Neutrophils use superoxide to control bacterial infection at a distance.

abstract：:The coordinated exit of intracellular pathogens from host cells is a process critical to the success and spread of an infection. While phospholipases have been shown to play important roles in bacteria host cell egress and virulence, their role in the release of intracellular eukaryotic parasites is largely unknown. W...

journal_title：PLoS pathogens

authors： Burda PC,Roelli MA,Schaffner M,Khan SM,Janse CJ,Heussler VT

更新日期：2015-03-18 00:00:00

abstract：:Influenza is a major cause of mortality and morbidity worldwide. Despite numerous studies of the pathogenesis of influenza in humans and animal models the dynamics of infection and transmission in individual hosts remain poorly characterized. In this study, we experimentally modelled transmission using the H1N1pdm09 i...

journal_title：PLoS pathogens

authors： Canini L,Holzer B,Morgan S,Dinie Hemmink J,Clark B,sLoLa Dynamics Consortium.,Woolhouse MEJ,Tchilian E,Charleston B

更新日期：2020-07-24 00:00:00

abstract：:Enteropathogenic E. coli (EPEC) is a human pathogen that causes acute and chronic pediatric diarrhea. The hallmark of EPEC infection is the formation of attaching and effacing (A/E) lesions in the intestinal epithelium. Formation of A/E lesions is mediated by genes located on the pathogenicity island locus of enterocy...

journal_title：PLoS pathogens

authors： Cepeda-Molero M,Berger CN,Walsham ADS,Ellis SJ,Wemyss-Holden S,Schüller S,Frankel G,Fernández LÁ

更新日期：2017-10-30 00:00:00

abstract：:The E3 ubiquitin ligase COP1 (Constitutive Photomorphogenesis 1) is a well known component of the light-mediated plant development that acts as a repressor of photomorphogenesis. Here we show that COP1 positively regulates defense against turnip crinkle virus (TCV) and avrRPM1 bacteria by contributing to stability of ...

journal_title：PLoS pathogens

authors： Lim GH,Hoey T,Zhu S,Clavel M,Yu K,Navarre D,Kachroo A,Deragon JM,Kachroo P

更新日期：2018-03-07 00:00:00

abstract：:Many viruses express factors that reduce host gene expression through widespread degradation of cellular mRNA. An example of this class of proteins is the mRNA-targeting endoribonuclease SOX from the gamma-herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV). Previous studies indicated that cleavage of messenger...

journal_title：PLoS pathogens

authors： Gaglia MM,Rycroft CH,Glaunsinger BA

更新日期：2015-12-08 00:00:00

abstract：:The rice blast fungus Magnaporthe oryzae is one of the most significant pathogens affecting global food security. To cause rice blast disease the fungus elaborates a specialised infection structure called an appressorium. Here, we report genome wide transcriptional profile analysis of appressorium development using ne...

journal_title：PLoS pathogens

authors： Soanes DM,Chakrabarti A,Paszkiewicz KH,Dawe AL,Talbot NJ

更新日期：2012-02-01 00:00:00

abstract：:Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low, with minimal apparent sequestration in endothelium-lined microvasculature, and pathogenesis thought unrelated to parasite biomass. However, the relationships bet...

journal_title：PLoS pathogens

authors： Barber BE,William T,Grigg MJ,Parameswaran U,Piera KA,Price RN,Yeo TW,Anstey NM

更新日期：2015-01-08 00:00:00

abstract：:The actions of the RIG-I like receptor (RLR) and type I interferon (IFN) signaling pathways are essential for a protective innate immune response against the emerging flavivirus West Nile virus (WNV). In mice lacking RLR or IFN signaling pathways, WNV exhibits enhanced tissue tropism, indicating that specific host fac...

journal_title：PLoS pathogens

authors： Suthar MS,Brassil MM,Blahnik G,McMillan A,Ramos HJ,Proll SC,Belisle SE,Katze MG,Gale M Jr

更新日期：2013-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) infection induces an atypical CD8 T cell response, termed inflationary, that is characterised by accumulation and maintenance of high numbers of effector memory like cells in circulation and peripheral tissues-a feature being successfully harnessed for vaccine purposes. Although stability of this...

