AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans.

abstract：:Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We report a new class of small molecule antiretroviral compounds that di...

journal_title：PLoS pathogens

authors： Blair WS,Pickford C,Irving SL,Brown DG,Anderson M,Bazin R,Cao J,Ciaramella G,Isaacson J,Jackson L,Hunt R,Kjerrstrom A,Nieman JA,Patick AK,Perros M,Scott AD,Whitby K,Wu H,Butler SL

更新日期：2010-12-09 00:00:00

abstract：:Virions are thought to contain all the essential proteins that govern virus egress from the host cell and initiation of replication in the target cell. It has been known for some time that influenza virions contain nine viral proteins; however, analyses of other enveloped viruses have revealed that proteins from the h...

journal_title：PLoS pathogens

authors： Shaw ML,Stone KL,Colangelo CM,Gulcicek EE,Palese P

更新日期：2008-06-06 00:00:00

abstract：:In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability modulates virulence factor production and biofilm formation by other ba...

journal_title：PLoS pathogens

authors： Szelestey BR,Heimlich DR,Raffel FK,Justice SS,Mason KM

更新日期：2013-01-01 00:00:00

abstract：:For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate cell attachment and twelve that are associated in a membrane compl...

journal_title：PLoS pathogens

authors： Laliberte JP,Weisberg AS,Moss B

更新日期：2011-12-01 00:00:00

abstract：:Successful infection of the host requires secretion of effector proteins to evade or suppress plant immunity. Secretion of effectors in root-infecting fungal pathogens, however, remains unexplored. We previously reported that Verticillium dahliae, a root-infecting phytopathogenic fungus, develops a penetration peg fro...

journal_title：PLoS pathogens

authors： Zhou TT,Zhao YL,Guo HS

更新日期：2017-03-10 00:00:00

abstract：:Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. Sumoylation has roles in the control of protein stability, activity and localization, and is involved in the regulation of transcription, gene expr...

journal_title：PLoS pathogens

authors： Sloan E,Tatham MH,Groslambert M,Glass M,Orr A,Hay RT,Everett RD

更新日期：2015-07-22 00:00:00

abstract：:The MHC class I D(k) molecule supplies vital host resistance during murine cytomegalovirus (MCMV) infection. Natural killer (NK) cells expressing the Ly49G2 inhibitory receptor, which specifically binds D(k), are required to control viral spread. The extent of D(k)-dependent host resistance, however, differs significa...

journal_title：PLoS pathogens

authors： Gillespie AL,Teoh J,Lee H,Prince J,Stadnisky MD,Anderson M,Nash W,Rival C,Wei H,Gamache A,Farber CR,Tung K,Brown MG

更新日期：2016-02-04 00:00:00

abstract：:Rice tungro disease is caused by synergistic interaction of an RNA picorna-like virus Rice tungro spherical virus (RTSV) and a DNA pararetrovirus Rice tungro bacilliform virus (RTBV). It is spread by insects owing to an RTSV-encoded transmission factor. RTBV has evolved a ribosome shunt mechanism to initiate translati...

journal_title：PLoS pathogens

authors： Pooggin MM,Rajeswaran R,Schepetilnikov MV,Ryabova LA

更新日期：2012-01-01 00:00:00

abstract：:The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic environmental change, during which successful pathogens gauge multiple parameters that signal host localization. The facultative human...

journal_title：PLoS pathogens

authors： Haber A,Friedman S,Lobel L,Burg-Golani T,Sigal N,Rose J,Livnat-Levanon N,Lewinson O,Herskovits AA

更新日期：2017-01-23 00:00:00

abstract：:Mosquito-borne flaviviruses are among the most significant arboviral pathogens worldwide. Vaccinations and mosquito population control programs remain the most reliable means for flavivirus disease prevention, and live attenuated viruses remain one of the most attractive flavivirus vaccine platforms. Some live attenua...

journal_title：PLoS pathogens

authors： Tsetsarkin KA,Liu G,Kenney H,Bustos-Arriaga J,Hanson CT,Whitehead SS,Pletnev AG

