Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.

abstract：:The strain designated Chlamydia trachomatis serovar that was used for experiments in this paper is Chlamydia muridarum, a species closely related to C. trachomatis (and formerly termed the Mouse Pneumonitis strain of C. trachomatis. [corrected]. The obligate intracellular pathogen Chlamydia trachomatis replicates with...

journal_title：PLoS pathogens

authors： Elwell CA,Jiang S,Kim JH,Lee A,Wittmann T,Hanada K,Melancon P,Engel JN

更新日期：2011-09-01 00:00:00

abstract：:Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed circular (RC) DNA capsids can be enveloped and secreted as stable vir...

journal_title：PLoS pathogens

authors： Heger-Stevic J,Zimmermann P,Lecoq L,Böttcher B,Nassal M

更新日期：2018-12-19 00:00:00

abstract：:Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (α/β hydrolase domain containing pro...

journal_title：PLoS pathogens

authors： Vieyres G,Welsch K,Gerold G,Gentzsch J,Kahl S,Vondran FW,Kaderali L,Pietschmann T

更新日期：2016-04-28 00:00:00

abstract：:HIV-1 replicative capacity (RC) provides a measure of within-host fitness and is determined in the context of phenotypic drug resistance testing. However it is unclear how these in-vitro measurements relate to in-vivo processes. Here we assess RCs in a clinical setting by combining a previously published machine-learn...

journal_title：PLoS pathogens

authors： Kouyos RD,von Wyl V,Hinkley T,Petropoulos CJ,Haddad M,Whitcomb JM,Böni J,Yerly S,Cellerai C,Klimkait T,Günthard HF,Bonhoeffer S,Swiss HIV Cohort Study.

更新日期：2011-11-01 00:00:00

abstract：:We report the identification of a novel polyomavirus present in respiratory secretions from human patients with symptoms of acute respiratory tract infection. The virus was initially detected in a nasopharyngeal aspirate from a 3-year-old child from Australia diagnosed with pneumonia. A random library was generated fr...

journal_title：PLoS pathogens

authors： Gaynor AM,Nissen MD,Whiley DM,Mackay IM,Lambert SB,Wu G,Brennan DC,Storch GA,Sloots TP,Wang D

更新日期：2007-05-04 00:00:00

abstract：:Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding. Curiously, the matrix proteins of a few paramyxoviruses have been found in the nucleus, although the biological function associat...

journal_title：PLoS pathogens

authors： Wang YE,Park A,Lake M,Pentecost M,Torres B,Yun TE,Wolf MC,Holbrook MR,Freiberg AN,Lee B

更新日期：2010-11-11 00:00:00

abstract：:RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins. These viral proteins can target one or more key points in the silencing...

journal_title：PLoS pathogens

authors： Giner A,Lakatos L,García-Chapa M,López-Moya JJ,Burgyán J

更新日期：2010-07-15 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IκB kinases (IKKs) and NF-κB and promote cell survival; however, the key ubiquitinated factors downstream of Tax involved in cell transformation are unknown. Using mass spectrometry, we undertook an unbiased pr...

journal_title：PLoS pathogens

authors： Choi YB,Harhaj EW

更新日期：2014-10-23 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that persists lifelong in the host. In ∼4% of infected people, HTLV-1 causes a chronic disabling neuroinflammatory disease known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathogenesis of HAM/TSP is unknown and treatment remain...

journal_title：PLoS pathogens

authors： Tattermusch S,Skinner JA,Chaussabel D,Banchereau J,Berry MP,McNab FW,O'Garra A,Taylor GP,Bangham CR

更新日期：2012-01-01 00:00:00

abstract：:HIV-1 replication normally requires Vif-mediated neutralization of APOBEC3 antiviral enzymes. Viruses lacking Vif succumb to deamination-dependent and -independent restriction processes. Here, HIV-1 adaptation studies were leveraged to ask whether viruses with an irreparable vif deletion could develop resistance to re...

journal_title：PLoS pathogens

authors： Ikeda T,Symeonides M,Albin JS,Li M,Thali M,Harris RS

更新日期：2018-04-20 00:00:00

abstract：:The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence i...

