Correction: A model of chronic, transmissible Otitis Media in mice.

abstract：:Environments such as light condition influence the spread of infectious diseases by affecting insect vector behavior. However, whether and how light affects the host defense which further affects insect preference and performance, remains unclear, nor has been demonstrated how pathogens co-adapt light condition to fac...

journal_title：PLoS pathogens

authors： Zhao P,Zhang X,Gong Y,Wang D,Xu D,Wang N,Sun Y,Gao L,Liu SS,Deng XW,Kliebenstein DJ,Zhou X,Fang RX,Ye J

更新日期：2021-01-11 00:00:00

abstract：:As well as their importance to nutrition, fatty acids (FA) represent a unique group of quorum sensing chemicals that modulate the behavior of bacterial population in virulence. However, the way in which full-length, membrane-bound receptors biochemically detect FA remains unclear. Here, we provide genetic, enzymologic...

journal_title：PLoS pathogens

authors： Cai Z,Yuan ZH,Zhang H,Pan Y,Wu Y,Tian XQ,Wang FF,Wang L,Qian W

更新日期：2017-04-03 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing relationship to disease onset is unknown. We developed two novel mo...

journal_title：PLoS pathogens

authors： Small CL,Xing L,McPhee JB,Law HT,Coombes BK

更新日期：2016-10-06 00:00:00

abstract：:All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is...

journal_title：PLoS pathogens

authors： Machiels B,Lété C,Guillaume A,Mast J,Stevenson PG,Vanderplasschen A,Gillet L

更新日期：2011-11-01 00:00:00

abstract：:Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6-7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2, among other targets in neutrophils. SKAP2 functions in reactive oxy...

journal_title：PLoS pathogens

authors： Shaban L,Nguyen GT,Mecsas-Faxon BD,Swanson KD,Tan S,Mecsas J

更新日期：2020-05-11 00:00:00

abstract：:Identification of the determinants of pathogen reservoir potential is central to understand disease emergence. It has been proposed that host lifespan is one such determinant: short-lived hosts will invest less in costly defenses against pathogens, so that they will be more susceptible to infection, more competent as ...

journal_title：PLoS pathogens

authors： Hily JM,García A,Moreno A,Plaza M,Wilkinson MD,Fereres A,Fraile A,García-Arenal F

更新日期：2014-11-06 00:00:00

abstract：:The two-component system (TCS) KdpD/KdpE, extensively studied for its regulatory role in potassium (K(+)) transport, has more recently been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria, including Staphylococcus aureus, entero-haemorrhagic Escherichia c...

journal_title：PLoS pathogens

authors： Freeman ZN,Dorus S,Waterfield NR

更新日期：2013-03-01 00:00:00

abstract：:During blood stage Plasmodium falciparum infection, merozoites invade uninfected erythrocytes via a complex, multistep process involving a series of distinct receptor-ligand binding events. Understanding each element in this process increases the potential to block the parasite's life cycle via drugs or vaccines. To i...

journal_title：PLoS pathogens

authors： Weiss GE,Gilson PR,Taechalertpaisarn T,Tham WH,de Jong NW,Harvey KL,Fowkes FJ,Barlow PN,Rayner JC,Wright GJ,Cowman AF,Crabb BS

更新日期：2015-02-27 00:00:00

abstract：:HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52:01-restricted T ce...

journal_title：PLoS pathogens

authors： Akahoshi T,Gatanaga H,Kuse N,Chikata T,Koyanagi M,Ishizuka N,Brumme CJ,Murakoshi H,Brumme ZL,Oka S,Takiguchi M

更新日期：2020-12-28 00:00:00

abstract：:Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion during P. chabaudi infection is...

journal_title：PLoS pathogens

authors： Fontana MF,de Melo GL,Anidi C,Hamburger R,Kim CY,Lee SY,Pham J,Kim CC

更新日期：2016-12-06 00:00:00

abstract：:Production of concatemeric DNA is an essential step during HSV infection, as the packaging machinery must recognize longer-than-unit-length concatemers; however, the mechanism by which they are formed is poorly understood. Although it has been proposed that the viral genome circularizes and rolling circle replication ...

