Tissue maintenance of CMV-specific inflationary memory T cells by IL-15.

abstract：:Plant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a...

journal_title：PLoS pathogens

authors： Warnock ND,Wilson L,Patten C,Fleming CC,Maule AG,Dalzell JJ

更新日期：2017-02-27 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:Bluetongue virus (BTV) causes hemorrhagic disease in economically important livestock. The BTV genome is organized into ten discrete double-stranded RNA molecules (S1-S10) which have been suggested to follow a sequential packaging pathway from smallest to largest segment during virus capsid assembly. To substantiate a...

journal_title：PLoS pathogens

authors： Fajardo T Jr,Sung PY,Roy P

更新日期：2015-12-08 00:00:00

abstract：:Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse). We identified approximately 20 TRIM proteins that, when transiently expressed in HE...

journal_title：PLoS pathogens

authors： Uchil PD,Quinlan BD,Chan WT,Luna JM,Mothes W

更新日期：2008-02-08 00:00:00

abstract：:Memory T cell inflation is a process in which a subset of cytomegalovirus (CMV) specific CD8 T cells continuously expands mainly during latent infection and establishes a large and stable population of effector memory cells in peripheral tissues. Here we set out to identify in vivo parameters that promote and limit CD...

journal_title：PLoS pathogens

authors： Baumann NS,Welten SPM,Torti N,Pallmer K,Borsa M,Barnstorf I,Oduro JD,Cicin-Sain L,Oxenius A

更新日期：2019-05-13 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1005822.]. ...

journal_title：PLoS pathogens

authors： Abdelrahman Y,Ouellette SP,Belland RJ,Cox JV

更新日期：2016-08-30 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today. In past years, studies on the entry of the virus into its host cell have led to the identification of a number of essential virus...

journal_title：PLoS pathogens

authors： Van Breedam W,Van Gorp H,Zhang JQ,Crocker PR,Delputte PL,Nauwynck HJ

更新日期：2010-01-15 00:00:00

abstract：:We have identified from the mutualistic grass endophyte Epichloë festucae a non-ribosomal peptide synthetase gene (sidN) encoding a siderophore synthetase. The enzymatic product of SidN is shown to be a novel extracellular siderophore designated as epichloënin A, related to ferrirubin from the ferrichrome family. Targ...

journal_title：PLoS pathogens

authors： Johnson LJ,Koulman A,Christensen M,Lane GA,Fraser K,Forester N,Johnson RD,Bryan GT,Rasmussen S

更新日期：2013-01-01 00:00:00

abstract：:Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directly regulating anti-micro...

journal_title：PLoS pathogens

authors： Tay HL,Kaiko GE,Plank M,Li J,Maltby S,Essilfie AT,Jarnicki A,Yang M,Mattes J,Hansbro PM,Foster PS

更新日期：2015-04-20 00:00:00

abstract：:The nervous and immune systems influence each other, allowing animals to rapidly protect themselves from changes in their internal and external environment. However, the complex nature of these systems in mammals makes it difficult to determine how neuronal signaling influences the immune response. Here we show that s...

journal_title：PLoS pathogens

authors： Anderson A,Laurenson-Schafer H,Partridge FA,Hodgkin J,McMullan R

更新日期：2013-01-01 00:00:00

abstract：:Glycolysis is a metabolic pathway that is central to the assimilation of carbon for either respiration or fermentation and therefore is critical for the growth of all organisms. Consequently, glycolytic transcriptional regulation is important for the metabolic flexibility of pathogens in their attempts to colonize div...

journal_title：PLoS pathogens

authors： Askew C,Sellam A,Epp E,Hogues H,Mullick A,Nantel A,Whiteway M

更新日期：2009-10-01 00:00:00

abstract：:Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of muscle disorders. Whilst neurotoxin expression by the spore-formin...

journal_title：PLoS pathogens

authors： Zhang Z,Korkeala H,Dahlsten E,Sahala E,Heap JT,Minton NP,Lindström M

更新日期：2013-03-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006551.]. ...

