Molecular determinants of Ebola virus virulence in mice.

abstract：:Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we test...

journal_title：PLoS pathogens

authors： Burke CM,Mark KMK,Kun J,Beauchemin KS,Supattapone S

更新日期：2020-05-18 00:00:00

abstract：:The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction. Since dendritic cells (DCs) typically initiate anti-leishmanial immunity, a role for DCs in aberrant LD clearance was inve...

journal_title：PLoS pathogens

authors： Haldar AK,Yadav V,Singhal E,Bisht KK,Singh A,Bhaumik S,Basu R,Sen P,Roy S

更新日期：2010-05-20 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recruitment of innate i...

journal_title：PLoS pathogens

authors： Ries LNA,Pardeshi L,Dong Z,Tan K,Steenwyk JL,Colabardini AC,Ferreira Filho JA,de Castro PA,Silva LP,Preite NW,Almeida F,de Assis LJ,Dos Santos RAC,Bowyer P,Bromley M,Owens RA,Doyle S,Demasi M,Hernández DCR,Netto LES

更新日期：2020-07-15 00:00:00

abstract：:Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrophages (MΦs) measuri...

journal_title：PLoS pathogens

authors： Rodríguez-Martín S,Kropp KA,Wilhelmi V,Lisnic VJ,Hsieh WY,Blanc M,Livingston A,Busche A,Tekotte H,Messerle M,Auer M,Fraser I,Jonjic S,Angulo A,Reddehase MJ,Ghazal P

更新日期：2012-01-01 00:00:00

abstract：:Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an essential mediator of the innate immune response and influenza viruses, like many viruses, have evolve...

journal_title：PLoS pathogens

authors： Ortigoza MB,Dibben O,Maamary J,Martinez-Gil L,Leyva-Grado VH,Abreu P Jr,Ayllon J,Palese P,Shaw ML

更新日期：2012-01-01 00:00:00

abstract：:Plants have evolved pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) to protect themselves from infection by diverse pathogens. Avirulence (Avr) effectors that trigger plant ETI as a result of recognition by plant resistance (R) gene products have been identif...

journal_title：PLoS pathogens

authors： Dong S,Yin W,Kong G,Yang X,Qutob D,Chen Q,Kale SD,Sui Y,Zhang Z,Dou D,Zheng X,Gijzen M,Tyler BM,Wang Y

更新日期：2011-11-01 00:00:00

abstract：:Microfold (M) cell host-pathogen interaction studies would benefit from the visual analysis of dynamic cellular and microbial interplays. We adapted a human in vitro M cell model to physiological bacterial infections, expression of fluorescent localization reporters and long-term three-dimensional time-lapse microscop...

journal_title：PLoS pathogens

authors： Rey C,Chang YY,Latour-Lambert P,Varet H,Proux C,Legendre R,Coppée JY,Enninga J

更新日期：2020-04-13 00:00:00

abstract：:Gastrointestinal infections caused by enteric yersiniae can become persistent and complicated by relapsing enteritis and severe autoimmune disorders. To establish a persistent infection, the bacteria have to cope with hostile surroundings when they transmigrate through the intestinal epithelium and colonize underlying...

journal_title：PLoS pathogens

authors： Heine W,Beckstette M,Heroven AK,Thiemann S,Heise U,Nuss AM,Pisano F,Strowig T,Dersch P

更新日期：2018-02-01 00:00:00

abstract：:The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in humans and other mammals, despite the development of potent host immune responses that constrain parasite numbers. The consistent, decades-long persistence of T. cruzi in human hosts arises at least in part from the remarkable level ...

journal_title：PLoS pathogens

authors： Wang W,Peng D,Baptista RP,Li Y,Kissinger JC,Tarleton RL

更新日期：2021-01-28 00:00:00

abstract：:Adenoviral vectors have shown significant promise as vaccine delivery vectors due to their ability to elicit both innate and adaptive immune responses. α-defensins are effector molecules of the innate immune response and have been shown to modulate natural infection with adenoviruses, but the majority of α-defensin-ad...

journal_title：PLoS pathogens

authors： Tartaglia LJ,Badamchi-Zadeh A,Abbink P,Blass E,Aid M,Gebre MS,Li Z,Pastores KC,Trott S,Gupte S,Larocca RA,Barouch DH

