The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner.

abstract：:Antigenic variation to evade host immunity has long been assumed to be a driving force of diversifying selection in pathogens. Colonization by Streptococcus pneumoniae, which is central to the organism's transmission and therefore evolution, is limited by two arms of the immune system: antibody- and T cell- mediated i...

journal_title：PLoS pathogens

authors： Li Y,Gierahn T,Thompson CM,Trzciński K,Ford CB,Croucher N,Gouveia P,Flechtner JB,Malley R,Lipsitch M

更新日期：2012-01-01 00:00:00

abstract：:Rice dwarf virus (RDV) replicates in and is transmitted by a leafhopper vector in a persistent-propagative manner. Previous cytopathologic and genetic data revealed that tubular structures, constructed by the nonstructural viral protein Pns10, contain viral particles and are directly involved in the intercellular spre...

journal_title：PLoS pathogens

authors： Chen Q,Chen H,Mao Q,Liu Q,Shimizu T,Uehara-Ichiki T,Wu Z,Xie L,Omura T,Wei T

更新日期：2012-01-01 00:00:00

abstract：:The root knot nematode, Meloidogyne incognita, is an obligate parasite that causes significant damage to a broad range of host plants. Infection is associated with secretion of proteins surrounded by proliferating cells. Many parasites are known to secrete effectors that interfere with plant innate immunity, enabling ...

journal_title：PLoS pathogens

authors： Bellafiore S,Shen Z,Rosso MN,Abad P,Shih P,Briggs SP

更新日期：2008-10-01 00:00:00

abstract：:Cyclic GMP-AMP (cGAMP) synthase (cGAS, a.k.a. MB21D1), a cytosolic DNA sensor, catalyzes formation of the second messenger 2'3'-cGAMP that activates the stimulator of interferon genes (STING) signaling. How the cGAS activity is modulated remains largely unknown. Here, we demonstrate that sentrin/SUMO-specific protease...

journal_title：PLoS pathogens

authors： Cui Y,Yu H,Zheng X,Peng R,Wang Q,Zhou Y,Wang R,Wang J,Qu B,Shen N,Guo Q,Liu X,Wang C

更新日期：2017-01-17 00:00:00

abstract：:Epstein-Barr virus (EBV) and related lymphocryptoviruses (LCV) from non-human primates infect B cells, transform their growth to facilitate life-long viral persistence in the host, and contribute to B cell oncogenesis. Co-evolution of LCV with their primate hosts has led to species-specificity so that LCVs preferentia...

journal_title：PLoS pathogens

authors： Mühe J,Wang F

更新日期：2017-12-20 00:00:00

abstract：:Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in...

journal_title：PLoS pathogens

authors： Huyse T,Webster BL,Geldof S,Stothard JR,Diaw OT,Polman K,Rollinson D

更新日期：2009-09-01 00:00:00

abstract：:Members of the major candidate phylum Dependentiae (a.k.a. TM6) are widespread across diverse environments from showerheads to peat bogs; yet, with the exception of two isolates infecting amoebae, they are only known from metagenomic data. The limited knowledge of their biology indicates that they have a long evolutio...

journal_title：PLoS pathogens

authors： Deeg CM,Zimmer MM,George EE,Husnik F,Keeling PJ,Suttle CA

更新日期：2019-05-31 00:00:00

abstract：:Magnaporthe oryzae, the fungus causing rice blast disease, should contend with host innate immunity to develop invasive hyphae (IH) within living host cells. However, molecular strategies to establish the biotrophic interactions are largely unknown. Here, we report the biological function of a M. oryzae-specific gene,...

journal_title：PLoS pathogens

authors： Nishimura T,Mochizuki S,Ishii-Minami N,Fujisawa Y,Kawahara Y,Yoshida Y,Okada K,Ando S,Matsumura H,Terauchi R,Minami E,Nishizawa Y

更新日期：2016-10-06 00:00:00

abstract：:The 14-3-3 molecular scaffolds promote type I interferon (IFN) responses by stabilizing the interaction of RIG-I with the TRIM25 ligase. Viruses have evolved unique strategies to halt this cellular response to support their replication and spread. Here, we report that the ubiquitin deconjugase (DUB) encoded in the N-t...

journal_title：PLoS pathogens

authors： Gupta S,Ylä-Anttila P,Sandalova T,Sun R,Achour A,Masucci MG

更新日期：2019-11-11 00:00:00

abstract：:Although the importance of humoral immunity to malaria has been established, factors that control antibody production are poorly understood. Follicular helper T cells (Tfh cells) are pivotal for generating high-affinity, long-lived antibody responses. While it has been proposed that expansion of antigen-specific Tfh c...

journal_title：PLoS pathogens

authors： Figueiredo MM,Costa PAC,Diniz SQ,Henriques PM,Kano FS,Tada MS,Pereira DB,Soares IS,Martins-Filho OA,Jankovic D,Gazzinelli RT,Antonelli LRDV

