Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2.

abstract：:SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV mutants, we longitud...

journal_title：PLoS pathogens

authors： Vanderford TH,Bleckwehl C,Engram JC,Dunham RM,Klatt NR,Feinberg MB,Garber DA,Betts MR,Silvestri G

更新日期：2011-05-01 00:00:00

abstract：:Immunocompromised individuals tend to suffer from influenza longer with more serious complications than otherwise healthy patients. Little is known about the impact of prolonged infection and the efficacy of antiviral therapy in these patients. Among all 189 influenza A virus infected immunocompromised patients admitt...

journal_title：PLoS pathogens

authors： van der Vries E,Stittelaar KJ,van Amerongen G,Veldhuis Kroeze EJ,de Waal L,Fraaij PL,Meesters RJ,Luider TM,van der Nagel B,Koch B,Vulto AG,Schutten M,Osterhaus AD

更新日期：2013-01-01 00:00:00

abstract：:Antiretroviral therapy, antibody and CD8+ T cell-mediated responses targeting human immunodeficiency virus-1 (HIV-1) exert selection pressure on the virus necessitating escape; however, the ability of CD4+ T cells to exert selective pressure remains unclear. Using a computational approach on HIV gag/pol/nef sequences ...

journal_title：PLoS pathogens

authors： Erdmann N,Du VY,Carlson J,Schaefer M,Jureka A,Sterrett S,Yue L,Dilernia D,Lakhi S,Tang J,Sidney J,Gilmour J,Allen S,Hunter E,Heath S,Bansal A,Goepfert PA

更新日期：2015-08-24 00:00:00

abstract：:Reactivation of Kaposi's sarcoma-associated herpesvirus (KSHV) is important for persistent infection in the host as well as viral oncogenesis. The replication and transcription activator (RTA) encoded by KSHV ORF50 plays a central role in the switch from viral latency to lytic replication. Given that RTA is a transcri...

journal_title：PLoS pathogens

authors： Wei X,Bai L,Dong L,Liu H,Xing P,Zhou Z,Wu S,Lan K

更新日期：2019-11-21 00:00:00

abstract：:A subset of high-risk Human Papillomaviruses (HPVs) are the causative agents of a large number of human cancers, of which cervical is the most common. Two viral oncoproteins, E6 and E7, contribute directly towards the development and maintenance of malignancy. A characteristic feature of the E6 oncoproteins from cance...

journal_title：PLoS pathogens

authors： Ganti K,Massimi P,Manzo-Merino J,Tomaić V,Pim D,Playford MP,Lizano M,Roberts S,Kranjec C,Doorbar J,Banks L

更新日期：2016-09-20 00:00:00

abstract：:Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-anno...

journal_title：PLoS pathogens

authors： Cho Y,Srivastava A,Ohm RA,Lawrence CB,Wang KH,Grigoriev IV,Marahatta SP

更新日期：2012-01-01 00:00:00

abstract：:Metalloproteases (MPs) have demonstrated roles in immune modulation. In some cases, these enzymes are produced by parasites to influence host immune responses such that parasite infection is facilitated. One of the best examples of parasite-mediated immune modulation is the matrix metalloprotease (MMP) leishmanolysin ...

journal_title：PLoS pathogens

authors： Hambrook JR,Kaboré AL,Pila EA,Hanington PC

更新日期：2018-10-29 00:00:00

abstract：:The Ras-GAP SH3 domain-binding proteins (G3BP) are essential regulators of the formation of stress granules (SG), cytosolic aggregates of proteins and RNA that are induced upon cellular stress, such as virus infection. Many viruses, including Semliki Forest virus (SFV), block SG induction by targeting G3BP. In this wo...

journal_title：PLoS pathogens

authors： Panas MD,Schulte T,Thaa B,Sandalova T,Kedersha N,Achour A,McInerney GM

更新日期：2015-02-06 00:00:00

abstract：:Zaire ebolavirus (ZEBOV) causes severe hemorrhagic fever in humans and nonhuman primates, with fatality rates in humans of up to 90%. The molecular basis for the extreme virulence of ZEBOV remains elusive. While adult mice resist ZEBOV infection, the Mayinga strain of the virus has been adapted to cause lethal infecti...

journal_title：PLoS pathogens

authors： Ebihara H,Takada A,Kobasa D,Jones S,Neumann G,Theriault S,Bray M,Feldmann H,Kawaoka Y

更新日期：2006-07-01 00:00:00

abstract：:The neuraminidase (NA) inhibitor (NAI) oseltamivir (OST) is the most widely used influenza antiviral drug. Several NA amino acid substitutions are reported to reduce viral susceptibility to OST in in vitro assays. However, whether there is a correlation between the level of reduction in susceptibility in vitro and the...

journal_title：PLoS pathogens

authors： Farrukee R,Tai CM,Oh DY,Anderson DE,Gunalan V,Hibberd M,Lau GY,Barr IG,Messling VV,Maurer-Stroh S,Hurt AC

