Emergence of prions selectively resistant to combination drug therapy.

abstract：:Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6-7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2, among other targets in neutrophils. SKAP2 functions in reactive oxy...

journal_title：PLoS pathogens

authors： Shaban L,Nguyen GT,Mecsas-Faxon BD,Swanson KD,Tan S,Mecsas J

更新日期：2020-05-11 00:00:00

abstract：:Host genetic variations play an important role in several pathogenic diseases, and we have previously provided strong evidences that these genetic variations contribute significantly to differences in susceptibility and clinical outcomes of invasive Group A Streptococcus (GAS) infections, including sepsis and necrotiz...

journal_title：PLoS pathogens

authors： Chella Krishnan K,Mukundan S,Alagarsamy J,Hur J,Nookala S,Siemens N,Svensson M,Hyldegaard O,Norrby-Teglund A,Kotb M

更新日期：2016-07-11 00:00:00

abstract：:Trypanosoma cruzi infection is characterized by chronic parasitism of non-lymphoid tissues and is rarely eliminated despite potent adaptive immune responses. This failure to cure has frequently been attributed to a loss or impairment of anti-T. cruzi T cell responses over time, analogous to the T cell dysfunction desc...

journal_title：PLoS pathogens

authors： Pack AD,Collins MH,Rosenberg CS,Tarleton RL

更新日期：2018-11-12 00:00:00

abstract：:The wide utilization of biocides poses a concern on the impact of these compounds on natural bacterial populations. Furthermore, it has been demonstrated that biocides can select, at least in laboratory experiments, antibiotic resistant bacteria. This situation has raised concerns, not just on scientists and clinician...

journal_title：PLoS pathogens

authors： Hernández A,Ruiz FM,Romero A,Martínez JL

更新日期：2011-06-01 00:00:00

abstract：:Human bocavirus 1 (HBoV1) belongs to the genus Bocaparvovirus of the Parvoviridae family, and is an emerging human pathogenic respiratory virus. In vitro, HBoV1 infects well-differentiated/polarized primary human airway epithelium (HAE) cultured at an air-liquid interface (HAE-ALI). Although it is well known that auto...

journal_title：PLoS pathogens

authors： Deng X,Yan Z,Cheng F,Engelhardt JF,Qiu J

更新日期：2016-01-14 00:00:00

abstract：:The extracellular bloodstream form parasite Trypanosoma brucei is supremely adapted to escape the host innate and adaptive immune system. Evasion is mediated through an antigenically variable Variant Surface Glycoprotein (VSG) coat, which is recycled at extraordinarily high rates. Blocking VSG synthesis triggers a pre...

journal_title：PLoS pathogens

authors： Cheung JL,Wand NV,Ooi CP,Ridewood S,Wheeler RJ,Rudenko G

更新日期：2016-11-28 00:00:00

abstract：:Viral infections of central nervous system (CNS) often trigger inflammatory responses that give rise to a wide range of pathological outcomes. The CNS is equipped with an elaborate network of innate immune sentinels (e.g. microglia, macrophages, dendritic cells) that routinely serve as first responders to these infect...

journal_title：PLoS pathogens

authors： Nayak D,Johnson KR,Heydari S,Roth TL,Zinselmeyer BH,McGavern DB

更新日期：2013-01-01 00:00:00

abstract：:Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that release their content upon host cell recognition. Dense granules are secreted in...

journal_title：PLoS pathogens

authors： Venugopal K,Chehade S,Werkmeister E,Barois N,Periz J,Lafont F,Tardieux I,Khalife J,Langsley G,Meissner M,Marion S

更新日期：2020-05-28 00:00:00

abstract：:Turnip yellow mosaic virus (TYMV)--a member of the alphavirus-like supergroup of viruses--serves as a model system for positive-stranded RNA virus membrane-bound replication. TYMV encodes a precursor replication polyprotein that is processed by the endoproteolytic activity of its internal cysteine proteinase domain (P...

journal_title：PLoS pathogens

authors： Lombardi C,Ayach M,Beaurepaire L,Chenon M,Andreani J,Guerois R,Jupin I,Bressanelli S

更新日期：2013-08-01 00:00:00

abstract：:Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce mTORC1 activation and the substrates regulated by mTORC1 during infl...

journal_title：PLoS pathogens

authors： Kuss-Duerkop SK,Wang J,Mena I,White K,Metreveli G,Sakthivel R,Mata MA,Muñoz-Moreno R,Chen X,Krammer F,Diamond MS,Chen ZJ,García-Sastre A,Fontoura BMA

更新日期：2017-09-27 00:00:00

abstract：:Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helminth infections induce polarised Th2 responses that may impair HIV vac...

journal_title：PLoS pathogens

authors： Dzhivhuho GA,Rehrl SA,Ndlovu H,Horsnell WGC,Brombacher F,Williamson AL,Chege GK

