Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival.

abstract：:The diversity of a highly variable RNA plant virus was considered to determine the range of virulence substitutions, the evolutionary pathways to virulence, and whether intraspecific diversity modulates virulence pathways and propensity. In all, 114 isolates representative of the genetic and geographic diversity of Ri...

journal_title：PLoS pathogens

authors： Pinel-Galzi A,Rakotomalala M,Sangu E,Sorho F,Kanyeka Z,Traoré O,Sérémé D,Poulicard N,Rabenantoandro Y,Séré Y,Konaté G,Ghesquière A,Hébrard E,Fargette D

更新日期：2007-11-01 00:00:00

abstract：:The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at residue 198 (T198F...

journal_title：PLoS pathogens

authors： Goo L,VanBlargan LA,Dowd KA,Diamond MS,Pierson TC

更新日期：2017-02-16 00:00:00

abstract：:The emergence of ceftriaxone-resistant strains of Neisseria gonorrhoeae may herald an era of untreatable gonorrhea. Vaccines against this infection are urgently needed. The 2C7 epitope is a conserved oligosaccharide (OS) structure, a part of lipooligosaccharide (LOS) on N gonorrhoeae. The epitope is expressed by 94% o...

journal_title：PLoS pathogens

authors： Gulati S,Zheng B,Reed GW,Su X,Cox AD,St Michael F,Stupak J,Lewis LA,Ram S,Rice PA

更新日期：2013-01-01 00:00:00

abstract：:The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives was investigated ag...

journal_title：PLoS pathogens

authors： Lupien A,Foo CS,Savina S,Vocat A,Piton J,Monakhova N,Benjak A,Lamprecht DA,Steyn AJC,Pethe K,Makarov VA,Cole ST

更新日期：2020-01-23 00:00:00

abstract：:Previous studies identified prion protein (PrP) mutants which act as dominant negative inhibitors of prion formation through a mechanism hypothesized to require an unidentified species-specific cofactor termed protein X. To study the mechanism of dominant negative inhibition in vitro, we used recombinant PrP(C) molecu...

journal_title：PLoS pathogens

authors： Geoghegan JC,Miller MB,Kwak AH,Harris BT,Supattapone S

更新日期：2009-07-01 00:00:00

abstract：:Prions are pathogens formed from abnormal conformers (PrPSc) of the host-encoded cellular prion protein (PrPC). PrPSc conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-dependent tropism for lymphoid tissues. Prions can be composed of several su...

journal_title：PLoS pathogens

authors： Béringue V,Tixador P,Andréoletti O,Reine F,Castille J,Laï TL,Le Dur A,Laisné A,Herzog L,Passet B,Rezaei H,Vilotte JL,Laude H

更新日期：2020-07-23 00:00:00

abstract：:The digestive tract is the first organ affected by the ingestion of foodborne bacteria. While commensal bacteria become resident, opportunistic or virulent bacteria are eliminated from the gut by the local innate immune system. Here we characterize a new mechanism of defense, independent of the immune system, in Droso...

journal_title：PLoS pathogens

authors： Benguettat O,Jneid R,Soltys J,Loudhaief R,Brun-Barale A,Osman D,Gallet A

更新日期：2018-09-04 00:00:00

abstract：:The process by which drug-resistant HIV-1 arises and spreads spatially within an infected individual is poorly understood. Studies have found variable results relating how HIV-1 in the blood differs from virus sampled in tissues, offering conflicting findings about whether HIV-1 throughout the body is homogeneously di...

journal_title：PLoS pathogens

authors： Feder AF,Kline C,Polacino P,Cottrell M,Kashuba ADM,Keele BF,Hu SL,Petrov DA,Pennings PS,Ambrose Z

更新日期：2017-05-25 00:00:00

abstract：:Rice dwarf virus (RDV) replicates in and is transmitted by a leafhopper vector in a persistent-propagative manner. Previous cytopathologic and genetic data revealed that tubular structures, constructed by the nonstructural viral protein Pns10, contain viral particles and are directly involved in the intercellular spre...

journal_title：PLoS pathogens

authors： Chen Q,Chen H,Mao Q,Liu Q,Shimizu T,Uehara-Ichiki T,Wu Z,Xie L,Omura T,Wei T

