Host prion protein expression levels impact prion tropism for the spleen.

abstract：:The development of next-generation sequencing platforms is set to reveal an unprecedented level of detail on short-term molecular evolutionary processes in bacteria. Here we re-analyse genome-wide single nucleotide polymorphism (SNP) datasets for recently emerged clones of methicillin resistant Staphylococcus aureus (...

journal_title：PLoS pathogens

authors： Castillo-Ramírez S,Harris SR,Holden MT,He M,Parkhill J,Bentley SD,Feil EJ

更新日期：2011-07-01 00:00:00

abstract：:Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition. As an intrinsic antiretroviral defense mechanism, APOBEC3 proteins induce extensive guanosine-to-adenosine (G-to-A) mutagenes...

journal_title：PLoS pathogens

authors： Kim EY,Lorenzo-Redondo R,Little SJ,Chung YS,Phalora PK,Maljkovic Berry I,Archer J,Penugonda S,Fischer W,Richman DD,Bhattacharya T,Malim MH,Wolinsky SM

更新日期：2014-07-31 00:00:00

abstract：:Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular receptors. Poly ICLC is a ...

journal_title：PLoS pathogens

authors： Stahl-Hennig C,Eisenblätter M,Jasny E,Rzehak T,Tenner-Racz K,Trumpfheller C,Salazar AM,Uberla K,Nieto K,Kleinschmidt J,Schulte R,Gissmann L,Müller M,Sacher A,Racz P,Steinman RM,Uguccioni M,Ignatius R

更新日期：2009-04-01 00:00:00

abstract：:A facile and efficient method for the precise editing of large viral genomes is required for the selection of attenuated vaccine strains and the construction of gene therapy vectors. The type II prokaryotic CRISPR-Cas (clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)) RNA-guided nucl...

journal_title：PLoS pathogens

authors： Bi Y,Sun L,Gao D,Ding C,Li Z,Li Y,Cun W,Li Q

更新日期：2014-05-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006219.]. ...

journal_title：PLoS pathogens

authors： Hirsch AJ,Smith JL,Haese NN,Broeckel RM,Parkins CJ,Kreklywich C,DeFilippis VR,Denton M,Smith PP,Messer WB,Colgin LM,Ducore RM,Grigsby PL,Hennebold JD,Swanson T,Legasse AW,Axthelm MK,MacAllister R,Wiley CA,Nelson JA

更新日期：2017-04-05 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:RNA interference (RNAi) pathways are widespread in metaozoans but the genes required show variable occurrence or activity in eukaryotic microbes, including many pathogens. While some Leishmania lack RNAi activity and Argonaute or Dicer genes, we show that Leishmania braziliensis and other species within the Leishmania...

journal_title：PLoS pathogens

authors： Lye LF,Owens K,Shi H,Murta SM,Vieira AC,Turco SJ,Tschudi C,Ullu E,Beverley SM

更新日期：2010-10-28 00:00:00

abstract：:Rabbit hemorrhagic disease, first described in China in 1984, causes hemorrhagic necrosis of the liver. Its etiological agent, rabbit hemorrhagic disease virus (RHDV), belongs to the Lagovirus genus in the family Caliciviridae. The detailed molecular structure of any lagovirus capsid has yet to be determined. Here, we...

journal_title：PLoS pathogens

authors： Wang X,Xu F,Liu J,Gao B,Liu Y,Zhai Y,Ma J,Zhang K,Baker TS,Schulten K,Zheng D,Pang H,Sun F

更新日期：2013-01-01 00:00:00

abstract：:RNA granules are cellular structures, which play an important role in mRNA translation, storage, and degradation. Animal (+)RNA viruses often co-opt RNA granule proteins for viral reproduction. However, the role of RNA granules in plant viral infections is poorly understood. Here we use Potato virus A (PVA) as a model...

journal_title：PLoS pathogens

authors： Hafrén A,Lõhmus A,Mäkinen K

更新日期：2015-12-07 00:00:00

abstract：:HIV and other lentiviruses can productively infect nondividing cells, whereas most other retroviruses, such as murine leukemia virus, require cell division for efficient infection. However, the determinants for this phenotype have been controversial. Here, we show that HIV-1 capsid (CA) is involved in facilitating HIV...

