C. elegans germ cells show temperature and age-dependent expression of Cer1, a Gypsy/Ty3-related retrotransposon.

abstract：:Successful infection of the host requires secretion of effector proteins to evade or suppress plant immunity. Secretion of effectors in root-infecting fungal pathogens, however, remains unexplored. We previously reported that Verticillium dahliae, a root-infecting phytopathogenic fungus, develops a penetration peg fro...

journal_title：PLoS pathogens

authors： Zhou TT,Zhao YL,Guo HS

更新日期：2017-03-10 00:00:00

abstract：:Pomalidomide (Pom) is an immunomodulatory drug that has efficacy against Kaposi's sarcoma, a tumor caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Pom also induces direct cytotoxicity in primary effusion lymphoma (PEL), a B-cell malignancy caused by KSHV, in part through downregulation of IRF4, cMyc, and CK1...

journal_title：PLoS pathogens

authors： Shrestha P,Davis DA,Jaeger HK,Stream A,Aisabor AI,Yarchoan R

更新日期：2021-01-07 00:00:00

abstract：:Current understanding of adaptive immune, particularly T cell, responses to human rhinoviruses (RV) is limited. Memory T cells are thought to be of a primarily T helper 1 type, but both T helper 1 and T helper 2 memory cells have been described, and heightened T helper 2/ lessened T helper 1 responses have been associ...

journal_title：PLoS pathogens

authors： Glanville N,Peel TJ,Schröder A,Aniscenko J,Walton RP,Finotto S,Johnston SL

更新日期：2016-09-28 00:00:00

abstract：:Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathoge...

journal_title：PLoS pathogens

authors： Liu F,He CX,Luo LJ,Zou QL,Zhao YX,Saini R,Han SF,Knölker HJ,Wang LS,Ge BX

更新日期：2013-01-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-1 (TREM-1) is a potent amplifier of pro-inflammatory innate immune reactions. While TREM-1-amplified responses likely aid an improved detection and elimination of pathogens, excessive production of cytokines and oxygen radicals can also severely harm the host. Studies add...

journal_title：PLoS pathogens

authors： Weber B,Schuster S,Zysset D,Rihs S,Dickgreber N,Schürch C,Riether C,Siegrist M,Schneider C,Pawelski H,Gurzeler U,Ziltener P,Genitsch V,Tacchini-Cottier F,Ochsenbein A,Hofstetter W,Kopf M,Kaufmann T,Oxenius A,Reith W

更新日期：2014-01-01 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using ne...

journal_title：PLoS pathogens

authors： Soanes DM,Chakrabarti A,Paszkiewicz KH,Dawe AL,Talbot NJ

更新日期：2012-02-01 00:00:00

abstract：:Clonorchis sinensis is a carcinogenic human liver fluke, prolonged infection which provokes chronic inflammation, epithelial hyperplasia, periductal fibrosis, and even cholangiocarcinoma (CCA). These effects are driven by direct physical damage caused by the worms, as well as chemical irritation from their excretory-s...

journal_title：PLoS pathogens

authors： Won J,Cho Y,Lee D,Jeon BY,Ju JW,Chung S,Pak JH

更新日期：2019-05-23 00:00:00

abstract：:The whipworm Trichuris trichiura is a soil-transmitted helminth that dwells in the epithelium of the caecum and proximal colon of their hosts causing the human disease, trichuriasis. Trichuriasis is characterized by colitis attributed to the inflammatory response elicited by the parasite while tunnelling through intes...

journal_title：PLoS pathogens

authors： Duque-Correa MA,Karp NA,McCarthy C,Forman S,Goulding D,Sankaranarayanan G,Jenkins TP,Reid AJ,Cambridge EL,Ballesteros Reviriego C,Sanger Mouse Genetics Project.,3i consortium.,Müller W,Cantacessi C,Dougan G,Grencis RK,Ber

更新日期：2019-01-14 00:00:00

abstract：:Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh) signaling pathway is an early response to infection that is fundamental to the initiation of H. pylori-induced gastritis. H. pylori also induces programmed death lig...

journal_title：PLoS pathogens

authors： Holokai L,Chakrabarti J,Broda T,Chang J,Hawkins JA,Sundaram N,Wroblewski LE,Peek RM Jr,Wang J,Helmrath M,Wells JM,Zavros Y

更新日期：2019-01-31 00:00:00

abstract：:The ability of DENV2 to display different morphologies (hence different antigenic properties) complicates vaccine and therapeutics development. Previous studies showed most strains of laboratory adapted DENV2 particles changed from smooth to "bumpy" surfaced morphology when the temperature is switched from 29°C at 37°...

