Species-Specific Adaptations of Trypanosome Morphology and Motility to the Mammalian Host.

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence attributes, the M1T1 clone secretes NAD+-glycohydrolase (NADase). When GAS binds to epithelial...

journal_title：PLoS pathogens

authors： Sharma O,O'Seaghdha M,Velarde JJ,Wessels MR

更新日期：2016-03-03 00:00:00

abstract：:The Epstein-Barr virus (EBV) nuclear proteins EBNA3A, EBNA3B, and EBNA3C interact with the cell DNA binding protein RBPJ and regulate cell and viral genes. Repression of the CDKN2A tumor suppressor gene products p16(INK4A) and p14(ARF) by EBNA3A and EBNA3C is critical for EBV mediated transformation of resting B lymph...

journal_title：PLoS pathogens

authors： Ohashi M,Holthaus AM,Calderwood MA,Lai CY,Krastins B,Sarracino D,Johannsen E

更新日期：2015-04-09 00:00:00

abstract：:Host genetic variation modifying HIV-1 acquisition risk can inform development of HIV-1 prevention strategies. However, associations between rare or intermediate-frequency variants and HIV-1 acquisition are not well studied. We tested for the association between variation in genic regions and extreme HIV-1 acquisition...

journal_title：PLoS pathogens

authors： Mackelprang RD,Bamshad MJ,Chong JX,Hou X,Buckingham KJ,Shively K,deBruyn G,Mugo NR,Mullins JI,McElrath MJ,Baeten JM,Celum C,Emond MJ,Lingappa JR,Partners in Prevention HSV\/HIV Transmission Study and the Partners PrEP Study T

更新日期：2017-11-06 00:00:00

abstract：:The Adeno-associated virus (AAV) gene delivery system is ushering in a new and exciting era in the United States; following the first approved gene therapy (Glybera) in Europe, the FDA has approved a second therapy, Luxturna [1]. However, challenges to this system remain. In viral gene therapy, the surface of the caps...

journal_title：PLoS pathogens

authors： Smith JK,Agbandje-McKenna M

更新日期：2018-05-03 00:00:00

abstract：:Mycobacterium leprae, an obligate intracellular bacillus, infects Schwann cells (SCs), leading to peripheral nerve damage, the most severe leprosy symptom. In the present study, we revisited the involvement of phenolic glycolipid I (PGL I), an abundant, private, surface M. leprae molecule, in M. leprae-SC interaction ...

journal_title：PLoS pathogens

authors： Díaz Acosta CC,Dias AA,Rosa TLSA,Batista-Silva LR,Rosa PS,Toledo-Pinto TG,Costa FDMR,Lara FA,Rodrigues LS,Mattos KA,Sarno EN,Bozza PT,Guilhot C,de Berrêdo-Pinho M,Pessolani MCV

更新日期：2018-07-06 00:00:00

abstract：:Rabbit hemorrhagic disease, first described in China in 1984, causes hemorrhagic necrosis of the liver. Its etiological agent, rabbit hemorrhagic disease virus (RHDV), belongs to the Lagovirus genus in the family Caliciviridae. The detailed molecular structure of any lagovirus capsid has yet to be determined. Here, we...

journal_title：PLoS pathogens

authors： Wang X,Xu F,Liu J,Gao B,Liu Y,Zhai Y,Ma J,Zhang K,Baker TS,Schulten K,Zheng D,Pang H,Sun F

更新日期：2013-01-01 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00

abstract：:The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated with the RNA dependent RNA polymerase, the viral components of which are a large protein (L) and an accessory phosphoprotein (P). The 241 kDa L protein contains al...

journal_title：PLoS pathogens

authors： Tekes G,Rahmeh AA,Whelan SP

更新日期：2011-06-01 00:00:00

abstract：:Since the advent of genome-wide small interfering RNA screening, large numbers of cellular cofactors important for viral infection have been discovered at a rapid pace, but the viral targets and the mechanism of action for many of these cofactors remain undefined. One such cofactor is cyclophilin A (CyPA), upon which ...

journal_title：PLoS pathogens

authors： Yang F,Robotham JM,Grise H,Frausto S,Madan V,Zayas M,Bartenschlager R,Robinson M,Greenstein AE,Nag A,Logan TM,Bienkiewicz E,Tang H

更新日期：2010-09-23 00:00:00

abstract：:Septic shock caused by Neisseria meningitidis is typically rapidly evolving and often fatal despite antibiotic therapy. Further understanding of the mechanisms underlying the disease is necessary to reduce fatality rates. Postmortem samples from the characteristic purpuric rashes of the infection show bacterial aggreg...