更新日期：2015-04-23 00:00:00

abstract：:Endemic Burkitt's lymphoma (eBL) arises from the germinal center (GC). It is a common tumor of young children in tropical Africa and its occurrence is closely linked geographically with the incidence of P. falciparum malaria. This association was noted more than 50 years ago. Since then we have learned that eBL contai...

journal_title：PLoS pathogens

authors： Torgbor C,Awuah P,Deitsch K,Kalantari P,Duca KA,Thorley-Lawson DA

更新日期：2014-05-29 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) remains a major public health problem, with an effective vaccine continuing to prove elusive. Progress in vaccination strategies has been hampered by a lack of appreciation of the bacterium's response to dynamic changes in the host immune environment. Here, we utilize reporter Mtb stra...

journal_title：PLoS pathogens

authors： Sukumar N,Tan S,Aldridge BB,Russell DG

更新日期：2014-09-18 00:00:00

abstract：:The host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae ("inflammation-inflicted bloo...

journal_title：PLoS pathogens

authors： Nedialkova LP,Denzler R,Koeppel MB,Diehl M,Ring D,Wille T,Gerlach RG,Stecher B

更新日期：2014-01-01 00:00:00

abstract：:Mosquito-borne alphaviruses such as chikungunya virus and Ross River virus (RRV) are emerging pathogens capable of causing large-scale epidemics of virus-induced arthritis and myositis. The pathology of RRV-induced disease in both humans and mice is associated with induction of the host inflammatory response within th...

journal_title：PLoS pathogens

authors： Gunn BM,Morrison TE,Whitmore AC,Blevins LK,Hueston L,Fraser RJ,Herrero LJ,Ramirez R,Smith PN,Mahalingam S,Heise MT

更新日期：2012-01-01 00:00:00

abstract：:Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death lig...

journal_title：PLoS pathogens

authors： Holokai L,Chakrabarti J,Broda T,Chang J,Hawkins JA,Sundaram N,Wroblewski LE,Peek RM Jr,Wang J,Helmrath M,Wells JM,Zavros Y

更新日期：2019-01-31 00:00:00

abstract：:Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and th...

journal_title：PLoS pathogens

authors： Denic M,Turlin E,Michel V,Fischer F,Khorasani-Motlagh M,Zamble D,Vinella D,de Reuse H

更新日期：2021-01-14 00:00:00

abstract：:Bacterial biofilm is considered as a particular lifestyle helping cells to survive hostile environments triggered by a variety of signals sensed and integrated through adequate regulatory pathways. Pseudomonas aeruginosa, a Gram-negative bacterium causing severe infections in humans, forms biofilms and is a fantastic ...

journal_title：PLoS pathogens

authors： de Bentzmann S,Giraud C,Bernard CS,Calderon V,Ewald F,Plésiat P,Nguyen C,Grunwald D,Attree I,Jeannot K,Fauvarque MO,Bordi C

更新日期：2012-01-01 00:00:00

abstract：:Schistosomiasis is a tropical parasitic disease afflicting ~200 million people worldwide and current therapy depends on a single drug (praziquantel) which exhibits several non-optimal features. These shortcomings underpin the need for next generation anthelmintics, but the process of validating physiologically relevan...

journal_title：PLoS pathogens

authors： Chan JD,McCorvy JD,Acharya S,Johns ME,Day TA,Roth BL,Marchant JS

更新日期：2016-05-17 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1007696.]. ...

journal_title：PLoS pathogens

authors： Dewan KK,Taylor-Mulneix DL,Campos LL,Skarlupka AL,Wagner SM,Ryman VE,Gestal MC,Ma L,Blas-Machado U,Faddis BT,Harvill ET

更新日期：2019-06-28 00:00:00

abstract：:Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycl...

journal_title：PLoS pathogens

authors： Zurnic I,Hütter S,Rzeha U,Stanke N,Reh J,Müllers E,Hamann MV,Kern T,Gerresheim GK,Lindel F,Serrao E,Lesbats P,Engelman AN,Cherepanov P,Lindemann D

更新日期：2016-08-31 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear proteins EBNA3A, EBNA3B, and EBNA3C interact with the cell DNA binding protein RBPJ and regulate cell and viral genes. Repression of the CDKN2A tumor suppressor gene products p16(INK4A) and p14(ARF) by EBNA3A and EBNA3C is critical for EBV mediated transformation of resting B lymph...

