Correction: Correction: A Novel Rhabdovirus Associated with Acute Hemorrhagic Fever in Central Africa.

abstract：:Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination (DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, cellular stress responses lead to gene-specific transcription downstream of genes (DoG). In this study, we performed a detailed comp...

journal_title：PLoS pathogens

authors： Hennig T,Michalski M,Rutkowski AJ,Djakovic L,Whisnant AW,Friedl MS,Jha BA,Baptista MAP,L'Hernault A,Erhard F,Dölken L,Friedel CC

更新日期：2018-03-26 00:00:00

abstract：:Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection that remains generally asymptomatic but can also lead to leukemia or lymphoma. These viruses replicate by infecting new lymphocytes (i.e. the infectious cycle) or via clonal expansion of t...

journal_title：PLoS pathogens

authors： Gillet NA,Gutiérrez G,Rodriguez SM,de Brogniez A,Renotte N,Alvarez I,Trono K,Willems L

更新日期：2013-01-01 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an attenuated double-stranded DNA poxvirus currently developed as a vaccine vector against HIV/AIDS. Profiling of the innate immune responses induced by MVA is essential for the design of vaccine vectors and for anticipating potential adverse interactions between naturally acqui...

journal_title：PLoS pathogens

authors： Delaloye J,Roger T,Steiner-Tardivel QG,Le Roy D,Knaup Reymond M,Akira S,Petrilli V,Gomez CE,Perdiguero B,Tschopp J,Pantaleo G,Esteban M,Calandra T

更新日期：2009-06-01 00:00:00

abstract：:Extracellular vesicles (EV) mediate intercellular communication events and alterations in normal vesicle content contribute to function and disease initiation or progression. The ability to package a variety of cargo and transmit molecular information between cells renders EVs important mediators of cell-to-cell cross...

journal_title：PLoS pathogens

authors： Nkosi D,Sun L,Duke LC,Meckes DG Jr

更新日期：2020-12-31 00:00:00

abstract：:Rice tungro disease is caused by synergistic interaction of an RNA picorna-like virus Rice tungro spherical virus (RTSV) and a DNA pararetrovirus Rice tungro bacilliform virus (RTBV). It is spread by insects owing to an RTSV-encoded transmission factor. RTBV has evolved a ribosome shunt mechanism to initiate translati...

journal_title：PLoS pathogens

authors： Pooggin MM,Rajeswaran R,Schepetilnikov MV,Ryabova LA

更新日期：2012-01-01 00:00:00

abstract：:PML (Promyelocytic Leukemia protein), also known as TRIM19, belongs to the family of tripartite motif (TRIM) proteins. PML is mainly expressed in the nucleus, where it forms dynamic structures known as PML nuclear bodies that recruit many other proteins, such as Sp100 and Daxx. While the role of PML/TRIM19 in antivira...

journal_title：PLoS pathogens

authors： Dutrieux J,Maarifi G,Portilho DM,Arhel NJ,Chelbi-Alix MK,Nisole S

更新日期：2015-11-13 00:00:00

abstract：:Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrPSc. This effect has been associated with differences in folding of the aggregates,...

journal_title：PLoS pathogens

authors： Groveman BR,Raymond GJ,Campbell KJ,Race B,Raymond LD,Hughson AG,Orrú CD,Kraus A,Phillips K,Caughey B

更新日期：2017-09-14 00:00:00

abstract：:The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Helix at 2.3 Å resolut...

journal_title：PLoS pathogens

authors： Sabin C,Corti D,Buzon V,Seaman MS,Lutje Hulsik D,Hinz A,Vanzetta F,Agatic G,Silacci C,Mainetti L,Scarlatti G,Sallusto F,Weiss R,Lanzavecchia A,Weissenhorn W

更新日期：2010-11-18 00:00:00

abstract：:Herpesviruses persist indefinitely in their host through complex and poorly defined interactions that mediate latent, chronic or productive states of infection. Human cytomegalovirus (CMV or HCMV), a ubiquitous β-herpesvirus, coordinates the expression of two viral genes, UL135 and UL138, which have opposing roles in ...

journal_title：PLoS pathogens

authors： Buehler J,Zeltzer S,Reitsma J,Petrucelli A,Umashankar M,Rak M,Zagallo P,Schroeder J,Terhune S,Goodrum F

更新日期：2016-05-24 00:00:00

abstract：:Replication of viroids, small non-protein-coding plant pathogenic RNAs, entails reiterative transcription of their incoming single-stranded circular genomes, to which the (+) polarity is arbitrarily assigned, cleavage of the oligomeric strands of one or both polarities to unit-length, and ligation to circular RNAs. Wh...

