Transmission pathways of foot-and-mouth disease virus in the United Kingdom in 2007.

abstract：:In an effort to suppress microbial outgrowth, the host sequesters essential nutrients in a process termed nutritional immunity. However, inflammatory responses to bacterial insult can restore nutritional resources. Given that nutrient availability modulates virulence factor production and biofilm formation by other ba...

journal_title：PLoS pathogens

authors： Szelestey BR,Heimlich DR,Raffel FK,Justice SS,Mason KM

更新日期：2013-01-01 00:00:00

abstract：:Schistosomiasis is a disease of great medical and veterinary importance in tropical and subtropical regions, caused by parasitic flatworms of the genus Schistosoma (subclass Digenea). Following major water development schemes in the 1980s, schistosomiasis has become an important parasitic disease of children living in...

journal_title：PLoS pathogens

authors： Huyse T,Webster BL,Geldof S,Stothard JR,Diaw OT,Polman K,Rollinson D

更新日期：2009-09-01 00:00:00

abstract：:Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little is known about its possible wider regulatory role in this organism...

journal_title：PLoS pathogens

authors： De Majumdar S,Yu J,Fookes M,McAteer SP,Llobet E,Finn S,Spence S,Monahan A,Monaghan A,Kissenpfennig A,Ingram RJ,Bengoechea J,Gally DL,Fanning S,Elborn JS,Schneiders T

更新日期：2015-01-29 00:00:00

abstract：:The Herpes Simplex Virus 1 (HSV-1) glycoprotein gE-gI is a transmembrane Fc receptor found on the surface of infected cells and virions that binds human immunoglobulin G (hIgG). gE-gI can also participate in antibody bipolar bridging (ABB), a process by which the antigen-binding fragments (Fabs) of the IgG bind a vira...

journal_title：PLoS pathogens

authors： Ndjamen B,Farley AH,Lee T,Fraser SE,Bjorkman PJ

更新日期：2014-03-06 00:00:00

abstract：:Although invasive cytomegalovirus (CMV) disease is uncommon in the era of antiretroviral therapy (ART), asymptomatic CMV coinfection is nearly ubiquitous in HIV infected individuals. While microbial translocation and gut epithelial barrier dysfunction may promote persistent immune activation in treated HIV infection, ...

journal_title：PLoS pathogens

authors： Maidji E,Somsouk M,Rivera JM,Hunt PW,Stoddart CA

更新日期：2017-02-27 00:00:00

abstract：:Understanding the roles of neutrophils and macrophages in fighting bacterial infections is a critical issue in human pathologies. Although phagocytic killing has been extensively studied, little is known about how bacteria are eliminated extracellularly in live vertebrates. We have recently developed an infection mode...

journal_title：PLoS pathogens

authors： Phan QT,Sipka T,Gonzalez C,Levraud JP,Lutfalla G,Nguyen-Chi M

更新日期：2018-07-17 00:00:00

abstract：:Two-component signal transduction systems (TCS) are used by bacteria to sense and respond to their environment. TCS are typically composed of a sensor histidine kinase (HK) and a response regulator (RR). The Vibrio cholerae genome encodes 52 RR, but the role of these RRs in V. cholerae pathogenesis is largely unknown....

journal_title：PLoS pathogens

authors： Cheng AT,Ottemann KM,Yildiz FH

更新日期：2015-05-22 00:00:00

abstract：:All pathogenesis and death associated with Plasmodium falciparum malaria is due to parasite-infected erythrocytes. Invasion of erythrocytes by P. falciparum merozoites requires specific interactions between host receptors and parasite ligands that are localized in apical organelles called micronemes. Here, we identify...

journal_title：PLoS pathogens

authors： Dawn A,Singh S,More KR,Siddiqui FA,Pachikara N,Ramdani G,Langsley G,Chitnis CE

更新日期：2014-12-18 00:00:00

abstract：:The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify the ancestry of titan c...

journal_title：PLoS pathogens

authors： Hommel B,Mukaremera L,Cordero RJB,Coelho C,Desjardins CA,Sturny-Leclère A,Janbon G,Perfect JR,Fraser JA,Casadevall A,Cuomo CA,Dromer F,Nielsen K,Alanio A

更新日期：2018-05-18 00:00:00

abstract：:Leishmania donovani causes visceral leishmaniasis (VL), which is typically fatal without treatment. There is substantial variation between individuals in rates of disease progression, response to treatment and incidence of post-treatment sequelae, specifically post-kala-azar dermal leishmaniasis (PKDL). Nevertheless, ...

journal_title：PLoS pathogens

authors： Lewis MD,Paun A,Romano A,Langston H,Langner CA,Moore IN,Bock KW,Francisco AF,Brenchley JM,Sacks DL

更新日期：2020-04-13 00:00:00

abstract：:Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have largely failed due to lack of protective efficacy. Group 1 CD1-restrict...