journal_title：PLoS pathogens

authors： Ohashi M,Holthaus AM,Calderwood MA,Lai CY,Krastins B,Sarracino D,Johannsen E

更新日期：2015-04-09 00:00:00

abstract：:CD4+ T cells support host defence against herpesviruses and other viral pathogens. We identified that CD4+ T cells from systemic and mucosal tissues of hosts infected with the β-herpesviridae human cytomegalovirus (HCMV) or murine cytomegalovirus (MCMV) express the regulatory cytokine interleukin (IL)-10. IL-10+CD4+ T...

journal_title：PLoS pathogens

authors： Clement M,Marsden M,Stacey MA,Abdul-Karim J,Gimeno Brias S,Costa Bento D,Scurr MJ,Ghazal P,Weaver CT,Carlesso G,Clare S,Jones SA,Godkin A,Jones GW,Humphreys IR

更新日期：2016-12-07 00:00:00

abstract：:Infection of the vascular system by Pseudomonas aeruginosa (Pa) occurs during bacterial dissemination in the body or in blood-borne infections. Type 3 secretion system (T3SS) toxins from Pa induce a massive retraction when injected into endothelial cells. Here, we addressed the role of type 2 secretion system (T2SS) e...

journal_title：PLoS pathogens

authors： Golovkine G,Faudry E,Bouillot S,Voulhoux R,Attrée I,Huber P

更新日期：2014-03-13 00:00:00

abstract：:Knowledge of the within-host frequencies of resistance-associated amino acid variants (RAVs) is important to the identification of optimal drug combinations for the treatment of hepatitis C virus (HCV) infection. Multiple RAVs may exist in infected individuals, often below detection limits, at any resistance locus, de...

journal_title：PLoS pathogens

authors： Raja R,Pareek A,Newar K,Dixit NM

更新日期：2019-04-01 00:00:00

abstract：:Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that release their content upon host cell recognition. Dense granules are secreted in...

journal_title：PLoS pathogens

authors： Venugopal K,Chehade S,Werkmeister E,Barois N,Periz J,Lafont F,Tardieux I,Khalife J,Langsley G,Meissner M,Marion S

更新日期：2020-05-28 00:00:00

abstract：:Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection has remained uncertain. Here we report that, following low dose aerosol infection with Mtb, mice lacking TLR2 (TLR2KO), in comparison wit...

journal_title：PLoS pathogens

authors： McBride A,Konowich J,Salgame P

更新日期：2013-01-01 00:00:00

abstract：:HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti...

journal_title：PLoS pathogens

authors： Leslie GJ,Wang J,Richardson MW,Haggarty BS,Hua KL,Duong J,Secreto AJ,Jordon AP,Romano J,Kumar KE,DeClercq JJ,Gregory PD,June CH,Root MJ,Riley JL,Holmes MC,Hoxie JA

更新日期：2016-11-17 00:00:00

abstract：:Competence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated receptor kinase ComD, a cascade of signaling events is initiated, leading to activation of the competence regulon by the response regulator ComE. Genes encoding...

journal_title：PLoS pathogens

authors： Zhu L,Lau GW

更新日期：2011-09-01 00:00:00

abstract：TRIAL REGISTRATION:ClinicalTrials.gov Clinical Trial NCT00594880. ...

journal_title：PLoS pathogens

authors： Chitre AS,Kattah MG,Rosli YY,Pao M,Deswal M,Deeks SG,Hunt PW,Abdel-Mohsen M,Montaner LJ,Kim CC,Ma A,Somsouk M,McCune JM

更新日期：2018-03-05 00:00:00

abstract：:The bunyavirus genome comprises a small (S), medium (M), and large (L) RNA segment of negative polarity. Although genome segmentation confers evolutionary advantages by enabling genome reassortment events with related viruses, genome segmentation also complicates genome replication and packaging. Accumulating evidence...

journal_title：PLoS pathogens

authors： Wichgers Schreur PJ,Kortekaas J

更新日期：2016-08-22 00:00:00