Abstract:
:Abnormal metabolism and uncontrolled angiogenesis are two important characteristics of malignant tumors. The occurrence of both events involves many key molecular changes including miRNA. However, EBV encoded miRNAs are rarely mentioned as capable of regulating tumor metabolism and tumor angiogenesis. Here, we reported that one of the key miRNAs encoded by EBV, EBV-miR-Bart1-5P, can significantly promote nasopharyngeal carcinoma (NPC) cell glycolysis and induces angiogenesis in vitro and in vivo. Mechanistically, EBV-miR-Bart1-5P directly targets the α1 catalytic subunit of AMP-activated protein kinase (AMPKα1) and consequently regulates the AMPK/mTOR/HIF1 pathway which impelled NPC cell anomalous aerobic glycolysis and angiogenesis, ultimately leads to uncontrolled growth of NPC. Our findings provide new insights into metabolism and angiogenesis of NPC and new opportunities for the development of targeted NPC therapy in the future.
journal_name
PLoS Pathogjournal_title
PLoS pathogensauthors
Lyu X,Wang J,Guo X,Wu G,Jiao Y,Faleti OD,Liu P,Liu T,Long Y,Chong T,Yang X,Huang J,He M,Tsang CM,Tsao SW,Wang Q,Jiang Q,Li Xdoi
10.1371/journal.ppat.1007484subject
Has Abstractpub_date
2018-12-17 00:00:00pages
e1007484issue
12eissn
1553-7366issn
1553-7374pii
PPATHOGENS-D-18-01071journal_volume
14pub_type
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