A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive. While adult mice resist ZEBOV infection, the Mayinga strain of the virus has been adapted to cause lethal infecti...

journal_title：PLoS pathogens

authors： Ebihara H,Takada A,Kobasa D,Jones S,Neumann G,Theriault S,Bray M,Feldmann H,Kawaoka Y

更新日期：2006-07-01 00:00:00

abstract：:Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated self-epitopes exceeds...

journal_title：PLoS pathogens

authors： Franceschini D,Del Porto P,Piconese S,Trella E,Accapezzato D,Paroli M,Morrone S,Piccolella E,Spada E,Mele A,Sidney J,Sette A,Barnaba V

更新日期：2012-01-01 00:00:00

abstract：:Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells in LN of cART-suppre...

journal_title：PLoS pathogens

authors： Pino M,Paganini S,Deleage C,Padhan K,Harper JL,King CT,Micci L,Cervasi B,Mudd JC,Gill KP,Jean SM,Easley K,Silvestri G,Estes JD,Petrovas C,Lederman MM,Paiardini M

更新日期：2019-10-18 00:00:00

abstract：:Cytomegalovirus (CMV) is a β-herpesvirus that establishes a lifelong latent or persistent infection. A hallmark of chronic CMV infection is the lifelong persistence of large numbers of virus-specific CD8+ effector/effector memory T cells, a phenomenon called "memory inflation". How the virus continuously stimulates th...

journal_title：PLoS pathogens

authors： Snyder CM,Cho KS,Bonnett EL,Allan JE,Hill AB

更新日期：2011-10-01 00:00:00

abstract：:HIV and other lentiviruses can productively infect nondividing cells, whereas most other retroviruses, such as murine leukemia virus, require cell division for efficient infection. However, the determinants for this phenotype have been controversial. Here, we show that HIV-1 capsid (CA) is involved in facilitating HIV...

journal_title：PLoS pathogens

authors： Yamashita M,Perez O,Hope TJ,Emerman M

更新日期：2007-10-26 00:00:00

abstract：:Many animal and plant viruses rely on vectors for their transmission from host to host. Grapevine fanleaf virus (GFLV), a picorna-like virus from plants, is transmitted specifically by the ectoparasitic nematode Xiphinema index. The icosahedral capsid of GFLV, which consists of 60 identical coat protein subunits (CP),...

journal_title：PLoS pathogens

authors： Schellenberger P,Sauter C,Lorber B,Bron P,Trapani S,Bergdoll M,Marmonier A,Schmitt-Keichinger C,Lemaire O,Demangeat G,Ritzenthaler C

更新日期：2011-05-01 00:00:00

abstract：:The low pathogenicity and replicative potential of HIV-2 are still poorly understood. We investigated whether HIV-2 reservoirs might follow the peculiar distribution reported in models of attenuated HIV-1/SIV infections, i.e. limited infection of central-memory CD4 T lymphocytes (TCM). Antiretroviral-naive HIV-2 infec...

journal_title：PLoS pathogens

authors： Samri A,Charpentier C,Diallo MS,Bertine M,Even S,Morin V,Oudin A,Parizot C,Collin G,Hosmalin A,Cheynier R,Thiébaut R,Matheron S,Collin F,Zoorob R,Brun-Vézinet F,Autran B,ANRS CO5 IMMUNOVIR-2 Study Group.

更新日期：2019-05-16 00:00:00

abstract：:The Spumaretrovirinae, or foamy viruses (FVs) are complex retroviruses that infect many species of monkey and ape. Despite little sequence homology, FV and orthoretroviral Gag proteins perform equivalent functions, including genome packaging, virion assembly, trafficking and membrane targeting. However, there is a pau...

journal_title：PLoS pathogens

authors： Ball NJ,Nicastro G,Dutta M,Pollard DJ,Goldstone DC,Sanz-Ramos M,Ramos A,Müllers E,Stirnnagel K,Stanke N,Lindemann D,Stoye JP,Taylor WR,Rosenthal PB,Taylor IA

更新日期：2016-11-09 00:00:00

abstract：:Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Nikolayevskyy V,Elkington PT,Hanifa Y,Islam K,Timms PM,Bothamley GH,Claxton AP,Packe GE,Darmalingam M,Davidson RN,Milburn HJ,Baker LV,Barker RD,Drobniewski FA,Mein CA,Bhaw-Rosun L,Nuamah RA,