journal_title：PLoS pathogens

authors： Melican K,Michea Veloso P,Martin T,Bruneval P,Duménil G

更新日期：2013-01-01 00:00:00

abstract：:Retroviruses encode cis-acting RNA nuclear export elements that override nuclear retention of intron-containing viral mRNAs including the full-length, unspliced genomic RNAs (gRNAs) packaged into assembling virions. The HIV-1 Rev-response element (RRE) recruits the cellular nuclear export receptor CRM1 (also known as ...

journal_title：PLoS pathogens

authors： Pocock GM,Becker JT,Swanson CM,Ahlquist P,Sherer NM

更新日期：2016-04-12 00:00:00

abstract：:Lymph nodes (LN) and their resident T follicular helper CD4+ T cells (Tfh) are a critical site for HIV replication and persistence. Therefore, optimizing antiviral activity in lymphoid tissues will be needed to reduce or eliminate the HIV reservoir. In this study, we retained effector immune cells in LN of cART-suppre...

journal_title：PLoS pathogens

authors： Pino M,Paganini S,Deleage C,Padhan K,Harper JL,King CT,Micci L,Cervasi B,Mudd JC,Gill KP,Jean SM,Easley K,Silvestri G,Estes JD,Petrovas C,Lederman MM,Paiardini M

更新日期：2019-10-18 00:00:00

abstract：:The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or in...

journal_title：PLoS pathogens

authors： Hovius JW,Bijlsma MF,van der Windt GJ,Wiersinga WJ,Boukens BJ,Coumou J,Oei A,de Beer R,de Vos AF,van 't Veer C,van Dam AP,Wang P,Fikrig E,Levi MM,Roelofs JJ,van der Poll T

更新日期：2009-05-01 00:00:00

abstract：:Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity to interfere with th...

journal_title：PLoS pathogens

authors： Fleming P,Kvansakul M,Voigt V,Kile BT,Kluck RM,Huang DC,Degli-Esposti MA,Andoniou CE

更新日期：2013-02-01 00:00:00

abstract：:APE1 is a multifunctional protein with a DNA base excision repair function in its C-terminal domain and a redox activity in its N-terminal domain. The redox function of APE1 converts certain transcription factors from inactive oxidized to active reduced forms. Given that among the APE1-regulated transcription factors ...

journal_title：PLoS pathogens

authors： Zhong C,Xu M,Wang Y,Xu J,Yuan Y

更新日期：2017-04-05 00:00:00

abstract：:Idiopathic chronic diarrhea (ICD) is a leading cause of morbidity amongst rhesus monkeys kept in captivity. Here, we show that exposure of affected animals to the whipworm Trichuris trichiura led to clinical improvement in fecal consistency, accompanied by weight gain, in four out of the five treated monkeys. By flow ...

journal_title：PLoS pathogens

authors： Broadhurst MJ,Ardeshir A,Kanwar B,Mirpuri J,Gundra UM,Leung JM,Wiens KE,Vujkovic-Cvijin I,Kim CC,Yarovinsky F,Lerche NW,McCune JM,Loke P

更新日期：2012-01-01 00:00:00

abstract：:In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory neurons. In humans, local opioids and opioid peptides significantly...

journal_title：PLoS pathogens

authors： Rittner HL,Hackel D,Voigt P,Mousa S,Stolz A,Labuz D,Schäfer M,Schaefer M,Stein C,Brack A

更新日期：2009-04-01 00:00:00

abstract：:This Pearl article recounts the story of a US corporation, Lennar, the nation's leading homebuilder, an essential function in the US (not allowed to lock down), when faced with the coronavirus disease 2019 (COVID-19) pandemic at the end of February 2020. The culture of the company, which allowed it to proceed safely, ...

journal_title：PLoS pathogens

authors： Goldschmidt-Clermont PJ

更新日期：2020-08-27 00:00:00

abstract：:As targets of adaptive immunity, influenza viruses are characterized by the fluidity with which they respond to the selective pressure applied by neutralizing antibodies. This mutability of structural determinants of protective immunity is the obstacle in developing universal influenza vaccines. Towards the developmen...

journal_title：PLoS pathogens

authors： Wang TT,Tan GS,Hai R,Pica N,Petersen E,Moran TM,Palese P

更新日期：2010-02-26 00:00:00

abstract：:The ability to switch between yeast and filamentous forms is central to Candida albicans biology. The yeast-hyphal transition is implicated in adherence, tissue invasion, biofilm formation, phagocyte escape, and pathogenesis. A second form of morphological plasticity in C. albicans involves epigenetic switching betwee...