journal_title：PLoS pathogens

authors： Lim XN,Shan C,Marzinek JK,Dong H,Ng TS,Ooi JSG,Fibriansah G,Wang J,Verma CS,Bond PJ,Shi PY,Lok SM

更新日期：2019-09-19 00:00:00

abstract：:The double-stranded RNA-activated protein kinase R (PKR) is a key regulator of the innate immune response. Activation of PKR during viral infection culminates in phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2alpha) to inhibit protein translation. A broad range of regulator...

journal_title：PLoS pathogens

authors： Sadler AJ,Latchoumanin O,Hawkes D,Mak J,Williams BR

更新日期：2009-02-01 00:00:00

abstract：:Plants are constantly exposed to a large and diverse array of microbes; however, most plants are immune to the majority of potential invaders and susceptible to only a small subset of pathogens. The cytoskeleton comprises a dynamic intracellular framework that responds rapidly to biotic stresses and supports numerous ...

journal_title：PLoS pathogens

authors： Henty-Ridilla JL,Shimono M,Li J,Chang JH,Day B,Staiger CJ

更新日期：2013-01-01 00:00:00

abstract：:Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood. Here we investigated the molecular mechanism by which apoptosis induced vi...

journal_title：PLoS pathogens

authors： Rajalingam K,Sharma M,Paland N,Hurwitz R,Thieck O,Oswald M,Machuy N,Rudel T

更新日期：2006-10-01 00:00:00

abstract：:The Aspergillus fumigatus sterol regulatory element binding protein (SREBP) SrbA belongs to the basic Helix-Loop-Helix (bHLH) family of transcription factors and is crucial for antifungal drug resistance and virulence. The latter phenotype is especially striking, as loss of SrbA results in complete loss of virulence i...

journal_title：PLoS pathogens

authors： Chung D,Barker BM,Carey CC,Merriman B,Werner ER,Lechner BE,Dhingra S,Cheng C,Xu W,Blosser SJ,Morohashi K,Mazurie A,Mitchell TK,Haas H,Mitchell AP,Cramer RA

更新日期：2014-11-06 00:00:00

abstract：:Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity to interfere with th...

journal_title：PLoS pathogens

authors： Fleming P,Kvansakul M,Voigt V,Kile BT,Kluck RM,Huang DC,Degli-Esposti MA,Andoniou CE

更新日期：2013-02-01 00:00:00

abstract：:The virulence of Francisella tularensis, the etiological agent of tularemia, relies on an atypical type VI secretion system (T6SS) encoded by a genomic island termed the Francisella Pathogenicity Island (FPI). While the importance of the FPI in F. tularensis virulence is clearly established, the precise role of most o...

journal_title：PLoS pathogens

authors： Rigard M,Bröms JE,Mosnier A,Hologne M,Martin A,Lindgren L,Punginelli C,Lays C,Walker O,Charbit A,Telouk P,Conlan W,Terradot L,Sjöstedt A,Henry T

更新日期：2016-09-07 00:00:00

abstract：:HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti...

journal_title：PLoS pathogens

authors： Leslie GJ,Wang J,Richardson MW,Haggarty BS,Hua KL,Duong J,Secreto AJ,Jordon AP,Romano J,Kumar KE,DeClercq JJ,Gregory PD,June CH,Root MJ,Riley JL,Holmes MC,Hoxie JA

更新日期：2016-11-17 00:00:00

abstract：:African trypanosomes of the Trypanosoma brucei species are extra-cellular parasites that cause human African trypanosomiasis (HAT) as well as infections in game animals and livestock. Trypanosomes are known to evade the immune response of their mammalian host by continuous antigenic variation of their surface coat. He...

journal_title：PLoS pathogens

authors： Radwanska M,Guirnalda P,De Trez C,Ryffel B,Black S,Magez S

更新日期：2008-05-30 00:00:00

abstract：:The infectious form of the parasitic nematode Strongyloides stercoralis is a developmentally arrested third-stage larva (L3i), which is morphologically similar to the developmentally arrested dauer larva in the free-living nematode Caenorhabditis elegans. We hypothesize that the molecular pathways regulating C. elegan...

journal_title：PLoS pathogens

authors： Stoltzfus JD,Bart SM,Lok JB

更新日期：2014-07-10 00:00:00

abstract：:The virions of enteroviruses such as poliovirus undergo a global conformational change after binding to the cellular receptor, characterized by a 4% expansion, and by the opening of holes at the two and quasi-three-fold symmetry axes of the capsid. The resultant particle is called a 135S particle or A-particle and is ...

