Intraspecies transmission of BASE induces clinical dullness and amyotrophic changes.

abstract：:IFNγ signaling drives dendritic cells (DCs) to promote type I T cell (Th1) immunity. Here, we show that activation of DCs by IFNγ is equally crucial for the differentiation of a population of T-bet+ regulatory T (Treg) cells specialized to inhibit Th1 immune responses. Conditional deletion of IFNγ receptor in DCs but ...

journal_title：PLoS pathogens

authors： Lee HM,Fleige A,Forman R,Cho S,Khan AA,Lin LL,Nguyen DT,O'Hara-Hall A,Yin Z,Hunter CA,Muller W,Lu LF

更新日期：2015-02-06 00:00:00

abstract：:CD8+ T cell responses to Epstein-Barr virus (EBV) lytic cycle expressed antigens display a hierarchy of immunodominance, in which responses to epitopes of immediate-early (IE) and some early (E) antigens are more frequently observed than responses to epitopes of late (L) expressed antigens. It has been proposed that t...

journal_title：PLoS pathogens

authors： Quinn LL,Zuo J,Abbott RJ,Shannon-Lowe C,Tierney RJ,Hislop AD,Rowe M

更新日期：2014-08-21 00:00:00

abstract：:We have previously shown that the Mycobacterium tuberculosis universal stress protein Rv2623 regulates mycobacterial growth and may be required for the establishment of tuberculous persistence. Here, yeast two-hybrid and affinity chromatography experiments have demonstrated that Rv2623 interacts with one of the two fo...

journal_title：PLoS pathogens

authors： Glass LN,Swapna G,Chavadi SS,Tufariello JM,Mi K,Drumm JE,Lam TT,Zhu G,Zhan C,Vilchéze C,Arcos J,Chen Y,Bi L,Mehta S,Porcelli SA,Almo SC,Yeh SR,Jacobs WR Jr,Torrelles JB,Chan J

更新日期：2017-07-28 00:00:00

abstract：:Paramyxovirus spread generally involves assembly of individual viral particles which then infect target cells. We show that infection of human bronchial airway cells with human metapneumovirus (HMPV), a recently identified paramyxovirus which causes significant respiratory disease, results in formation of intercellula...

journal_title：PLoS pathogens

authors： El Najjar F,Cifuentes-Muñoz N,Chen J,Zhu H,Buchholz UJ,Moncman CL,Dutch RE

更新日期：2016-09-28 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease in humans, is exposed to reactive oxygen and nitrogen species (ROS and RNS) in both the tick vector and vertebrate reservoir hosts. B. burgdorferi contains a limited repertoire of canonical oxidative stress response genes, suggesting that novel gene functions m...

journal_title：PLoS pathogens

authors： Ramsey ME,Hyde JA,Medina-Perez DN,Lin T,Gao L,Lundt ME,Li X,Norris SJ,Skare JT,Hu LT

更新日期：2017-02-17 00:00:00

abstract：:We report the identification of a novel polyomavirus present in respiratory secretions from human patients with symptoms of acute respiratory tract infection. The virus was initially detected in a nasopharyngeal aspirate from a 3-year-old child from Australia diagnosed with pneumonia. A random library was generated fr...

journal_title：PLoS pathogens

authors： Gaynor AM,Nissen MD,Whiley DM,Mackay IM,Lambert SB,Wu G,Brennan DC,Storch GA,Sloots TP,Wang D

更新日期：2007-05-04 00:00:00

abstract：:Malaria, caused by the apicomplexan parasite Plasmodium, still represents a major threat to human health and welfare and leads to about one million human deaths annually. Plasmodium is a rapidly multiplying unicellular organism undergoing a complex developmental cycle in man and mosquito - a life style that requires r...

journal_title：PLoS pathogens

authors： Kehr S,Sturm N,Rahlfs S,Przyborski JM,Becker K

更新日期：2010-12-23 00:00:00

abstract：:Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [P...

journal_title：PLoS pathogens

authors： Sáez-Cirión A,Bacchus C,Hocqueloux L,Avettand-Fenoel V,Girault I,Lecuroux C,Potard V,Versmisse P,Melard A,Prazuck T,Descours B,Guergnon J,Viard JP,Boufassa F,Lambotte O,Goujard C,Meyer L,Costagliola D,Venet A,Pancin

更新日期：2013-03-01 00:00:00

abstract：:The survival and persistence of Mycobacterium tuberculosis depends on its capacity to manipulate multiple host defense pathways, including the ability to actively inhibit the death by apoptosis of infected host cells. The genetic basis for this anti-apoptotic activity and its implication for mycobacterial virulence ha...

journal_title：PLoS pathogens

authors： Velmurugan K,Chen B,Miller JL,Azogue S,Gurses S,Hsu T,Glickman M,Jacobs WR Jr,Porcelli SA,Briken V

