HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation.

abstract：:In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV...

journal_title：PLoS pathogens

authors： Kadaja M,Isok-Paas H,Laos T,Ustav E,Ustav M

更新日期：2009-04-01 00:00:00

abstract：:Streptococcus agalactiae is a common human commensal and a major life-threatening pathogen in neonates. Adherence to host epithelial cells is the first critical step of the infectious process. Pili have been observed on the surface of several gram-positive bacteria including S. agalactiae. We previously characterized ...

journal_title：PLoS pathogens

authors： Konto-Ghiorghi Y,Mairey E,Mallet A,Duménil G,Caliot E,Trieu-Cuot P,Dramsi S

更新日期：2009-05-01 00:00:00

abstract：:RNA silencing is an evolutionarily conserved sequence-specific gene-inactivation system that also functions as an antiviral mechanism in higher plants and insects. To overcome antiviral RNA silencing, viruses express silencing-suppressor proteins. These viral proteins can target one or more key points in the silencing...

journal_title：PLoS pathogens

authors： Giner A,Lakatos L,García-Chapa M,López-Moya JJ,Burgyán J

更新日期：2010-07-15 00:00:00

abstract：:Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV infection of CD4+ T cells-by up to 37-fold...

journal_title：PLoS pathogens

authors： Neidleman JA,Chen JC,Kohgadai N,Müller JA,Laustsen A,Thavachelvam K,Jang KS,Stürzel CM,Jones JJ,Ochsenbauer C,Chitre A,Somsouk M,Garcia MM,Smith JF,Greenblatt RM,Münch J,Jakobsen MR,Giudice LC,Greene WC,Roan NR

更新日期：2017-02-16 00:00:00

abstract：:Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment and associated health care practices have provided a niche for the rapid evolution of microbial pathogens that are well adapted to surviving and proliferating in this setting, after which they can i...

journal_title：PLoS pathogens

authors： Carter GP,Douce GR,Govind R,Howarth PM,Mackin KE,Spencer J,Buckley AM,Antunes A,Kotsanas D,Jenkin GA,Dupuy B,Rood JI,Lyras D

更新日期：2011-10-01 00:00:00

abstract：:The envelope glycoprotein (Env) complexes of the human and simian immunodeficiency viruses (HIV and SIV, respectively) mediate viral entry and are a target for neutralizing antibodies. The receptor binding surfaces of Env are in large part sterically occluded or conformationally masked prior to receptor binding. Knowl...

journal_title：PLoS pathogens

authors： Zanetti G,Briggs JA,Grünewald K,Sattentau QJ,Fuller SD

更新日期：2006-08-01 00:00:00

abstract：:Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive. While adult mice resist ZEBOV infection, the Mayinga strain of the virus has been adapted to cause lethal infecti...

journal_title：PLoS pathogens

authors： Ebihara H,Takada A,Kobasa D,Jones S,Neumann G,Theriault S,Bray M,Feldmann H,Kawaoka Y

更新日期：2006-07-01 00:00:00

abstract：:The Trypanosoma brucei flagellum is a multifunctional organelle with critical roles in motility, cellular morphogenesis, and cell division. Although motility is thought to be important throughout the trypanosome lifecycle, most studies of flagellum structure and function have been restricted to the procyclic lifecycle...

journal_title：PLoS pathogens

authors： Ralston KS,Hill KL

更新日期：2006-09-01 00:00:00

abstract：:The Pseudomonas syringae acetyltransferase HopZ1a is delivered into host cells by the type III secretion system to promote bacterial growth. However, in the model plant host Arabidopsis thaliana, HopZ1a activity results in an effector-triggered immune response (ETI) that limits bacterial proliferation. HopZ1a-triggere...

journal_title：PLoS pathogens

authors： Bastedo DP,Khan M,Martel A,Seto D,Kireeva I,Zhang J,Masud W,Millar D,Lee JY,Lee AH,Gong Y,Santos-Severino A,Guttman DS,Desveaux D

更新日期：2019-07-03 00:00:00

abstract：:Parasitic nematodes are of medical and veterinary importance, adversely affecting human health and animal welfare. Ascaris suum is a gastrointestinal parasite of pigs; in addition to its veterinary significance it is a good model of the human parasite Ascaris lumbricoides, estimated to infect approximately 1.4 billion...