更新日期：2020-06-18 00:00:00

abstract：:Virus-like particles (VLPs) have not been observed in Caenorhabditis germ cells, although nematode genomes contain low numbers of retrotransposon and retroviral sequences. We used electron microscopy to search for VLPs in various wild strains of Caenorhabditis, and observed very rare candidate VLPs in some strains, in...

journal_title：PLoS pathogens

authors： Dennis S,Sheth U,Feldman JL,English KA,Priess JR

更新日期：2012-01-01 00:00:00

abstract：:DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis showed an altered leuk...

journal_title：PLoS pathogens

authors： Szappanos D,Tschismarov R,Perlot T,Westermayer S,Fischer K,Platanitis E,Kallinger F,Novatchkova M,Lassnig C,Müller M,Sexl V,Bennett KL,Foong-Sobis M,Penninger JM,Decker T

更新日期：2018-11-26 00:00:00

abstract：:The life long relationship between herpes simplex virus and its host hinges on the ability of the virus to aggressively replicate in epithelial cells at the site of infection and transport into the nervous system through axons innervating the infection site. Interaction between the virus and the sensory neuron represe...

journal_title：PLoS pathogens

authors： Sawtell NM,Thompson RL

更新日期：2016-09-08 00:00:00

abstract：:Antibody-dependent enhancement (ADE) of Ebola virus (EBOV) infection has been demonstrated in vitro, raising concerns about the detrimental potential of some anti-EBOV antibodies. ADE has been described for many viruses and mostly depends on the cross-linking of virus-antibody complexes to cell surface Fc receptors, l...

journal_title：PLoS pathogens

authors： Furuyama W,Marzi A,Carmody AB,Maruyama J,Kuroda M,Miyamoto H,Nanbo A,Manzoor R,Yoshida R,Igarashi M,Feldmann H,Takada A

更新日期：2016-12-30 00:00:00

abstract：:The macrophage is the primary host cell for the fungal pathogen Histoplasma capsulatum during mammalian infections, yet little is known about fungal genes required for intracellular replication in the host. Since the ability to scavenge iron from the host is important for the virulence of most pathogens, we investigat...

journal_title：PLoS pathogens

authors： Hwang LH,Mayfield JA,Rine J,Sil A

更新日期：2008-04-11 00:00:00

abstract：:The structure of the infectious prion protein (PrPSc), which is responsible for Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy, has escaped all attempts at elucidation due to its insolubility and propensity to aggregate. PrPSc replicates by converting the non-infectious, cellular prion protei...

journal_title：PLoS pathogens

authors： Vázquez-Fernández E,Vos MR,Afanasyev P,Cebey L,Sevillano AM,Vidal E,Rosa I,Renault L,Ramos A,Peters PJ,Fernández JJ,van Heel M,Young HS,Requena JR,Wille H

更新日期：2016-09-08 00:00:00

abstract：:Pneumonic plague is a fatal disease caused by Yersinia pestis that is associated with a delayed immune response in the lungs. Because neutrophils are the first immune cells recruited to sites of infection, we investigated the mechanisms responsible for their delayed homing to the lung. During the first 24 hr after pul...

journal_title：PLoS pathogens

authors： Vagima Y,Zauberman A,Levy Y,Gur D,Tidhar A,Aftalion M,Shafferman A,Mamroud E

更新日期：2015-05-14 00:00:00

abstract：:Enterovirus 71 (EV71) is the most virulent pathogen among enteroviruses that cause hand, foot and mouth disease in children but rarely in adults. The mechanisms that determine the age-dependent susceptibility remain largely unclear. Here, we found that the paucity of invariant natural killer T (iNKT) cells together wi...

journal_title：PLoS pathogens

authors： Zhu K,Yang J,Luo K,Yang C,Zhang N,Xu R,Chen J,Jin M,Xu B,Guo N,Wang J,Chen Z,Cui Y,Zhao H,Wang Y,Deng C,Bai L,Ge B,Qin CF,Shen H,Yang CF,Leng Q

更新日期：2015-01-23 00:00:00

abstract：:Hepatitis C virus (HCV) and human pegivirus (HPgV), formerly GBV-C, are the only known human viruses in the Hepacivirus and Pegivirus genera, respectively, of the family Flaviviridae. We present the discovery of a second pegivirus, provisionally designated human pegivirus 2 (HPgV-2), by next-generation sequencing of p...

journal_title：PLoS pathogens

authors： Berg MG,Lee D,Coller K,Frankel M,Aronsohn A,Cheng K,Forberg K,Marcinkus M,Naccache SN,Dawson G,Brennan C,Jensen DM,Hackett J Jr,Chiu CY

更新日期：2015-12-11 00:00:00

abstract：:The ability of pathogens to escape the host's immune response is crucial for the establishment of persistent infections and can influence virulence. Recombination has been observed to contribute to this process by generating novel genetic variants. Although distinctive recombination patterns have been described in man...

journal_title：PLoS pathogens

authors： Simon-Loriere E,Galetto R,Hamoudi M,Archer J,Lefeuvre P,Martin DP,Robertson DL,Negroni M

