Exploitation of Mycobacterium tuberculosis reporter strains to probe the impact of vaccination at sites of infection.

abstract：:The prevalence of antibiotic resistance genes in pathogenic bacteria is a major challenge to treating many infectious diseases. The spread of these genes is driven by the strong selection imposed by the use of antibacterial drugs. However, in the absence of drug selection, antibiotic resistance genes impose a fitness ...

journal_title：PLoS pathogens

authors： Albarracín Orio AG,Piñas GE,Cortes PR,Cian MB,Echenique J

更新日期：2011-02-01 00:00:00

abstract：:Parasitic nematodes infect over 1 billion people worldwide and cause some of the most common neglected tropical diseases. Despite their prevalence, our understanding of the biology of parasitic nematodes has been limited by the lack of tools for genetic intervention. In particular, it has not yet been possible to gene...

journal_title：PLoS pathogens

authors： Gang SS,Castelletto ML,Bryant AS,Yang E,Mancuso N,Lopez JB,Pellegrini M,Hallem EA

更新日期：2017-10-10 00:00:00

abstract：:Vibrio parahaemolyticus is an emerging bacterial pathogen which colonizes the gastrointestinal tract and can cause severe enteritis and bacteraemia. During infection, V. parahaemolyticus primarily attaches to the small intestine, where it causes extensive tissue damage and compromises epithelial barrier integrity. We ...

journal_title：PLoS pathogens

authors： Lim J,Stones DH,Hawley CA,Watson CA,Krachler AM

更新日期：2014-09-25 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most virulent enteroviruses, but the specific molecular features that enhance its ability to disseminate in humans remain unknown. We analyzed the genomic features of EV71 in an immunocompromised host with disseminated disease according to the different sites of infection. Compariso...

journal_title：PLoS pathogens

authors： Cordey S,Petty TJ,Schibler M,Martinez Y,Gerlach D,van Belle S,Turin L,Zdobnov E,Kaiser L,Tapparel C

更新日期：2012-01-01 00:00:00

abstract：:Recombination, complementation and competition profoundly influence virus evolution and epidemiology. Since viruses are intracellular parasites, the basic parameter determining the potential for such interactions is the multiplicity of cellular infection (cellular MOI), i.e. the number of viral genome units that effec...

journal_title：PLoS pathogens

authors： Gutiérrez S,Yvon M,Thébaud G,Monsion B,Michalakis Y,Blanc S

更新日期：2010-09-16 00:00:00

abstract：:Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of muscle disorders. Whilst neurotoxin expression by the spore-formin...

journal_title：PLoS pathogens

authors： Zhang Z,Korkeala H,Dahlsten E,Sahala E,Heap JT,Minton NP,Lindström M

更新日期：2013-03-01 00:00:00

abstract：:The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pat...

journal_title：PLoS pathogens

authors： Bewley MA,Marriott HM,Tulone C,Francis SE,Mitchell TJ,Read RC,Chain B,Kroemer G,Whyte MK,Dockrell DH

更新日期：2011-01-27 00:00:00

abstract：:Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [P...

journal_title：PLoS pathogens

authors： Sáez-Cirión A,Bacchus C,Hocqueloux L,Avettand-Fenoel V,Girault I,Lecuroux C,Potard V,Versmisse P,Melard A,Prazuck T,Descours B,Guergnon J,Viard JP,Boufassa F,Lambotte O,Goujard C,Meyer L,Costagliola D,Venet A,Pancin

更新日期：2013-03-01 00:00:00

abstract：:Highly pathogenic avian influenza A viruses (HPAIV) of the H5N1 subtype occasionally transmit from birds to humans and can cause severe systemic infections in both hosts. PB1-F2 is an alternative translation product of the viral PB1 segment that was initially characterized as a pro-apoptotic mitochondrial viral pathog...

journal_title：PLoS pathogens

authors： Schmolke M,Manicassamy B,Pena L,Sutton T,Hai R,Varga ZT,Hale BG,Steel J,Pérez DR,García-Sastre A

更新日期：2011-08-01 00:00:00

abstract：:Interferon-γ (IFN-γ) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including human herpesviruses. Human N-myc interactor (Nmi) protein, which has been shown to interact with signal transducer and activator of transcription (STAT) proteins including ...

journal_title：PLoS pathogens

authors： Feng L,Sheng J,Vu GP,Liu Y,Foo C,Wu S,Trang P,Paliza-Carre M,Ran Y,Yang X,Sun X,Deng Z,Zhou T,Lu S,Li H,Liu F

