Norovirus infection results in eIF2α independent host translation shut-off and remodels the G3BP1 interactome evading stress granule formation.

abstract：:Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. However, reduced susceptibility to antibiotics-even below this breakpoint-is associated with poor treatment outcomes in the clinic, including in tub...

journal_title：PLoS pathogens

authors： Hicks ND,Giffen SR,Culviner PH,Chao MC,Dulberger CL,Liu Q,Stanley S,Brown J,Sixsmith J,Wolf ID,Fortune SM

更新日期：2020-11-30 00:00:00

abstract：:The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in humans and other mammals, despite the development of potent host immune responses that constrain parasite numbers. The consistent, decades-long persistence of T. cruzi in human hosts arises at least in part from the remarkable level ...

journal_title：PLoS pathogens

authors： Wang W,Peng D,Baptista RP,Li Y,Kissinger JC,Tarleton RL

更新日期：2021-01-28 00:00:00

abstract：:The clinical course of prion diseases is accurately predictable despite long latency periods, suggesting that prion pathogenesis is driven by precisely timed molecular events. We constructed a searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inoculated mice....

journal_title：PLoS pathogens

authors： Sorce S,Nuvolone M,Russo G,Chincisan A,Heinzer D,Avar M,Pfammatter M,Schwarz P,Delic M,Müller M,Hornemann S,Sanoudou D,Scheckel C,Aguzzi A

更新日期：2020-06-29 00:00:00

abstract：:Regulated protein secretion is required for malaria parasite life cycle progression and transmission between the mammalian host and mosquito vector. During transmission from the host to the vector, exocytosis of highly specialised secretory vesicles, such as osmiophilic bodies, is key to the dissolution of the red blo...

journal_title：PLoS pathogens

authors： Kehrer J,Singer M,Lemgruber L,Silva PA,Frischknecht F,Mair GR

更新日期：2016-07-18 00:00:00

abstract：:The host's immune system plays a key role in modulating growth of pathogens and the intestinal microbiota in the gut. In particular, inflammatory bowel disorders and pathogen infections induce shifts of the resident commensal microbiota which can result in overgrowth of Enterobacteriaceae ("inflammation-inflicted bloo...

journal_title：PLoS pathogens

authors： Nedialkova LP,Denzler R,Koeppel MB,Diehl M,Ring D,Wille T,Gerlach RG,Stecher B

更新日期：2014-01-01 00:00:00

abstract：:Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed with a variety of functions, including the uptake and clearance of blood and lymph-borne pathogens, little is known about the effector mechanisms they employ aft...

journal_title：PLoS pathogens

authors： Phillips R,Svensson M,Aziz N,Maroof A,Brown N,Beattie L,Signoret N,Kaye PM

更新日期：2010-03-12 00:00:00

abstract：:Dissemination of HIV in the host involves transit of the virus and virus-infected cells across the lymphatic endothelium. HIV may alter lymphatic endothelial permeability to foster dissemination, but the mechanism is largely unexplored. Using a primary human lymphatic endothelial cell model, we found that HIV-1 envelo...

journal_title：PLoS pathogens

authors： Zhang X,Yu J,Kuzontkoski PM,Zhu W,Li DY,Groopman JE

更新日期：2012-01-01 00:00:00

abstract：:Competence stimulating peptide (CSP) is a 17-amino acid peptide pheromone secreted by Streptococcus pneumoniae. Upon binding of CSP to its membrane-associated receptor kinase ComD, a cascade of signaling events is initiated, leading to activation of the competence regulon by the response regulator ComE. Genes encoding...

journal_title：PLoS pathogens

authors： Zhu L,Lau GW

更新日期：2011-09-01 00:00:00

abstract：:Specific types of human papillomaviruses (HPVs) cause cervical cancer. Cervical cancers exhibit aberrant cellular microRNA (miRNA) expression patterns. By genome-wide analyses, we investigate whether the intracellular and exosomal miRNA compositions of HPV-positive cancer cells are dependent on endogenous E6/E7 oncoge...

journal_title：PLoS pathogens

authors： Honegger A,Schilling D,Bastian S,Sponagel J,Kuryshev V,Sültmann H,Scheffner M,Hoppe-Seyler K,Hoppe-Seyler F

更新日期：2015-03-11 00:00:00

abstract：:Extracellular signaling is a mechanism that higher eukaryotes have evolved to facilitate organismal homeostasis. Recent years have seen an emerging interest in the role of secreted microvesicles, termed extracellular vesicles (EV) or exosomes in this signaling network. EV contents can be modified by the cell in respon...