journal_title：PLoS pathogens

authors： Schumacher AJ,Mohni KN,Kan Y,Hendrickson EA,Stark JM,Weller SK

更新日期：2012-01-01 00:00:00

abstract：:Some pathogens have evolved mechanisms to overcome host immune defenses by inhibiting host defense signaling pathways and suppressing the expression of host defense effectors. We present evidence that Pseudomonas aeruginosa is able to suppress the expression of a subset of immune defense genes in the animal host Caeno...

journal_title：PLoS pathogens

authors： Evans EA,Kawli T,Tan MW

更新日期：2008-10-01 00:00:00

abstract：:To replicate, HIV-1 capitalizes on endogenous cellular activation pathways resulting in recruitment of key host transcription factors to its viral enhancer. RNA interference has been a powerful tool for blocking key checkpoints in HIV-1 entry into cells. Here we apply RNA interference to HIV-1 transcription in primary...

journal_title：PLoS pathogens

authors： Ranjbar S,Tsytsykova AV,Lee SK,Rajsbaum R,Falvo JV,Lieberman J,Shankar P,Goldfeld AE

更新日期：2006-12-01 00:00:00

abstract：:Kaposi's sarcoma (KS), an enigmatic endothelial cell vascular neoplasm, is characterized by the proliferation of spindle shaped endothelial cells, inflammatory cytokines (ICs), growth factors (GFs) and angiogenic factors. KSHV is etiologically linked to KS and expresses its latent genes in KS lesion endothelial cells....

journal_title：PLoS pathogens

authors： Sharma-Walia N,Paul AG,Bottero V,Sadagopan S,Veettil MV,Kerur N,Chandran B

更新日期：2010-02-12 00:00:00

abstract：:Previously, we demonstrated that Pseudomonas aeruginosa ExoT induces potent apoptosis in host epithelial cells in a manner that primarily depends on its ADP-ribosyltransferase domain (ADPRT) activity. However, the mechanism underlying ExoT/ADPRT-induced apoptosis remains undetermined. We now report that ExoT/ADPRT dis...

journal_title：PLoS pathogens

authors： Wood S,Goldufsky J,Shafikhani SH

更新日期：2015-05-28 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection in blood and SIV i...

journal_title：PLoS pathogens

authors： Chew GM,Fujita T,Webb GM,Burwitz BJ,Wu HL,Reed JS,Hammond KB,Clayton KL,Ishii N,Abdel-Mohsen M,Liegler T,Mitchell BI,Hecht FM,Ostrowski M,Shikuma CM,Hansen SG,Maurer M,Korman AJ,Deeks SG,Sacha JB,Ndhlovu LC

更新日期：2016-01-07 00:00:00

abstract：:The Spumaretrovirinae, or foamy viruses (FVs) are complex retroviruses that infect many species of monkey and ape. Despite little sequence homology, FV and orthoretroviral Gag proteins perform equivalent functions, including genome packaging, virion assembly, trafficking and membrane targeting. However, there is a pau...

journal_title：PLoS pathogens

authors： Ball NJ,Nicastro G,Dutta M,Pollard DJ,Goldstone DC,Sanz-Ramos M,Ramos A,Müllers E,Stirnnagel K,Stanke N,Lindemann D,Stoye JP,Taylor WR,Rosenthal PB,Taylor IA

更新日期：2016-11-09 00:00:00

abstract：:Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far abou...

journal_title：PLoS pathogens

authors： Doerflinger SY,Cortese M,Romero-Brey I,Menne Z,Tubiana T,Schenk C,White PA,Bartenschlager R,Bressanelli S,Hansman GS,Lohmann V

更新日期：2017-10-27 00:00:00

abstract：:Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and th...

journal_title：PLoS pathogens

authors： Denic M,Turlin E,Michel V,Fischer F,Khorasani-Motlagh M,Zamble D,Vinella D,de Reuse H

更新日期：2021-01-14 00:00:00

abstract：:Extracellular vesicles (EV) mediate intercellular communication events and alterations in normal vesicle content contribute to function and disease initiation or progression. The ability to package a variety of cargo and transmit molecular information between cells renders EVs important mediators of cell-to-cell cross...

journal_title：PLoS pathogens

authors： Nkosi D,Sun L,Duke LC,Meckes DG Jr

更新日期：2020-12-31 00:00:00

abstract：:Cholera, the pandemic diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, continues to be a major public health challenge in the developing world. Cholera toxin, which is responsible for the voluminous stools of cholera, causes constitutive activation of adenylyl cyclase, resulting in the export o...