journal_title：PLoS pathogens

authors： Williamson SM,Robertson AP,Brown L,Williams T,Woods DJ,Martin RJ,Sattelle DB,Wolstenholme AJ

更新日期：2009-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1008654.]. ...

journal_title：PLoS pathogens

authors： Ghirardini E,Restelli E,Morini R,Bertani I,Ortolan D,Perrucci F,Pozzi D,Matteoli M,Chiesa R

更新日期：2020-12-22 00:00:00

abstract：:Since mucosal surfaces may be simultaneously colonized by multiple species, the success of an organism may be determined by its ability to compete with co-inhabitants of its niche. To explore the contribution of host factors to polymicrobial competition, a murine model was used to study the initiation of colonization ...

journal_title：PLoS pathogens

authors： Lysenko ES,Ratner AJ,Nelson AL,Weiser JN

更新日期：2005-09-01 00:00:00

abstract：:CD8+ T cell responses to Epstein-Barr virus (EBV) lytic cycle expressed antigens display a hierarchy of immunodominance, in which responses to epitopes of immediate-early (IE) and some early (E) antigens are more frequently observed than responses to epitopes of late (L) expressed antigens. It has been proposed that t...

journal_title：PLoS pathogens

authors： Quinn LL,Zuo J,Abbott RJ,Shannon-Lowe C,Tierney RJ,Hislop AD,Rowe M

更新日期：2014-08-21 00:00:00

abstract：:Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional importance of macrophage-intrinsic adaptation to changing environments vs. recruitment ...

journal_title：PLoS pathogens

authors： Rückerl D,Campbell SM,Duncan S,Sutherland TE,Jenkins SJ,Hewitson JP,Barr TA,Jackson-Jones LH,Maizels RM,Allen JE

更新日期：2017-03-23 00:00:00

abstract：:Many bacterial pathogens and symbionts use type III secretion machines to interact with their hosts by injecting bacterial effector proteins into host target cells. A central component of this complex machine is the cytoplasmic sorting platform, which orchestrates the engagement and preparation of type III secreted pr...

journal_title：PLoS pathogens

authors： Lara-Tejero M,Qin Z,Hu B,Butan C,Liu J,Galán JE

更新日期：2019-01-22 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage, but also for infectious virus production. To identify cellular factors that interact with NS2 and are important for HCV propagation, we screened a human liver cDNA library by sp...

journal_title：PLoS pathogens

authors： Suzuki R,Matsuda M,Watashi K,Aizaki H,Matsuura Y,Wakita T,Suzuki T

更新日期：2013-01-01 00:00:00

abstract：:Memory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific CD8 T cells continuously expands mainly during latent infection and establishes a large and stable population of effector memory cells in peripheral tissues. Here we set out to identify in vivo parameters that promote and limit CD...

journal_title：PLoS pathogens

authors： Baumann NS,Welten SPM,Torti N,Pallmer K,Borsa M,Barnstorf I,Oduro JD,Cicin-Sain L,Oxenius A

更新日期：2019-05-13 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) genome encodes a G protein-coupled receptor (vGPCR). vGPCR is a ligand-independent, constitutively active signaling molecule that promotes cell growth and proliferation; however, it is not clear how vGPCR is negatively regulated. We report here that the KSHV K7 small ...

journal_title：PLoS pathogens

authors： Feng H,Dong X,Negaard A,Feng P

更新日期：2008-09-19 00:00:00

abstract：:Toxoplasma gondii and Hammondia hammondi are closely-related coccidian intracellular parasites that differ in their ability to cause disease in animal and (likely) humans. The role of the host response in these phenotypic differences is not known and to address this we performed a transcriptomic analysis of a monocyte...

journal_title：PLoS pathogens

authors： Wong ZS,Sokol-Borrelli SL,Olias P,Dubey JP,Boyle JP

更新日期：2020-06-23 00:00:00

abstract：:The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however, little is known about its relationship to early disease progression. To better understand the relationship between the lung microbiome and early respiratory disease, we characterized the lower airways microbiome using bronchoalv...

journal_title：PLoS pathogens

authors： Muhlebach MS,Zorn BT,Esther CR,Hatch JE,Murray CP,Turkovic L,Ranganathan SC,Boucher RC,Stick SM,Wolfgang MC