journal_title：PLoS pathogens

authors： Gas ME,Hernández C,Flores R,Daròs JA

更新日期：2007-11-01 00:00:00

abstract：:We assessed the role of myeloid dendritic cells (mDCs) in the outcome of SIV infection by comparing and contrasting their frequency, mobilization, phenotype, cytokine production and apoptosis in pathogenic (pigtailed macaques, PTMs), nonpathogenic (African green monkeys, AGMs) and controlled (rhesus macaques, RMs) SIV...

journal_title：PLoS pathogens

authors： Wijewardana V,Kristoff J,Xu C,Ma D,Haret-Richter G,Stock JL,Policicchio BB,Mobley AD,Nusbaum R,Aamer H,Trichel A,Ribeiro RM,Apetrei C,Pandrea I

更新日期：2013-01-01 00:00:00

abstract：:Since 2003, more than 380 cases of H5N1 influenza virus infection of humans have been reported. Although the resultant disease in these cases was often severe or fatal, transmission of avian influenza viruses between humans is rare. The precise nature of the barrier blocking human-to-human spread is unknown. It is cle...

journal_title：PLoS pathogens

authors： Steel J,Lowen AC,Mubareka S,Palese P

更新日期：2009-01-01 00:00:00

abstract：:The nuclear lamina lines the inner nuclear membrane providing a structural framework for the nucleus. Cellular processes, such as nuclear envelope breakdown during mitosis or nuclear export of large ribonucleoprotein complexes, are functionally linked to the disassembly of the nuclear lamina. In general, lamina disass...

journal_title：PLoS pathogens

authors： Milbradt J,Hutterer C,Bahsi H,Wagner S,Sonntag E,Horn AH,Kaufer BB,Mori Y,Sticht H,Fossen T,Marschall M

更新日期：2016-08-24 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) are at the forefront of host-microbe interactions. Molecular and cell-based studies suggest that HSPG-pathogen interactions promote pathogenesis by facilitating microbial attachment and invasion of host cells. However, the specific identity of HSPGs, precise mechanisms by which HS...

journal_title：PLoS pathogens

authors： Aquino RS,Hayashida A,Park PW

更新日期：2020-05-26 00:00:00

abstract：:Adjunctive vitamin D treatment for pulmonary tuberculosis enhances resolution of inflammation but has modest effects on bacterial clearance. Sodium 4-phenylbutyrate (PBA) is in clinical use for a range of conditions and has been shown to synergise with vitamin D metabolites to upregulate cathelicidin antimicrobial pep...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Martineau AR

更新日期：2015-07-02 00:00:00

abstract：:This Pearl article recounts the story of a US corporation, Lennar, the nation's leading homebuilder, an essential function in the US (not allowed to lock down), when faced with the coronavirus disease 2019 (COVID-19) pandemic at the end of February 2020. The culture of the company, which allowed it to proceed safely, ...

journal_title：PLoS pathogens

authors： Goldschmidt-Clermont PJ

更新日期：2020-08-27 00:00:00

abstract：:Foot-and-mouth disease (FMD) virus causes an acute vesicular disease of domesticated and wild ruminants and pigs. Identifying sources of FMD outbreaks is often confounded by incomplete epidemiological evidence and the numerous routes by which virus can spread (movements of infected animals or their products, contamina...

journal_title：PLoS pathogens

authors： Cottam EM,Wadsworth J,Shaw AE,Rowlands RJ,Goatley L,Maan S,Maan NS,Mertens PP,Ebert K,Li Y,Ryan ED,Juleff N,Ferris NP,Wilesmith JW,Haydon DT,King DP,Paton DJ,Knowles NJ

更新日期：2008-04-18 00:00:00

abstract：:Ebolaviruses, highly lethal zoonotic pathogens, possess longer genomes than most other non-segmented negative-strand RNA viruses due in part to long 5' and 3' untranslated regions (UTRs) present in the seven viral transcriptional units. To date, specific functions have not been assigned to these UTRs. With reporter as...

journal_title：PLoS pathogens

authors： Shabman RS,Hoenen T,Groseth A,Jabado O,Binning JM,Amarasinghe GK,Feldmann H,Basler CF

更新日期：2013-01-01 00:00:00

abstract：:The wide utilization of biocides poses a concern on the impact of these compounds on natural bacterial populations. Furthermore, it has been demonstrated that biocides can select, at least in laboratory experiments, antibiotic resistant bacteria. This situation has raised concerns, not just on scientists and clinician...

journal_title：PLoS pathogens

authors： Hernández A,Ruiz FM,Romero A,Martínez JL

更新日期：2011-06-01 00:00:00

abstract：:Microbial pathogens often establish infection within particular niches of their host for replication. Determining how infection occurs preferentially in specific host tissues is a key aspect of understanding host-microbe interactions. Here, we describe the discovery of a natural microsporidian parasite of the nematode...

