Ecological Contexts of Index Cases and Spillover Events of Different Ebolaviruses.

abstract：:This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible mink encephalopathy (TME) agent resulted in a prominent infection of the olfactory bulb and the olfactory sensory epithelium in...

journal_title：PLoS pathogens

authors： Bessen RA,Shearin H,Martinka S,Boharski R,Lowe D,Wilham JM,Caughey B,Wiley JA

更新日期：2010-04-15 00:00:00

abstract：:Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense mechanisms. The cellular transcriptional repressor Daxx prevents ...

journal_title：PLoS pathogens

authors： Schreiner S,Martinez R,Groitl P,Rayne F,Vaillant R,Wimmer P,Bossis G,Sternsdorf T,Marcinowski L,Ruzsics Z,Dobner T,Wodrich H

更新日期：2012-02-01 00:00:00

abstract：:Phagocytosis is an ancient mechanism central to both tissue homeostasis and immune defense. Both the identity of the receptors that mediate bacterial phagocytosis and the nature of the interactions between phagocytosis and other defense mechanisms remain elusive. Here, we report that Croquemort (Crq), a Drosophila mem...

journal_title：PLoS pathogens

authors： Guillou A,Troha K,Wang H,Franc NC,Buchon N

更新日期：2016-10-25 00:00:00

abstract：:MicroRNAs (miRNAs) are 19 to 23 nucleotide-long RNAs that post-transcriptionally regulate gene expression. Human cells express several hundred miRNAs which regulate important biological pathways such as development, proliferation, and apoptosis. Recently, 12 miRNA genes have been identified within the genome of Kaposi...

journal_title：PLoS pathogens

authors： Samols MA,Skalsky RL,Maldonado AM,Riva A,Lopez MC,Baker HV,Renne R

更新日期：2007-05-11 00:00:00

abstract：:The Gram-negative bacterium, Legionella pneumophila, is a protozoan parasite and accidental intracellular pathogen of humans. We propose a model in which cycling through multiple protozoan hosts in the environment holds L. pneumophila in a state of evolutionary stasis as a broad host-range pathogen. Using an experimen...

journal_title：PLoS pathogens

authors： Ensminger AW,Yassin Y,Miron A,Isberg RR

更新日期：2012-01-01 00:00:00

abstract：:The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity a...

journal_title：PLoS pathogens

authors： Refsland EW,Hultquist JF,Harris RS

更新日期：2012-01-01 00:00:00

abstract：:The interplay between autophagy and intracellular pathogens is intricate as autophagy is an essential cellular response to fight against infections, whereas numerous microbes have developed strategies to escape this process or even exploit it to their own benefit. The fine tuned timing and/or selective molecular pathw...

journal_title：PLoS pathogens

authors： Richetta C,Grégoire IP,Verlhac P,Azocar O,Baguet J,Flacher M,Tangy F,Rabourdin-Combe C,Faure M

更新日期：2013-01-01 00:00:00

abstract：:The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little is known about this interaction. We used isothermal titration calorimetry, X-ray crystallography and mutagenesis-validated modeling to...

journal_title：PLoS pathogens

authors： Fisher CR,Sutton HJ,Kaczmarski JA,McNamara HA,Clifton B,Mitchell J,Cai Y,Dups JN,D'Arcy NJ,Singh M,Chuah A,Peat TS,Jackson CJ,Cockburn IA

更新日期：2017-07-31 00:00:00

abstract：:Hepatitis B virus infection (HBV) is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA) that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein HBx ...

journal_title：PLoS pathogens

authors： Ducroux A,Benhenda S,Rivière L,Semmes OJ,Benkirane M,Neuveut C

更新日期：2014-09-11 00:00:00

abstract：:Lactoferrin binding protein B (LbpB) is a bi-lobed outer membrane-bound lipoprotein that comprises part of the lactoferrin (Lf) receptor complex in Neisseria meningitidis and other Gram-negative pathogens. Recent studies have demonstrated that LbpB plays a role in protecting the bacteria from cationic antimicrobial pe...

journal_title：PLoS pathogens

authors： Ostan NK,Yu RH,Ng D,Lai CC,Pogoutse AK,Sarpe V,Hepburn M,Sheff J,Raval S,Schriemer DC,Moraes TF,Schryvers AB