更新日期：2018-01-29 00:00:00

abstract：:HIV-1 assembly and release are believed to occur at the plasma membrane in most host cells with the exception of primary macrophages, for which exclusive budding at late endosomes has been reported. Here, we applied a novel ultrastructural approach to assess HIV-1 budding in primary macrophages in an immunomarker-inde...

journal_title：PLoS pathogens

authors： Welsch S,Keppler OT,Habermann A,Allespach I,Krijnse-Locker J,Kräusslich HG

更新日期：2007-03-01 00:00:00

abstract：:Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutio...

journal_title：PLoS pathogens

authors： Deeg CM,Zimmer MM,George EE,Husnik F,Keeling PJ,Suttle CA

更新日期：2019-05-31 00:00:00

abstract：:This study investigated the role of prion infection of the olfactory mucosa in the shedding of prion infectivity into nasal secretions. Prion infection with the HY strain of the transmissible mink encephalopathy (TME) agent resulted in a prominent infection of the olfactory bulb and the olfactory sensory epithelium in...

journal_title：PLoS pathogens

authors： Bessen RA,Shearin H,Martinka S,Boharski R,Lowe D,Wilham JM,Caughey B,Wiley JA

更新日期：2010-04-15 00:00:00

abstract：:The function of Toll pathway defense against bacterial infection has been well established in shrimp, however how this pathway responds to viral infection is still largely unknown. In this study, we report the Toll4-Dorsal-AMPs cascade restricts the white spot syndrome virus (WSSV) infection of shrimp. A total of nine...

journal_title：PLoS pathogens

authors： Li H,Yin B,Wang S,Fu Q,Xiao B,Lǚ K,He J,Li C

更新日期：2018-09-26 00:00:00

abstract：:Increasing evidence suggests important roles for long noncoding RNAs (lncRNAs) as new gene modulators involved in various biological processes. However, the function roles of lncRNAs in lower vertebrates are still unknown. Here, we firstly identify a lncRNA, named MAVS antiviral-related lncRNA (MARL), as a key regulat...

journal_title：PLoS pathogens

authors： Chu Q,Xu T,Zheng W,Chang R,Zhang L

更新日期：2020-07-17 00:00:00

abstract：:The ascomycete fungus Fusarium graminearum causes stalk rot in maize. We tracked this pathogen's growth in wound-inoculated maize stalks using a fluorescence-labeled fungal isolate and observed that invasive hyphae grew intercellularly up to 24 h post inoculation, grew intra- and inter-cellularly between 36-48 h, and ...

journal_title：PLoS pathogens

authors： Zhang Y,He J,Jia LJ,Yuan TL,Zhang D,Guo Y,Wang Y,Tang WH

更新日期：2016-03-14 00:00:00

abstract：:Both iron starvation and excess are detrimental to cellular life, especially for animal and plant pathogens since they always live in iron-limited environments produced by host immune responses. However, how organisms sense and respond to iron is incompletely understood. Herein, we reveal that in the phytopathogenic b...

journal_title：PLoS pathogens

authors： Wang L,Pan Y,Yuan ZH,Zhang H,Peng BY,Wang FF,Qian W

更新日期：2016-12-30 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1002924.]. ...

journal_title：PLoS pathogens

authors： Grard G,Fair JN,Lee D,Slikas E,Steffen I,Muyembe JJ,Sittler T,Veeraraghavan N,Ruby JG,Wang C,Makuwa M,Mulembakani P,Tesh RB,Mazet J,Rimoin AW,Taylor T,Schneider BS,Simmons G,Delwart E,Wolfe ND,Chiu CY,Leroy EM

更新日期：2017-09-07 00:00:00

abstract：:Ebola virus disease afflicts both human and animal populations and is caused by four ebolaviruses. These different ebolaviruses may have distinct reservoir hosts and ecological contexts that determine how, where, and when different ebolavirus spillover events occur. Understanding these virus-specific relationships is ...

journal_title：PLoS pathogens

authors： Judson SD,Fischer R,Judson A,Munster VJ

更新日期：2016-08-05 00:00:00

abstract：:Effectors are molecules used by microbial pathogens to facilitate infection via effector-triggered susceptibility or tissue necrosis in their host. Much research has been focussed on the identification and elucidating the function of fungal effectors during plant pathogenesis. By comparison, knowledge of how phytopath...

journal_title：PLoS pathogens

authors： Tan KC,Oliver RP

更新日期：2017-04-20 00:00:00

abstract：:The intracellular pathogen Listeria monocytogenes is distinguished by its ability to invade and replicate within mammalian cells. Remarkably, of the 15 serovars within the genus, strains belonging to serovar 4b cause the majority of listeriosis clinical cases and outbreaks. The Listeria O-antigens are defined by subtl...