更新日期：2018-07-26 00:00:00

abstract：:Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrPSc. This effect has been associated with differences in folding of the aggregates,...

journal_title：PLoS pathogens

authors： Groveman BR,Raymond GJ,Campbell KJ,Race B,Raymond LD,Hughson AG,Orrú CD,Kraus A,Phillips K,Caughey B

更新日期：2017-09-14 00:00:00

abstract：:Gene expression of DNA viruses requires nuclear import of the viral genome. Human Adenoviruses (Ads), like most DNA viruses, encode factors within early transcription units promoting their own gene expression and counteracting cellular antiviral defense mechanisms. The cellular transcriptional repressor Daxx prevents ...

journal_title：PLoS pathogens

authors： Schreiner S,Martinez R,Groitl P,Rayne F,Vaillant R,Wimmer P,Bossis G,Sternsdorf T,Marcinowski L,Ruzsics Z,Dobner T,Wodrich H

更新日期：2012-02-01 00:00:00

abstract：:Unlike the pandemic form of HIV-1 (group M), group O viruses are endemic in west central Africa, especially in Cameroon. However, little is known about group O's genetic evolution, and why this highly divergent lineage has not become pandemic. Using a unique and large set of group O sequences from samples collected fr...

journal_title：PLoS pathogens

authors： Leoz M,Feyertag F,Kfutwah A,Mauclère P,Lachenal G,Damond F,De Oliveira F,Lemée V,Simon F,Robertson DL,Plantier JC

更新日期：2015-08-04 00:00:00

abstract：:Gut microbiota facilitate many aspects of human health and development, but dysbiotic microbiota can promote hyperplasia and inflammation and contribute to human diseases such as cancer. Human patients infected with the gastric cancer-causing bacterium Helicobacter pylori have altered microbiota; however, whether dysb...

journal_title：PLoS pathogens

authors： Jones TA,Hernandez DZ,Wong ZC,Wandler AM,Guillemin K

更新日期：2017-10-19 00:00:00

abstract：:The disease phenotype of bovine spongiform encephalopathy (BSE) and the molecular/ biological properties of its prion strain, including the host range and the characteristics of BSE-related disorders, have been extensively studied since its discovery in 1986. In recent years, systematic testing of the brains of cattle...

journal_title：PLoS pathogens

authors： Lombardi G,Casalone C,D' Angelo A,Gelmetti D,Torcoli G,Barbieri I,Corona C,Fasoli E,Farinazzo A,Fiorini M,Gelati M,Iulini B,Tagliavini F,Ferrari S,Caramelli M,Monaco S,Capucci L,Zanusso G

更新日期：2008-05-23 00:00:00

abstract：:Heme metabolism is central to malaria parasite biology. The parasite acquires heme from host hemoglobin in the intraerythrocytic stages and stores it as hemozoin to prevent free heme toxicity. The parasite can also synthesize heme de novo, and all the enzymes in the pathway are characterized. To study the role of the ...

journal_title：PLoS pathogens

authors： Nagaraj VA,Sundaram B,Varadarajan NM,Subramani PA,Kalappa DM,Ghosh SK,Padmanaban G

更新日期：2013-01-01 00:00:00

abstract：:Toxoplasma gondii and Hammondia hammondi are closely-related coccidian intracellular parasites that differ in their ability to cause disease in animal and (likely) humans. The role of the host response in these phenotypic differences is not known and to address this we performed a transcriptomic analysis of a monocyte...

journal_title：PLoS pathogens

authors： Wong ZS,Sokol-Borrelli SL,Olias P,Dubey JP,Boyle JP

更新日期：2020-06-23 00:00:00

abstract：:Next to the two-component and quorum sensing systems, cell-surface signaling (CSS) has been recently identified as an important regulatory system in Pseudomonas aeruginosa. CSS systems sense signals from outside the cell and transmit them into the cytoplasm. They generally consist of a TonB-dependent outer membrane re...

journal_title：PLoS pathogens

authors： Llamas MA,van der Sar A,Chu BC,Sparrius M,Vogel HJ,Bitter W

更新日期：2009-09-01 00:00:00

abstract：:Cholera, the pandemic diarrheal disease caused by the gram-negative bacterium Vibrio cholerae, continues to be a major public health challenge in the developing world. Cholera toxin, which is responsible for the voluminous stools of cholera, causes constitutive activation of adenylyl cyclase, resulting in the export o...

journal_title：PLoS pathogens

authors： Blow NS,Salomon RN,Garrity K,Reveillaud I,Kopin A,Jackson FR,Watnick PI

更新日期：2005-09-01 00:00:00

abstract：:Hospitalization of the elderly for invasive pneumococcal disease is frequently accompanied by the occurrence of an adverse cardiac event; these are primarily new or worsened heart failure and cardiac arrhythmia. Herein, we describe previously unrecognized microscopic lesions (microlesions) formed within the myocardium...