journal_title：PLoS pathogens

authors： McNamara RP,Chugh PE,Bailey A,Costantini LM,Ma Z,Bigi R,Cheves A,Eason AB,Landis JT,Host KM,Xiong J,Griffith JD,Damania B,Dittmer DP

更新日期：2019-02-04 00:00:00

abstract：:The bank vole is a rodent susceptible to different prion strains from humans and various animal species. We analyzed the transmission features of different prions in a panel of seven rodent species which showed various degrees of phylogenetic affinity and specific prion protein (PrP) sequence divergences in order to i...

journal_title：PLoS pathogens

authors： Agrimi U,Nonno R,Dell'Omo G,Di Bari MA,Conte M,Chiappini B,Esposito E,Di Guardo G,Windl O,Vaccari G,Lipp HP

更新日期：2008-07-25 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:Paramount to the success of persistent viral infection is the ability of viruses to navigate hostile environments en route to future targets. In response to such obstacles, many viruses have developed the ability of establishing actin rich-membrane bridges to aid in future infections. Herein through dynamic imaging of...

journal_title：PLoS pathogens

authors： Aggarwal A,Iemma TL,Shih I,Newsome TP,McAllery S,Cunningham AL,Turville SG

更新日期：2012-01-01 00:00:00

abstract：:Bluetongue virus (BTV) causes hemorrhagic disease in economically important livestock. The BTV genome is organized into ten discrete double-stranded RNA molecules (S1-S10) which have been suggested to follow a sequential packaging pathway from smallest to largest segment during virus capsid assembly. To substantiate a...

journal_title：PLoS pathogens

authors： Fajardo T Jr,Sung PY,Roy P

更新日期：2015-12-08 00:00:00

abstract：:The origin recognition complex (ORC) coordinates a series of events that lead to initiation of DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV) genome resembles a mini-chromosome in infected cells. To initiate its replication, the viral E2 protein binds to and recruits the E1 D...

journal_title：PLoS pathogens

authors： DeSmet M,Kanginakudru S,Rietz A,Wu WH,Roden R,Androphy EJ

更新日期：2016-10-04 00:00:00

abstract：:Tm-2² is a coiled coil-nucleotide binding-leucine rich repeat resistance protein that confers durable extreme resistance against Tomato mosaic virus (ToMV) and Tobacco mosaic virus (TMV) by recognizing the viral movement protein (MP). Here we report that the Nicotiana benthamiana J-domain MIP1 proteins (NbMIP1s) assoc...

journal_title：PLoS pathogens

authors： Du Y,Zhao J,Chen T,Liu Q,Zhang H,Wang Y,Hong Y,Xiao F,Zhang L,Shen Q,Liu Y

更新日期：2013-01-01 00:00:00

abstract：:Pomalidomide (Pom) is an immunomodulatory drug that has efficacy against Kaposi's sarcoma, a tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Pom also induces direct cytotoxicity in primary effusion lymphoma (PEL), a B-cell malignancy caused by KSHV, in part through downregulation of IRF4, cMyc, and CK1...

journal_title：PLoS pathogens

authors： Shrestha P,Davis DA,Jaeger HK,Stream A,Aisabor AI,Yarchoan R

更新日期：2021-01-07 00:00:00

abstract：:Fusogenic reoviruses encode fusion-associated small transmembrane (FAST) protein, which induces cell-cell fusion. FAST protein is the only known fusogenic protein in non-enveloped viruses, and its role in virus replication is not yet known. We generated replication-competent, FAST protein-deficient pteropine orthoreov...

journal_title：PLoS pathogens

authors： Kanai Y,Kawagishi T,Sakai Y,Nouda R,Shimojima M,Saijo M,Matsuura Y,Kobayashi T

更新日期：2019-04-25 00:00:00

abstract：:Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage, but also for infectious virus production. To identify cellular factors that interact with NS2 and are important for HCV propagation, we screened a human liver cDNA library by sp...

journal_title：PLoS pathogens

authors： Suzuki R,Matsuda M,Watashi K,Aizaki H,Matsuura Y,Wakita T,Suzuki T

更新日期：2013-01-01 00:00:00

abstract：:Eliciting broad tier 2 neutralizing antibodies (nAbs) is a major goal of HIV-1 vaccine research. Here we investigated the ability of native, membrane-expressed JR-FL Env trimers to elicit nAbs. Unusually potent nAb titers developed in 2 of 8 rabbits immunized with virus-like particles (VLPs) expressing trimers (trimer...

