Cellular Tracking and Gene Profiling of Fusarium graminearum during Maize Stalk Rot Disease Development Elucidates Its Strategies in Confronting Phosphorus Limitation in the Host Apoplast.

abstract：:In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory neurons. In humans, local opioids and opioid peptides significantly...

journal_title：PLoS pathogens

authors： Rittner HL,Hackel D,Voigt P,Mousa S,Stolz A,Labuz D,Schäfer M,Schaefer M,Stein C,Brack A

更新日期：2009-04-01 00:00:00

abstract：:The NLRP3 inflammasome has emerged as a central immune regulator that senses virulence factors expressed by microbial pathogens for triggering inflammation. Inflammation can be harmful and therefore this response must be tightly controlled. The mechanisms by which immune cells, such as macrophages, discriminate benign...

journal_title：PLoS pathogens

authors： Tucey TM,Verma J,Olivier FAB,Lo TL,Robertson AAB,Naderer T,Traven A

更新日期：2020-08-04 00:00:00

abstract：:Zika virus (ZIKV) infects pregnant women and causes devastating congenital zika syndrome (CZS). How the virus is vertically transmitted to the fetus and induces neuronal loss remains unclear. We previously reported that Pellino (Peli)1, an E3 ubiquitin ligase, promotes p38MAPK activation in microglia and induction of ...

journal_title：PLoS pathogens

authors： Luo H,Li G,Wang B,Tian B,Gao J,Zou J,Shi S,Zhu S,Peng BH,Adam A,Martinez A,Hein K,Winkelmann ER,Mahmoud Y,Zhou X,Shan C,Rossi S,Weaver S,Barrett ADT,Sun SC,Zhang W,Shi PY,Wu P,Wang T

更新日期：2020-06-16 00:00:00

abstract：:Endogenous retroviruses (ERVs) arise from retroviruses chromosomally integrated in the host germline. ERVs are common in vertebrate genomes and provide a valuable fossil record of past retroviral infections to investigate the biology and evolution of retroviruses over a deep time scale, including cross-species transmi...

journal_title：PLoS pathogens

authors： Zhuo X,Feschotte C

更新日期：2015-11-12 00:00:00

abstract：:PB1-F2 is a 90 amino acid protein that is expressed from the +1 open reading frame in the PB1 gene of some influenza A viruses and has been shown to contribute to viral pathogenicity. Notably, a serine at position 66 (66S) in PB1-F2 is known to increase virulence compared to an isogenic virus with an asparagine (66N) ...

journal_title：PLoS pathogens

authors： Varga ZT,Ramos I,Hai R,Schmolke M,García-Sastre A,Fernandez-Sesma A,Palese P

更新日期：2011-06-01 00:00:00

abstract：:RsaE is a conserved small regulatory RNA (sRNA) which was previously reported to represent a riboregulator of central carbon flow and other metabolic pathways in Staphylococcus aureus and Bacillus subtilis. Here we show that RsaE contributes to extracellular (e)DNA release and biofilm-matrix switching towards polysacc...

journal_title：PLoS pathogens

authors： Schoenfelder SMK,Lange C,Prakash SA,Marincola G,Lerch MF,Wencker FDR,Förstner KU,Sharma CM,Ziebuhr W

更新日期：2019-03-14 00:00:00

abstract：:Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease...

journal_title：PLoS pathogens

authors： Cui Y,Yu H,Zheng X,Peng R,Wang Q,Zhou Y,Wang R,Wang J,Qu B,Shen N,Guo Q,Liu X,Wang C

更新日期：2017-01-17 00:00:00

abstract：:The DNA deaminase APOBEC3G converts cytosines to uracils in retroviral cDNA, which are immortalized as genomic strand G-to-A hypermutations by reverse transcription. A single round of APOBEC3G-dependent mutagenesis can be catastrophic, but evidence suggests that sublethal levels contribute to viral genetic diversity a...

journal_title：PLoS pathogens

authors： Refsland EW,Hultquist JF,Harris RS

更新日期：2012-01-01 00:00:00

abstract：:Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate...

journal_title：PLoS pathogens

authors： Liang J,Sagum CA,Bedford MT,Sidhu SS,Sudol M,Han Z,Harty RN

更新日期：2017-01-11 00:00:00

abstract：:TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are often associated with the cellular antiviral response. In this report, we provide evidence that Kaposi's sarcoma-associated herpesvirus (KSHV) overcomes the host antiviral response by inhibition of SG formation via a viral lytic p...