journal_title：PLoS pathogens

authors： Visvabharathy L,Genardi S,Cao L,He Y,Alonzo F 3rd,Berdyshev E,Wang CR

更新日期：2020-04-28 00:00:00

abstract：:Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injection into host cells is facilitated by a so-called injectisome. Its small hydrop...

journal_title：PLoS pathogens

authors： Dietsche T,Tesfazgi Mebrhatu M,Brunner MJ,Abrusci P,Yan J,Franz-Wachtel M,Schärfe C,Zilkenat S,Grin I,Galán JE,Kohlbacher O,Lea S,Macek B,Marlovits TC,Robinson CV,Wagner S

更新日期：2016-12-15 00:00:00

abstract：:The Ras-GAP SH3 domain-binding proteins (G3BP) are essential regulators of the formation of stress granules (SG), cytosolic aggregates of proteins and RNA that are induced upon cellular stress, such as virus infection. Many viruses, including Semliki Forest virus (SFV), block SG induction by targeting G3BP. In this wo...

journal_title：PLoS pathogens

authors： Panas MD,Schulte T,Thaa B,Sandalova T,Kedersha N,Achour A,McInerney GM

更新日期：2015-02-06 00:00:00

abstract：:Bacterial bloodstream infections (BSI) are a major health concern and can cause up to 40% mortality. Pseudomonas aeruginosa BSI is often of nosocomial origin and is associated with a particularly poor prognosis. The mechanism of bacterial persistence in blood is still largely unknown. Here, we analyzed the behavior of...

journal_title：PLoS pathogens

authors： Pont S,Fraikin N,Caspar Y,Van Melderen L,Attrée I,Cretin F

更新日期：2020-12-16 00:00:00

abstract：:Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce mTORC1 activation and the substrates regulated by mTORC1 during infl...

journal_title：PLoS pathogens

authors： Kuss-Duerkop SK,Wang J,Mena I,White K,Metreveli G,Sakthivel R,Mata MA,Muñoz-Moreno R,Chen X,Krammer F,Diamond MS,Chen ZJ,García-Sastre A,Fontoura BMA

更新日期：2017-09-27 00:00:00

abstract：:Human noroviruses (huNoV) are the most frequent cause of non-bacterial acute gastroenteritis worldwide, particularly genogroup II genotype 4 (GII.4) variants. The viral nonstructural (NS) proteins encoded by the ORF1 polyprotein induce vesical clusters harboring the viral replication sites. Little is known so far abou...

journal_title：PLoS pathogens

authors： Doerflinger SY,Cortese M,Romero-Brey I,Menne Z,Tubiana T,Schenk C,White PA,Bartenschlager R,Bressanelli S,Hansman GS,Lohmann V

更新日期：2017-10-27 00:00:00

abstract：:Herpes Simplex Virus 1 (HSV1) is amongst the most clinically advanced oncolytic virus platforms. However, efficient and sustained viral replication within tumours is limiting. Rapamycin can stimulate HSV1 replication in cancer cells, but active-site dual mTORC1 and mTORC2 (mammalian target of rapamycin complex 1 and 2...

journal_title：PLoS pathogens

authors： Zakaria C,Sean P,Hoang HD,Leroux LP,Watson M,Workenhe ST,Hearnden J,Pearl D,Truong VT,Robichaud N,Yanagiya A,Tahmasebi S,Jafarnejad SM,Jia JJ,Pelin A,Diallo JS,Le Boeuf F,Bell JC,Mossman KL,Graber TE,Jaramillo M,

更新日期：2018-08-23 00:00:00

abstract：:Mycoplasma pneumoniae, a human pathogenic bacterium, glides on host cell surfaces by a unique and unknown mechanism. It forms an attachment organelle at a cell pole as a membrane protrusion composed of surface and internal structures, with a highly organized architecture. In the present study, we succeeded in isolatin...

journal_title：PLoS pathogens

authors： Nakane D,Kenri T,Matsuo L,Miyata M

更新日期：2015-12-03 00:00:00

abstract：:The microbiome and the phage meta-genome within the human gut are influenced by antibiotic treatments. Identifying a novel mechanism, here we demonstrate that bacteria use the universal communication molecule AI-2 to induce virulence genes and transfer them via phage release. High concentrations (i.e. 100 μM) of AI-2 ...

journal_title：PLoS pathogens

authors： Rossmann FS,Racek T,Wobser D,Puchalka J,Rabener EM,Reiger M,Hendrickx AP,Diederich AK,Jung K,Klein C,Huebner J

更新日期：2015-02-23 00:00:00

abstract：:All gammaherpesviruses encode a major glycoprotein homologous to the Epstein-Barr virus gp350. These glycoproteins are often involved in cell binding, and some provide neutralization targets. However, the capacity of gammaherpesviruses for long-term transmission from immune hosts implies that in vivo neutralization is...

journal_title：PLoS pathogens

authors： Machiels B,Lété C,Guillaume A,Mast J,Stevenson PG,Vanderplasschen A,Gillet L