更新日期：2013-01-01 00:00:00

abstract：:The SUPPRESSOR OF rps4-RLD1 (SRFR1) gene was identified based on enhanced AvrRps4-triggered resistance in the naturally susceptible Arabidopsis accession RLD. No other phenotypic effects were recorded, and the extent of SRFR1 involvement in regulating effector-triggered immunity was unknown. Here we show that mutation...

journal_title：PLoS pathogens

authors： Kim SH,Gao F,Bhattacharjee S,Adiasor JA,Nam JC,Gassmann W

更新日期：2010-11-04 00:00:00

abstract：:Mycobacterial infection leads to activation of the RIG-I/MAVS/TBK1 RNA sensing pathway in macrophages but the consequences of this activation remains poorly defined. In this study, we determined that activation of this RNA sensing pathway stimulates ICAM-1 expression in M.avium-infected macrophage through the inhibiti...

journal_title：PLoS pathogens

authors： Cheng Y,Kiene NJ,Tatarian A,Eix EF,Schorey JS

更新日期：2020-05-28 00:00:00

abstract：:The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5), sense cytoplasmic viral RNA and initiate innate antiviral responses. How RIG-I and MDA5 are differentially regulated remains enigmatic. In this study, we identified the guanylate-bin...

journal_title：PLoS pathogens

authors： Zhong X,Feng L,Zang R,Lei CQ,Yang Q,Shu HB

更新日期：2020-04-06 00:00:00

abstract：:The NLRP3 inflammasome has emerged as a central immune regulator that senses virulence factors expressed by microbial pathogens for triggering inflammation. Inflammation can be harmful and therefore this response must be tightly controlled. The mechanisms by which immune cells, such as macrophages, discriminate benign...

journal_title：PLoS pathogens

authors： Tucey TM,Verma J,Olivier FAB,Lo TL,Robertson AAB,Naderer T,Traven A

更新日期：2020-08-04 00:00:00

abstract：:The virulence of Francisella tularensis, the etiological agent of tularemia, relies on an atypical type VI secretion system (T6SS) encoded by a genomic island termed the Francisella Pathogenicity Island (FPI). While the importance of the FPI in F. tularensis virulence is clearly established, the precise role of most o...

journal_title：PLoS pathogens

authors： Rigard M,Bröms JE,Mosnier A,Hologne M,Martin A,Lindgren L,Punginelli C,Lays C,Walker O,Charbit A,Telouk P,Conlan W,Terradot L,Sjöstedt A,Henry T

更新日期：2016-09-07 00:00:00

abstract：:Dengue virus (DENV) is an enveloped RNA virus that causes the most common arthropod-borne infection worldwide. The mechanism by which DENV infects the host cell remains unclear. In this work, we used live-cell imaging and single-virus tracking to investigate the cell entry, endocytic trafficking, and fusion behavior o...

journal_title：PLoS pathogens

authors： van der Schaar HM,Rust MJ,Chen C,van der Ende-Metselaar H,Wilschut J,Zhuang X,Smit JM

更新日期：2008-12-01 00:00:00

abstract：TRIAL REGISTRATION:ClinicalTrials.gov Clinical Trial NCT00594880. ...

journal_title：PLoS pathogens

authors： Chitre AS,Kattah MG,Rosli YY,Pao M,Deswal M,Deeks SG,Hunt PW,Abdel-Mohsen M,Montaner LJ,Kim CC,Ma A,Somsouk M,McCune JM

更新日期：2018-03-05 00:00:00

abstract：:The disease phenotype of bovine spongiform encephalopathy (BSE) and the molecular/ biological properties of its prion strain, including the host range and the characteristics of BSE-related disorders, have been extensively studied since its discovery in 1986. In recent years, systematic testing of the brains of cattle...

journal_title：PLoS pathogens

authors： Lombardi G,Casalone C,D' Angelo A,Gelmetti D,Torcoli G,Barbieri I,Corona C,Fasoli E,Farinazzo A,Fiorini M,Gelati M,Iulini B,Tagliavini F,Ferrari S,Caramelli M,Monaco S,Capucci L,Zanusso G

更新日期：2008-05-23 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00

abstract：:Extracellular signaling is a mechanism that higher eukaryotes have evolved to facilitate organismal homeostasis. Recent years have seen an emerging interest in the role of secreted microvesicles, termed extracellular vesicles (EV) or exosomes in this signaling network. EV contents can be modified by the cell in respon...