journal_title：PLoS pathogens

authors： Si H,Hernday AD,Hirakawa MP,Johnson AD,Bennett RJ

更新日期：2013-03-01 00:00:00

abstract：:The influenza A virus (IAV) HA protein must be activated by host cells proteases in order to prime the molecule for fusion. Consequently, the availability of activating proteases and the susceptibility of HA to protease activity represents key factors in facilitating virus infection. As such, understanding the intrica...

journal_title：PLoS pathogens

authors： Galloway SE,Reed ML,Russell CJ,Steinhauer DA

更新日期：2013-02-01 00:00:00

abstract：:The bank vole is a rodent susceptible to different prion strains from humans and various animal species. We analyzed the transmission features of different prions in a panel of seven rodent species which showed various degrees of phylogenetic affinity and specific prion protein (PrP) sequence divergences in order to i...

journal_title：PLoS pathogens

authors： Agrimi U,Nonno R,Dell'Omo G,Di Bari MA,Conte M,Chiappini B,Esposito E,Di Guardo G,Windl O,Vaccari G,Lipp HP

更新日期：2008-07-25 00:00:00

abstract：:Heme metabolism is central to malaria parasite biology. The parasite acquires heme from host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free heme toxicity. The parasite can also synthesize heme de novo, and all the enzymes in the pathway are characterized. To study the role of the ...

journal_title：PLoS pathogens

authors： Nagaraj VA,Sundaram B,Varadarajan NM,Subramani PA,Kalappa DM,Ghosh SK,Padmanaban G

更新日期：2013-01-01 00:00:00

abstract：:To cause infections microbes need to evade host defense systems, one of these being the evolutionarily old and important arm of innate immunity, the alternative pathway of complement. It can attack all kinds of targets and is tightly controlled in plasma and on host cells by plasma complement regulator factor H (FH). ...

journal_title：PLoS pathogens

authors： Meri T,Amdahl H,Lehtinen MJ,Hyvärinen S,McDowell JV,Bhattacharjee A,Meri S,Marconi R,Goldman A,Jokiranta TS

更新日期：2013-01-01 00:00:00

abstract：:The Trypanosoma brucei flagellum is a multifunctional organelle with critical roles in motility, cellular morphogenesis, and cell division. Although motility is thought to be important throughout the trypanosome lifecycle, most studies of flagellum structure and function have been restricted to the procyclic lifecycle...

journal_title：PLoS pathogens

authors： Ralston KS,Hill KL

更新日期：2006-09-01 00:00:00

abstract：:Streptococcus gallolyticus subspecies gallolyticus (Sgg) has a strong clinical association with colorectal cancer (CRC) and actively promotes the development of colon tumors. However, the molecular determinants involved in Sgg pathogenicity in the gut are unknown. Bacterial type VII secretion systems (T7SS) mediate pa...

journal_title：PLoS pathogens

authors： Taylor JC,Gao X,Xu J,Holder M,Petrosino J,Kumar R,Liu W,Höök M,Mackenzie C,Hillhouse A,Brashear W,Nunez MP,Xu Y

更新日期：2021-01-06 00:00:00

abstract：:Mycobacterial infection leads to activation of the RIG-I/MAVS/TBK1 RNA sensing pathway in macrophages but the consequences of this activation remains poorly defined. In this study, we determined that activation of this RNA sensing pathway stimulates ICAM-1 expression in M.avium-infected macrophage through the inhibiti...

journal_title：PLoS pathogens

authors： Cheng Y,Kiene NJ,Tatarian A,Eix EF,Schorey JS

更新日期：2020-05-28 00:00:00

abstract：:During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal survival. Despite the importance of invasion into the bloodstream in the meningococcal disease process, little is known about how Nm adapts to permit survival a...

journal_title：PLoS pathogens

authors： Echenique-Rivera H,Muzzi A,Del Tordello E,Seib KL,Francois P,Rappuoli R,Pizza M,Serruto D

更新日期：2011-05-01 00:00:00

abstract：:Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 and MASP-2, the two key activator proteases of the complement lec...

journal_title：PLoS pathogens

authors： Nagy ZA,Szakács D,Boros E,Héja D,Vígh E,Sándor N,Józsi M,Oroszlán G,Dobó J,Gál P,Pál G

更新日期：2019-12-20 00:00:00