RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication.

abstract：:Herpes simplex virus type 1 (HSV-1) latency in sensory ganglia such as trigeminal ganglia (TG) is associated with a persistent immune infiltrate that includes effector memory CD8+ T cells that can influence HSV-1 reactivation. In C57BL/6 mice, HSV-1 induces a highly skewed CD8+ T cell repertoire, in which half of CD8+...

journal_title：PLoS pathogens

authors： Treat BR,Bidula SM,Ramachandran S,St Leger AJ,Hendricks RL,Kinchington PR

更新日期：2017-12-04 00:00:00

abstract：:Although the intracellular bacterium Listeria monocytogenes has an established predilection for disseminated infection during pregnancy that often results in spontaneous abortion or stillbirth, the specific host-pathogen interaction that dictates these disastrous complications remain incompletely defined. Herein, we d...

journal_title：PLoS pathogens

authors： Rowe JH,Ertelt JM,Xin L,Way SS

更新日期：2012-01-01 00:00:00

abstract：:Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we test...

journal_title：PLoS pathogens

authors： Burke CM,Mark KMK,Kun J,Beauchemin KS,Supattapone S

更新日期：2020-05-18 00:00:00

abstract：:The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. We therefore perform...

journal_title：PLoS pathogens

authors： Torrents de la Peña A,Rantalainen K,Cottrell CA,Allen JD,van Gils MJ,Torres JL,Crispin M,Sanders RW,Ward AB

更新日期：2019-07-15 00:00:00

abstract：:Chronic immune activation and progression to AIDS are observed after SIV infection in macaques but not in natural host primate species. To better understand this dichotomy, we compared acute pathogenic SIV infection in pigtailed macaques (PTs) to non-pathogenic infection in African green monkeys (AGMs). SIVagm-infecte...

journal_title：PLoS pathogens

authors： Favre D,Lederer S,Kanwar B,Ma ZM,Proll S,Kasakow Z,Mold J,Swainson L,Barbour JD,Baskin CR,Palermo R,Pandrea I,Miller CJ,Katze MG,McCune JM

更新日期：2009-02-01 00:00:00

abstract：:Mycobacterium abscessus is considered the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria. Infections with M. abscessus are increasingly found in patients with chronic lung diseases, especially cystic fibrosis, and are often refractory to antibiotic therapy. M. abscessus has two...

journal_title：PLoS pathogens

authors： Bernut A,Nguyen-Chi M,Halloum I,Herrmann JL,Lutfalla G,Kremer L

更新日期：2016-11-02 00:00:00

abstract：:My father was diagnosed with stomach cancer recently. Luckily, it was still at an early stage, and endoscopic surgery successfully took care of it. My father was fortunate; since people with stomach cancer do not show clear symptoms in the early stages, the disease is often not diagnosed until it becomes advanced. In ...

journal_title：PLoS pathogens

authors： Shinohara ML

更新日期：2017-08-10 00:00:00

abstract：:Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment sequelae, specifically post-kala-azar dermal leishmaniasis (PKDL). Nevertheless, ...

journal_title：PLoS pathogens

authors： Lewis MD,Paun A,Romano A,Langston H,Langner CA,Moore IN,Bock KW,Francisco AF,Brenchley JM,Sacks DL

更新日期：2020-04-13 00:00:00

abstract：:The virulence of Francisella tularensis, the etiological agent of tularemia, relies on an atypical type VI secretion system (T6SS) encoded by a genomic island termed the Francisella Pathogenicity Island (FPI). While the importance of the FPI in F. tularensis virulence is clearly established, the precise role of most o...

journal_title：PLoS pathogens

authors： Rigard M,Bröms JE,Mosnier A,Hologne M,Martin A,Lindgren L,Punginelli C,Lays C,Walker O,Charbit A,Telouk P,Conlan W,Terradot L,Sjöstedt A,Henry T

更新日期：2016-09-07 00:00:00

abstract：:The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in humans and other mammals, despite the development of potent host immune responses that constrain parasite numbers. The consistent, decades-long persistence of T. cruzi in human hosts arises at least in part from the remarkable level ...

journal_title：PLoS pathogens

authors： Wang W,Peng D,Baptista RP,Li Y,Kissinger JC,Tarleton RL

更新日期：2021-01-28 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed by the NS2 autopro...

