Fatty acid DSF binds and allosterically activates histidine kinase RpfC of phytopathogenic bacterium Xanthomonas campestris pv. campestris to regulate quorum-sensing and virulence.

abstract：:Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host. By utilizing in-silico testing of a transmembrane sequence library derived from virus protein sequences, we have pin-pointed a nine amino-acid motif sh...

journal_title：PLoS pathogens

authors： Cohen T,Cohen SJ,Antonovsky N,Cohen IR,Shai Y

更新日期：2010-09-02 00:00:00

abstract：:Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress granules to limit the use of energy and nutrients. Because this threatens viral gene expression,...

journal_title：PLoS pathogens

authors： Brocard M,Iadevaia V,Klein P,Hall B,Lewis G,Lu J,Burke J,Willcocks MM,Parker R,Goodfellow IG,Ruggieri A,Locker N

更新日期：2020-01-06 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:Giardia intestinalis is a major cause of diarrheal disease worldwide and two major Giardia genotypes, assemblages A and B, infect humans. The genome of assemblage A parasite WB was recently sequenced, and the structurally compact 11.7 Mbp genome contains simplified basic cellular machineries and metabolism. We here pe...

journal_title：PLoS pathogens

authors： Franzén O,Jerlström-Hultqvist J,Castro E,Sherwood E,Ankarklev J,Reiner DS,Palm D,Andersson JO,Andersson B,Svärd SG

更新日期：2009-08-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel coronavirus that has caused a worldwide pandemic of the human respiratory illness COVID-19, resulting in a severe threat to public health and safety. Analysis of the genetic tree suggests that SARS-CoV-2 belongs to the same Betacoronavirus group a...

journal_title：PLoS pathogens

authors： Tang D,Comish P,Kang R

更新日期：2020-05-22 00:00:00

abstract：:Hepatitis B virus (HBV) capsid or core protein (HBc) contains an N-terminal domain (NTD) and a C-terminal domain (CTD) connected by a short linker peptide. HBc plays a critical role in virtually every step of viral replication, which is further modulated by dynamic phosphorylation and dephosphorylation of its CTD. Whi...

journal_title：PLoS pathogens

authors： Xi J,Luckenbaugh L,Hu J

更新日期：2021-01-25 00:00:00

abstract：:Respiratory syncytial virus (RSV) is an RNA virus in the Family Paramyxoviridae. Here, the activities performed by the RSV polymerase when it encounters the viral antigenomic promoter were examined. RSV RNA synthesis was reconstituted in vitro using recombinant, isolated polymerase and an RNA oligonucleotide template ...

journal_title：PLoS pathogens

authors： Noton SL,Deflubé LR,Tremaglio CZ,Fearns R

更新日期：2012-01-01 00:00:00

abstract：:In the United States, the introduction of the heptavalent pneumococcal conjugate vaccine (PCV) largely eliminated vaccine serotypes (VT); non-vaccine serotypes (NVT) subsequently increased in carriage and disease. Vaccination also disrupts the composition of the pneumococcal pangenome, which includes mobile genetic el...

journal_title：PLoS pathogens

authors： Azarian T,Grant LR,Arnold BJ,Hammitt LL,Reid R,Santosham M,Weatherholtz R,Goklish N,Thompson CM,Bentley SD,O'Brien KL,Hanage WP,Lipsitch M

更新日期：2018-04-04 00:00:00

abstract：:Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the crystal structure of flavivirus NS5 is known, no data about the quater...

journal_title：PLoS pathogens

authors： Klema VJ,Ye M,Hindupur A,Teramoto T,Gottipati K,Padmanabhan R,Choi KH

更新日期：2016-02-19 00:00:00

abstract：:Human T Lymphotropic virus (HTLV) infection can persist in individuals resulting, at least in part, from viral escape of the innate immunity, including inhibition of type I interferon response in infected T-cells. Plasmacytoid dendritic cells (pDCs) are known to bypass viral escape by their robust type I interferon pr...

journal_title：PLoS pathogens

authors： Assil S,Futsch N,Décembre E,Alais S,Gessain A,Cosset FL,Mahieux R,Dreux M,Dutartre H