更新日期：2017-07-10 00:00:00

abstract：:Type I interferons (IFN) are important for antiviral responses. Melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-induced gene I (RIG-I) proteins detect cytosolic double-stranded RNA (dsRNA) or 5'-triphosphate (5'-ppp) RNA and mediate IFN production. Cytosolic 5'-ppp RNA and dsRNA are generated duri...

journal_title：PLoS pathogens

authors： Nikonov A,Mölder T,Sikut R,Kiiver K,Männik A,Toots U,Lulla A,Lulla V,Utt A,Merits A,Ustav M

更新日期：2013-01-01 00:00:00

abstract：:Infection with Mycobacterium tuberculosis is one of the leading causes of death worldwide. Recognition of M. tuberculosis by pattern recognition receptors is crucial for activation of both innate and adaptive immune responses. In the present study, we demonstrate that nucleotide-binding oligomerization domain 2 (NOD2)...

journal_title：PLoS pathogens

authors： Ferwerda G,Girardin SE,Kullberg BJ,Le Bourhis L,de Jong DJ,Langenberg DM,van Crevel R,Adema GJ,Ottenhoff TH,Van der Meer JW,Netea MG

更新日期：2005-11-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006551.]. ...

journal_title：PLoS pathogens

authors： Gidon A,Åsberg SE,Louet C,Ryan L,Haug M,Flo TH

更新日期：2017-11-07 00:00:00

abstract：:Plants have evolved pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) to protect themselves from infection by diverse pathogens. Avirulence (Avr) effectors that trigger plant ETI as a result of recognition by plant resistance (R) gene products have been identif...

journal_title：PLoS pathogens

authors： Dong S,Yin W,Kong G,Yang X,Qutob D,Chen Q,Kale SD,Sui Y,Zhang Z,Dou D,Zheng X,Gijzen M,Tyler BM,Wang Y

更新日期：2011-11-01 00:00:00

abstract：:The RNA synthesis machinery of vesicular stomatitis virus (VSV) comprises the genomic RNA encapsidated by the viral nucleocapsid protein (N) and associated with the RNA dependent RNA polymerase, the viral components of which are a large protein (L) and an accessory phosphoprotein (P). The 241 kDa L protein contains al...

journal_title：PLoS pathogens

authors： Tekes G,Rahmeh AA,Whelan SP

更新日期：2011-06-01 00:00:00

abstract：:The COVID-19 pandemic highlights the substantial public health, economic, and societal consequences of virus spillover from a wildlife reservoir. Widespread human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also presents a new set of challenges when considering viral spillover from peo...

journal_title：PLoS pathogens

authors： Olival KJ,Cryan PM,Amman BR,Baric RS,Blehert DS,Brook CE,Calisher CH,Castle KT,Coleman JTH,Daszak P,Epstein JH,Field H,Frick WF,Gilbert AT,Hayman DTS,Ip HS,Karesh WB,Johnson CK,Kading RC,Kingston T,Lorch JM,Mend

更新日期：2020-09-03 00:00:00

abstract：:Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral DNA, resulting in inh...

journal_title：PLoS pathogens

authors： Liang G,Liu G,Kitamura K,Wang Z,Chowdhury S,Monjurul AM,Wakae K,Koura M,Shimadu M,Kinoshita K,Muramatsu M

更新日期：2015-04-02 00:00:00

abstract：:Necrotrophic plant pathogens acquire nutrients from dead plant cells, which requires the disintegration of the plant cell wall and tissue structures by the pathogen. Infected plants lose tissue integrity and functional immunity as a result, exposing the nutrient rich, decayed tissues to the environment. One challenge ...

journal_title：PLoS pathogens

authors： Cui Z,Yang CH,Kharadi RR,Yuan X,Sundin GW,Triplett LR,Wang J,Zeng Q

更新日期：2019-08-05 00:00:00

abstract：:Trichothecenes are a family of terpenoid toxins produced by multiple genera of fungi, including plant and insect pathogens. Some trichothecenes produced by the fungus Fusarium are among the mycotoxins of greatest concern to food and feed safety because of their toxicity and frequent occurrence in cereal crops, and tri...

journal_title：PLoS pathogens

authors： Proctor RH,McCormick SP,Kim HS,Cardoza RE,Stanley AM,Lindo L,Kelly A,Brown DW,Lee T,Vaughan MM,Alexander NJ,Busman M,Gutiérrez S

更新日期：2018-04-12 00:00:00

abstract：:The strain designated Chlamydia trachomatis serovar that was used for experiments in this paper is Chlamydia muridarum, a species closely related to C. trachomatis (and formerly termed the Mouse Pneumonitis strain of C. trachomatis. [corrected]. The obligate intracellular pathogen Chlamydia trachomatis replicates with...