journal_title：PLoS pathogens

authors： Shah PNM,Filman DJ,Karunatilaka KS,Hesketh EL,Groppelli E,Strauss M,Hogle JM

更新日期：2020-09-30 00:00:00

abstract：:Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Nikolayevskyy V,Elkington PT,Hanifa Y,Islam K,Timms PM,Bothamley GH,Claxton AP,Packe GE,Darmalingam M,Davidson RN,Milburn HJ,Baker LV,Barker RD,Drobniewski FA,Mein CA,Bhaw-Rosun L,Nuamah RA,

更新日期：2013-01-01 00:00:00

abstract：:Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the lea...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-09 00:00:00

abstract：:The SUPPRESSOR OF rps4-RLD1 (SRFR1) gene was identified based on enhanced AvrRps4-triggered resistance in the naturally susceptible Arabidopsis accession RLD. No other phenotypic effects were recorded, and the extent of SRFR1 involvement in regulating effector-triggered immunity was unknown. Here we show that mutation...

journal_title：PLoS pathogens

authors： Kim SH,Gao F,Bhattacharjee S,Adiasor JA,Nam JC,Gassmann W

更新日期：2010-11-04 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) remains a major public health problem, with an effective vaccine continuing to prove elusive. Progress in vaccination strategies has been hampered by a lack of appreciation of the bacterium's response to dynamic changes in the host immune environment. Here, we utilize reporter Mtb stra...

journal_title：PLoS pathogens

authors： Sukumar N,Tan S,Aldridge BB,Russell DG

更新日期：2014-09-18 00:00:00

abstract：:Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env)...

journal_title：PLoS pathogens

authors： Del Prete GQ,Keele BF,Fode J,Thummar K,Swanstrom AE,Rodriguez A,Raymond A,Estes JD,LaBranche CC,Montefiori DC,KewalRamani VN,Lifson JD,Bieniasz PD,Hatziioannou T

更新日期：2017-09-25 00:00:00

abstract：:Peptides presentation to T cells by MHC class II molecules is of importance in initiation of immune response to a pathogen. The level of MHC II expression directly influences T lymphocyte activation and is often targeted by various viruses. Kaposi's sarcoma-associated herpesvirus (KSHV) encoded LANA is known to evade ...

journal_title：PLoS pathogens

authors： Cai Q,Banerjee S,Cervini A,Lu J,Hislop AD,Dzeng R,Robertson ES

更新日期：2013-10-01 00:00:00

abstract：:The progression of a natural bacterial infection is a dynamic process influenced by the physiological characteristics of the target organ. Recent developments in live animal imaging allow for the study of the dynamic microbe-host interplay in real-time as the infection progresses within an organ of a live host. Here w...

journal_title：PLoS pathogens

authors： Melican K,Sandoval RM,Kader A,Josefsson L,Tanner GA,Molitoris BA,Richter-Dahlfors A

更新日期：2011-02-01 00:00:00

abstract：:Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nucleus of coronavirus-infected cells, first, transcriptome dynamics was...

journal_title：PLoS pathogens

authors： Poppe M,Wittig S,Jurida L,Bartkuhn M,Wilhelm J,Müller H,Beuerlein K,Karl N,Bhuju S,Ziebuhr J,Schmitz ML,Kracht M

更新日期：2017-03-29 00:00:00

abstract：:Ecotin is a serine protease inhibitor produced by hundreds of microbial species, including pathogens. Here we show, that ecotin orthologs from Escherichia coli, Yersinia pestis, Pseudomonas aeruginosa and Leishmania major are potent inhibitors of MASP-1 and MASP-2, the two key activator proteases of the complement lec...

journal_title：PLoS pathogens

authors： Nagy ZA,Szakács D,Boros E,Héja D,Vígh E,Sándor N,Józsi M,Oroszlán G,Dobó J,Gál P,Pál G

更新日期：2019-12-20 00:00:00

abstract：:Yersinia utilizes a sophisticated type III secretion system to enhance its chances of survival and to overcome the host immune system. SmpB (small protein B) and SsrA (small stable RNA A) are components of a unique bacterial translational control system that help maintain the bacterial translational machinery in a ful...

journal_title：PLoS pathogens

authors： Okan NA,Bliska JB,Karzai AW

更新日期：2006-01-01 00:00:00