更新日期：2019-12-16 00:00:00

abstract：:Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and secreted as stable vir...

journal_title：PLoS pathogens

authors： Heger-Stevic J,Zimmermann P,Lecoq L,Böttcher B,Nassal M

更新日期：2018-12-19 00:00:00

abstract：:Cells of the innate immune system act in synergy to provide a first line of defense against pathogens. Here we describe that dendritic cells (DCs), matured with viral products or mimics thereof, including Epstein-Barr virus (EBV), activated natural killer (NK) cells more efficiently than other mature DC preparations. ...

journal_title：PLoS pathogens

authors： Strowig T,Brilot F,Arrey F,Bougras G,Thomas D,Muller WA,Münz C

更新日期：2008-02-08 00:00:00

abstract：:The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a major barrier to the design of vaccines and therapeutic approaches to prevent infection or limit disease. This deficit...

journal_title：PLoS pathogens

authors： Graham JB,Swarts JL,Leist SR,Schäfer A,Menachery VD,Gralinski LE,Jeng S,Miller DR,Mooney MA,McWeeney SK,Ferris MT,Pardo-Manuel de Villena F,Heise MT,Baric RS,Lund JM

更新日期：2021-01-29 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease in humans, is exposed to reactive oxygen and nitrogen species (ROS and RNS) in both the tick vector and vertebrate reservoir hosts. B. burgdorferi contains a limited repertoire of canonical oxidative stress response genes, suggesting that novel gene functions m...

journal_title：PLoS pathogens

authors： Ramsey ME,Hyde JA,Medina-Perez DN,Lin T,Gao L,Lundt ME,Li X,Norris SJ,Skare JT,Hu LT

更新日期：2017-02-17 00:00:00

abstract：:Tm-2² is a coiled coil-nucleotide binding-leucine rich repeat resistance protein that confers durable extreme resistance against Tomato mosaic virus (ToMV) and Tobacco mosaic virus (TMV) by recognizing the viral movement protein (MP). Here we report that the Nicotiana benthamiana J-domain MIP1 proteins (NbMIP1s) assoc...

journal_title：PLoS pathogens

authors： Du Y,Zhao J,Chen T,Liu Q,Zhang H,Wang Y,Hong Y,Xiao F,Zhang L,Shen Q,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:KSHV is the etiological agent of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and a subset of multicentricCastleman's disease (MCD). The fact that KSHV-encoded miRNAs are readily detectable in all KSHV-associated tumors suggests a potential role in viral pathogenesis and tumorigenesis. MiRNA-mediated regula...

journal_title：PLoS pathogens

authors： Haecker I,Gay LA,Yang Y,Hu J,Morse AM,McIntyre LM,Renne R

更新日期：2012-01-01 00:00:00

abstract：:In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital infection. The guinea pig is the only small animal model for congenit...

journal_title：PLoS pathogens

authors： Coleman S,Choi KY,Root M,McGregor A

更新日期：2016-07-07 00:00:00

abstract：:The interplay between autophagy and intracellular pathogens is intricate as autophagy is an essential cellular response to fight against infections, whereas numerous microbes have developed strategies to escape this process or even exploit it to their own benefit. The fine tuned timing and/or selective molecular pathw...

journal_title：PLoS pathogens

authors： Richetta C,Grégoire IP,Verlhac P,Azocar O,Baguet J,Flacher M,Tangy F,Rabourdin-Combe C,Faure M

更新日期：2013-01-01 00:00:00

abstract：:The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood. Recent studies demonstrated that CCR5-tropic HIV-1 efficiently enters tissue-derived memory CD4+ T cells expressin...

journal_title：PLoS pathogens

authors： Hsiao F,Frouard J,Gramatica A,Xie G,Telwatte S,Lee GQ,Roychoudhury P,Schwarzer R,Luo X,Yukl SA,Lee S,Hoh R,Deeks SG,Jones RB,Cavrois M,Greene WC,Roan NR

更新日期：2020-04-30 00:00:00

abstract：:The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives was investigated ag...

journal_title：PLoS pathogens

authors： Lupien A,Foo CS,Savina S,Vocat A,Piton J,Monakhova N,Benjak A,Lamprecht DA,Steyn AJC,Pethe K,Makarov VA,Cole ST