更新日期：2012-01-01 00:00:00

abstract：:The survival and persistence of Mycobacterium tuberculosis depends on its capacity to manipulate multiple host defense pathways, including the ability to actively inhibit the death by apoptosis of infected host cells. The genetic basis for this anti-apoptotic activity and its implication for mycobacterial virulence ha...

journal_title：PLoS pathogens

authors： Velmurugan K,Chen B,Miller JL,Azogue S,Gurses S,Hsu T,Glickman M,Jacobs WR Jr,Porcelli SA,Briken V

更新日期：2007-07-01 00:00:00

abstract：:Israeli acute paralysis virus (IAPV) is a widespread RNA virus of honey bees that has been linked with colony losses. Here we describe the transmission, prevalence, and genetic traits of this virus, along with host transcriptional responses to infections. Further, we present RNAi-based strategies for limiting an impor...

journal_title：PLoS pathogens

authors： Chen YP,Pettis JS,Corona M,Chen WP,Li CJ,Spivak M,Visscher PK,DeGrandi-Hoffman G,Boncristiani H,Zhao Y,vanEngelsdorp D,Delaplane K,Solter L,Drummond F,Kramer M,Lipkin WI,Palacios G,Hamilton MC,Smith B,Huang SK,Zhe

更新日期：2014-07-31 00:00:00

abstract：:The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation...

journal_title：PLoS pathogens

authors： Khurana S,Frasca D,Blomberg B,Golding H

更新日期：2012-09-01 00:00:00

abstract：:Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells in LN of cART-suppre...

journal_title：PLoS pathogens

authors： Pino M,Paganini S,Deleage C,Padhan K,Harper JL,King CT,Micci L,Cervasi B,Mudd JC,Gill KP,Jean SM,Easley K,Silvestri G,Estes JD,Petrovas C,Lederman MM,Paiardini M

更新日期：2019-10-18 00:00:00

abstract：:Targeting of permissive entry sites is crucial for bacterial infection. The targeting mechanisms are incompletely understood. We have analyzed target-site selection by S. Typhimurium. This enteropathogenic bacterium employs adhesins (e.g. fim) and the type III secretion system 1 (TTSS-1) for host cell binding, the tri...

journal_title：PLoS pathogens

authors： Misselwitz B,Barrett N,Kreibich S,Vonaesch P,Andritschke D,Rout S,Weidner K,Sormaz M,Songhet P,Horvath P,Chabria M,Vogel V,Spori DM,Jenny P,Hardt WD

更新日期：2012-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use. Alternative antiviral strategies may include inhibition of entry. We show that soluble derivatives of th...

journal_title：PLoS pathogens

authors： Stegmann C,Hochdorfer D,Lieber D,Subramanian N,Stöhr D,Laib Sampaio K,Sinzger C

更新日期：2017-04-12 00:00:00

abstract：:HIV and other lentiviruses can productively infect nondividing cells, whereas most other retroviruses, such as murine leukemia virus, require cell division for efficient infection. However, the determinants for this phenotype have been controversial. Here, we show that HIV-1 capsid (CA) is involved in facilitating HIV...

journal_title：PLoS pathogens

authors： Yamashita M,Perez O,Hope TJ,Emerman M

更新日期：2007-10-26 00:00:00

abstract：:Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus anthracis, disrupts endocytic recycling mediated by the small GTPase Rab11. As a result, cargo proteins such as cadherins fail to reach inter-cellu...

journal_title：PLoS pathogens

authors： Guichard A,Jain P,Moayeri M,Schwartz R,Chin S,Zhu L,Cruz-Moreno B,Liu JZ,Aguilar B,Hollands A,Leppla SH,Nizet V,Bier E

更新日期：2017-09-25 00:00:00

abstract：:In prion diseases, synapse dysfunction, axon retraction and loss of neuronal polarity precede neuronal death. The mechanisms driving such polarization defects, however, remain unclear. Here, we examined the contribution of RhoA-associated coiled-coil containing kinases (ROCK), key players in neuritogenesis, to prion d...

journal_title：PLoS pathogens

authors： Alleaume-Butaux A,Nicot S,Pietri M,Baudry A,Dakowski C,Tixador P,Ardila-Osorio H,Haeberlé AM,Bailly Y,Peyrin JM,Launay JM,Kellermann O,Schneider B