更新日期：2009-05-01 00:00:00

abstract：:There are 25 auxin response factors (ARFs) in the rice genome, which play critical roles in regulating myriad aspects of plant development, but their role (s) in host antiviral immune defense and the underneath mechanism remain largely unknown. By using the rice-rice dwarf virus (RDV) model system, here we report that...

journal_title：PLoS pathogens

authors： Qin Q,Li G,Jin L,Huang Y,Wang Y,Wei C,Xu Z,Yang Z,Wang H,Li Y

更新日期：2020-12-02 00:00:00

abstract：:Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV infection of CD4+ T cells-by up to 37-fold...

journal_title：PLoS pathogens

authors： Neidleman JA,Chen JC,Kohgadai N,Müller JA,Laustsen A,Thavachelvam K,Jang KS,Stürzel CM,Jones JJ,Ochsenbauer C,Chitre A,Somsouk M,Garcia MM,Smith JF,Greenblatt RM,Münch J,Jakobsen MR,Giudice LC,Greene WC,Roan NR

更新日期：2017-02-16 00:00:00

abstract：:In order to complete their life cycle, papillomaviruses have evolved to manipulate a plethora of cellular pathways. The products of the human Alphapapillomavirus E6 proteins specifically interact with and target PDZ containing proteins for degradation. This viral phenotype has been suggested to play a role in viral on...

journal_title：PLoS pathogens

authors： Van Doorslaer K,DeSalle R,Einstein MH,Burk RD

更新日期：2015-06-18 00:00:00

abstract：:Metabolomics coupled with heavy-atom isotope-labelled glucose has been used to probe the metabolic pathways active in cultured bloodstream form trypomastigotes of Trypanosoma brucei, a parasite responsible for human African trypanosomiasis. Glucose enters many branches of metabolism beyond glycolysis, which has been w...

journal_title：PLoS pathogens

authors： Creek DJ,Mazet M,Achcar F,Anderson J,Kim DH,Kamour R,Morand P,Millerioux Y,Biran M,Kerkhoven EJ,Chokkathukalam A,Weidt SK,Burgess KE,Breitling R,Watson DG,Bringaud F,Barrett MP

更新日期：2015-03-16 00:00:00

abstract：:Parasitic nematodes infect over 1 billion people worldwide and cause some of the most common neglected tropical diseases. Despite their prevalence, our understanding of the biology of parasitic nematodes has been limited by the lack of tools for genetic intervention. In particular, it has not yet been possible to gene...

journal_title：PLoS pathogens

authors： Gang SS,Castelletto ML,Bryant AS,Yang E,Mancuso N,Lopez JB,Pellegrini M,Hallem EA

更新日期：2017-10-10 00:00:00

abstract：:Bdellovibrio bacteriovorus is a Delta-proteobacterium that oscillates between free-living growth and predation on Gram-negative bacteria including important pathogens of man, animals and plants. After entering the prey periplasm, killing the prey and replicating inside the prey bdelloplast, several motile B. bacteriov...

journal_title：PLoS pathogens

authors： Hobley L,Fung RK,Lambert C,Harris MA,Dabhi JM,King SS,Basford SM,Uchida K,Till R,Ahmad R,Aizawa S,Gomelsky M,Sockett RE

更新日期：2012-02-01 00:00:00

abstract：:A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the expression of surf...

journal_title：PLoS pathogens

authors： Ogbechi J,Ruf MT,Hall BS,Bodman-Smith K,Vogel M,Wu HL,Stainer A,Esmon CT,Ahnström J,Pluschke G,Simmonds RE

更新日期：2015-07-16 00:00:00

abstract：:Community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) is a socially problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is more virulent than hospital associated-MRSA (HA-MRSA). The underlying mechanism for the high virulence of CA-MRSA is not known. The transcript...

journal_title：PLoS pathogens

authors： Kaito C,Saito Y,Ikuo M,Omae Y,Mao H,Nagano G,Fujiyuki T,Numata S,Han X,Obata K,Hasegawa S,Yamaguchi H,Inokuchi K,Ito T,Hiramatsu K,Sekimizu K

更新日期：2013-01-01 00:00:00

abstract：:The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a major barrier to the design of vaccines and therapeutic approaches to prevent infection or limit disease. This deficit...

journal_title：PLoS pathogens

authors： Graham JB,Swarts JL,Leist SR,Schäfer A,Menachery VD,Gralinski LE,Jeng S,Miller DR,Mooney MA,McWeeney SK,Ferris MT,Pardo-Manuel de Villena F,Heise MT,Baric RS,Lund JM

更新日期：2021-01-29 00:00:00

abstract：:The process by which drug-resistant HIV-1 arises and spreads spatially within an infected individual is poorly understood. Studies have found variable results relating how HIV-1 in the blood differs from virus sampled in tissues, offering conflicting findings about whether HIV-1 throughout the body is homogeneously di...

journal_title：PLoS pathogens

authors： Feder AF,Kline C,Polacino P,Cottrell M,Kashuba ADM,Keele BF,Hu SL,Petrov DA,Pennings PS,Ambrose Z

更新日期：2017-05-25 00:00:00