journal_title：PLoS pathogens

authors： Brown AO,Mann B,Gao G,Hankins JS,Humann J,Giardina J,Faverio P,Restrepo MI,Halade GV,Mortensen EM,Lindsey ML,Hanes M,Happel KI,Nelson S,Bagby GJ,Lorent JA,Cardinal P,Granados R,Esteban A,LeSaux CJ,Tuomanen EI,Or

更新日期：2014-09-18 00:00:00

abstract：:Marburg virus (family Filoviridae) causes sporadic outbreaks of severe hemorrhagic disease in sub-Saharan Africa. Bats have been implicated as likely natural reservoir hosts based most recently on an investigation of cases among miners infected in 2007 at the Kitaka mine, Uganda, which contained a large population of ...

journal_title：PLoS pathogens

authors： Amman BR,Carroll SA,Reed ZD,Sealy TK,Balinandi S,Swanepoel R,Kemp A,Erickson BR,Comer JA,Campbell S,Cannon DL,Khristova ML,Atimnedi P,Paddock CD,Crockett RJ,Flietstra TD,Warfield KL,Unfer R,Katongole-Mbidde E,Downin

更新日期：2012-01-01 00:00:00

abstract：:In host-pathogen interactions, the struggle for iron may have major consequences on the outcome of the disease. To overcome the low solubility and bio-availability of iron, bacteria have evolved multiple systems to acquire iron from various sources such as heme, hemoglobin and ferritin. The molecular basis of iron acq...

journal_title：PLoS pathogens

authors： Segond D,Abi Khalil E,Buisson C,Daou N,Kallassy M,Lereclus D,Arosio P,Bou-Abdallah F,Nielsen Le Roux C

更新日期：2014-02-13 00:00:00

abstract：:Both iron starvation and excess are detrimental to cellular life, especially for animal and plant pathogens since they always live in iron-limited environments produced by host immune responses. However, how organisms sense and respond to iron is incompletely understood. Herein, we reveal that in the phytopathogenic b...

journal_title：PLoS pathogens

authors： Wang L,Pan Y,Yuan ZH,Zhang H,Peng BY,Wang FF,Qian W

更新日期：2016-12-30 00:00:00

abstract：:RNA polyadenylation (pA) is one of the major steps in regulation of gene expression at the posttranscriptional level. In this report, a genome landscape of pA sites of viral transcripts in B lymphocytes with Kaposi sarcoma-associated herpesvirus (KSHV) infection was constructed using a modified PA-seq strategy. We ide...

journal_title：PLoS pathogens

authors： Majerciak V,Ni T,Yang W,Meng B,Zhu J,Zheng ZM

更新日期：2013-01-01 00:00:00

abstract：:The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A major cause for this lack in effectiveness has been attributed to the egg-based vaccine production process. Substitutions on the hemagglutinin glycoprotein (HA...

journal_title：PLoS pathogens

authors： Wu NC,Zost SJ,Thompson AJ,Oyen D,Nycholat CM,McBride R,Paulson JC,Hensley SE,Wilson IA

更新日期：2017-10-23 00:00:00

abstract：:Successful replication and transmission of large DNA viruses such as the cytomegaloviruses (CMV) family of viruses depends on the ability to interfere with multiple aspects of the host immune response. Apoptosis functions as a host innate defence mechanism against viral infection, and the capacity to interfere with th...

journal_title：PLoS pathogens

authors： Fleming P,Kvansakul M,Voigt V,Kile BT,Kluck RM,Huang DC,Degli-Esposti MA,Andoniou CE

更新日期：2013-02-01 00:00:00

abstract：:Toll-like receptor (TLR) ligands are being considered as adjuvants for the induction of antigen-specific immune responses, as in the design of vaccines. Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular receptors. Poly ICLC is a ...

journal_title：PLoS pathogens

authors： Stahl-Hennig C,Eisenblätter M,Jasny E,Rzehak T,Tenner-Racz K,Trumpfheller C,Salazar AM,Uberla K,Nieto K,Kleinschmidt J,Schulte R,Gissmann L,Müller M,Sacher A,Racz P,Steinman RM,Uguccioni M,Ignatius R

更新日期：2009-04-01 00:00:00

abstract：:Staphylococcus aureus USA300 strains cause a highly inflammatory necrotizing pneumonia. The virulence of this strain has been attributed to its expression of multiple toxins that have diverse targets including ADAM10, NLRP3 and CD11b. We demonstrate that induction of necroptosis through RIP1/RIP3/MLKL signaling is a m...

journal_title：PLoS pathogens

authors： Kitur K,Parker D,Nieto P,Ahn DS,Cohen TS,Chung S,Wachtel S,Bueno S,Prince A

更新日期：2015-04-16 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1006634.]. ...

journal_title：PLoS pathogens

authors： Walsh D

更新日期：2018-01-04 00:00:00