更新日期：2019-02-28 00:00:00

abstract：:An increasing number of broadly neutralizing antibodies (bnAbs) are considered leads for HIV-1 vaccine development and novel therapeutics. Here, we systematically explored the capacity of bnAbs to neutralize HIV-1 prior to and post-CD4 engagement and to block HIV-1 cell-cell transmission. Cell-cell spread is known to ...

journal_title：PLoS pathogens

authors： Reh L,Magnus C,Schanz M,Weber J,Uhr T,Rusert P,Trkola A

更新日期：2015-07-09 00:00:00

abstract：:IFNγ signaling drives dendritic cells (DCs) to promote type I T cell (Th1) immunity. Here, we show that activation of DCs by IFNγ is equally crucial for the differentiation of a population of T-bet+ regulatory T (Treg) cells specialized to inhibit Th1 immune responses. Conditional deletion of IFNγ receptor in DCs but ...

journal_title：PLoS pathogens

authors： Lee HM,Fleige A,Forman R,Cho S,Khan AA,Lin LL,Nguyen DT,O'Hara-Hall A,Yin Z,Hunter CA,Muller W,Lu LF

更新日期：2015-02-06 00:00:00

abstract：:The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires thro...

journal_title：PLoS pathogens

authors： Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ

更新日期：2014-01-01 00:00:00

abstract：:Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies. While natural killer (NK) cells can directly contribute to the control of viral replication, whet...

journal_title：PLoS pathogens

authors： Robbins SH,Bessou G,Cornillon A,Zucchini N,Rupp B,Ruzsics Z,Sacher T,Tomasello E,Vivier E,Koszinowski UH,Dalod M

更新日期：2007-08-24 00:00:00

abstract：:Many Gram-negative bacteria use Type Three Secretion Systems (T3SS) to deliver effector proteins into host cells. These protein delivery machines are composed of cytosolic components that recognize substrates and generate the force needed for translocation, the secretion conduit, formed by a needle complex and associa...

journal_title：PLoS pathogens

authors： Archuleta TL,Spiller BW

更新日期：2014-11-06 00:00:00

abstract：:Viroids are small, non-protein-coding RNAs which can induce disease symptoms in a variety of plant species. Potato (Solanum tuberosum L.) is the natural host of Potato spindle tuber viroid (PSTVd) where infection results in stunting, distortion of leaves and tubers and yield loss. Replication of PSTVd is accompanied b...

journal_title：PLoS pathogens

authors： Bao S,Owens RA,Sun Q,Song H,Liu Y,Eamens AL,Feng H,Tian H,Wang MB,Zhang R

更新日期：2019-12-02 00:00:00

abstract：:The Haemophilus influenzae HMW1 adhesin is a high-molecular weight protein that is secreted by the bacterial two-partner secretion pathway and mediates adherence to respiratory epithelium, an essential early step in the pathogenesis of H. influenzae disease. In recent work, we discovered that HMW1 is a glycoprotein an...

journal_title：PLoS pathogens

authors： Grass S,Lichti CF,Townsend RR,Gross J,St Geme JW 3rd

更新日期：2010-05-27 00:00:00

abstract：:The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

journal_title：PLoS pathogens

authors： Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

更新日期：2013-01-01 00:00:00

abstract：:Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Given that RTA is a transcri...

journal_title：PLoS pathogens

authors： Wei X,Bai L,Dong L,Liu H,Xing P,Zhou Z,Wu S,Lan K

更新日期：2019-11-21 00:00:00

abstract：:Isolated influenza A virus nucleoprotein exists in an equilibrium between monomers and trimers. Samples containing only monomers or only trimers can be stabilized by respectively low and high salt. The trimers bind RNA with high affinity but remain trimmers, whereas the monomers polymerise onto RNA forming nucleoprote...

journal_title：PLoS pathogens

authors： Chenavas S,Estrozi LF,Slama-Schwok A,Delmas B,Di Primo C,Baudin F,Li X,Crépin T,Ruigrok RW

更新日期：2013-03-01 00:00:00

abstract：:Chlamydia trachomatis remains one of the few major human pathogens for which there is no transformation system. C. trachomatis has a unique obligate intracellular developmental cycle. The extracellular infectious elementary body (EB) is an infectious, electron-dense structure that, following host cell infection, diffe...

