Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006750.]. ...

journal_title：PLoS pathogens

authors： Patterson Ross Z,Klunk J,Fornaciari G,Giuffra V,Duchêne S,Duggan AT,Poinar D,Douglas MW,Eden JS,Holmes EC,Poinar HN

更新日期：2018-02-09 00:00:00

abstract：:Wolbachia are maternally transmitted intracellular bacterial symbionts that infect approximately 40% of all insect species. Though several strains of Wolbachia naturally infect Drosophila melanogaster and provide resistance against viral pathogens, or provision metabolites during periods of nutritional stress, one vir...

journal_title：PLoS pathogens

authors： Rohrscheib CE,Frentiu FD,Horn E,Ritchie FK,van Swinderen B,Weible MW 2nd,O'Neill SL,Brownlie JC

更新日期：2016-09-23 00:00:00

abstract：:While immunological memory has long been considered the province of T- and B-lymphocytes, it has recently been reported that innate cell populations are capable of mediating memory responses. We now show that an innate memory immune response is generated in mice following infection with vaccinia virus, a poxvirus for ...

journal_title：PLoS pathogens

authors： Gillard GO,Bivas-Benita M,Hovav AH,Grandpre LE,Panas MW,Seaman MS,Haynes BF,Letvin NL

更新日期：2011-08-01 00:00:00

abstract：:The cytidine deaminases APOBEC3G and APOBEC3F exert anti-HIV-1 activity that is countered by the HIV-1 vif protein. Based on potential transcription factor binding sites in their putative promoters, we hypothesized that expression of APOBEC3G and APOBEC3F would vary with T helper lymphocyte differentiation. Naive CD4+...

journal_title：PLoS pathogens

authors： Vetter ML,Johnson ME,Antons AK,Unutmaz D,D'Aquila RT

更新日期：2009-02-01 00:00:00

abstract：:Elucidating virus-host interactions responsible for HIV-1 transmission is important for advancing HIV-1 prevention strategies. To this end, single genome amplification (SGA) and sequencing of HIV-1 within the context of a model of random virus evolution has made possible for the first time an unambiguous identificatio...

journal_title：PLoS pathogens

authors： Li H,Bar KJ,Wang S,Decker JM,Chen Y,Sun C,Salazar-Gonzalez JF,Salazar MG,Learn GH,Morgan CJ,Schumacher JE,Hraber P,Giorgi EE,Bhattacharya T,Korber BT,Perelson AS,Eron JJ,Cohen MS,Hicks CB,Haynes BF,Markowitz M,K

更新日期：2010-05-13 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006551.]. ...

journal_title：PLoS pathogens

authors： Gidon A,Åsberg SE,Louet C,Ryan L,Haug M,Flo TH

更新日期：2017-11-07 00:00:00

abstract：:Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 vir...

journal_title：PLoS pathogens

authors： Galilee M,Alian A

更新日期：2018-01-24 00:00:00

abstract：:This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible mink encephalopathy (TME) agent resulted in a prominent infection of the olfactory bulb and the olfactory sensory epithelium in...

journal_title：PLoS pathogens

authors： Bessen RA,Shearin H,Martinka S,Boharski R,Lowe D,Wilham JM,Caughey B,Wiley JA

更新日期：2010-04-15 00:00:00

abstract：:Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in Bundibugyo District, Wester...

journal_title：PLoS pathogens

authors： Towner JS,Sealy TK,Khristova ML,Albariño CG,Conlan S,Reeder SA,Quan PL,Lipkin WI,Downing R,Tappero JW,Okware S,Lutwama J,Bakamutumaho B,Kayiwa J,Comer JA,Rollin PE,Ksiazek TG,Nichol ST

更新日期：2008-11-01 00:00:00

abstract：:Infection of the vascular system by Pseudomonas aeruginosa (Pa) occurs during bacterial dissemination in the body or in blood-borne infections. Type 3 secretion system (T3SS) toxins from Pa induce a massive retraction when injected into endothelial cells. Here, we addressed the role of type 2 secretion system (T2SS) e...

journal_title：PLoS pathogens

authors： Golovkine G,Faudry E,Bouillot S,Voulhoux R,Attrée I,Huber P

更新日期：2014-03-13 00:00:00

abstract：:Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrophages (MΦs) measuri...

journal_title：PLoS pathogens

authors： Rodríguez-Martín S,Kropp KA,Wilhelmi V,Lisnic VJ,Hsieh WY,Blanc M,Livingston A,Busche A,Tekotte H,Messerle M,Auer M,Fraser I,Jonjic S,Angulo A,Reddehase MJ,Ghazal P