journal_title：PLoS pathogens

authors： Sumrall ET,Shen Y,Keller AP,Rismondo J,Pavlou M,Eugster MR,Boulos S,Disson O,Thouvenot P,Kilcher S,Wollscheid B,Cabanes D,Lecuit M,Gründling A,Loessner MJ

更新日期：2019-10-07 00:00:00

abstract：:The coordinated exit of intracellular pathogens from host cells is a process critical to the success and spread of an infection. While phospholipases have been shown to play important roles in bacteria host cell egress and virulence, their role in the release of intracellular eukaryotic parasites is largely unknown. W...

journal_title：PLoS pathogens

authors： Burda PC,Roelli MA,Schaffner M,Khan SM,Janse CJ,Heussler VT

更新日期：2015-03-18 00:00:00

abstract：:APE1 is a multifunctional protein with a DNA base excision repair function in its C-terminal domain and a redox activity in its N-terminal domain. The redox function of APE1 converts certain transcription factors from inactive oxidized to active reduced forms. Given that among the APE1-regulated transcription factors ...

journal_title：PLoS pathogens

authors： Zhong C,Xu M,Wang Y,Xu J,Yuan Y

更新日期：2017-04-05 00:00:00

abstract：:Hepatitis C virus (HCV) core protein is directed to the surface of lipid droplets (LD), a step that is essential for infectious virus production. However, the process by which core is recruited from LD into nascent virus particles is not well understood. To investigate the kinetics of core trafficking, we developed me...

journal_title：PLoS pathogens

authors： Counihan NA,Rawlinson SM,Lindenbach BD

更新日期：2011-10-01 00:00:00

abstract：:Wolbachia are maternally transmitted intracellular bacterial symbionts that infect approximately 40% of all insect species. Though several strains of Wolbachia naturally infect Drosophila melanogaster and provide resistance against viral pathogens, or provision metabolites during periods of nutritional stress, one vir...

journal_title：PLoS pathogens

authors： Rohrscheib CE,Frentiu FD,Horn E,Ritchie FK,van Swinderen B,Weible MW 2nd,O'Neill SL,Brownlie JC

更新日期：2016-09-23 00:00:00

abstract：:Since 2003, more than 380 cases of H5N1 influenza virus infection of humans have been reported. Although the resultant disease in these cases was often severe or fatal, transmission of avian influenza viruses between humans is rare. The precise nature of the barrier blocking human-to-human spread is unknown. It is cle...

journal_title：PLoS pathogens

authors： Steel J,Lowen AC,Mubareka S,Palese P

更新日期：2009-01-01 00:00:00

abstract：:The process by which drug-resistant HIV-1 arises and spreads spatially within an infected individual is poorly understood. Studies have found variable results relating how HIV-1 in the blood differs from virus sampled in tissues, offering conflicting findings about whether HIV-1 throughout the body is homogeneously di...

journal_title：PLoS pathogens

authors： Feder AF,Kline C,Polacino P,Cottrell M,Kashuba ADM,Keele BF,Hu SL,Petrov DA,Pennings PS,Ambrose Z

更新日期：2017-05-25 00:00:00

abstract：:Intracellular bacteria have evolved mechanisms that promote survival within hostile host environments, often resulting in functional dysregulation and disease. Using the Anaplasma phagocytophilum-infected granulocyte model, we establish a link between host chromatin modifications, defense gene transcription and intrac...

journal_title：PLoS pathogens

authors： Garcia-Garcia JC,Barat NC,Trembley SJ,Dumler JS

更新日期：2009-06-01 00:00:00

abstract：:Trichothecenes are a family of terpenoid toxins produced by multiple genera of fungi, including plant and insect pathogens. Some trichothecenes produced by the fungus Fusarium are among the mycotoxins of greatest concern to food and feed safety because of their toxicity and frequent occurrence in cereal crops, and tri...

journal_title：PLoS pathogens

authors： Proctor RH,McCormick SP,Kim HS,Cardoza RE,Stanley AM,Lindo L,Kelly A,Brown DW,Lee T,Vaughan MM,Alexander NJ,Busman M,Gutiérrez S

更新日期：2018-04-12 00:00:00

abstract：:Specific types of human papillomaviruses (HPVs) cause cervical cancer. Cervical cancers exhibit aberrant cellular microRNA (miRNA) expression patterns. By genome-wide analyses, we investigate whether the intracellular and exosomal miRNA compositions of HPV-positive cancer cells are dependent on endogenous E6/E7 oncoge...

journal_title：PLoS pathogens

authors： Honegger A,Schilling D,Bastian S,Sponagel J,Kuryshev V,Sültmann H,Scheffner M,Hoppe-Seyler K,Hoppe-Seyler F

更新日期：2015-03-11 00:00:00