更新日期：2018-01-18 00:00:00

abstract：:Mycoplasma pneumoniae, a human pathogenic bacterium, glides on host cell surfaces by a unique and unknown mechanism. It forms an attachment organelle at a cell pole as a membrane protrusion composed of surface and internal structures, with a highly organized architecture. In the present study, we succeeded in isolatin...

journal_title：PLoS pathogens

authors： Nakane D,Kenri T,Matsuo L,Miyata M

更新日期：2015-12-03 00:00:00

abstract：:Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth and virulence, disease progression, and infection control. However, our understanding of this crucial process is still rather limited because of experimental and conceptual challenges. Here, we used proteomics, microbial genetics,...

journal_title：PLoS pathogens

authors： Steeb B,Claudi B,Burton NA,Tienz P,Schmidt A,Farhan H,Mazé A,Bumann D

更新日期：2013-01-01 00:00:00

abstract：:Influenza viruses continue to pose a major public health threat worldwide and options for antiviral therapy are limited by the emergence of drug-resistant virus strains. The antiviral cytokine, interferon (IFN) is an essential mediator of the innate immune response and influenza viruses, like many viruses, have evolve...

journal_title：PLoS pathogens

authors： Ortigoza MB,Dibben O,Maamary J,Martinez-Gil L,Leyva-Grado VH,Abreu P Jr,Ayllon J,Palese P,Shaw ML

更新日期：2012-01-01 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:Acute resistance to low dose M. tuberculosis (Mtb) infection is not dependent on Toll-like receptor (TLR) 2. However, whether TLR2 contributes to resistance in chronic Mtb infection has remained uncertain. Here we report that, following low dose aerosol infection with Mtb, mice lacking TLR2 (TLR2KO), in comparison wit...

journal_title：PLoS pathogens

authors： McBride A,Konowich J,Salgame P

更新日期：2013-01-01 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using ne...

journal_title：PLoS pathogens

authors： Soanes DM,Chakrabarti A,Paszkiewicz KH,Dawe AL,Talbot NJ

更新日期：2012-02-01 00:00:00

abstract：:Shoot apical meristems (SAM) are resistant to most plant viruses due to RNA silencing, which is restrained by viral suppressors of RNA silencing (VSRs) to facilitate transient viral invasion of the SAM. In many cases chronic symptoms and long-term virus recovery occur, but the underlying mechanisms are poorly understo...

journal_title：PLoS pathogens

authors： Zhang XP,Liu DS,Yan T,Fang XD,Dong K,Xu J,Wang Y,Yu JL,Wang XB

更新日期：2017-07-20 00:00:00

abstract：:Pili of pathogenic Neisseria are major virulence factors associated with adhesion, twitching motility, auto-aggregation, and DNA transformation. Pili of N. meningitidis are subject to several different post-translational modifications. Among these pilin modifications, the presence of phosphorylcholine (ChoP) and a gly...

journal_title：PLoS pathogens

authors： Jen FE,Warren MJ,Schulz BL,Power PM,Swords WE,Weiser JN,Apicella MA,Edwards JL,Jennings MP

更新日期：2013-01-01 00:00:00

abstract：:Phylogenetic analyses have provided strong evidence that amino acid changes in spike (S) protein of animal and human SARS coronaviruses (SARS-CoVs) during and between two zoonotic transfers (2002/03 and 2003/04) are the result of positive selection. While several studies support that some amino acid changes between an...

journal_title：PLoS pathogens

authors： Sui J,Aird DR,Tamin A,Murakami A,Yan M,Yammanuru A,Jing H,Kan B,Liu X,Zhu Q,Yuan QA,Adams GP,Bellini WJ,Xu J,Anderson LJ,Marasco WA

更新日期：2008-11-01 00:00:00

abstract：:The primary role of cytoplasmic viral RNA-dependent RNA polymerase (RdRp) is viral genome replication in the cellular cytoplasm. However, picornaviral RdRp denoted 3D polymerase (3D(pol)) also enters the host nucleus, where its function remains unclear. In this study, we describe a novel mechanism of viral attack in w...

journal_title：PLoS pathogens

authors： Liu YC,Kuo RL,Lin JY,Huang PN,Huang Y,Liu H,Arnold JJ,Chen SJ,Wang RY,Cameron CE,Shih SR

更新日期：2014-06-26 00:00:00