Transcription factor Amr1 induces melanin biosynthesis and suppresses virulence in Alternaria brassicicola.

abstract：:Modern agriculture favours the selection and spread of novel plant diseases. Furthermore, crop genetic resistance against pathogens is often rendered ineffective within a few years of its commercial deployment. Leptosphaeria maculans, the cause of phoma stem canker of oilseed rape, develops gene-for-gene interactions ...

journal_title：PLoS pathogens

authors： Daverdin G,Rouxel T,Gout L,Aubertot JN,Fudal I,Meyer M,Parlange F,Carpezat J,Balesdent MH

更新日期：2012-01-01 00:00:00

abstract：:Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to such obstacles, many viruses have developed the ability of establishing actin rich-membrane bridges to aid in future infections. Herein through dynamic imaging of...

journal_title：PLoS pathogens

authors： Aggarwal A,Iemma TL,Shih I,Newsome TP,McAllery S,Cunningham AL,Turville SG

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell-mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the...

journal_title：PLoS pathogens

authors： Chen CY,Huang D,Wang RC,Shen L,Zeng G,Yao S,Shen Y,Halliday L,Fortman J,McAllister M,Estep J,Hunt R,Vasconcelos D,Du G,Porcelli SA,Larsen MH,Jacobs WR Jr,Haynes BF,Letvin NL,Chen ZW

更新日期：2009-04-01 00:00:00

abstract：:Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitochondrial viral pathog...

journal_title：PLoS pathogens

authors： Schmolke M,Manicassamy B,Pena L,Sutton T,Hai R,Varga ZT,Hale BG,Steel J,Pérez DR,García-Sastre A

更新日期：2011-08-01 00:00:00

abstract：:The Venus kinase receptor (VKR) is a single transmembrane molecule composed of an intracellular tyrosine kinase domain close to that of insulin receptor and an extracellular Venus Flytrap (VFT) structure similar to the ligand binding domain of many class C G protein coupled receptors. This receptor tyrosine kinase (RT...

journal_title：PLoS pathogens

authors： Vanderstraete M,Gouignard N,Cailliau K,Morel M,Hahnel S,Leutner S,Beckmann S,Grevelding CG,Dissous C

更新日期：2014-05-29 00:00:00

abstract：:The heterosexual risk group has become the largest HIV infected group in the United Kingdom during the last 10 years, but little is known of the network structure and dynamics of viral transmission in this group. The overwhelming majority of UK heterosexual infections are of non-B HIV subtypes, indicating viruses orig...

journal_title：PLoS pathogens

authors： Hughes GJ,Fearnhill E,Dunn D,Lycett SJ,Rambaut A,Leigh Brown AJ,UK HIV Drug Resistance Collaboration.

更新日期：2009-09-01 00:00:00

abstract：:Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and liver disease. The characterization of viral populations that successfully initiate infection, and also those that drive progression to chronicity is instrumental for understanding pathogenesis and vaccine design. A comprehensive an...

journal_title：PLoS pathogens

authors： Bull RA,Luciani F,McElroy K,Gaudieri S,Pham ST,Chopra A,Cameron B,Maher L,Dore GJ,White PA,Lloyd AR

更新日期：2011-09-01 00:00:00

abstract：:More than half of the world population is at risk of dengue virus (DENV) infection because of the global distribution of its mosquito vectors. DENV is an envelope virus that relies on host lipid membranes for its life-cycle. Here, we characterized how DENV hijacks the mosquito lipidome to identify targets for novel tr...

journal_title：PLoS pathogens

authors： Vial T,Tan WL,Wong Wei Xiang B,Missé D,Deharo E,Marti G,Pompon J

更新日期：2019-12-09 00:00:00

abstract：:MicroRNAs (miRNAs) suppress the transcriptional and post-transcriptional expression of genes in plants. Several miRNA families target genes encoding nucleotide-binding site-leucine-rich repeat (NB-LRR) plant innate immune receptors. The fungus Fusarium oxysporum f. sp. lycopersici causes vascular wilt disease in tomat...