journal_title：PLoS pathogens

authors： Chung D,Barker BM,Carey CC,Merriman B,Werner ER,Lechner BE,Dhingra S,Cheng C,Xu W,Blosser SJ,Morohashi K,Mazurie A,Mitchell TK,Haas H,Mitchell AP,Cramer RA

更新日期：2014-11-06 00:00:00

abstract：:Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of muscle disorders. Whilst neurotoxin expression by the spore-formin...

journal_title：PLoS pathogens

authors： Zhang Z,Korkeala H,Dahlsten E,Sahala E,Heap JT,Minton NP,Lindström M

更新日期：2013-03-01 00:00:00

abstract：:Previous studies identified prion protein (PrP) mutants which act as dominant negative inhibitors of prion formation through a mechanism hypothesized to require an unidentified species-specific cofactor termed protein X. To study the mechanism of dominant negative inhibition in vitro, we used recombinant PrP(C) molecu...

journal_title：PLoS pathogens

authors： Geoghegan JC,Miller MB,Kwak AH,Harris BT,Supattapone S

更新日期：2009-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage, but also for infectious virus production. To identify cellular factors that interact with NS2 and are important for HCV propagation, we screened a human liver cDNA library by sp...

journal_title：PLoS pathogens

authors： Suzuki R,Matsuda M,Watashi K,Aizaki H,Matsuura Y,Wakita T,Suzuki T

更新日期：2013-01-01 00:00:00

abstract：:Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, the relationships bet...

journal_title：PLoS pathogens

authors： Barber BE,William T,Grigg MJ,Parameswaran U,Piera KA,Price RN,Yeo TW,Anstey NM

更新日期：2015-01-08 00:00:00

abstract：:Pili of pathogenic Neisseria are major virulence factors associated with adhesion, twitching motility, auto-aggregation, and DNA transformation. Pili of N. meningitidis are subject to several different post-translational modifications. Among these pilin modifications, the presence of phosphorylcholine (ChoP) and a gly...

journal_title：PLoS pathogens

authors： Jen FE,Warren MJ,Schulz BL,Power PM,Swords WE,Weiser JN,Apicella MA,Edwards JL,Jennings MP

更新日期：2013-01-01 00:00:00

abstract：:The survival and persistence of Mycobacterium tuberculosis depends on its capacity to manipulate multiple host defense pathways, including the ability to actively inhibit the death by apoptosis of infected host cells. The genetic basis for this anti-apoptotic activity and its implication for mycobacterial virulence ha...

journal_title：PLoS pathogens

authors： Velmurugan K,Chen B,Miller JL,Azogue S,Gurses S,Hsu T,Glickman M,Jacobs WR Jr,Porcelli SA,Briken V

更新日期：2007-07-01 00:00:00

abstract：:HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T lymphocytes or enter into endosomes resulting in degradation. HIV-1 binding and fusion with the DC membrane results in low level de novo infection that can also be tra...

journal_title：PLoS pathogens

authors： Mercier SK,Donaghy H,Botting RA,Turville SG,Harman AN,Nasr N,Ji H,Kusebauch U,Mendoza L,Shteynberg D,Sandgren K,Simpson RJ,Moritz RL,Cunningham AL

更新日期：2013-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) capsids are found in many forms: immature single-stranded RNA-filled cores, single-stranded DNA-filled replication intermediates, mature cores with relaxed circular double-stranded DNA, and empty capsids. A capsid, the protein shell of the core, is a complex of 240 copies of core protein. Matur...

journal_title：PLoS pathogens

authors： Chen C,Wang JC,Pierson EE,Keifer DZ,Delaleau M,Gallucci L,Cazenave C,Kann M,Jarrold MF,Zlotnick A

更新日期：2016-08-12 00:00:00

abstract：:Vibrio parahaemolyticus is an emerging bacterial pathogen which colonizes the gastrointestinal tract and can cause severe enteritis and bacteraemia. During infection, V. parahaemolyticus primarily attaches to the small intestine, where it causes extensive tissue damage and compromises epithelial barrier integrity. We ...

journal_title：PLoS pathogens

authors： Lim J,Stones DH,Hawley CA,Watson CA,Krachler AM

更新日期：2014-09-25 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chick embryo fibroblast...