更新日期：2011-11-01 00:00:00

abstract：:Abilities of bacterial pathogens to adapt to the iron limitation present in hosts is critical to their virulence. Bacterial pathogens have evolved diverse strategies to coordinately regulate iron metabolism and virulence associated functions to maintain iron homeostasis in response to changing iron availability in the...

journal_title：PLoS pathogens

authors： Pandey SS,Patnana PK,Lomada SK,Tomar A,Chatterjee S

更新日期：2016-11-30 00:00:00

abstract：:The apicomplexan, Cryptosporidium parvum, possesses a bacterial-type lactate dehydrogenase (CpLDH). This is considered to be an essential enzyme, as this parasite lacks the Krebs cycle and cytochrome-based respiration, and mainly-if not solely, relies on glycolysis to produce ATP. Here, we provide evidence that in ext...

journal_title：PLoS pathogens

authors： Zhang H,Guo F,Zhu G

更新日期：2015-11-12 00:00:00

abstract：:The life cycle of the mammalian pathogen Trypanosoma brucei involves commuting between two markedly different environments: the homeothermic mammalian host and the poikilothermic invertebrate vector. The ability to resist temperature and other stresses is essential for trypanosome survival. Trypanosome gene expression...

journal_title：PLoS pathogens

authors： Minia I,Clayton C

更新日期：2016-03-22 00:00:00

abstract：:T-follicular helper (Tfh) cells, co-expressing PD-1 and TIGIT, serve as a major cell reservoir for HIV-1 and are responsible for active and persistent HIV-1 transcription after prolonged antiretroviral therapy (ART). However, the precise mechanisms regulating HIV-1 transcription in lymph nodes (LNs) remain unclear. In...

journal_title：PLoS pathogens

authors： Banga R,Rebecchini C,Procopio FA,Noto A,Munoz O,Ioannidou K,Fenwick C,Ohmiti K,Cavassini M,Corpataux JM,de Leval L,Pantaleo G,Perreau M

更新日期：2019-07-22 00:00:00

abstract：:We assessed the role of myeloid dendritic cells (mDCs) in the outcome of SIV infection by comparing and contrasting their frequency, mobilization, phenotype, cytokine production and apoptosis in pathogenic (pigtailed macaques, PTMs), nonpathogenic (African green monkeys, AGMs) and controlled (rhesus macaques, RMs) SIV...

journal_title：PLoS pathogens

authors： Wijewardana V,Kristoff J,Xu C,Ma D,Haret-Richter G,Stock JL,Policicchio BB,Mobley AD,Nusbaum R,Aamer H,Trichel A,Ribeiro RM,Apetrei C,Pandrea I

更新日期：2013-01-01 00:00:00

abstract：:The role of Activation-Induced Cytidine Deaminase (AID) in somatic hypermutation and polyclonal antibody affinity maturation has not been shown for polyclonal responses in humans. We investigated whether AID induction in human B cells following H1N1pdm09 vaccination correlated with in-vivo antibody affinity maturation...

journal_title：PLoS pathogens

authors： Khurana S,Frasca D,Blomberg B,Golding H

更新日期：2012-09-01 00:00:00

abstract：:The factors determining the functional avidity and its relationship with the broad heterogeneity of antiviral T cell responses remain partially understood. We investigated HIV-specific CD8 T cell responses in 85 patients with primary HIV infection (PHI) or chronic (progressive and non-progressive) infection. The funct...

journal_title：PLoS pathogens

authors： Viganò S,Bellutti Enders F,Miconnet I,Cellerai C,Savoye AL,Rozot V,Perreau M,Faouzi M,Ohmiti K,Cavassini M,Bart PA,Pantaleo G,Harari A

更新日期：2013-01-01 00:00:00

abstract：:Magnaporthe oryzae is the causal agent of rice blast disease, a devastating problem worldwide. This fungus has caused breakdown of resistance conferred by newly developed commercial cultivars. To address how the rice blast fungus adapts itself to new resistance genes so quickly, we examined chromosomal locations of AV...

journal_title：PLoS pathogens

authors： Chuma I,Isobe C,Hotta Y,Ibaragi K,Futamata N,Kusaba M,Yoshida K,Terauchi R,Fujita Y,Nakayashiki H,Valent B,Tosa Y

更新日期：2011-07-01 00:00:00

abstract：:Altered cell metabolism is inherently connected with pathological conditions including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). KS tumour cells display features of lymphatic endothelial differentiation and in their vast majority are ...

journal_title：PLoS pathogens

authors： Yogev O,Lagos D,Enver T,Boshoff C

更新日期：2014-09-25 00:00:00

abstract：:Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helminth infections induce polarised Th2 responses that may impair HIV vac...

journal_title：PLoS pathogens

authors： Dzhivhuho GA,Rehrl SA,Ndlovu H,Horsnell WGC,Brombacher F,Williamson AL,Chege GK

更新日期：2018-07-26 00:00:00