journal_title：PLoS pathogens

authors： Crooks ET,Tong T,Chakrabarti B,Narayan K,Georgiev IS,Menis S,Huang X,Kulp D,Osawa K,Muranaka J,Stewart-Jones G,Destefano J,O'Dell S,LaBranche C,Robinson JE,Montefiori DC,McKee K,Du SX,Doria-Rose N,Kwong PD,Mascola

更新日期：2015-05-29 00:00:00

abstract：:In bacteria, transformation and restriction-modification (R-M) systems play potentially antagonistic roles. While the former, proposed as a form of sexuality, relies on internalized foreign DNA to create genetic diversity, the latter degrade foreign DNA to protect from bacteriophage attack. The human pathogen Streptoc...

journal_title：PLoS pathogens

authors： Johnston C,Martin B,Granadel C,Polard P,Claverys JP

更新日期：2013-02-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV latent and lytic transcripts. F...

journal_title：PLoS pathogens

authors： Lang F,Singh RK,Pei Y,Zhang S,Sun K,Robertson ES

更新日期：2019-06-21 00:00:00

abstract：:Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk and severe constraints to livestock health and economic development. The complete genome sequence was undertaken to facilitate vaccine antigen discovery, and to allow for comparative analysis with the related apicomplexan hemop...

journal_title：PLoS pathogens

authors： Brayton KA,Lau AO,Herndon DR,Hannick L,Kappmeyer LS,Berens SJ,Bidwell SL,Brown WC,Crabtree J,Fadrosh D,Feldblum T,Forberger HA,Haas BJ,Howell JM,Khouri H,Koo H,Mann DJ,Norimine J,Paulsen IT,Radune D,Ren Q,Smith

更新日期：2007-10-19 00:00:00

abstract：:Environments such as light condition influence the spread of infectious diseases by affecting insect vector behavior. However, whether and how light affects the host defense which further affects insect preference and performance, remains unclear, nor has been demonstrated how pathogens co-adapt light condition to fac...

journal_title：PLoS pathogens

authors： Zhao P,Zhang X,Gong Y,Wang D,Xu D,Wang N,Sun Y,Gao L,Liu SS,Deng XW,Kliebenstein DJ,Zhou X,Fang RX,Ye J

更新日期：2021-01-11 00:00:00

abstract：:Candida albicans is the most frequent cause of oral fungal infections. However, the exact pathogenicity mechanisms that this fungus employs are largely unknown and many of the genes expressed during oral infection are uncharacterized. In this study we sought to functionally characterize 12 previously unknown function ...

journal_title：PLoS pathogens

authors： Mayer FL,Wilson D,Jacobsen ID,Miramón P,Große K,Hube B

更新日期：2012-01-01 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00

abstract：:As a canonical adaptor for the Toll-like receptor (TLR) family, myeloid differentiation primary response protein 88 (MyD88) has crucial roles in host defense against infection by microbial pathogens, and its dysregulation might induce autoimmune diseases. Here, we demonstrate that the chicken Cullin 3-based ubiquitin ...

journal_title：PLoS pathogens

authors： Li Q,Wang F,Wang Q,Zhang N,Zheng J,Zheng M,Liu R,Cui H,Wen J,Zhao G

更新日期：2020-05-04 00:00:00

abstract：:The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a time from one of about 15 subtelomeric VSG expression sites (ESs). For an...

journal_title：PLoS pathogens

authors： Povelones ML,Gluenz E,Dembek M,Gull K,Rudenko G

更新日期：2012-01-01 00:00:00

abstract：:The influenza A virus (IAV) HA protein must be activated by host cells proteases in order to prime the molecule for fusion. Consequently, the availability of activating proteases and the susceptibility of HA to protease activity represents key factors in facilitating virus infection. As such, understanding the intrica...

journal_title：PLoS pathogens

authors： Galloway SE,Reed ML,Russell CJ,Steinhauer DA

更新日期：2013-02-01 00:00:00

abstract：:The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression. These viruses have evolved countermeasures to disperse PML-NBs,...

journal_title：PLoS pathogens

authors： Reichelt M,Wang L,Sommer M,Perrino J,Nour AM,Sen N,Baiker A,Zerboni L,Arvin AM

更新日期：2011-02-03 00:00:00