journal_title：PLoS pathogens

authors： McNamara RP,Chugh PE,Bailey A,Costantini LM,Ma Z,Bigi R,Cheves A,Eason AB,Landis JT,Host KM,Xiong J,Griffith JD,Damania B,Dittmer DP

更新日期：2019-02-04 00:00:00

abstract：:Human cytomegalovirus (HCMV) infects about 50% of the US population, is the leading infectious cause of birth defects, and is considered the most important infectious agent in transplant recipients. The virus infects many cell types in vivo and in vitro. While previous studies have identified several cellular proteins...

journal_title：PLoS pathogens

authors： Li Q,Wilkie AR,Weller M,Liu X,Cohen JI

更新日期：2015-07-06 00:00:00

abstract：:Rice dwarf virus (RDV) replicates in and is transmitted by a leafhopper vector in a persistent-propagative manner. Previous cytopathologic and genetic data revealed that tubular structures, constructed by the nonstructural viral protein Pns10, contain viral particles and are directly involved in the intercellular spre...

journal_title：PLoS pathogens

authors： Chen Q,Chen H,Mao Q,Liu Q,Shimizu T,Uehara-Ichiki T,Wu Z,Xie L,Omura T,Wei T

更新日期：2012-01-01 00:00:00

abstract：:Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense mechanism against the human pathogens Group A Streptococcus (GAS) and Group B Stre...

journal_title：PLoS pathogens

authors： van Hensbergen VP,Movert E,de Maat V,Lüchtenborg C,Le Breton Y,Lambeau G,Payré C,Henningham A,Nizet V,van Strijp JAG,Brügger B,Carlsson F,McIver KS,van Sorge NM

更新日期：2018-10-15 00:00:00

abstract：:Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of...

journal_title：PLoS pathogens

authors： Pont S,Fraikin N,Caspar Y,Van Melderen L,Attrée I,Cretin F

更新日期：2020-12-16 00:00:00

abstract：:Epstein-Barr virus (EBV) lytic replication proceeds through an ordered cascade of gene expression that integrates lytic DNA amplification and late gene transcription. We and others previously demonstrated that 6 EBV proteins that have orthologs in β- and γ-, but not in α-herpesviruses, mediate late gene transcription ...

journal_title：PLoS pathogens

authors： Djavadian R,Hayes M,Johannsen E

更新日期：2018-06-04 00:00:00

abstract：:SARS coronavirus (SCoV) nonstructural protein (nsp) 1, a potent inhibitor of host gene expression, possesses a unique mode of action: it binds to 40S ribosomes to inactivate their translation functions and induces host mRNA degradation. Our previous study demonstrated that nsp1 induces RNA modification near the 5'-end...

journal_title：PLoS pathogens

authors： Huang C,Lokugamage KG,Rozovics JM,Narayanan K,Semler BL,Makino S

更新日期：2011-12-01 00:00:00

abstract：:The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in the Cpn transcriptome during its biphasic developmental cycle (the acute infection) and persistence. The latter stage has been linked to chronic diseases. To analyze Cpn C...

journal_title：PLoS pathogens

authors： Mäurer AP,Mehlitz A,Mollenkopf HJ,Meyer TF

更新日期：2007-06-01 00:00:00

abstract：:Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helminth infections induce polarised Th2 responses that may impair HIV vac...

journal_title：PLoS pathogens

authors： Dzhivhuho GA,Rehrl SA,Ndlovu H,Horsnell WGC,Brombacher F,Williamson AL,Chege GK

更新日期：2018-07-26 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear proteins EBNA3A, EBNA3B, and EBNA3C interact with the cell DNA binding protein RBPJ and regulate cell and viral genes. Repression of the CDKN2A tumor suppressor gene products p16(INK4A) and p14(ARF) by EBNA3A and EBNA3C is critical for EBV mediated transformation of resting B lymph...

journal_title：PLoS pathogens

authors： Ohashi M,Holthaus AM,Calderwood MA,Lai CY,Krastins B,Sarracino D,Johannsen E

更新日期：2015-04-09 00:00:00

abstract：:NKT cells play an important role in autoimmune diseases, tumor surveillance, and infectious diseases, providing in most cases protection against infection. NKT cells are reactive to CD1d presented glycolipid antigens. They can modulate immune responses by promoting the secretion of type 1, type 2, or immune regulatory...

journal_title：PLoS pathogens

authors： Karmakar S,Bhaumik SK,Paul J,De T

更新日期：2012-01-01 00:00:00