journal_title：PLoS pathogens

authors： Sharma NR,Majerciak V,Kruhlak MJ,Zheng ZM

更新日期：2017-10-30 00:00:00

abstract：:The role of regulatory T cells (Tregs) in vaccination has been poorly investigated. We have reported that vaccination with ex vivo-generated dendritic-cells (DC) loaded with HIV-lipopeptides (LIPO-5-DC vaccine) in HIV-infected patients was well tolerated and highly immunogenic. These responses and their relation to vi...

journal_title：PLoS pathogens

authors： Brezar V,Ruffin N,Richert L,Surenaud M,Lacabaratz C,Palucka K,Thiébaut R,Banchereau J,Levy Y,Seddiki N

更新日期：2015-03-27 00:00:00

abstract：:Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacterial invasion mechanism. Its ectopic expression in eukaryotic cells inh...

journal_title：PLoS pathogens

authors： Patot S,Imbert PR,Baude J,Martins Simões P,Campergue JB,Louche A,Nijland R,Bès M,Tristan A,Laurent F,Fischer A,Schrenzel J,Vandenesch F,Salcedo SP,François P,Lina G

更新日期：2017-01-06 00:00:00

abstract：:Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the lea...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-09 00:00:00

abstract：:The widespread use of antibiotics is selecting for a variety of resistance mechanisms that seriously challenge our ability to treat bacterial infections. Resistant bacteria can be selected at the high concentrations of antibiotics used therapeutically, but what role the much lower antibiotic concentrations present in ...

journal_title：PLoS pathogens

authors： Gullberg E,Cao S,Berg OG,Ilbäck C,Sandegren L,Hughes D,Andersson DI

更新日期：2011-07-01 00:00:00

abstract：:Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-anno...

journal_title：PLoS pathogens

authors： Cho Y,Srivastava A,Ohm RA,Lawrence CB,Wang KH,Grigoriev IV,Marahatta SP

更新日期：2012-01-01 00:00:00

abstract：:Type I interferons (IFN) are important for antiviral responses. Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and mediate IFN production. Cytosolic 5'-ppp RNA and dsRNA are generated duri...

journal_title：PLoS pathogens

authors： Nikonov A,Mölder T,Sikut R,Kiiver K,Männik A,Toots U,Lulla A,Lulla V,Utt A,Merits A,Ustav M

更新日期：2013-01-01 00:00:00

abstract：:The high environmental adaptability of bacteria is contingent upon their ability to sense changes in their surroundings. Bacterial pathogen entry into host poses an abrupt and dramatic environmental change, during which successful pathogens gauge multiple parameters that signal host localization. The facultative human...

journal_title：PLoS pathogens

authors： Haber A,Friedman S,Lobel L,Burg-Golani T,Sigal N,Rose J,Livnat-Levanon N,Lewinson O,Herskovits AA

更新日期：2017-01-23 00:00:00

abstract：:Idiopathic chronic diarrhea (ICD) is a leading cause of morbidity amongst rhesus monkeys kept in captivity. Here, we show that exposure of affected animals to the whipworm Trichuris trichiura led to clinical improvement in fecal consistency, accompanied by weight gain, in four out of the five treated monkeys. By flow ...

journal_title：PLoS pathogens

authors： Broadhurst MJ,Ardeshir A,Kanwar B,Mirpuri J,Gundra UM,Leung JM,Wiens KE,Vujkovic-Cvijin I,Kim CC,Yarovinsky F,Lerche NW,McCune JM,Loke P

更新日期：2012-01-01 00:00:00

abstract：:Yersinia utilizes a sophisticated type III secretion system to enhance its chances of survival and to overcome the host immune system. SmpB (small protein B) and SsrA (small stable RNA A) are components of a unique bacterial translational control system that help maintain the bacterial translational machinery in a ful...

journal_title：PLoS pathogens

authors： Okan NA,Bliska JB,Karzai AW

更新日期：2006-01-01 00:00:00

abstract：:Plants and animals mediate early steps of the innate immune response through pathogen recognition receptors (PRRs). PRRs commonly associate with or contain members of a monophyletic group of kinases called the interleukin-1 receptor-associated kinase (IRAK) family that include Drosophila Pelle, human IRAKs, rice XA21 ...