更新日期：2015-08-04 00:00:00

abstract：:Sepsis is characterized by a dysregulated host-pathogen response, leading to high cytokine levels, excessive coagulation and failure to eradicate invasive bacteria. Novel therapeutic strategies that address crucial pathogenetic steps during infection are urgently needed. Here, we describe novel bioactive roles and the...

journal_title：PLoS pathogens

authors： Papareddy P,Kalle M,Sørensen OE,Malmsten M,Mörgelin M,Schmidtchen A

更新日期：2013-01-01 00:00:00

abstract：:Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum. In this study, we have examined the effect of sub-inhibitory concentrations of human α-defen...

journal_title：PLoS pathogens

authors： Demirkhanyan L,Marin M,Lu W,Melikyan GB

更新日期：2013-01-01 00:00:00

abstract：:Entamoeba histolytica transmembrane kinases (EhTMKs) can be grouped into six distinct families on the basis of motifs and sequences. Analysis of the E. histolytica genome revealed the presence of 35 EhTMKB1 members on the basis of sequence identity (>or=95%). Only six homologs were full length containing an extracellu...

journal_title：PLoS pathogens

authors： Shrimal S,Bhattacharya S,Bhattacharya A

更新日期：2010-06-03 00:00:00

abstract：:Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health. Such knowledge may assist in the development of new effective vaccines and in the appropriate use of antimalarial drugs. By performing a full-genome s...

journal_title：PLoS pathogens

authors： Kidgell C,Volkman SK,Daily J,Borevitz JO,Plouffe D,Zhou Y,Johnson JR,Le Roch K,Sarr O,Ndir O,Mboup S,Batalov S,Wirth DF,Winzeler EA

更新日期：2006-06-01 00:00:00

abstract：:Ebola virus (EBOV) is a highly pathogenic filovirus that causes hemorrhagic fever in humans and animals. Currently, how EBOV fuses its envelope membrane within an endosomal membrane to cause infection is poorly understood. We successfully measure cell-cell fusion mediated by the EBOV fusion protein, GP, assayed by the...

journal_title：PLoS pathogens

authors： Markosyan RM,Miao C,Zheng YM,Melikyan GB,Liu SL,Cohen FS

更新日期：2016-01-05 00:00:00

abstract：:During immature capsid assembly, HIV-1 genome packaging is initiated when Gag first associates with unspliced HIV-1 RNA by a poorly understood process. Previously, we defined a pathway of sequential intracellular HIV-1 capsid assembly intermediates; here we sought to identify the intermediate in which HIV-1 Gag first ...

journal_title：PLoS pathogens

authors： Barajas BC,Tanaka M,Robinson BA,Phuong DJ,Chutiraka K,Reed JC,Lingappa JR

更新日期：2018-04-17 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, invades and replicates within macrophages and protozoan cells inside a vacuole. The type IVB Icm/Dot secretion system is necessary for the translocation of effector proteins that modulate vesicle trafficking pathways in the host cell, thus avoiding ...

journal_title：PLoS pathogens

authors： Franco IS,Shohdy N,Shuman HA

更新日期：2012-02-01 00:00:00

abstract：:There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown. By using the rice-rice dwarf virus (RDV) model system, here we report that...

journal_title：PLoS pathogens

authors： Qin Q,Li G,Jin L,Huang Y,Wang Y,Wei C,Xu Z,Yang Z,Wang H,Li Y

更新日期：2020-12-02 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and secreted as stable vir...

journal_title：PLoS pathogens

authors： Heger-Stevic J,Zimmermann P,Lecoq L,Böttcher B,Nassal M

更新日期：2018-12-19 00:00:00

abstract：:IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response DNA sensor and induces the IL-1β and antiviral type-1 interferon-β (IFN-β) cytokines. We have shown that IFI16, in association with BRCA1, functions as a se...

journal_title：PLoS pathogens

authors： Iqbal J,Ansari MA,Kumar B,Dutta D,Roy A,Chikoti L,Pisano G,Dutta S,Vahedi S,Veettil MV,Chandran B

更新日期：2016-10-20 00:00:00

abstract：:Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Wester...

journal_title：PLoS pathogens

authors： Towner JS,Sealy TK,Khristova ML,Albariño CG,Conlan S,Reeder SA,Quan PL,Lipkin WI,Downing R,Tappero JW,Okware S,Lutwama J,Bakamutumaho B,Kayiwa J,Comer JA,Rollin PE,Ksiazek TG,Nichol ST

更新日期：2008-11-01 00:00:00