Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity.

abstract：:Turnip yellow mosaic virus (TYMV)--a member of the alphavirus-like supergroup of viruses--serves as a model system for positive-stranded RNA virus membrane-bound replication. TYMV encodes a precursor replication polyprotein that is processed by the endoproteolytic activity of its internal cysteine proteinase domain (P...

journal_title：PLoS pathogens

authors： Lombardi C,Ayach M,Beaurepaire L,Chenon M,Andreani J,Guerois R,Jupin I,Bressanelli S

更新日期：2013-08-01 00:00:00

abstract：:Many viral pathogens are persistently transmitted by insect vectors and cause agricultural or health problems. Generally, an insect vector can use autophagy as an intrinsic antiviral defense mechanism against viral infection. Whether viruses can evolve to exploit autophagy to promote their transmission by insect vecto...

journal_title：PLoS pathogens

authors： Chen Y,Chen Q,Li M,Mao Q,Chen H,Wu W,Jia D,Wei T

更新日期：2017-11-10 00:00:00

abstract：:Mycobacterium abscessus is considered the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. Infections with M. abscessus are increasingly found in patients with chronic lung diseases, especially cystic fibrosis, and are often refractory to antibiotic therapy. M. abscessus has two...

journal_title：PLoS pathogens

authors： Bernut A,Nguyen-Chi M,Halloum I,Herrmann JL,Lutfalla G,Kremer L

更新日期：2016-11-02 00:00:00

abstract：:It is poorly understood how progressive brain swelling in experimental cerebral malaria (ECM) evolves in space and over time, and whether mechanisms of inflammation or microvascular sequestration/obstruction dominate the underlying pathophysiology. We therefore monitored in the Plasmodium berghei ANKA-C57BL/6 murine E...

journal_title：PLoS pathogens

authors： Hoffmann A,Pfeil J,Alfonso J,Kurz FT,Sahm F,Heiland S,Monyer H,Bendszus M,Mueller AK,Helluy X,Pham M

更新日期：2016-03-10 00:00:00

abstract：:Caspase-dependent cleavage of antigens associated with apoptotic cells plays a prominent role in the generation of CD8⁺ T cell responses in various infectious diseases. We found that the emergence of a large population of autoreactive CD8⁺ T effector cells specific for apoptotic T cell-associated self-epitopes exceeds...

journal_title：PLoS pathogens

authors： Franceschini D,Del Porto P,Piconese S,Trella E,Accapezzato D,Paroli M,Morrone S,Piccolella E,Spada E,Mele A,Sidney J,Sette A,Barnaba V

更新日期：2012-01-01 00:00:00

abstract：:Clinical strains of HCMV encode 20 putative ORFs within a region of the genome termed ULb' that are postulated to encode functions related to persistence or immune evasion. We have previously identified ULb'-encoded pUL138 as necessary, but not sufficient, for HCMV latency in CD34+ hematopoietic progenitor cells (HPCs...

journal_title：PLoS pathogens

authors： Umashankar M,Petrucelli A,Cicchini L,Caposio P,Kreklywich CN,Rak M,Bughio F,Goldman DC,Hamlin KL,Nelson JA,Fleming WH,Streblow DN,Goodrum F

更新日期：2011-12-01 00:00:00

abstract：:Iron, an essential co-factor of respiratory chain proteins, is critical for mitochondrial function and maintenance of its redox balance. We previously reported a role for iron uptake in differentiation of Leishmania amazonensis into virulent amastigotes, by a mechanism that involves reactive oxygen species (ROS) produ...

journal_title：PLoS pathogens

authors： Mittra B,Laranjeira-Silva MF,Perrone Bezerra de Menezes J,Jensen J,Michailowsky V,Andrews NW

更新日期：2016-01-07 00:00:00

abstract：:Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have identified MV-infected keratinocytes and mononuclear cells in the ...

journal_title：PLoS pathogens

authors： Laksono BM,Fortugno P,Nijmeijer BM,de Vries RD,Cordisco S,Kuiken T,Geijtenbeek TBH,Duprex WP,Brancati F,de Swart RL