journal_title：PLoS pathogens

authors： Dardick C,Ronald P

更新日期：2006-01-01 00:00:00

abstract：:Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To eluc...

journal_title：PLoS pathogens

authors： Hagiwara D,Miura D,Shimizu K,Paul S,Ohba A,Gonoi T,Watanabe A,Kamei K,Shintani T,Moye-Rowley WS,Kawamoto S,Gomi K

更新日期：2017-01-04 00:00:00

abstract：:Cardioviruses, including encephalomyocarditis virus (EMCV) and the human Saffold virus, are small non-enveloped viruses belonging to the Picornaviridae, a large family of positive-sense RNA [(+)RNA] viruses. All (+)RNA viruses remodel intracellular membranes into unique structures for viral genome replication. Accumul...

journal_title：PLoS pathogens

authors： Dorobantu CM,Albulescu L,Harak C,Feng Q,van Kampen M,Strating JR,Gorbalenya AE,Lohmann V,van der Schaar HM,van Kuppeveld FJ

更新日期：2015-09-25 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005032.]. ...

journal_title：PLoS pathogens

authors： Yelamanchili SV,Lamberty BG,Rennard DA,Morsey BM,Hochfelder CG,Meays BM,Levy E,Fox HS

更新日期：2018-05-14 00:00:00

abstract：:Ebolaviruses, highly lethal zoonotic pathogens, possess longer genomes than most other non-segmented negative-strand RNA viruses due in part to long 5' and 3' untranslated regions (UTRs) present in the seven viral transcriptional units. To date, specific functions have not been assigned to these UTRs. With reporter as...

journal_title：PLoS pathogens

authors： Shabman RS,Hoenen T,Groseth A,Jabado O,Binning JM,Amarasinghe GK,Feldmann H,Basler CF

更新日期：2013-01-01 00:00:00

abstract：:Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis (Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes siderophores, small molecules with high affinity for iron, and takes up iron-loaded mycobactins (MBT) and carboxymycobactins (cMBT), from the...

journal_title：PLoS pathogens

authors： Zhang L,Hendrickson RC,Meikle V,Lefkowitz EJ,Ioerger TR,Niederweis M

更新日期：2020-02-18 00:00:00

abstract：:PML (Promyelocytic Leukemia protein), also known as TRIM19, belongs to the family of tripartite motif (TRIM) proteins. PML is mainly expressed in the nucleus, where it forms dynamic structures known as PML nuclear bodies that recruit many other proteins, such as Sp100 and Daxx. While the role of PML/TRIM19 in antivira...

journal_title：PLoS pathogens

authors： Dutrieux J,Maarifi G,Portilho DM,Arhel NJ,Chelbi-Alix MK,Nisole S

更新日期：2015-11-13 00:00:00

abstract：:All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions between host receptors and parasite ligands that are localized in apical organelles called micronemes. Here, we identify...

journal_title：PLoS pathogens

authors： Dawn A,Singh S,More KR,Siddiqui FA,Pachikara N,Ramdani G,Langsley G,Chitnis CE

更新日期：2014-12-18 00:00:00

abstract：:Cytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary, that is characterised by accumulation and maintenance of high numbers of effector memory like cells in circulation and peripheral tissues-a feature being successfully harnessed for vaccine purposes. Although stability of this...

journal_title：PLoS pathogens

authors： Baumann NS,Torti N,Welten SPM,Barnstorf I,Borsa M,Pallmer K,Oduro JD,Cicin-Sain L,Ikuta K,Ludewig B,Oxenius A

更新日期：2018-04-13 00:00:00

abstract：:Interferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis; however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate the antiviral effect. A prominent family of ISGs is the interferon-induced with tetratricopeptide repeats (Ifit) genes comprising three mem...

journal_title：PLoS pathogens

authors： Fensterl V,Wetzel JL,Ramachandran S,Ogino T,Stohlman SA,Bergmann CC,Diamond MS,Virgin HW,Sen GC

更新日期：2012-01-01 00:00:00

abstract：:Both iron starvation and excess are detrimental to cellular life, especially for animal and plant pathogens since they always live in iron-limited environments produced by host immune responses. However, how organisms sense and respond to iron is incompletely understood. Herein, we reveal that in the phytopathogenic b...

journal_title：PLoS pathogens

authors： Wang L,Pan Y,Yuan ZH,Zhang H,Peng BY,Wang FF,Qian W

更新日期：2016-12-30 00:00:00