更新日期：2007-07-01 00:00:00

abstract：:Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To eluc...

journal_title：PLoS pathogens

authors： Hagiwara D,Miura D,Shimizu K,Paul S,Ohba A,Gonoi T,Watanabe A,Kamei K,Shintani T,Moye-Rowley WS,Kawamoto S,Gomi K

更新日期：2017-01-04 00:00:00

abstract：:Nasal colonization by both gram-positive and gram-negative pathogens induces expression of the innate immune protein lipocalin 2 (Lcn2). Lcn2 binds and sequesters the iron-scavenging siderophore enterobactin (Ent), preventing bacterial iron acquisition. In addition, Lcn2 bound to Ent induces release of IL-8 from cultu...

journal_title：PLoS pathogens

authors： Bachman MA,Miller VL,Weiser JN

更新日期：2009-10-01 00:00:00

abstract：:Production of concatemeric DNA is an essential step during HSV infection, as the packaging machinery must recognize longer-than-unit-length concatemers; however, the mechanism by which they are formed is poorly understood. Although it has been proposed that the viral genome circularizes and rolling circle replication ...

journal_title：PLoS pathogens

authors： Schumacher AJ,Mohni KN,Kan Y,Hendrickson EA,Stark JM,Weller SK

更新日期：2012-01-01 00:00:00

abstract：:The microbiome and the phage meta-genome within the human gut are influenced by antibiotic treatments. Identifying a novel mechanism, here we demonstrate that bacteria use the universal communication molecule AI-2 to induce virulence genes and transfer them via phage release. High concentrations (i.e. 100 μM) of AI-2 ...

journal_title：PLoS pathogens

authors： Rossmann FS,Racek T,Wobser D,Puchalka J,Rabener EM,Reiger M,Hendrickx AP,Diederich AK,Jung K,Klein C,Huebner J

更新日期：2015-02-23 00:00:00

abstract：:The primary role of cytoplasmic viral RNA-dependent RNA polymerase (RdRp) is viral genome replication in the cellular cytoplasm. However, picornaviral RdRp denoted 3D polymerase (3D(pol)) also enters the host nucleus, where its function remains unclear. In this study, we describe a novel mechanism of viral attack in w...

journal_title：PLoS pathogens

authors： Liu YC,Kuo RL,Lin JY,Huang PN,Huang Y,Liu H,Arnold JJ,Chen SJ,Wang RY,Cameron CE,Shih SR

更新日期：2014-06-26 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today. In past years, studies on the entry of the virus into its host cell have led to the identification of a number of essential virus...

journal_title：PLoS pathogens

authors： Van Breedam W,Van Gorp H,Zhang JQ,Crocker PR,Delputte PL,Nauwynck HJ

更新日期：2010-01-15 00:00:00

abstract：:Our skin is our first line of defense against environmental and pathogenic challenges. It is densely populated by a flora of bacteria, fungi, and viruses that normally interact with each other and with our immune system to promote skin health and homeostasis. Staphylococcus epidermidis is one of the most abundant bact...

journal_title：PLoS pathogens

authors： Brown MM,Horswill AR

更新日期：2020-11-12 00:00:00

abstract：:Parvoviruses exploit transferrin receptor type-1 (TfR) for cellular entry in carnivores, and specific interactions are key to control of host range. We show that several key mutations acquired by TfR during the evolution of Caniforms (dogs and related species) modified the interactions with parvovirus capsids by reduc...

journal_title：PLoS pathogens

authors： Kaelber JT,Demogines A,Harbison CE,Allison AB,Goodman LB,Ortega AN,Sawyer SL,Parrish CR

更新日期：2012-01-01 00:00:00

abstract：:Trypanosoma cruzi infection is characterized by chronic parasitism of non-lymphoid tissues and is rarely eliminated despite potent adaptive immune responses. This failure to cure has frequently been attributed to a loss or impairment of anti-T. cruzi T cell responses over time, analogous to the T cell dysfunction desc...

journal_title：PLoS pathogens

authors： Pack AD,Collins MH,Rosenberg CS,Tarleton RL

更新日期：2018-11-12 00:00:00

abstract：:Intracellular pathogens must withstand nitric oxide (NO.) generated by host phagocytes. Salmonella enterica serovar Typhimurium interferes with intracellular trafficking of inducible nitric oxide synthase (iNOS) and possesses multiple systems to detoxify NO.. Consequently, the level of NO. stress encountered by S. Typ...

