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Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children.

Abstract：

:The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however, little is known about its relationship to early disease progression. To better understand the relationship between the lung microbiome and early respiratory disease, we characterized the lower airways microbiome using bronchoalveolar lavage (BAL) samples obtained from clinically stable CF infants and preschoolers who underwent bronchoscopy and chest computed tomography (CT). Cross-sectional samples suggested a progression of the lower airways microbiome with age, beginning with relatively sterile airways in infancy. By age two, bacterial sequences typically associated with the oral cavity dominated lower airways samples in many CF subjects. The presence of an oral-like lower airways microbiome correlated with a significant increase in bacterial density and inflammation. These early changes occurred in many patients, despite the use of antibiotic prophylaxis in our cohort during the first two years of life. The majority of CF subjects older than four harbored a pathogen dominated airway microbiome, which was associated with a further increase in inflammation and the onset of structural lung disease, despite a negligible increase in bacterial density compared to younger patients with an oral-like airway microbiome. Our findings suggest that changes within the CF lower airways microbiome occur during the first years of life and that distinct microbial signatures are associated with the progression of early CF lung disease.

journal_name

PLoS Pathog

journal_title

PLoS pathogens

authors

Muhlebach MS,Zorn BT,Esther CR,Hatch JE,Murray CP,Turkovic L,Ranganathan SC,Boucher RC,Stick SM,Wolfgang MC

doi

10.1371/journal.ppat.1006798

subject

Has Abstract

pub_date

2018-01-18 00:00:00

pages

e1006798

issue

1

eissn

1553-7366

issn

1553-7374

pii

PPATHOGENS-D-17-00390

journal_volume

14

pub_type

杂志文章

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