journal_title：PLoS pathogens

authors： Elwell CA,Jiang S,Kim JH,Lee A,Wittmann T,Hanada K,Melancon P,Engel JN

更新日期：2011-09-01 00:00:00

abstract：:The host response to mycobacterial infection depends on host and pathogen genetic factors. Recent studies in human populations suggest a strain specific genetic control of tuberculosis. To test for mycobacterial-strain specific genetic control of susceptibility to infection under highly controlled experimental conditi...

journal_title：PLoS pathogens

authors： Di Pietrantonio T,Hernandez C,Girard M,Verville A,Orlova M,Belley A,Behr MA,Loredo-Osti JC,Schurr E

更新日期：2010-10-28 00:00:00

abstract：:Flavivirus nonstructural protein 5 (NS5) consists of methyltransferase (MTase) and RNA-dependent RNA polymerase (RdRp) domains, which catalyze 5'-RNA capping/methylation and RNA synthesis, respectively, during viral genome replication. Although the crystal structure of flavivirus NS5 is known, no data about the quater...

journal_title：PLoS pathogens

authors： Klema VJ,Ye M,Hindupur A,Teramoto T,Gottipati K,Padmanabhan R,Choi KH

更新日期：2016-02-19 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:Influenza A virus (IAV) infection can be severe or even lethal in toddlers, the elderly and patients with certain medical conditions. Infection of apparently healthy individuals nonetheless accounts for many severe disease cases and deaths, suggesting that viruses with increased pathogenicity co-circulate with pandemi...

journal_title：PLoS pathogens

authors： Vasilijevic J,Zamarreño N,Oliveros JC,Rodriguez-Frandsen A,Gómez G,Rodriguez G,Pérez-Ruiz M,Rey S,Barba I,Pozo F,Casas I,Nieto A,Falcón A

更新日期：2017-10-12 00:00:00

abstract：:Cellular responses to Plasmodium falciparum parasites, in particular interferon-gamma (IFNγ) production, play an important role in anti-malarial immunity. However, clinical immunity to malaria develops slowly amongst naturally exposed populations, the dynamics of cellular responses in relation to exposure are difficul...

journal_title：PLoS pathogens

authors： Teirlinck AC,McCall MB,Roestenberg M,Scholzen A,Woestenenk R,de Mast Q,van der Ven AJ,Hermsen CC,Luty AJ,Sauerwein RW

更新日期：2011-12-01 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an attenuated double-stranded DNA poxvirus currently developed as a vaccine vector against HIV/AIDS. Profiling of the innate immune responses induced by MVA is essential for the design of vaccine vectors and for anticipating potential adverse interactions between naturally acqui...

journal_title：PLoS pathogens

authors： Delaloye J,Roger T,Steiner-Tardivel QG,Le Roy D,Knaup Reymond M,Akira S,Petrilli V,Gomez CE,Perdiguero B,Tschopp J,Pantaleo G,Esteban M,Calandra T

更新日期：2009-06-01 00:00:00

abstract：:Phytopathogenic ascomycete fungi possess huge effector repertoires that are dominated by hundreds of sequence-unrelated small secreted proteins. The molecular function of these effectors and the evolutionary mechanisms that generate this tremendous number of singleton genes are largely unknown. To get a deeper underst...

journal_title：PLoS pathogens

authors： de Guillen K,Ortiz-Vallejo D,Gracy J,Fournier E,Kroj T,Padilla A

更新日期：2015-10-27 00:00:00

abstract：:Dengue virus (DENV) is the leading cause of mosquito-borne viral illness and death in humans. Like many viruses, DENV has evolved potent mechanisms that abolish the antiviral response within infected cells. Nevertheless, several in vivo studies have demonstrated a key role of the innate immune response in controlling ...

journal_title：PLoS pathogens

authors： Décembre E,Assil S,Hillaire ML,Dejnirattisai W,Mongkolsapaya J,Screaton GR,Davidson AD,Dreux M

更新日期：2014-10-23 00:00:00

abstract：:Identification of the determinants of pathogen reservoir potential is central to understand disease emergence. It has been proposed that host lifespan is one such determinant: short-lived hosts will invest less in costly defenses against pathogens, so that they will be more susceptible to infection, more competent as ...

journal_title：PLoS pathogens

authors： Hily JM,García A,Moreno A,Plaza M,Wilkinson MD,Fereres A,Fraile A,García-Arenal F

更新日期：2014-11-06 00:00:00

abstract：:Cytomegalovirus (CMV) is a β-herpesvirus that establishes a lifelong latent or persistent infection. A hallmark of chronic CMV infection is the lifelong persistence of large numbers of virus-specific CD8+ effector/effector memory T cells, a phenomenon called "memory inflation". How the virus continuously stimulates th...

journal_title：PLoS pathogens

authors： Snyder CM,Cho KS,Bonnett EL,Allan JE,Hill AB

更新日期：2011-10-01 00:00:00