更新日期：2020-10-08 00:00:00

abstract：:As humans age, they experience a progressive loss of thymic function and a corresponding shift in the makeup of the circulating CD8+ T cell population from naïve to memory phenotype. These alterations are believed to result in impaired CD8+ T cell responses in older individuals; however, evidence that these global cha...

journal_title：PLoS pathogens

authors： Lelic A,Verschoor CP,Ventresca M,Parsons R,Evelegh C,Bowdish D,Betts MR,Loeb MB,Bramson JL

更新日期：2012-01-01 00:00:00

abstract：:The metabolic events associated with maintaining redox homeostasis in Mycobacterium tuberculosis (Mtb) during infection are poorly understood. Here, we discovered a novel redox switching mechanism by which Mtb WhiB3 under defined oxidizing and reducing conditions differentially modulates the assimilation of propionate...

journal_title：PLoS pathogens

authors： Singh A,Crossman DK,Mai D,Guidry L,Voskuil MI,Renfrow MB,Steyn AJ

更新日期：2009-08-01 00:00:00

abstract：:Reverse transcriptase (RT) is the target for the majority of anti-HIV-1 drugs. As with all anti-AIDS treatments, continued success of RT inhibitors is persistently disrupted by the occurrence of resistance mutations. To explore latent resistance mechanisms potentially accessible to therapeutically challenged HIV-1 vir...

journal_title：PLoS pathogens

authors： Galilee M,Alian A

更新日期：2018-01-24 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use. Alternative antiviral strategies may include inhibition of entry. We show that soluble derivatives of th...

journal_title：PLoS pathogens

authors： Stegmann C,Hochdorfer D,Lieber D,Subramanian N,Stöhr D,Laib Sampaio K,Sinzger C

更新日期：2017-04-12 00:00:00

abstract：:Bacterial superantigens (SAgs) cause Vβ-dependent T-cell proliferation leading to immune dysregulation associated with the pathogenesis of life-threatening infections such as toxic shock syndrome, and necrotizing pneumonia. Previously, we demonstrated that staphylococcal enterotoxin-like toxin X (SElX) from Staphyloco...

journal_title：PLoS pathogens

authors： Tuffs SW,James DBA,Bestebroer J,Richards AC,Goncheva MI,O'Shea M,Wee BA,Seo KS,Schlievert PM,Lengeling A,van Strijp JA,Torres VJ,Fitzgerald JR

更新日期：2017-09-07 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithel...

journal_title：PLoS pathogens

authors： Crowley JT,Toledo AM,LaRocca TJ,Coleman JL,London E,Benach JL

更新日期：2013-01-01 00:00:00

abstract：:The phosphoinositide-3 kinase (PI3K) pathway regulates diverse cellular activities related to cell growth, migration, survival, and vesicular trafficking. It is known that Ebola virus requires endocytosis to establish an infection. However, the cellular signals that mediate this uptake were unknown for Ebola virus as ...

journal_title：PLoS pathogens

authors： Saeed MF,Kolokoltsov AA,Freiberg AN,Holbrook MR,Davey RA

更新日期：2008-08-29 00:00:00

abstract：:HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contain an incomplete spherical shell where Gag is arranged with the N-term...

journal_title：PLoS pathogens

authors： de Marco A,Müller B,Glass B,Riches JD,Kräusslich HG,Briggs JA

更新日期：2010-11-24 00:00:00

abstract：:Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses, particularly of the herpesvirus family, have been shown to express their own miRNAs to control both viral a...

journal_title：PLoS pathogens

authors： Dölken L,Krmpotic A,Kothe S,Tuddenham L,Tanguy M,Marcinowski L,Ruzsics Z,Elefant N,Altuvia Y,Margalit H,Koszinowski UH,Jonjic S,Pfeffer S

更新日期：2010-10-14 00:00:00

abstract：:The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this process, we asked whether adaptation also required interference with the metabolic machinery of the host cell. Temporal profiling of the metabolic flux, in cells ...

journal_title：PLoS pathogens

authors： Mehrotra P,Jamwal SV,Saquib N,Sinha N,Siddiqui Z,Manivel V,Chatterjee S,Rao KV

