector are urgen...

journal_title：PLoS pathogens

authors： Childs LM,Cai FY,Kakani EG,Mitchell SN,Paton D,Gabrieli P,Buckee CO,Catteruccia F

更新日期：2016-12-15 00:00:00

abstract：:Magnaporthe oryzae, the fungus causing rice blast disease, should contend with host innate immunity to develop invasive hyphae (IH) within living host cells. However, molecular strategies to establish the biotrophic interactions are largely unknown. Here, we report the biological function of a M. oryzae-specific gene,...

journal_title：PLoS pathogens

authors： Nishimura T,Mochizuki S,Ishii-Minami N,Fujisawa Y,Kawahara Y,Yoshida Y,Okada K,Ando S,Matsumura H,Terauchi R,Minami E,Nishizawa Y

更新日期：2016-10-06 00:00:00

abstract：:Identification of the determinants of pathogen reservoir potential is central to understand disease emergence. It has been proposed that host lifespan is one such determinant: short-lived hosts will invest less in costly defenses against pathogens, so that they will be more susceptible to infection, more competent as ...

journal_title：PLoS pathogens

authors： Hily JM,García A,Moreno A,Plaza M,Wilkinson MD,Fereres A,Fraile A,García-Arenal F

更新日期：2014-11-06 00:00:00

abstract：:The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5), sense cytoplasmic viral RNA and initiate innate antiviral responses. How RIG-I and MDA5 are differentially regulated remains enigmatic. In this study, we identified the guanylate-bin...

journal_title：PLoS pathogens

authors： Zhong X,Feng L,Zang R,Lei CQ,Yang Q,Shu HB

更新日期：2020-04-06 00:00:00

abstract：:Protein C inhibitor (PCI) is a heparin-binding serine proteinase inhibitor belonging to the family of serpin proteins. Here we describe that PCI exerts broad antimicrobial activity against bacterial pathogens. This ability is mediated by the interaction of PCI with lipid membranes, which subsequently leads to their pe...

journal_title：PLoS pathogens

authors： Malmström E,Mörgelin M,Malmsten M,Johansson L,Norrby-Teglund A,Shannon O,Schmidtchen A,Meijers JC,Herwald H

更新日期：2009-12-01 00:00:00

abstract：:The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic environmental change, during which successful pathogens gauge multiple parameters that signal host localization. The facultative human...

journal_title：PLoS pathogens

authors： Haber A,Friedman S,Lobel L,Burg-Golani T,Sigal N,Rose J,Livnat-Levanon N,Lewinson O,Herskovits AA

更新日期：2017-01-23 00:00:00

abstract：:Hepadnavirus covalently closed circular (ccc) DNA is the bona fide viral transcription template, which plays a pivotal role in viral infection and persistence. Upon infection, the non-replicative cccDNA is converted from the incoming and de novo synthesized viral genomic relaxed circular (rc) DNA, presumably through e...

journal_title：PLoS pathogens

authors： Long Q,Yan R,Hu J,Cai D,Mitra B,Kim ES,Marchetti A,Zhang H,Wang S,Liu Y,Huang A,Guo H

更新日期：2017-12-29 00:00:00