journal_title：PLoS pathogens

authors： Ouyang S,Park G,Atamian HS,Han CS,Stajich JE,Kaloshian I,Borkovich KA

更新日期：2014-10-16 00:00:00

abstract：:After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding interaction between TRIM5...

journal_title：PLoS pathogens

authors： Ohkura S,Goldstone DC,Yap MW,Holden-Dye K,Taylor IA,Stoye JP

更新日期：2011-03-01 00:00:00

abstract：:Regulated protein secretion is required for malaria parasite life cycle progression and transmission between the mammalian host and mosquito vector. During transmission from the host to the vector, exocytosis of highly specialised secretory vesicles, such as osmiophilic bodies, is key to the dissolution of the red blo...

journal_title：PLoS pathogens

authors： Kehrer J,Singer M,Lemgruber L,Silva PA,Frischknecht F,Mair GR

更新日期：2016-07-18 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage, but also for infectious virus production. To identify cellular factors that interact with NS2 and are important for HCV propagation, we screened a human liver cDNA library by sp...

journal_title：PLoS pathogens

authors： Suzuki R,Matsuda M,Watashi K,Aizaki H,Matsuura Y,Wakita T,Suzuki T

更新日期：2013-01-01 00:00:00

abstract：:Vertical transmission (VT) and horizontal transmission (HT) of pathogens refer to parental and non-parental chains of host-to-host transmission. Combining HT with VT enlarges considerably the range of ecological conditions in which a pathogen can persist, but the factors governing the relative frequency of each transm...

journal_title：PLoS pathogens

authors： Lequime S,Paul RE,Lambrechts L

更新日期：2016-05-12 00:00:00

abstract：:Two-component signal transduction systems (TCS) are used by bacteria to sense and respond to their environment. TCS are typically composed of a sensor histidine kinase (HK) and a response regulator (RR). The Vibrio cholerae genome encodes 52 RR, but the role of these RRs in V. cholerae pathogenesis is largely unknown....

journal_title：PLoS pathogens

authors： Cheng AT,Ottemann KM,Yildiz FH

更新日期：2015-05-22 00:00:00

abstract：:Ebola virus disease afflicts both human and animal populations and is caused by four ebolaviruses. These different ebolaviruses may have distinct reservoir hosts and ecological contexts that determine how, where, and when different ebolavirus spillover events occur. Understanding these virus-specific relationships is ...

journal_title：PLoS pathogens

authors： Judson SD,Fischer R,Judson A,Munster VJ

更新日期：2016-08-05 00:00:00

abstract：:Many broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus type 1 (HIV-1) were shown effective in animal models, and are currently evaluated in clinical trials. However, use of these antibodies in humans is hampered by the rapid emergence of resistant viruses. Here we show that soft-randomizatio...

journal_title：PLoS pathogens

authors： Otsuka Y,Schmitt K,Quinlan BD,Gardner MR,Alfant B,Reich A,Farzan M,Choe H

更新日期：2018-08-20 00:00:00

abstract：:Human cytomegalovirus (HCMV), a dsDNA, enveloped virus, is a ubiquitous pathogen that establishes lifelong latent infections and caused disease in persons with compromised immune systems, e.g., organ transplant recipients or AIDS patients. HCMV is also a leading cause of congenital viral infections in newborns. Entry ...

journal_title：PLoS pathogens

authors： Burke HG,Heldwein EE

更新日期：2015-10-20 00:00:00

abstract：:Abilities of bacterial pathogens to adapt to the iron limitation present in hosts is critical to their virulence. Bacterial pathogens have evolved diverse strategies to coordinately regulate iron metabolism and virulence associated functions to maintain iron homeostasis in response to changing iron availability in the...

journal_title：PLoS pathogens

authors： Pandey SS,Patnana PK,Lomada SK,Tomar A,Chatterjee S

更新日期：2016-11-30 00:00:00

abstract：:The Vibrio cholerae type VI secretion system (T6SS) assembles as a molecular syringe that injects toxic protein effectors into both eukaryotic and prokaryotic cells. We previously reported that the V. cholerae O37 serogroup strain V52 maintains a constitutively active T6SS to kill other Gram-negative bacteria while be...