更新日期：2014-07-24 00:00:00

abstract：:Exosomes can transfer genetic materials between cells. Their roles in viral infections are beginning to be appreciated. Researches have shown that exosomes released from virus-infected cells contain a variety of viral and host cellular factors that are able to modulate recipient's cellular response and result in produ...

journal_title：PLoS pathogens

authors： Fu Y,Zhang L,Zhang F,Tang T,Zhou Q,Feng C,Jin Y,Wu Z

更新日期：2017-09-14 00:00:00

abstract：:Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in...

journal_title：PLoS pathogens

authors： Huyse T,Webster BL,Geldof S,Stothard JR,Diaw OT,Polman K,Rollinson D

更新日期：2009-09-01 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IκB kinases (IKKs) and NF-κB and promote cell survival; however, the key ubiquitinated factors downstream of Tax involved in cell transformation are unknown. Using mass spectrometry, we undertook an unbiased pr...

journal_title：PLoS pathogens

authors： Choi YB,Harhaj EW

更新日期：2014-10-23 00:00:00

abstract：:In human cytomegalovirus (HCMV), tropism to epithelial and endothelial cells is dependent upon a pentameric complex (PC). Given the structure of the placenta, the PC is potentially an important neutralizing antibody target antigen against congenital infection. The guinea pig is the only small animal model for congenit...

journal_title：PLoS pathogens

authors： Coleman S,Choi KY,Root M,McGregor A

更新日期：2016-07-07 00:00:00

abstract：:Marek's Disease Virus (MDV) is an alphaherpesvirus that infects chickens, transforms CD4+ T cells and causes deadly lymphomas. In addition, MDV induces immunosuppression early during infection by inducing cell death of the infected lymphocytes, and potentially due to activation of regulatory T (Treg)-cells. Furthermor...

journal_title：PLoS pathogens

authors： Gurung A,Kamble N,Kaufer BB,Pathan A,Behboudi S

更新日期：2017-12-21 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV latent and lytic transcripts. F...

journal_title：PLoS pathogens

authors： Lang F,Singh RK,Pei Y,Zhang S,Sun K,Robertson ES

更新日期：2019-06-21 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using ne...

journal_title：PLoS pathogens

authors： Soanes DM,Chakrabarti A,Paszkiewicz KH,Dawe AL,Talbot NJ

更新日期：2012-02-01 00:00:00

abstract：:Type I interferons (T1-IFN) are critical in the innate immune response, acting upon infected and uninfected cells to initiate an antiviral state by expressing genes that inhibit multiple stages of the lifecycle of many viruses. T1-IFN triggers the production of Interferon-Stimulated Genes (ISGs), activating an antivir...

journal_title：PLoS pathogens

authors： Parekh NJ,Krouse TE,Reider IE,Hobbs RP,Ward BM,Norbury CC

更新日期：2019-10-11 00:00:00

abstract：:Open reading frame (ORF) 45 of Kaposi's sarcoma-associated herpesvirus (KSHV) is a tegument protein. A genetic analysis with a null mutant suggested a possible role for this protein in the events leading to viral egress. In this study, ORF45 was found to interact with KIF3A, a kinesin-2 motor protein that transports c...

journal_title：PLoS pathogens

authors： Sathish N,Zhu FX,Yuan Y

更新日期：2009-03-01 00:00:00

abstract：:The type III secretion system is an essential component for virulence in many Gram-negative bacteria. Though components of the secretion system apparatus are conserved, its substrates--effector proteins--are not. We have used a novel computational approach to confidently identify new secreted effectors by integrating ...

journal_title：PLoS pathogens

authors： Samudrala R,Heffron F,McDermott JE

更新日期：2009-04-01 00:00:00

abstract：:Candida albicans is the most frequent cause of oral fungal infections. However, the exact pathogenicity mechanisms that this fungus employs are largely unknown and many of the genes expressed during oral infection are uncharacterized. In this study we sought to functionally characterize 12 previously unknown function ...

journal_title：PLoS pathogens

authors： Mayer FL,Wilson D,Jacobsen ID,Miramón P,Große K,Hube B

更新日期：2012-01-01 00:00:00