更新日期：2020-01-23 00:00:00

abstract：:Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored. Using a primary human lymphatic endothelial cell model, we found that HIV-1 envelo...

journal_title：PLoS pathogens

authors： Zhang X,Yu J,Kuzontkoski PM,Zhu W,Li DY,Groopman JE

更新日期：2012-01-01 00:00:00

abstract：:To ensure their survival, microbial pathogens have evolved diverse strategies to subvert host immune defenses. The human retrovirus HIV-1 has been proposed to hijack the natural endocytic function of dendritic cells (DCs) to infect interacting CD4 T cells in a process termed trans-infection. Although DCs can be direct...

journal_title：PLoS pathogens

authors： Cavrois M,Neidleman J,Greene WC

更新日期：2008-06-27 00:00:00

abstract：:RsaE is a conserved small regulatory RNA (sRNA) which was previously reported to represent a riboregulator of central carbon flow and other metabolic pathways in Staphylococcus aureus and Bacillus subtilis. Here we show that RsaE contributes to extracellular (e)DNA release and biofilm-matrix switching towards polysacc...

journal_title：PLoS pathogens

authors： Schoenfelder SMK,Lange C,Prakash SA,Marincola G,Lerch MF,Wencker FDR,Förstner KU,Sharma CM,Ziebuhr W

更新日期：2019-03-14 00:00:00

abstract：:Hepatitis C virus (HCV) induces interferon (IFN) stimulated genes in the liver despite of distinct innate immune evasion mechanisms, suggesting that beyond HCV infected cells other cell types contribute to innate immune activation. Upon coculture with HCV replicating cells, human CD141+ myeloid dendritic cells (DC) pr...

journal_title：PLoS pathogens

authors： Pfaender S,Grabski E,Detje CN,Riebesehl N,Lienenklaus S,Steinmann E,Kalinke U,Pietschmann T

更新日期：2016-07-06 00:00:00

abstract：:Host genetic variations play an important role in several pathogenic diseases, and we have previously provided strong evidences that these genetic variations contribute significantly to differences in susceptibility and clinical outcomes of invasive Group A Streptococcus (GAS) infections, including sepsis and necrotiz...

journal_title：PLoS pathogens

authors： Chella Krishnan K,Mukundan S,Alagarsamy J,Hur J,Nookala S,Siemens N,Svensson M,Hyldegaard O,Norrby-Teglund A,Kotb M

更新日期：2016-07-11 00:00:00

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC), particularly serotype O157:H7, causes hemorrhagic colitis, hemolytic uremic syndrome, and even death. In vitro studies showed that Shiga toxin 2 (Stx2), the primary virulence factor expressed by EDL933 (an O157:H7 strain), is encoded by the 933W prophage. And the bacterial su...

journal_title：PLoS pathogens

authors： Tyler JS,Beeri K,Reynolds JL,Alteri CJ,Skinner KG,Friedman JH,Eaton KA,Friedman DI

更新日期：2013-03-01 00:00:00

abstract：:Transformation is an important mechanism of microbial evolution through which bacteria have been observed to rapidly adapt in response to clinical interventions; examples include facilitating vaccine evasion and the development of penicillin resistance in the major respiratory pathogen Streptococcus pneumoniae. To cha...

journal_title：PLoS pathogens

authors： Croucher NJ,Harris SR,Barquist L,Parkhill J,Bentley SD

更新日期：2012-01-01 00:00:00

abstract：:Exosomes can transfer genetic materials between cells. Their roles in viral infections are beginning to be appreciated. Researches have shown that exosomes released from virus-infected cells contain a variety of viral and host cellular factors that are able to modulate recipient's cellular response and result in produ...

journal_title：PLoS pathogens

authors： Fu Y,Zhang L,Zhang F,Tang T,Zhou Q,Feng C,Jin Y,Wu Z

更新日期：2017-09-14 00:00:00

abstract：:Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-anno...

journal_title：PLoS pathogens

authors： Cho Y,Srivastava A,Ohm RA,Lawrence CB,Wang KH,Grigoriev IV,Marahatta SP

更新日期：2012-01-01 00:00:00