journal_title：PLoS pathogens

authors： Isken O,Langerwisch U,Jirasko V,Rehders D,Redecke L,Ramanathan H,Lindenbach BD,Bartenschlager R,Tautz N

更新日期：2015-03-16 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1002924.]. ...

journal_title：PLoS pathogens

authors： Grard G,Fair JN,Lee D,Slikas E,Steffen I,Muyembe JJ,Sittler T,Veeraraghavan N,Ruby JG,Wang C,Makuwa M,Mulembakani P,Tesh RB,Mazet J,Rimoin AW,Taylor T,Schneider BS,Simmons G,Delwart E,Wolfe ND,Chiu CY,Leroy EM

更新日期：2017-09-07 00:00:00

abstract：:Host heterogeneity in disease transmission is widespread but precisely how different host traits drive this heterogeneity remains poorly understood. Part of the difficulty in linking individual variation to population-scale outcomes is that individual hosts can differ on multiple behavioral, physiological and immunolo...

journal_title：PLoS pathogens

authors： Siva-Jothy JA,Vale PF

更新日期：2021-01-19 00:00:00

abstract：:The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A major cause for this lack in effectiveness has been attributed to the egg-based vaccine production process. Substitutions on the hemagglutinin glycoprotein (HA...

journal_title：PLoS pathogens

authors： Wu NC,Zost SJ,Thompson AJ,Oyen D,Nycholat CM,McBride R,Paulson JC,Hensley SE,Wilson IA

更新日期：2017-10-23 00:00:00

abstract：:MicroRNAs (miRNAs) suppress the transcriptional and post-transcriptional expression of genes in plants. Several miRNA families target genes encoding nucleotide-binding site-leucine-rich repeat (NB-LRR) plant innate immune receptors. The fungus Fusarium oxysporum f. sp. lycopersici causes vascular wilt disease in tomat...

journal_title：PLoS pathogens

authors： Ouyang S,Park G,Atamian HS,Han CS,Stajich JE,Kaloshian I,Borkovich KA

更新日期：2014-10-16 00:00:00

abstract：:Ingested Vibrio cholerae pass through the stomach and colonize the small intestines of its host. Here, we show that V. cholerae requires at least two types of DNA repair systems to efficiently compete for colonization of the infant mouse intestine. These results show that V. cholerae experiences increased DNA damage i...

journal_title：PLoS pathogens

authors： Davies BW,Bogard RW,Dupes NM,Gerstenfeld TA,Simmons LA,Mekalanos JJ

更新日期：2011-02-01 00:00:00

abstract：:The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this process, we asked whether adaptation also required interference with the metabolic machinery of the host cell. Temporal profiling of the metabolic flux, in cells ...

journal_title：PLoS pathogens

authors： Mehrotra P,Jamwal SV,Saquib N,Sinha N,Siddiqui Z,Manivel V,Chatterjee S,Rao KV

更新日期：2014-07-24 00:00:00

abstract：:RANTES (CCL5) is a chemokine expressed by many hematopoietic and non-hematopoietic cell types that plays an important role in homing and migration of effector and memory T cells during acute infections. The RANTES receptor, CCR5, is a major target of anti-HIV drugs based on blocking viral entry. However, defects in RA...

journal_title：PLoS pathogens

authors： Crawford A,Angelosanto JM,Nadwodny KL,Blackburn SD,Wherry EJ

更新日期：2011-07-01 00:00:00

abstract：:The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation...

journal_title：PLoS pathogens

authors： Khurana S,Frasca D,Blomberg B,Golding H

更新日期：2012-09-01 00:00:00

abstract：:HIV-1 replicative capacity (RC) provides a measure of within-host fitness and is determined in the context of phenotypic drug resistance testing. However it is unclear how these in-vitro measurements relate to in-vivo processes. Here we assess RCs in a clinical setting by combining a previously published machine-learn...

journal_title：PLoS pathogens

authors： Kouyos RD,von Wyl V,Hinkley T,Petropoulos CJ,Haddad M,Whitcomb JM,Böni J,Yerly S,Cellerai C,Klimkait T,Günthard HF,Bonhoeffer S,Swiss HIV Cohort Study.