更新日期：2017-03-03 00:00:00

abstract：:The prevalence of antibiotic resistance genes in pathogenic bacteria is a major challenge to treating many infectious diseases. The spread of these genes is driven by the strong selection imposed by the use of antibacterial drugs. However, in the absence of drug selection, antibiotic resistance genes impose a fitness ...

journal_title：PLoS pathogens

authors： Albarracín Orio AG,Piñas GE,Cortes PR,Cian MB,Echenique J

更新日期：2011-02-01 00:00:00

abstract：:Community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) is a socially problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is more virulent than hospital associated-MRSA (HA-MRSA). The underlying mechanism for the high virulence of CA-MRSA is not known. The transcript...

journal_title：PLoS pathogens

authors： Kaito C,Saito Y,Ikuo M,Omae Y,Mao H,Nagano G,Fujiyuki T,Numata S,Han X,Obata K,Hasegawa S,Yamaguchi H,Inokuchi K,Ito T,Hiramatsu K,Sekimizu K

更新日期：2013-01-01 00:00:00

abstract：:Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV gag/pol/nef sequences ...

journal_title：PLoS pathogens

authors： Erdmann N,Du VY,Carlson J,Schaefer M,Jureka A,Sterrett S,Yue L,Dilernia D,Lakhi S,Tang J,Sidney J,Gilmour J,Allen S,Hunter E,Heath S,Bansal A,Goepfert PA

更新日期：2015-08-24 00:00:00

abstract：:Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through downregulation of MHC class I molecules (MHC-I). Here we show that US2 function goes far beyond MHC-I degradation. A systematic proteomic study using Plasma Membrane ...

journal_title：PLoS pathogens

authors： Hsu JL,van den Boomen DJ,Tomasec P,Weekes MP,Antrobus R,Stanton RJ,Ruckova E,Sugrue D,Wilkie GS,Davison AJ,Wilkinson GW,Lehner PJ

更新日期：2015-04-14 00:00:00

abstract：:Many bacterial pathogens and symbionts use type III secretion machines to interact with their hosts by injecting bacterial effector proteins into host target cells. A central component of this complex machine is the cytoplasmic sorting platform, which orchestrates the engagement and preparation of type III secreted pr...

journal_title：PLoS pathogens

authors： Lara-Tejero M,Qin Z,Hu B,Butan C,Liu J,Galán JE

更新日期：2019-01-22 00:00:00

abstract：:Trichothecenes are a family of terpenoid toxins produced by multiple genera of fungi, including plant and insect pathogens. Some trichothecenes produced by the fungus Fusarium are among the mycotoxins of greatest concern to food and feed safety because of their toxicity and frequent occurrence in cereal crops, and tri...

journal_title：PLoS pathogens

authors： Proctor RH,McCormick SP,Kim HS,Cardoza RE,Stanley AM,Lindo L,Kelly A,Brown DW,Lee T,Vaughan MM,Alexander NJ,Busman M,Gutiérrez S

更新日期：2018-04-12 00:00:00

abstract：:Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, infects human neutrophils and inhibits mitochondria-mediated apoptosis. Bacterial factors involved in this process are unknown. In the present study, we screened a genomic DNA library of A. phagocytophilum for effectors of the type IV s...

journal_title：PLoS pathogens

authors： Niu H,Kozjak-Pavlovic V,Rudel T,Rikihisa Y

更新日期：2010-02-19 00:00:00

abstract：:The apicomplexan, Cryptosporidium parvum, possesses a bacterial-type lactate dehydrogenase (CpLDH). This is considered to be an essential enzyme, as this parasite lacks the Krebs cycle and cytochrome-based respiration, and mainly-if not solely, relies on glycolysis to produce ATP. Here, we provide evidence that in ext...

journal_title：PLoS pathogens

authors： Zhang H,Guo F,Zhu G

更新日期：2015-11-12 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IκB kinases (IKKs) and NF-κB and promote cell survival; however, the key ubiquitinated factors downstream of Tax involved in cell transformation are unknown. Using mass spectrometry, we undertook an unbiased pr...

journal_title：PLoS pathogens

authors： Choi YB,Harhaj EW

更新日期：2014-10-23 00:00:00

abstract：:Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-micro...

journal_title：PLoS pathogens

authors： Tay HL,Kaiko GE,Plank M,Li J,Maltby S,Essilfie AT,Jarnicki A,Yang M,Mattes J,Hansbro PM,Foster PS

更新日期：2015-04-20 00:00:00

abstract：:The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence i...

