Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.

abstract：:Inhalation of fungal spores (conidia) occurs commonly and, in specific circumstances, can result in invasive disease. We investigated the murine inflammatory response to conidia of Aspergillus fumigatus, the most common invasive mold in immunocompromised hosts. In contrast to dormant spores, germinating conidia induce...

journal_title：PLoS pathogens

authors： Hohl TM,Van Epps HL,Rivera A,Morgan LA,Chen PL,Feldmesser M,Pamer EG

更新日期：2005-11-01 00:00:00

abstract：:Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome. Its small hydrop...

journal_title：PLoS pathogens

authors： Dietsche T,Tesfazgi Mebrhatu M,Brunner MJ,Abrusci P,Yan J,Franz-Wachtel M,Schärfe C,Zilkenat S,Grin I,Galán JE,Kohlbacher O,Lea S,Macek B,Marlovits TC,Robinson CV,Wagner S

更新日期：2016-12-15 00:00:00

abstract：:Adenoviral vectors have shown significant promise as vaccine delivery vectors due to their ability to elicit both innate and adaptive immune responses. α-defensins are effector molecules of the innate immune response and have been shown to modulate natural infection with adenoviruses, but the majority of α-defensin-ad...

journal_title：PLoS pathogens

authors： Tartaglia LJ,Badamchi-Zadeh A,Abbink P,Blass E,Aid M,Gebre MS,Li Z,Pastores KC,Trott S,Gupte S,Larocca RA,Barouch DH

更新日期：2019-12-16 00:00:00

abstract：:The Gram-negative bacterium, Legionella pneumophila, is a protozoan parasite and accidental intracellular pathogen of humans. We propose a model in which cycling through multiple protozoan hosts in the environment holds L. pneumophila in a state of evolutionary stasis as a broad host-range pathogen. Using an experimen...

journal_title：PLoS pathogens

authors： Ensminger AW,Yassin Y,Miron A,Isberg RR

更新日期：2012-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006120.]. ...

journal_title：PLoS pathogens

authors： Kinosada H,Yasunaga JI,Shimura K,Miyazato P,Onishi C,Iyoda T,Inaba K,Matsuoka M

更新日期：2017-02-23 00:00:00

abstract：:Hepatitis B virus infection (HBV) is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA) that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein HBx ...

journal_title：PLoS pathogens

authors： Ducroux A,Benhenda S,Rivière L,Semmes OJ,Benkirane M,Neuveut C

更新日期：2014-09-11 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs. The aptitude of ba...

journal_title：PLoS pathogens

authors： Felden B,Vandenesch F,Bouloc P,Romby P

更新日期：2011-03-01 00:00:00

abstract：:The binding of human complement inhibitors to vaccine antigens in vivo could diminish their immunogenicity. A meningococcal ligand for the complement down-regulator, factor H (fH), is fH-binding protein (fHbp), which is specific for human fH. Vaccines containing recombinant fHbp or native outer membrane vesicles (NOMV...

journal_title：PLoS pathogens

authors： Beernink PT,Shaughnessy J,Pajon R,Braga EM,Ram S,Granoff DM

更新日期：2012-01-01 00:00:00

abstract：:Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored. Using a primary human lymphatic endothelial cell model, we found that HIV-1 envelo...

journal_title：PLoS pathogens

authors： Zhang X,Yu J,Kuzontkoski PM,Zhu W,Li DY,Groopman JE

更新日期：2012-01-01 00:00:00

abstract：:Wolbachia are maternally transmitted intracellular bacterial symbionts that infect approximately 40% of all insect species. Though several strains of Wolbachia naturally infect Drosophila melanogaster and provide resistance against viral pathogens, or provision metabolites during periods of nutritional stress, one vir...

journal_title：PLoS pathogens

authors： Rohrscheib CE,Frentiu FD,Horn E,Ritchie FK,van Swinderen B,Weible MW 2nd,O'Neill SL,Brownlie JC

更新日期：2016-09-23 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in ...

journal_title：PLoS pathogens

authors： Gullberg E,Cao S,Berg OG,Ilbäck C,Sandegren L,Hughes D,Andersson DI

更新日期：2011-07-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recruitment of innate i...

journal_title：PLoS pathogens

authors： Ries LNA,Pardeshi L,Dong Z,Tan K,Steenwyk JL,Colabardini AC,Ferreira Filho JA,de Castro PA,Silva LP,Preite NW,Almeida F,de Assis LJ,Dos Santos RAC,Bowyer P,Bromley M,Owens RA,Doyle S,Demasi M,Hernández DCR,Netto LES

更新日期：2020-07-15 00:00:00

abstract：:Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death lig...

journal_title：PLoS pathogens

authors： Holokai L,Chakrabarti J,Broda T,Chang J,Hawkins JA,Sundaram N,Wroblewski LE,Peek RM Jr,Wang J,Helmrath M,Wells JM,Zavros Y

更新日期：2019-01-31 00:00:00

abstract：:RNA viruses typically occur in genetically diverse populations due to their error-prone genome replication. Genetic diversity is thought to be important in allowing RNA viruses to explore sequence space, facilitating adaptation to changing environments and hosts. Some arboviruses that infect both a mosquito vector and...

journal_title：PLoS pathogens

authors： Forrester NL,Guerbois M,Seymour RL,Spratt H,Weaver SC

更新日期：2012-09-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006750.]. ...