更新日期：2012-01-01 00:00:00

abstract：:Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract. Colonization of these different niches involves an N-acetylglucosamine binding protein (GbpA) that has been reported to mediate bacterial attachment to both marine chitin and mam...

journal_title：PLoS pathogens

authors： Wong E,Vaaje-Kolstad G,Ghosh A,Hurtado-Guerrero R,Konarev PV,Ibrahim AF,Svergun DI,Eijsink VG,Chatterjee NS,van Aalten DM

更新日期：2012-01-01 00:00:00

abstract：:For many viruses, one or two proteins allow cell attachment and entry, which occurs through the plasma membrane or following endocytosis at low pH. In contrast, vaccinia virus (VACV) enters cells by both neutral and low pH routes; four proteins mediate cell attachment and twelve that are associated in a membrane compl...

journal_title：PLoS pathogens

authors： Laliberte JP,Weisberg AS,Moss B

更新日期：2011-12-01 00:00:00

abstract：:Apicomplexans are obligate intracellular parasites that actively penetrate their host cells to create an intracellular niche for replication. Commitment to invasion is thought to be mediated by the rhoptries, specialized apical secretory organelles that inject a protein complex into the host cell to form a tight-junct...

journal_title：PLoS pathogens

authors： Beck JR,Fung C,Straub KW,Coppens I,Vashisht AA,Wohlschlegel JA,Bradley PJ

更新日期：2013-02-01 00:00:00

abstract：:Transformation is an important mechanism of microbial evolution through which bacteria have been observed to rapidly adapt in response to clinical interventions; examples include facilitating vaccine evasion and the development of penicillin resistance in the major respiratory pathogen Streptococcus pneumoniae. To cha...

journal_title：PLoS pathogens

authors： Croucher NJ,Harris SR,Barquist L,Parkhill J,Bentley SD

更新日期：2012-01-01 00:00:00

abstract：:Recognition of peptidoglycan (PGN) is paramount for insect antibacterial defenses. In the fruit fly Drosophila melanogaster, the transmembrane PGN Recognition Protein LC (PGRP-LC) is a receptor of the Imd signaling pathway that is activated after infection with bacteria, mainly Gram-negative (Gram-). Here we demonstra...

journal_title：PLoS pathogens

authors： Meister S,Agianian B,Turlure F,Relógio A,Morlais I,Kafatos FC,Christophides GK

更新日期：2009-08-01 00:00:00

abstract：:Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related ...

journal_title：PLoS pathogens

authors： Cotter PD,Draper LA,Lawton EM,Daly KM,Groeger DS,Casey PG,Ross RP,Hill C

更新日期：2008-09-12 00:00:00

abstract：:Cells of the immune system are derived from hematopoietic stem cells (HSCs) residing in the bone marrow. HSCs become activated in response to stress, such as acute infections, which adapt the bone marrow output to the needs of the immune response. However, the impact of infection-adapted HSC activation and differentia...

journal_title：PLoS pathogens

authors： Abidin BM,Hammami A,Stäger S,Heinonen KM

更新日期：2017-08-07 00:00:00

abstract：:Plants possess active defense systems and can protect themselves from pathogenic invasion by secretion of a variety of small antimicrobial or antifungal proteins such as thionins. The antibacterial and antifungal properties of thionins are derived from their ability to induce open pore formation on cell membranes of p...

journal_title：PLoS pathogens

authors： Asano T,Miwa A,Maeda K,Kimura M,Nishiuchi T

更新日期：2013-01-01 00:00:00

abstract：:The metabolic events associated with maintaining redox homeostasis in Mycobacterium tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel redox switching mechanism by which Mtb WhiB3 under defined oxidizing and reducing conditions differentially modulates the assimilation of propionate...

journal_title：PLoS pathogens

authors： Singh A,Crossman DK,Mai D,Guidry L,Voskuil MI,Renfrow MB,Steyn AJ

更新日期：2009-08-01 00:00:00

abstract：:Experimental visceral leishmaniasis (VL) represents an exquisite model to study CD8(+) T cell responses in a context of chronic inflammation and antigen persistence, since it is characterized by chronic infection in the spleen and CD8(+) T cells are required for the development of protective immunity. However, antigen...