journal_title：PLoS pathogens

authors： Miyata ST,Unterweger D,Rudko SP,Pukatzki S

更新日期：2013-01-01 00:00:00

abstract：:Poxviruses subvert the host immune response by producing immunomodulatory proteins, including a complement regulatory protein. Ectromelia virus provides a mouse model for smallpox where the virus and the host's immune response have co-evolved. Using this model, our study investigated the role of the complement system ...

journal_title：PLoS pathogens

authors： Moulton EA,Atkinson JP,Buller RM

更新日期：2008-12-01 00:00:00

abstract：:The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle. Although many proteins involved in kDNA replication and segregation are now known, several key steps in the replication...

journal_title：PLoS pathogens

authors： Peña-Diaz P,Vancová M,Resl C,Field MC,Lukeš J

更新日期：2017-04-07 00:00:00

abstract：:Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon pr...

journal_title：PLoS pathogens

authors： Assil S,Futsch N,Décembre E,Alais S,Gessain A,Cosset FL,Mahieux R,Dreux M,Dutartre H

更新日期：2019-02-28 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear proteins EBNA3A, EBNA3B, and EBNA3C interact with the cell DNA binding protein RBPJ and regulate cell and viral genes. Repression of the CDKN2A tumor suppressor gene products p16(INK4A) and p14(ARF) by EBNA3A and EBNA3C is critical for EBV mediated transformation of resting B lymph...

journal_title：PLoS pathogens

authors： Ohashi M,Holthaus AM,Calderwood MA,Lai CY,Krastins B,Sarracino D,Johannsen E

更新日期：2015-04-09 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithel...

journal_title：PLoS pathogens

authors： Crowley JT,Toledo AM,LaRocca TJ,Coleman JL,London E,Benach JL

更新日期：2013-01-01 00:00:00

abstract：:An unprecedented epidemic of chikungunya virus (CHIKV) infection recently started in countries of the Indian Ocean area, causing an acute and painful syndrome with strong fever, asthenia, skin rash, polyarthritis, and lethal cases of encephalitis. The basis for chikungunya disease and the tropism of CHIKV remain unkno...

journal_title：PLoS pathogens

authors： Sourisseau M,Schilte C,Casartelli N,Trouillet C,Guivel-Benhassine F,Rudnicka D,Sol-Foulon N,Le Roux K,Prevost MC,Fsihi H,Frenkiel MP,Blanchet F,Afonso PV,Ceccaldi PE,Ozden S,Gessain A,Schuffenecker I,Verhasselt B,Zamb

更新日期：2007-06-01 00:00:00

abstract：:The combination of drug resistance, lack of an effective vaccine, and ongoing conflict and poverty means that malaria remains a major global health crisis. Understanding metabolic pathways at all parasite life stages is important in prioritising and targeting novel anti-parasitic compounds. The unusual heme synthesis ...

journal_title：PLoS pathogens

authors： Rathnapala UL,Goodman CD,McFadden GI

更新日期：2017-06-15 00:00:00

abstract：:Malaria vaccine candidate Apical Membrane Antigen-1 (AMA1) induces protection, but only against parasite strains that are closely related to the vaccine. Overcoming the AMA1 diversity problem will require an understanding of the structural basis of cross-strain invasion inhibition. A vaccine containing four diverse al...

journal_title：PLoS pathogens

authors： Dutta S,Dlugosz LS,Drew DR,Ge X,Ababacar D,Rovira YI,Moch JK,Shi M,Long CA,Foley M,Beeson JG,Anders RF,Miura K,Haynes JD,Batchelor AH

更新日期：2013-01-01 00:00:00

abstract：:Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of muscle disorders. Whilst neurotoxin expression by the spore-formin...

journal_title：PLoS pathogens

authors： Zhang Z,Korkeala H,Dahlsten E,Sahala E,Heap JT,Minton NP,Lindström M

更新日期：2013-03-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV latent and lytic transcripts. F...

journal_title：PLoS pathogens

authors： Lang F,Singh RK,Pei Y,Zhang S,Sun K,Robertson ES

更新日期：2019-06-21 00:00:00