journal_title：PLoS pathogens

authors： Yamashita M,Perez O,Hope TJ,Emerman M

更新日期：2007-10-26 00:00:00

abstract：:The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature is switched from 29°C at 37°...

journal_title：PLoS pathogens

authors： Lim XN,Shan C,Marzinek JK,Dong H,Ng TS,Ooi JSG,Fibriansah G,Wang J,Verma CS,Bond PJ,Shi PY,Lok SM

更新日期：2019-09-19 00:00:00

abstract：:The Venus kinase receptor (VKR) is a single transmembrane molecule composed of an intracellular tyrosine kinase domain close to that of insulin receptor and an extracellular Venus Flytrap (VFT) structure similar to the ligand binding domain of many class C G protein coupled receptors. This receptor tyrosine kinase (RT...

journal_title：PLoS pathogens

authors： Vanderstraete M,Gouignard N,Cailliau K,Morel M,Hahnel S,Leutner S,Beckmann S,Grevelding CG,Dissous C

更新日期：2014-05-29 00:00:00

abstract：:Dendritic cells (DCs) are specialized phagocytes that internalize exogenous antigens and microbes at peripheral sites, and then migrate to lymphatic organs to display foreign peptides to naïve T cells. There are several examples where DCs have been shown to be more efficient at restricting the intracellular replicatio...

journal_title：PLoS pathogens

authors： Nogueira CV,Lindsten T,Jamieson AM,Case CL,Shin S,Thompson CB,Roy CR

更新日期：2009-06-01 00:00:00

abstract：:HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti...

journal_title：PLoS pathogens

authors： Leslie GJ,Wang J,Richardson MW,Haggarty BS,Hua KL,Duong J,Secreto AJ,Jordon AP,Romano J,Kumar KE,DeClercq JJ,Gregory PD,June CH,Root MJ,Riley JL,Holmes MC,Hoxie JA

更新日期：2016-11-17 00:00:00

abstract：:Interferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis; however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate the antiviral effect. A prominent family of ISGs is the interferon-induced with tetratricopeptide repeats (Ifit) genes comprising three mem...

journal_title：PLoS pathogens

authors： Fensterl V,Wetzel JL,Ramachandran S,Ogino T,Stohlman SA,Bergmann CC,Diamond MS,Virgin HW,Sen GC

更新日期：2012-01-01 00:00:00

abstract：:HIV-1 maturation inhibitors (MIs) disrupt the final step in the HIV-1 protease-mediated cleavage of the Gag polyprotein between capsid p24 capsid (CA) and spacer peptide 1 (SP1), leading to the production of infectious virus. BMS-955176 is a second generation MI with improved antiviral activity toward polymorphic Gag ...

journal_title：PLoS pathogens

authors： Lin Z,Cantone J,Lu H,Nowicka-Sans B,Protack T,Yuan T,Yang H,Liu Z,Drexler D,Regueiro-Ren A,Meanwell NA,Cockett M,Krystal M,Lataillade M,Dicker IB

更新日期：2016-11-28 00:00:00

abstract：:Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades are clip-domain serine protease homologs (cSPHs), which are non-catalytic, but essential for activating the enzyme prophenoloxidase (PPO) in the melanization res...

journal_title：PLoS pathogens

authors： El Moussawi L,Nakhleh J,Kamareddine L,Osta MA

更新日期：2019-11-25 00:00:00

abstract：:Crohn's disease (CD) is a chronic inflammatory condition of diverse etiology. Exposure to foodborne pathogens causing acute gastroenteritis produces a long-term risk of CD well into the post-infectious period but the mechanistic basis for this ongoing relationship to disease onset is unknown. We developed two novel mo...

journal_title：PLoS pathogens

authors： Small CL,Xing L,McPhee JB,Law HT,Coombes BK

更新日期：2016-10-06 00:00:00

abstract：:It has been proposed that in wild ecosystems viruses are often plant mutualists, whereas agroecosystems favour pathogenicity. We seek evidence for virus pathogenicity in wild ecosystems through the analysis of plant-virus coevolution, which requires a negative effect of infection on the host fitness. We focus on the i...