更新日期：2011-11-01 00:00:00

abstract：:Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral DNA, resulting in inh...

journal_title：PLoS pathogens

authors： Liang G,Liu G,Kitamura K,Wang Z,Chowdhury S,Monjurul AM,Wakae K,Koura M,Shimadu M,Kinoshita K,Muramatsu M

更新日期：2015-04-02 00:00:00

abstract：:Hepatitis C is a pandemic human RNA virus, which commonly causes chronic infection and liver disease. The characterization of viral populations that successfully initiate infection, and also those that drive progression to chronicity is instrumental for understanding pathogenesis and vaccine design. A comprehensive an...

journal_title：PLoS pathogens

authors： Bull RA,Luciani F,McElroy K,Gaudieri S,Pham ST,Chopra A,Cameron B,Maher L,Dore GJ,White PA,Lloyd AR

更新日期：2011-09-01 00:00:00

abstract：:Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. Several A. brassicicola genes have been characterized as affecting pathogenesis of Brassica species. To study regulatory mechanisms of pathogenesis, we mined 421 genes in silico encoding putative transcription factors in a machine-anno...

journal_title：PLoS pathogens

authors： Cho Y,Srivastava A,Ohm RA,Lawrence CB,Wang KH,Grigoriev IV,Marahatta SP

更新日期：2012-01-01 00:00:00

abstract：:Endemic Burkitt's lymphoma (eBL) arises from the germinal center (GC). It is a common tumor of young children in tropical Africa and its occurrence is closely linked geographically with the incidence of P. falciparum malaria. This association was noted more than 50 years ago. Since then we have learned that eBL contai...

journal_title：PLoS pathogens

authors： Torgbor C,Awuah P,Deitsch K,Kalantari P,Duca KA,Thorley-Lawson DA

更新日期：2014-05-29 00:00:00

abstract：:Paramyxoviruses are known to replicate in the cytoplasm and bud from the plasma membrane. Matrix is the major structural protein in paramyxoviruses that mediates viral assembly and budding. Curiously, the matrix proteins of a few paramyxoviruses have been found in the nucleus, although the biological function associat...

journal_title：PLoS pathogens

authors： Wang YE,Park A,Lake M,Pentecost M,Torres B,Yun TE,Wolf MC,Holbrook MR,Freiberg AN,Lee B

更新日期：2010-11-11 00:00:00

abstract：:Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate...

journal_title：PLoS pathogens

authors： Liang J,Sagum CA,Bedford MT,Sidhu SS,Sudol M,Han Z,Harty RN

更新日期：2017-01-11 00:00:00

abstract：:The primary role of cytoplasmic viral RNA-dependent RNA polymerase (RdRp) is viral genome replication in the cellular cytoplasm. However, picornaviral RdRp denoted 3D polymerase (3D(pol)) also enters the host nucleus, where its function remains unclear. In this study, we describe a novel mechanism of viral attack in w...

journal_title：PLoS pathogens

authors： Liu YC,Kuo RL,Lin JY,Huang PN,Huang Y,Liu H,Arnold JJ,Chen SJ,Wang RY,Cameron CE,Shih SR

更新日期：2014-06-26 00:00:00

abstract：:The mechanisms involved in the persistence of activated CD4+ T lymphocytes following primary human T leukemia/lymphoma virus type 1 (HTLV-1) infection remain unclear. Here, we demonstrate that the HTLV-1 Tax oncoprotein modulates phosphorylation and transcriptional activity of the FOXO3a transcription factor, via upst...

journal_title：PLoS pathogens

authors： Olagnier D,Sze A,Bel Hadj S,Chiang C,Steel C,Han X,Routy JP,Lin R,Hiscott J,van Grevenynghe J

更新日期：2014-12-18 00:00:00

abstract：:We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains ...

journal_title：PLoS pathogens

authors： Domingues S,Harms K,Fricke WF,Johnsen PJ,da Silva GJ,Nielsen KM

更新日期：2012-01-01 00:00:00

abstract：:Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed with a variety of functions, including the uptake and clearance of blood and lymph-borne pathogens, little is known about the effector mechanisms they employ aft...

journal_title：PLoS pathogens

authors： Phillips R,Svensson M,Aziz N,Maroof A,Brown N,Beattie L,Signoret N,Kaye PM

更新日期：2010-03-12 00:00:00