journal_title：PLoS pathogens

authors： Chung D,Barker BM,Carey CC,Merriman B,Werner ER,Lechner BE,Dhingra S,Cheng C,Xu W,Blosser SJ,Morohashi K,Mazurie A,Mitchell TK,Haas H,Mitchell AP,Cramer RA

更新日期：2014-11-06 00:00:00

abstract：:The bunyavirus genome comprises a small (S), medium (M), and large (L) RNA segment of negative polarity. Although genome segmentation confers evolutionary advantages by enabling genome reassortment events with related viruses, genome segmentation also complicates genome replication and packaging. Accumulating evidence...

journal_title：PLoS pathogens

authors： Wichgers Schreur PJ,Kortekaas J

更新日期：2016-08-22 00:00:00

abstract：:Ribonuclease L (RNase L) is an important effector of the innate antiviral response. Mutations or variants that impair function of RNase L, particularly R462Q, have been proposed as susceptibility factors for prostate cancer. Given the role of this gene in viral defense, we sought to explore the possibility that a vira...

journal_title：PLoS pathogens

authors： Urisman A,Molinaro RJ,Fischer N,Plummer SJ,Casey G,Klein EA,Malathi K,Magi-Galluzzi C,Tubbs RR,Ganem D,Silverman RH,DeRisi JL

更新日期：2006-03-01 00:00:00

abstract：:Many biological processes are controlled by intricate networks of transcriptional regulators. With the development of microarray technology, transcriptional changes can be examined at the whole-genome level. However, such analysis often lacks information on the hierarchical relationship between components of a given s...

journal_title：PLoS pathogens

authors： Wang D,Amornsiripanitch N,Dong X

更新日期：2006-11-01 00:00:00

abstract：:Mycobacterial infection leads to activation of the RIG-I/MAVS/TBK1 RNA sensing pathway in macrophages but the consequences of this activation remains poorly defined. In this study, we determined that activation of this RNA sensing pathway stimulates ICAM-1 expression in M.avium-infected macrophage through the inhibiti...

journal_title：PLoS pathogens

authors： Cheng Y,Kiene NJ,Tatarian A,Eix EF,Schorey JS

更新日期：2020-05-28 00:00:00

abstract：:Cholera, the pandemic diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, continues to be a major public health challenge in the developing world. Cholera toxin, which is responsible for the voluminous stools of cholera, causes constitutive activation of adenylyl cyclase, resulting in the export o...

journal_title：PLoS pathogens

authors： Blow NS,Salomon RN,Garrity K,Reveillaud I,Kopin A,Jackson FR,Watnick PI

更新日期：2005-09-01 00:00:00

abstract：:A pandemic-capable influenza virus requires a hemagglutinin (HA) surface glycoprotein that is immunologically unseen by most people and is capable of supporting replication and transmission in humans. HA stabilization has been linked to 2009 pH1N1 pandemic potential in humans and H5N1 airborne transmissibility in the ...

journal_title：PLoS pathogens

authors： Russier M,Yang G,Marinova-Petkova A,Vogel P,Kaplan BS,Webby RJ,Russell CJ

更新日期：2017-03-10 00:00:00

abstract：:The agr quorum-sensing system of Staphylococcus aureus modulates the expression of virulence factors in response to autoinducing peptides (AIPs). Recent studies have suggested a role for the agr system in S. aureus biofilm development, as agr mutants exhibit a high propensity to form biofilms, and cells dispersing fro...

journal_title：PLoS pathogens

authors： Boles BR,Horswill AR

更新日期：2008-04-25 00:00:00

abstract：:The emergence of ceftriaxone-resistant strains of Neisseria gonorrhoeae may herald an era of untreatable gonorrhea. Vaccines against this infection are urgently needed. The 2C7 epitope is a conserved oligosaccharide (OS) structure, a part of lipooligosaccharide (LOS) on N gonorrhoeae. The epitope is expressed by 94% o...

journal_title：PLoS pathogens

authors： Gulati S,Zheng B,Reed GW,Su X,Cox AD,St Michael F,Stupak J,Lewis LA,Ram S,Rice PA

更新日期：2013-01-01 00:00:00

abstract：:The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives was investigated ag...

journal_title：PLoS pathogens

authors： Lupien A,Foo CS,Savina S,Vocat A,Piton J,Monakhova N,Benjak A,Lamprecht DA,Steyn AJC,Pethe K,Makarov VA,Cole ST

更新日期：2020-01-23 00:00:00