journal_title：PLoS pathogens

authors： Montes N,Alonso-Blanco C,García-Arenal F

更新日期：2019-05-28 00:00:00

abstract：:Epstein-Barr virus (EBV), a ubiquitous human herpesvirus, can latently infect the human population. EBV is associated with several types of malignancies originating from lymphoid and epithelial cell types. EBV latent antigen 3C (EBNA3C) is essential for EBV-induced immortalization of B-cells. The Moloney murine leukem...

journal_title：PLoS pathogens

authors： Banerjee S,Lu J,Cai Q,Sun Z,Jha HC,Robertson ES

更新日期：2014-08-14 00:00:00

abstract：:Surface recognition and penetration are critical steps in the infection cycle of many plant pathogenic fungi. In Magnaporthe oryzae, cAMP signaling is involved in surface recognition and pathogenesis. Deletion of the MAC1 adenylate cyclase gene affected appressorium formation and plant infection. In this study, we use...

journal_title：PLoS pathogens

authors： Zhou X,Zhang H,Li G,Shaw B,Xu JR

更新日期：2012-09-01 00:00:00

abstract：:Innate immune cells shape the host response to microbial pathogens. Here we elucidate critical differences in the molecular response of macrophages vs. dendritic cells (DCs) to Histoplasma capsulatum, an intracellular fungal pathogen of humans. It has long been known that macrophages are permissive for Histoplasma gro...

journal_title：PLoS pathogens

authors： Van Prooyen N,Henderson CA,Hocking Murray D,Sil A

更新日期：2016-07-26 00:00:00

abstract：:Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment and associated health care practices have provided a niche for the rapid evolution of microbial pathogens that are well adapted to surviving and proliferating in this setting, after which they can i...

journal_title：PLoS pathogens

authors： Carter GP,Douce GR,Govind R,Howarth PM,Mackin KE,Spencer J,Buckley AM,Antunes A,Kotsanas D,Jenkin GA,Dupuy B,Rood JI,Lyras D

更新日期：2011-10-01 00:00:00

abstract：:Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysb...

journal_title：PLoS pathogens

authors： Jones TA,Hernandez DZ,Wong ZC,Wandler AM,Guillemin K

更新日期：2017-10-19 00:00:00

abstract：:All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions between host receptors and parasite ligands that are localized in apical organelles called micronemes. Here, we identify...

journal_title：PLoS pathogens

authors： Dawn A,Singh S,More KR,Siddiqui FA,Pachikara N,Ramdani G,Langsley G,Chitnis CE

更新日期：2014-12-18 00:00:00

abstract：:Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (α/β hydrolase domain containing pro...

journal_title：PLoS pathogens

authors： Vieyres G,Welsch K,Gerold G,Gentzsch J,Kahl S,Vondran FW,Kaderali L,Pietschmann T

更新日期：2016-04-28 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are at the forefront of host-microbe interactions. Molecular and cell-based studies suggest that HSPG-pathogen interactions promote pathogenesis by facilitating microbial attachment and invasion of host cells. However, the specific identity of HSPGs, precise mechanisms by which HS...

journal_title：PLoS pathogens

authors： Aquino RS,Hayashida A,Park PW

更新日期：2020-05-26 00:00:00

abstract：:Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory T cells are thought to be of a primarily T helper 1 type, but both T helper 1 and T helper 2 memory cells have been described, and heightened T helper 2/ lessened T helper 1 responses have been associ...

journal_title：PLoS pathogens

authors： Glanville N,Peel TJ,Schröder A,Aniscenko J,Walton RP,Finotto S,Johnston SL

更新日期：2016-09-28 00:00:00

abstract：:The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or in...

journal_title：PLoS pathogens

authors： Hovius JW,Bijlsma MF,van der Windt GJ,Wiersinga WJ,Boukens BJ,Coumou J,Oei A,de Beer R,de Vos AF,van 't Veer C,van Dam AP,Wang P,Fikrig E,Levi MM,Roelofs JJ,van der Poll T

更新日期：2009-05-01 00:00:00