journal_title：PLoS pathogens

authors： Gidon A,Åsberg SE,Louet C,Ryan L,Haug M,Flo TH

更新日期：2017-11-07 00:00:00

abstract：:Certain pathogens deliver effectors into plant cells to modify host protein targets and thereby suppress immunity. These target modifications can be detected by intracellular immune receptors, or Resistance (R) proteins, that trigger strong immune responses including localized host cell death. The accelerated cell dea...

journal_title：PLoS pathogens

authors： Palma K,Thorgrimsen S,Malinovsky FG,Fiil BK,Nielsen HB,Brodersen P,Hofius D,Petersen M,Mundy J

更新日期：2010-10-07 00:00:00

abstract：:Plants have evolved pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) to protect themselves from infection by diverse pathogens. Avirulence (Avr) effectors that trigger plant ETI as a result of recognition by plant resistance (R) gene products have been identif...

journal_title：PLoS pathogens

authors： Dong S,Yin W,Kong G,Yang X,Qutob D,Chen Q,Kale SD,Sui Y,Zhang Z,Dou D,Zheng X,Gijzen M,Tyler BM,Wang Y

更新日期：2011-11-01 00:00:00

abstract：:Epigenetic mechanisms and chromatin structure play an important role in development. Their impact is therefore expected to be strong in parasites with complex life cycles and multiple, strikingly different, developmental stages, i.e. developmental plasticity. Some studies have already described how the chromatin struc...

journal_title：PLoS pathogens

authors： Roquis D,Taudt A,Geyer KK,Padalino G,Hoffmann KF,Holroyd N,Berriman M,Aliaga B,Chaparro C,Grunau C,Augusto RC

更新日期：2018-05-21 00:00:00

abstract：:Herpes simplex virus type 1 (HSV-1) latency in sensory ganglia such as trigeminal ganglia (TG) is associated with a persistent immune infiltrate that includes effector memory CD8+ T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8+ T cell repertoire, in which half of CD8+...

journal_title：PLoS pathogens

authors： Treat BR,Bidula SM,Ramachandran S,St Leger AJ,Hendricks RL,Kinchington PR

更新日期：2017-12-04 00:00:00

abstract：:We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes involved in detoxification processes, including oxidative stress response and metal ion homeostasis,...

journal_title：PLoS pathogens

authors： Soutourina O,Dubrac S,Poupel O,Msadek T,Martin-Verstraete I

更新日期：2010-05-13 00:00:00

abstract：:Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus that induces many cancers. N6-Methyladenosine (m6A) modification regulates many cellular processes. We explored the role of m6A in EBV gene regulation and associated cancers. We have comprehensively defined m6A modification of EBV latent and lytic transcripts. F...

journal_title：PLoS pathogens

authors： Lang F,Singh RK,Pei Y,Zhang S,Sun K,Robertson ES

更新日期：2019-06-21 00:00:00

abstract：:Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait we identified human polo-like kinase 2 (hPLK2), a member of cell cycl...

journal_title：PLoS pathogens

authors： Zurnic I,Hütter S,Rzeha U,Stanke N,Reh J,Müllers E,Hamann MV,Kern T,Gerresheim GK,Lindel F,Serrao E,Lesbats P,Engelman AN,Cherepanov P,Lindemann D

更新日期：2016-08-31 00:00:00

abstract：:Promyelocytic leukemia protein (PML) has antiviral functions and many viruses encode gene products that disrupt PML nuclear bodies (PML NBs). However, evidence of the relevance of PML NB modification for viral pathogenesis is limited and little is known about viral gene functions required for PML NB disruption in infe...

journal_title：PLoS pathogens

authors： Wang L,Oliver SL,Sommer M,Rajamani J,Reichelt M,Arvin AM

更新日期：2011-08-01 00:00:00

abstract：:Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrPSc. This effect has been associated with differences in folding of the aggregates,...