journal_title：PLoS pathogens

authors： Luallen RJ,Reinke AW,Tong L,Botts MR,Félix MA,Troemel ER

更新日期：2016-06-30 00:00:00

abstract：:Cerebrovascular dysfunction plays a key role in the pathogenesis of cerebral malaria. In experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA, cerebrovascular dysfunction characterized by vascular constriction, occlusion and damage results in impaired perfusion and reduced cerebral blood flow and oxy...

journal_title：PLoS pathogens

authors： Ong PK,Melchior B,Martins YC,Hofer A,Orjuela-Sánchez P,Cabrales P,Zanini GM,Frangos JA,Carvalho LJ

更新日期：2013-01-01 00:00:00

abstract：:Little is known about the role of viral genes in modulating host cytokine responses. Here we report a new functional role of the viral encoded IE1 protein of the murine cytomegalovirus in sculpting the inflammatory response in an acute infection. In time course experiments of infected primary macrophages (MΦs) measuri...

journal_title：PLoS pathogens

authors： Rodríguez-Martín S,Kropp KA,Wilhelmi V,Lisnic VJ,Hsieh WY,Blanc M,Livingston A,Busche A,Tekotte H,Messerle M,Auer M,Fraser I,Jonjic S,Angulo A,Reddehase MJ,Ghazal P

更新日期：2012-01-01 00:00:00

abstract：:Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of...

journal_title：PLoS pathogens

authors： Pont S,Fraikin N,Caspar Y,Van Melderen L,Attrée I,Cretin F

更新日期：2020-12-16 00:00:00

abstract：:Rift Valley fever virus (RVFV) (genus Phlebovirus, family Bunyaviridae) is a negative-stranded RNA virus with a tripartite genome. RVFV is transmitted by mosquitoes and causes fever and severe hemorrhagic illness among humans, and fever and high rates of abortions in livestock. A nonstructural RVFV NSs protein inhibit...

journal_title：PLoS pathogens

authors： Ikegami T,Narayanan K,Won S,Kamitani W,Peters CJ,Makino S

更新日期：2009-02-01 00:00:00

abstract：:[This corrects the article DOI: 10.1371/journal.ppat.1004331.]. ...

journal_title：PLoS pathogens

authors： PLOS Pathogens Staff.

更新日期：2015-02-19 00:00:00

abstract：:Host cells infected with obligate intracellular bacteria Chlamydia trachomatis are profoundly resistant to diverse apoptotic stimuli. The molecular mechanisms underlying the block in apoptotic signaling of infected cells is not well understood. Here we investigated the molecular mechanism by which apoptosis induced vi...

journal_title：PLoS pathogens

authors： Rajalingam K,Sharma M,Paland N,Hurwitz R,Thieck O,Oswald M,Machuy N,Rudel T

更新日期：2006-10-01 00:00:00

abstract：:Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. Sumoylation has roles in the control of protein stability, activity and localization, and is involved in the regulation of transcription, gene expr...

journal_title：PLoS pathogens

authors： Sloan E,Tatham MH,Groslambert M,Glass M,Orr A,Hay RT,Everett RD

更新日期：2015-07-22 00:00:00

abstract：:Immunocompromised individuals tend to suffer from influenza longer with more serious complications than otherwise healthy patients. Little is known about the impact of prolonged infection and the efficacy of antiviral therapy in these patients. Among all 189 influenza A virus infected immunocompromised patients admitt...

journal_title：PLoS pathogens

authors： van der Vries E,Stittelaar KJ,van Amerongen G,Veldhuis Kroeze EJ,de Waal L,Fraaij PL,Meesters RJ,Luider TM,van der Nagel B,Koch B,Vulto AG,Schutten M,Osterhaus AD

更新日期：2013-01-01 00:00:00

abstract：:The African sleeping sickness parasite Trypanosoma brucei evades the host immune system through antigenic variation of its variant surface glycoprotein (VSG) coat. Although the T. brucei genome contains ∼1500 VSGs, only one VSG is expressed at a time from one of about 15 subtelomeric VSG expression sites (ESs). For an...

journal_title：PLoS pathogens

authors： Povelones ML,Gluenz E,Dembek M,Gull K,Rudenko G

更新日期：2012-01-01 00:00:00

abstract：:Mycobacterium leprae, an obligate intracellular bacillus, infects Schwann cells (SCs), leading to peripheral nerve damage, the most severe leprosy symptom. In the present study, we revisited the involvement of phenolic glycolipid I (PGL I), an abundant, private, surface M. leprae molecule, in M. leprae-SC interaction ...

journal_title：PLoS pathogens

authors： Díaz Acosta CC,Dias AA,Rosa TLSA,Batista-Silva LR,Rosa PS,Toledo-Pinto TG,Costa FDMR,Lara FA,Rodrigues LS,Mattos KA,Sarno EN,Bozza PT,Guilhot C,de Berrêdo-Pinho M,Pessolani MCV

更新日期：2018-07-06 00:00:00