journal_title：PLoS pathogens

authors： Wang Y,Kahane S,Cutcliffe LT,Skilton RJ,Lambden PR,Clarke IN

更新日期：2011-09-01 00:00:00

abstract：:The structural flexibility or 'breathing' of the envelope (E) protein of flaviviruses allows virions to sample an ensemble of conformations at equilibrium. The molecular basis and functional consequences of virus conformational dynamics are poorly understood. Here, we identified a single mutation at residue 198 (T198F...

journal_title：PLoS pathogens

authors： Goo L,VanBlargan LA,Dowd KA,Diamond MS,Pierson TC

更新日期：2017-02-16 00:00:00

abstract：:In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV...

journal_title：PLoS pathogens

authors： Kadaja M,Isok-Paas H,Laos T,Ustav E,Ustav M

更新日期：2009-04-01 00:00:00

abstract：:Positive-strand RNA viruses replicate in host cells by forming large viral replication organelles, which harbor numerous membrane-bound viral replicase complexes (VRCs). In spite of its essential role in viral replication, the biogenesis of the VRCs is not fully understood. The authors identified critical roles of cel...

journal_title：PLoS pathogens

authors： Feng Z,Kovalev N,Nagy PD

更新日期：2020-12-28 00:00:00

abstract：:Shigella flexneri has evolved the ability to modify host cell function with intracellular active effectors to overcome the intestinal barrier. The detection of these microbial effectors and the initiation of innate immune responses are critical for rapid mucosal defense activation. The guanine nucleotide exchange fact...

journal_title：PLoS pathogens

authors： Fukazawa A,Alonso C,Kurachi K,Gupta S,Lesser CF,McCormick BA,Reinecker HC

更新日期：2008-11-01 00:00:00

abstract：:HIV-1 assembly and release are believed to occur at the plasma membrane in most host cells with the exception of primary macrophages, for which exclusive budding at late endosomes has been reported. Here, we applied a novel ultrastructural approach to assess HIV-1 budding in primary macrophages in an immunomarker-inde...

journal_title：PLoS pathogens

authors： Welsch S,Keppler OT,Habermann A,Allespach I,Krijnse-Locker J,Kräusslich HG

更新日期：2007-03-01 00:00:00

abstract：:The microbiome and the phage meta-genome within the human gut are influenced by antibiotic treatments. Identifying a novel mechanism, here we demonstrate that bacteria use the universal communication molecule AI-2 to induce virulence genes and transfer them via phage release. High concentrations (i.e. 100 μM) of AI-2 ...

journal_title：PLoS pathogens

authors： Rossmann FS,Racek T,Wobser D,Puchalka J,Rabener EM,Reiger M,Hendrickx AP,Diederich AK,Jung K,Klein C,Huebner J

更新日期：2015-02-23 00:00:00

abstract：:The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypic cell-based assay enabling individual sub-cellular analysis of over ...

journal_title：PLoS pathogens

authors： Brodin P,Poquet Y,Levillain F,Peguillet I,Larrouy-Maumus G,Gilleron M,Ewann F,Christophe T,Fenistein D,Jang J,Jang MS,Park SJ,Rauzier J,Carralot JP,Shrimpton R,Genovesio A,Gonzalo-Asensio JA,Puzo G,Martin C,Brosch R

更新日期：2010-09-09 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most virulent enteroviruses, but the specific molecular features that enhance its ability to disseminate in humans remain unknown. We analyzed the genomic features of EV71 in an immunocompromised host with disseminated disease according to the different sites of infection. Compariso...

journal_title：PLoS pathogens

authors： Cordey S,Petty TJ,Schibler M,Martinez Y,Gerlach D,van Belle S,Turin L,Zdobnov E,Kaiser L,Tapparel C

更新日期：2012-01-01 00:00:00

abstract：:Over 200 million people have, and another 600 million are at risk of contracting, schistosomiasis, one of the major neglected tropical diseases. Transmission of this infection, which is caused by helminth parasites of the genus Schistosoma, depends upon the release of parasite eggs from the human host. However, approx...

journal_title：PLoS pathogens

authors： Freitas TC,Jung E,Pearce EJ

更新日期：2007-04-01 00:00:00