journal_title：PLoS pathogens

authors： Baumann NS,Torti N,Welten SPM,Barnstorf I,Borsa M,Pallmer K,Oduro JD,Cicin-Sain L,Ikuta K,Ludewig B,Oxenius A

更新日期：2018-04-13 00:00:00

abstract：:The AraC Negative Regulators (ANR) comprise a large family of virulence regulators distributed among diverse clinically important Gram-negative pathogens, including Vibrio spp., Salmonella spp., Shigella spp., Yersinia spp., Citrobacter spp., and pathogenic E. coli strains. We have previously reported broad effects of...

journal_title：PLoS pathogens

authors： Santiago AE,Yan MB,Hazen TH,Sauder B,Meza-Segura M,Rasko DA,Kendall MM,Ruiz-Perez F,Nataro JP

更新日期：2017-08-14 00:00:00

abstract：:Toll/interleukin-1 receptor (TIR) domains in Toll-like receptors are essential for initiating and propagating the eukaryotic innate immune signaling cascade. Here, we investigate TirS, a Staphylococcus aureus TIR mimic that is part of a novel bacterial invasion mechanism. Its ectopic expression in eukaryotic cells inh...

journal_title：PLoS pathogens

authors： Patot S,Imbert PR,Baude J,Martins Simões P,Campergue JB,Louche A,Nijland R,Bès M,Tristan A,Laurent F,Fischer A,Schrenzel J,Vandenesch F,Salcedo SP,François P,Lina G

更新日期：2017-01-06 00:00:00

abstract：:In plants, innate immune responses are initiated by plasma membrane-located pattern recognition receptors (PRRs) upon recognition of elicitors, including exogenous pathogen-associated molecular patterns (PAMPs) and endogenous damage-associated molecular patterns (DAMPs). Arabidopsis thaliana produces more than 1000 se...

journal_title：PLoS pathogens

authors： Hou S,Wang X,Chen D,Yang X,Wang M,Turrà D,Di Pietro A,Zhang W

更新日期：2014-09-04 00:00:00

abstract：:Borrelia burgdorferi, the agent of Lyme disease, has cholesterol and cholesterol-glycolipids that are essential for bacterial fitness, are antigenic, and could be important in mediating interactions with cells of the eukaryotic host. We show that the spirochetes can acquire cholesterol from plasma membranes of epithel...

journal_title：PLoS pathogens

authors： Crowley JT,Toledo AM,LaRocca TJ,Coleman JL,London E,Benach JL

更新日期：2013-01-01 00:00:00

abstract：:Tsetse flies are vectors of the protozoan parasite African trypanosomes, which cause sleeping sickness disease in humans and nagana in livestock. Although there are no effective vaccines and efficacious drugs against this parasite, vector reduction methods have been successful in curbing the disease, especially for na...

journal_title：PLoS pathogens

authors： Alam U,Medlock J,Brelsfoard C,Pais R,Lohs C,Balmand S,Carnogursky J,Heddi A,Takac P,Galvani A,Aksoy S

更新日期：2011-12-01 00:00:00

abstract：:The phosphoinositide-3 kinase (PI3K) pathway regulates diverse cellular activities related to cell growth, migration, survival, and vesicular trafficking. It is known that Ebola virus requires endocytosis to establish an infection. However, the cellular signals that mediate this uptake were unknown for Ebola virus as ...

journal_title：PLoS pathogens

authors： Saeed MF,Kolokoltsov AA,Freiberg AN,Holbrook MR,Davey RA

更新日期：2008-08-29 00:00:00

abstract：:The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in humans and other mammals, despite the development of potent host immune responses that constrain parasite numbers. The consistent, decades-long persistence of T. cruzi in human hosts arises at least in part from the remarkable level ...

journal_title：PLoS pathogens

authors： Wang W,Peng D,Baptista RP,Li Y,Kissinger JC,Tarleton RL

更新日期：2021-01-28 00:00:00

abstract：:Although invasive cytomegalovirus (CMV) disease is uncommon in the era of antiretroviral therapy (ART), asymptomatic CMV coinfection is nearly ubiquitous in HIV infected individuals. While microbial translocation and gut epithelial barrier dysfunction may promote persistent immune activation in treated HIV infection, ...