journal_title：PLoS pathogens

authors： Richardson AR,Soliven KC,Castor ME,Barnes PD,Libby SJ,Fang FC

更新日期：2009-05-01 00:00:00

abstract：:Lactoferrin binding protein B (LbpB) is a bi-lobed outer membrane-bound lipoprotein that comprises part of the lactoferrin (Lf) receptor complex in Neisseria meningitidis and other Gram-negative pathogens. Recent studies have demonstrated that LbpB plays a role in protecting the bacteria from cationic antimicrobial pe...

journal_title：PLoS pathogens

authors： Ostan NK,Yu RH,Ng D,Lai CC,Pogoutse AK,Sarpe V,Hepburn M,Sheff J,Raval S,Schriemer DC,Moraes TF,Schryvers AB

更新日期：2017-03-03 00:00:00

abstract：:There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown. By using the rice-rice dwarf virus (RDV) model system, here we report that...

journal_title：PLoS pathogens

authors： Qin Q,Li G,Jin L,Huang Y,Wang Y,Wei C,Xu Z,Yang Z,Wang H,Li Y

更新日期：2020-12-02 00:00:00

abstract：:The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolut...

journal_title：PLoS pathogens

authors： Sabin C,Corti D,Buzon V,Seaman MS,Lutje Hulsik D,Hinz A,Vanzetta F,Agatic G,Silacci C,Mainetti L,Scarlatti G,Sallusto F,Weiss R,Lanzavecchia A,Weissenhorn W

更新日期：2010-11-18 00:00:00

abstract：:The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade and replicate within mammalian cells. Remarkably, of the 15 serovars within the genus, strains belonging to serovar 4b cause the majority of listeriosis clinical cases and outbreaks. The Listeria O-antigens are defined by subtl...

journal_title：PLoS pathogens

authors： Sumrall ET,Shen Y,Keller AP,Rismondo J,Pavlou M,Eugster MR,Boulos S,Disson O,Thouvenot P,Kilcher S,Wollscheid B,Cabanes D,Lecuit M,Gründling A,Loessner MJ

更新日期：2019-10-07 00:00:00

abstract：:Several naked virus species, including members of the Picornaviridae family, have recently been described to escape their host cells and spread infection via enclosure in extracellular vesicles (EV). EV are 50-300 nm sized lipid membrane-enclosed particles produced by all cells that are broadly recognized for playing ...

journal_title：PLoS pathogens

authors： van der Grein SG,Defourny KAY,Rabouw HH,Galiveti CR,Langereis MA,Wauben MHM,Arkesteijn GJA,van Kuppeveld FJM,Nolte-'t Hoen ENM

更新日期：2019-02-19 00:00:00

abstract：:Ingested Vibrio cholerae pass through the stomach and colonize the small intestines of its host. Here, we show that V. cholerae requires at least two types of DNA repair systems to efficiently compete for colonization of the infant mouse intestine. These results show that V. cholerae experiences increased DNA damage i...

journal_title：PLoS pathogens

authors： Davies BW,Bogard RW,Dupes NM,Gerstenfeld TA,Simmons LA,Mekalanos JJ

更新日期：2011-02-01 00:00:00

abstract：:Although invasive cytomegalovirus (CMV) disease is uncommon in the era of antiretroviral therapy (ART), asymptomatic CMV coinfection is nearly ubiquitous in HIV infected individuals. While microbial translocation and gut epithelial barrier dysfunction may promote persistent immune activation in treated HIV infection, ...

journal_title：PLoS pathogens

authors： Maidji E,Somsouk M,Rivera JM,Hunt PW,Stoddart CA

更新日期：2017-02-27 00:00:00

abstract：:Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Here, we reporte...

journal_title：PLoS pathogens

authors： Lyu X,Wang J,Guo X,Wu G,Jiao Y,Faleti OD,Liu P,Liu T,Long Y,Chong T,Yang X,Huang J,He M,Tsang CM,Tsao SW,Wang Q,Jiang Q,Li X

更新日期：2018-12-17 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) remains a major public health problem, with an effective vaccine continuing to prove elusive. Progress in vaccination strategies has been hampered by a lack of appreciation of the bacterium's response to dynamic changes in the host immune environment. Here, we utilize reporter Mtb stra...

journal_title：PLoS pathogens

authors： Sukumar N,Tan S,Aldridge BB,Russell DG

更新日期：2014-09-18 00:00:00

abstract：:Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (α/β hydrolase domain containing pro...

journal_title：PLoS pathogens

authors： Vieyres G,Welsch K,Gerold G,Gentzsch J,Kahl S,Vondran FW,Kaderali L,Pietschmann T

更新日期：2016-04-28 00:00:00

abstract：:Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have largely failed due to lack of protective efficacy. Group 1 CD1-restrict...

journal_title：PLoS pathogens

authors： Visvabharathy L,Genardi S,Cao L,He Y,Alonzo F 3rd,Berdyshev E,Wang CR

更新日期：2020-04-28 00:00:00