journal_title：PLoS pathogens

authors： Blow NS,Salomon RN,Garrity K,Reveillaud I,Kopin A,Jackson FR,Watnick PI

更新日期：2005-09-01 00:00:00

abstract：:The influenza A virus (IAV) HA protein must be activated by host cells proteases in order to prime the molecule for fusion. Consequently, the availability of activating proteases and the susceptibility of HA to protease activity represents key factors in facilitating virus infection. As such, understanding the intrica...

journal_title：PLoS pathogens

authors： Galloway SE,Reed ML,Russell CJ,Steinhauer DA

更新日期：2013-02-01 00:00:00

abstract：:Expression of genes of the locus of enterocyte effacement (LEE) is essential for adherence of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells. Gut factors that may modulate LEE gene expression may therefore influence the outcome of the infection. Because nitric oxide (NO) is a critical effecto...

journal_title：PLoS pathogens

authors： Branchu P,Matrat S,Vareille M,Garrivier A,Durand A,Crépin S,Harel J,Jubelin G,Gobert AP

更新日期：2014-01-01 00:00:00

abstract：:Foot-and-mouth disease (FMD) virus causes an acute vesicular disease of domesticated and wild ruminants and pigs. Identifying sources of FMD outbreaks is often confounded by incomplete epidemiological evidence and the numerous routes by which virus can spread (movements of infected animals or their products, contamina...

journal_title：PLoS pathogens

authors： Cottam EM,Wadsworth J,Shaw AE,Rowlands RJ,Goatley L,Maan S,Maan NS,Mertens PP,Ebert K,Li Y,Ryan ED,Juleff N,Ferris NP,Wilesmith JW,Haydon DT,King DP,Paton DJ,Knowles NJ

更新日期：2008-04-18 00:00:00

abstract：:Phase variable expression, mediated by high frequency reversible changes in the length of simple sequence repeats, facilitates adaptation of bacterial populations to changing environments and is frequently important in bacterial virulence. Here we elucidate a novel phase variable mechanism for NadA, an adhesin and inv...

journal_title：PLoS pathogens

authors： Metruccio MM,Pigozzi E,Roncarati D,Berlanda Scorza F,Norais N,Hill SA,Scarlato V,Delany I

更新日期：2009-12-01 00:00:00

abstract：:Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process. Pili have been observed on the surface of several gram-positive bacteria including S. agalactiae. We previously characterized ...

journal_title：PLoS pathogens

authors： Konto-Ghiorghi Y,Mairey E,Mallet A,Duménil G,Caliot E,Trieu-Cuot P,Dramsi S

更新日期：2009-05-01 00:00:00

abstract：:Candida bloodstream infection, i.e. candidemia, is the most frequently encountered life-threatening fungal infection worldwide, with mortality rates up to almost 50%. In the majority of candidemia cases, Candida albicans is responsible. Worryingly, a global increase in the number of patients who are susceptible to inf...

journal_title：PLoS pathogens

authors： de Vries DH,Matzaraki V,Bakker OB,Brugge H,Westra HJ,Netea MG,Franke L,Kumar V,van der Wijst MGP

更新日期：2020-04-06 00:00:00

abstract：:Several naked virus species, including members of the Picornaviridae family, have recently been described to escape their host cells and spread infection via enclosure in extracellular vesicles (EV). EV are 50-300 nm sized lipid membrane-enclosed particles produced by all cells that are broadly recognized for playing ...

journal_title：PLoS pathogens

authors： van der Grein SG,Defourny KAY,Rabouw HH,Galiveti CR,Langereis MA,Wauben MHM,Arkesteijn GJA,van Kuppeveld FJM,Nolte-'t Hoen ENM

更新日期：2019-02-19 00:00:00

abstract：:Salmonella spp. are Gram-negative enteropathogenic bacteria that infect a variety of vertebrate hosts. Like any other living organism, protein secretion is a fundamental process essential for various aspects of Salmonella biology. Herein we report the identification and characterization of a horizontally acquired, aut...

journal_title：PLoS pathogens

authors： Gal-Mor O,Gibson DL,Baluta D,Vallance BA,Finlay BB

更新日期：2008-04-04 00:00:00