journal_title：PLoS pathogens

authors： Patterson Ross Z,Klunk J,Fornaciari G,Giuffra V,Duchêne S,Duggan AT,Poinar D,Douglas MW,Eden JS,Holmes EC,Poinar HN

更新日期：2018-02-09 00:00:00

abstract：:Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion during P. chabaudi infection is...

journal_title：PLoS pathogens

authors： Fontana MF,de Melo GL,Anidi C,Hamburger R,Kim CY,Lee SY,Pham J,Kim CC

更新日期：2016-12-06 00:00:00

abstract：:Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment sequelae, specifically post-kala-azar dermal leishmaniasis (PKDL). Nevertheless, ...

journal_title：PLoS pathogens

authors： Lewis MD,Paun A,Romano A,Langston H,Langner CA,Moore IN,Bock KW,Francisco AF,Brenchley JM,Sacks DL

更新日期：2020-04-13 00:00:00

abstract：:Amyloidosis describes a group of protein folding diseases in which amyloid proteins are abnormally deposited in organs and/or tissues as fine fibrils. Mouse senile amyloidosis is a disorder in which apolipoprotein A-II (apoA-II) deposits as amyloid fibrils (AApoAII) and can be transmitted from one animal to another bo...

journal_title：PLoS pathogens

authors： Qian J,Yan J,Ge F,Zhang B,Fu X,Tomozawa H,Sawashita J,Mori M,Higuchi K

更新日期：2010-05-20 00:00:00

abstract：:During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the importance of invasion into the bloodstream in the meningococcal disease process, little is known about how Nm adapts to permit survival a...

journal_title：PLoS pathogens

authors： Echenique-Rivera H,Muzzi A,Del Tordello E,Seib KL,Francois P,Rappuoli R,Pizza M,Serruto D

更新日期：2011-05-01 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00

abstract：:As well as their importance to nutrition, fatty acids (FA) represent a unique group of quorum sensing chemicals that modulate the behavior of bacterial population in virulence. However, the way in which full-length, membrane-bound receptors biochemically detect FA remains unclear. Here, we provide genetic, enzymologic...

journal_title：PLoS pathogens

authors： Cai Z,Yuan ZH,Zhang H,Pan Y,Wu Y,Tian XQ,Wang FF,Wang L,Qian W

更新日期：2017-04-03 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1008639.]. ...

journal_title：PLoS pathogens

authors： Bonhomme D,Santecchia I,Vernel-Pauillac F,Caroff M,Germon P,Murray G,Adler B,Boneca IG,Werts C

更新日期：2020-12-23 00:00:00

abstract：:Vibrio cholerae has evolved to adeptly transition between the human small intestine and aquatic environments, leading to water-borne spread and transmission of the lethal diarrheal disease cholera. Using a host model that mimics the pathology of human cholera, we applied high density transposon mutagenesis combined wi...

journal_title：PLoS pathogens

authors： Kamp HD,Patimalla-Dipali B,Lazinski DW,Wallace-Gadsden F,Camilli A

更新日期：2013-01-01 00:00:00

abstract：:Phosphorylated derivatives of phosphatidylinositol (PIPs) are key membrane lipid residues involved in clathrin-mediated endocytosis (CME). CME relies on PIP species PI(4,5)P2 to mark endocytic sites at the plasma membrane (PM) associated to clathrin-coated vesicle (CCV) formation. The highly diverged parasitic protist...

journal_title：PLoS pathogens

authors： Cernikova L,Faso C,Hehl AB

更新日期：2020-02-24 00:00:00

abstract：:Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasite Ascaris lumbricoides, estimated to infect approximately 1.4 billion...

journal_title：PLoS pathogens

authors： Williamson SM,Robertson AP,Brown L,Williams T,Woods DJ,Martin RJ,Sattelle DB,Wolstenholme AJ

更新日期：2009-07-01 00:00:00

abstract：:Epstein-Barr virus (EBV) and related lymphocryptoviruses (LCV) from non-human primates infect B cells, transform their growth to facilitate life-long viral persistence in the host, and contribute to B cell oncogenesis. Co-evolution of LCV with their primate hosts has led to species-specificity so that LCVs preferentia...

journal_title：PLoS pathogens

authors： Mühe J,Wang F

更新日期：2017-12-20 00:00:00

abstract：:The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represe...

journal_title：PLoS pathogens

authors： Sawtell NM,Thompson RL

更新日期：2016-09-08 00:00:00

abstract：:The NLRP3 inflammasome has emerged as a central immune regulator that senses virulence factors expressed by microbial pathogens for triggering inflammation. Inflammation can be harmful and therefore this response must be tightly controlled. The mechanisms by which immune cells, such as macrophages, discriminate benign...

journal_title：PLoS pathogens

authors： Tucey TM,Verma J,Olivier FAB,Lo TL,Robertson AAB,Naderer T,Traven A

更新日期：2020-08-04 00:00:00

abstract：:Giardia intestinalis is a major cause of diarrheal disease worldwide and two major Giardia genotypes, assemblages A and B, infect humans. The genome of assemblage A parasite WB was recently sequenced, and the structurally compact 11.7 Mbp genome contains simplified basic cellular machineries and metabolism. We here pe...

journal_title：PLoS pathogens

authors： Franzén O,Jerlström-Hultqvist J,Castro E,Sherwood E,Ankarklev J,Reiner DS,Palm D,Andersson JO,Andersson B,Svärd SG

更新日期：2009-08-01 00:00:00