journal_title：PLoS pathogens

authors： Groveman BR,Raymond GJ,Campbell KJ,Race B,Raymond LD,Hughson AG,Orrú CD,Kraus A,Phillips K,Caughey B

更新日期：2017-09-14 00:00:00

abstract：:RNA interference (RNAi) pathways are widespread in metaozoans but the genes required show variable occurrence or activity in eukaryotic microbes, including many pathogens. While some Leishmania lack RNAi activity and Argonaute or Dicer genes, we show that Leishmania braziliensis and other species within the Leishmania...

journal_title：PLoS pathogens

authors： Lye LF,Owens K,Shi H,Murta SM,Vieira AC,Turco SJ,Tschudi C,Ullu E,Beverley SM

更新日期：2010-10-28 00:00:00

abstract：:Remodelling of the actin cytoskeleton in response to external stimuli is obligatory for many cellular processes in the amoebic cell. A rapid and local rearrangement of the actin cytoskeleton is required for the development of the cellular protrusions during phagocytosis, trogocytosis, migration, and invasion. Here, we...

journal_title：PLoS pathogens

authors： Tripathi A,Jain M,Chandra M,Parveen S,Yadav R,Collins BM,Maiti S,Datta S

更新日期：2020-05-04 00:00:00

abstract：:The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated with the RNA dependent RNA polymerase, the viral components of which are a large protein (L) and an accessory phosphoprotein (P). The 241 kDa L protein contains al...

journal_title：PLoS pathogens

authors： Tekes G,Rahmeh AA,Whelan SP

更新日期：2011-06-01 00:00:00

abstract：:Mycobacterium tuberculosis is sensitive to nitric oxide generated by inducible nitric oxide synthase (iNOS). Consequently, to ensure its survival in macrophages, M. tuberculosis inhibits iNOS recruitment to its phagosome by an unknown mechanism. Here we report the mechanism underlying this process, whereby mycobacteri...

journal_title：PLoS pathogens

authors： Davis AS,Vergne I,Master SS,Kyei GB,Chua J,Deretic V

更新日期：2007-12-01 00:00:00

abstract：:Inhalation of fungal spores (conidia) occurs commonly and, in specific circumstances, can result in invasive disease. We investigated the murine inflammatory response to conidia of Aspergillus fumigatus, the most common invasive mold in immunocompromised hosts. In contrast to dormant spores, germinating conidia induce...

journal_title：PLoS pathogens

authors： Hohl TM,Van Epps HL,Rivera A,Morgan LA,Chen PL,Feldmesser M,Pamer EG

更新日期：2005-11-01 00:00:00

abstract：:During immature capsid assembly, HIV-1 genome packaging is initiated when Gag first associates with unspliced HIV-1 RNA by a poorly understood process. Previously, we defined a pathway of sequential intracellular HIV-1 capsid assembly intermediates; here we sought to identify the intermediate in which HIV-1 Gag first ...

journal_title：PLoS pathogens

authors： Barajas BC,Tanaka M,Robinson BA,Phuong DJ,Chutiraka K,Reed JC,Lingappa JR

更新日期：2018-04-17 00:00:00

abstract：:Endogenous retroviruses (ERVs) arise from retroviruses chromosomally integrated in the host germline. ERVs are common in vertebrate genomes and provide a valuable fossil record of past retroviral infections to investigate the biology and evolution of retroviruses over a deep time scale, including cross-species transmi...

journal_title：PLoS pathogens

authors： Zhuo X,Feschotte C

更新日期：2015-11-12 00:00:00

abstract：:Candida albicans is the most frequent cause of oral fungal infections. However, the exact pathogenicity mechanisms that this fungus employs are largely unknown and many of the genes expressed during oral infection are uncharacterized. In this study we sought to functionally characterize 12 previously unknown function ...

journal_title：PLoS pathogens

authors： Mayer FL,Wilson D,Jacobsen ID,Miramón P,Große K,Hube B

更新日期：2012-01-01 00:00:00