journal_title：PLoS pathogens

authors： Peng C,Wyatt LS,Glushakow-Smith SG,Lal-Nag M,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:Yersinia utilizes a sophisticated type III secretion system to enhance its chances of survival and to overcome the host immune system. SmpB (small protein B) and SsrA (small stable RNA A) are components of a unique bacterial translational control system that help maintain the bacterial translational machinery in a ful...

journal_title：PLoS pathogens

authors： Okan NA,Bliska JB,Karzai AW

更新日期：2006-01-01 00:00:00

abstract：:Apicomplexans are obligate intracellular parasites that actively penetrate their host cells to create an intracellular niche for replication. Commitment to invasion is thought to be mediated by the rhoptries, specialized apical secretory organelles that inject a protein complex into the host cell to form a tight-junct...

journal_title：PLoS pathogens

authors： Beck JR,Fung C,Straub KW,Coppens I,Vashisht AA,Wohlschlegel JA,Bradley PJ

更新日期：2013-02-01 00:00:00

abstract：:The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from peo...

journal_title：PLoS pathogens

authors： Olival KJ,Cryan PM,Amman BR,Baric RS,Blehert DS,Brook CE,Calisher CH,Castle KT,Coleman JTH,Daszak P,Epstein JH,Field H,Frick WF,Gilbert AT,Hayman DTS,Ip HS,Karesh WB,Johnson CK,Kading RC,Kingston T,Lorch JM,Mend

更新日期：2020-09-03 00:00:00

abstract：:Eradication of tuberculosis (TB), the world's leading cause of death due to infectious disease, requires a highly efficacious TB vaccine. Many TB vaccine candidates are in pre-clinical and clinical development but only a few can be advanced to large-scale efficacy trials due to limited global resources. We aimed to pe...

journal_title：PLoS pathogens

authors： Rodo MJ,Rozot V,Nemes E,Dintwe O,Hatherill M,Little F,Scriba TJ

更新日期：2019-03-04 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recruitment of innate i...

journal_title：PLoS pathogens

authors： Ries LNA,Pardeshi L,Dong Z,Tan K,Steenwyk JL,Colabardini AC,Ferreira Filho JA,de Castro PA,Silva LP,Preite NW,Almeida F,de Assis LJ,Dos Santos RAC,Bowyer P,Bromley M,Owens RA,Doyle S,Demasi M,Hernández DCR,Netto LES

更新日期：2020-07-15 00:00:00

abstract：:A central question in Leishmania research is why most species cause cutaneous infections but others cause fatal visceral disease. Interestingly, L. donovani causes both visceral and cutaneous leishmaniasis in Sri Lanka. L. donovani clinical isolates were therefore obtained from cutaneous leishmaniasis (CL-SL) and visc...

journal_title：PLoS pathogens

authors： Zhang WW,Ramasamy G,McCall LI,Haydock A,Ranasinghe S,Abeygunasekara P,Sirimanna G,Wickremasinghe R,Myler P,Matlashewski G

更新日期：2014-07-03 00:00:00

abstract：:Staphylococcus aureus is a major human pathogen causing a wide spectrum of nosocomial and community-associated infections with high morbidity and mortality. S. aureus generates a large number of virulence factors whose timing and expression levels are precisely tuned by regulatory proteins and RNAs. The aptitude of ba...

journal_title：PLoS pathogens

authors： Felden B,Vandenesch F,Bouloc P,Romby P

更新日期：2011-03-01 00:00:00

abstract：:Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this family from Pseudomonas aeruginosa, targets susceptible strains of this species through recognition of the common polysaccharide antigen (CPA) of...

journal_title：PLoS pathogens

authors： McCaughey LC,Grinter R,Josts I,Roszak AW,Waløen KI,Cogdell RJ,Milner J,Evans T,Kelly S,Tucker NP,Byron O,Smith B,Walker D

更新日期：2014-02-06 00:00:00

abstract：:DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis showed an altered leuk...

journal_title：PLoS pathogens

authors： Szappanos D,Tschismarov R,Perlot T,Westermayer S,Fischer K,Platanitis E,Kallinger F,Novatchkova M,Lassnig C,Müller M,Sexl V,Bennett KL,Foong-Sobis M,Penninger JM,Decker T

更新日期：2018-11-26 00:00:00