journal_title：PLoS pathogens

authors： Joshi T,Rodriguez S,Perovic V,Cockburn IA,Stäger S

更新日期：2009-05-01 00:00:00

abstract：:Laboratory strains of the mouse polyoma virus differ markedly in their abilities to replicate and induce tumors in newborn mice. Major determinants of pathogenicity lie in the sialic binding pocket of the major capsid protein Vp1 and dictate receptor-binding properties of the virus. Substitutions at two sites in Vp1 d...

journal_title：PLoS pathogens

authors： Carroll J,Dey D,Kreisman L,Velupillai P,Dahl J,Telford S,Bronson R,Benjamin T

更新日期：2007-12-01 00:00:00

abstract：:Neisseria gonorrhoeae causes the sexually-transmitted infection gonorrhea, a global disease that is difficult to treat and for which there is no vaccine. This pathogen employs an arsenal of conserved outer membrane proteins called TonB-dependent transporters (TdTs) that allow the gonococcus to overcome nutritional imm...

journal_title：PLoS pathogens

authors： Maurakis S,Keller K,Maxwell CN,Pereira K,Chazin WJ,Criss AK,Cornelissen CN

更新日期：2019-08-01 00:00:00

abstract：:Malaria starts with the infection of the liver of the host by Plasmodium sporozoites, the parasite form transmitted by infected mosquitoes. Sporozoites migrate through several hepatocytes by breaching their plasma membranes before finally infecting one with the formation of an internalization vacuole. Migration throug...

journal_title：PLoS pathogens

authors： Ono T,Cabrita-Santos L,Leitao R,Bettiol E,Purcell LA,Diaz-Pulido O,Andrews LB,Tadakuma T,Bhanot P,Mota MM,Rodriguez A

更新日期：2008-02-29 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1004331.]. ...

journal_title：PLoS pathogens

authors： PLOS Pathogens Staff.

更新日期：2015-02-19 00:00:00

abstract：:Herpesviruses infect most humans. Their infections can be associated with pathological conditions and significant changes in T cell repertoire but evidences of symbiotic effects of herpesvirus latency have never been demonstrated. We tested the hypothesis that HCMV and EBV-specific CD8 T cells contribute to the hetero...

journal_title：PLoS pathogens

authors： Sandalova E,Laccabue D,Boni C,Tan AT,Fink K,Ooi EE,Chua R,Shafaeddin Schreve B,Ferrari C,Bertoletti A

更新日期：2010-08-19 00:00:00

abstract：:Pathogenic hantaviruses, genus Orthohantaviridae, are maintained in rodent reservoirs with zoonotic transmission to humans occurring through inhalation of rodent excreta. Hantavirus disease in humans is characterized by localized vascular leakage and elevated levels of circulating proinflammatory cytokines. Despite th...

journal_title：PLoS pathogens

authors： Kell AM,Hemann EA,Turnbull JB,Gale M Jr

更新日期：2020-04-24 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006219.]. ...

journal_title：PLoS pathogens

authors： Hirsch AJ,Smith JL,Haese NN,Broeckel RM,Parkins CJ,Kreklywich C,DeFilippis VR,Denton M,Smith PP,Messer WB,Colgin LM,Ducore RM,Grigsby PL,Hennebold JD,Swanson T,Legasse AW,Axthelm MK,MacAllister R,Wiley CA,Nelson JA

更新日期：2017-04-05 00:00:00

abstract：:The virulence of Francisella tularensis, the etiological agent of tularemia, relies on an atypical type VI secretion system (T6SS) encoded by a genomic island termed the Francisella Pathogenicity Island (FPI). While the importance of the FPI in F. tularensis virulence is clearly established, the precise role of most o...

journal_title：PLoS pathogens

authors： Rigard M,Bröms JE,Mosnier A,Hologne M,Martin A,Lindgren L,Punginelli C,Lays C,Walker O,Charbit A,Telouk P,Conlan W,Terradot L,Sjöstedt A,Henry T

更新日期：2016-09-07 00:00:00

abstract：:The genus Henipavirus in the family Paramyxoviridae contains two viruses, Hendra virus (HeV) and Nipah virus (NiV) for which pteropid bats act as the main natural reservoir. Each virus also causes serious and commonly lethal infection of people as well as various species of domestic animals, however little is known ab...

journal_title：PLoS pathogens

authors： Marsh GA,de Jong C,Barr JA,Tachedjian M,Smith C,Middleton D,Yu M,Todd S,Foord AJ,Haring V,Payne J,Robinson R,Broz I,Crameri G,Field HE,Wang LF

更新日期：2012-01-01 00:00:00