journal_title：PLoS pathogens

authors： Maidji E,Somsouk M,Rivera JM,Hunt PW,Stoddart CA

更新日期：2017-02-27 00:00:00

abstract：:Laboratory strains of the mouse polyoma virus differ markedly in their abilities to replicate and induce tumors in newborn mice. Major determinants of pathogenicity lie in the sialic binding pocket of the major capsid protein Vp1 and dictate receptor-binding properties of the virus. Substitutions at two sites in Vp1 d...

journal_title：PLoS pathogens

authors： Carroll J,Dey D,Kreisman L,Velupillai P,Dahl J,Telford S,Bronson R,Benjamin T

更新日期：2007-12-01 00:00:00

abstract：:Bacteria of the Burkholderia cepacia complex (Bcc) can cause devastating pulmonary infections in cystic fibrosis (CF) patients, yet the precise mechanisms underlying inflammation, recurrent exacerbations and transition from chronic stages to acute infection and septicemia are not known. Bcc bacteria are generally beli...

journal_title：PLoS pathogens

authors： Mesureur J,Feliciano JR,Wagner N,Gomes MC,Zhang L,Blanco-Gonzalez M,van der Vaart M,O'Callaghan D,Meijer AH,Vergunst AC

更新日期：2017-06-26 00:00:00

abstract：:Hepatitis B virus (HBV) capsid or core protein (HBc) contains an N-terminal domain (NTD) and a C-terminal domain (CTD) connected by a short linker peptide. HBc plays a critical role in virtually every step of viral replication, which is further modulated by dynamic phosphorylation and dephosphorylation of its CTD. Whi...

journal_title：PLoS pathogens

authors： Xi J,Luckenbaugh L,Hu J

更新日期：2021-01-25 00:00:00

abstract：:Plant pathogens secrete an arsenal of effector proteins to impair host immunity. Some effectors possess enzymatic activities that can modify their host targets. Previously, we demonstrated that a Phytophthora sojae RXLR effector Avr3b acts as a Nudix hydrolase when expressed in planta; and this enzymatic activity is r...

journal_title：PLoS pathogens

authors： Kong G,Zhao Y,Jing M,Huang J,Yang J,Xia Y,Kong L,Ye W,Xiong Q,Qiao Y,Dong S,Ma W,Wang Y

更新日期：2015-08-28 00:00:00

abstract：:We have characterized a novel pleiotropic role for CymR, the master regulator of cysteine metabolism. We show here that CymR plays an important role both in stress response and virulence of Staphylococcus aureus. Genes involved in detoxification processes, including oxidative stress response and metal ion homeostasis,...

journal_title：PLoS pathogens

authors： Soutourina O,Dubrac S,Poupel O,Msadek T,Martin-Verstraete I

更新日期：2010-05-13 00:00:00

abstract：:Human Group IIA secreted phospholipase A2 (hGIIA) is an acute phase protein with bactericidal activity against Gram-positive bacteria. Infection models in hGIIA transgenic mice have suggested the importance of hGIIA as an innate defense mechanism against the human pathogens Group A Streptococcus (GAS) and Group B Stre...

journal_title：PLoS pathogens

authors： van Hensbergen VP,Movert E,de Maat V,Lüchtenborg C,Le Breton Y,Lambeau G,Payré C,Henningham A,Nizet V,van Strijp JAG,Brügger B,Carlsson F,McIver KS,van Sorge NM

更新日期：2018-10-15 00:00:00

abstract：:Bartonellae are Gram-negative facultative-intracellular pathogens that use a type-IV-secretion system (T4SS) to translocate a cocktail of Bartonella effector proteins (Beps) into host cells to modulate diverse cellular functions. BepC was initially reported to act in concert with BepF in triggering major actin cytoske...

journal_title：PLoS pathogens

authors： Marlaire S,Dehio C

更新日期：2021-01-28 00:00:00

abstract：:Hepatitis C virus (HCV) core protein is directed to the surface of lipid droplets (LD), a step that is essential for infectious virus production. However, the process by which core is recruited from LD into nascent virus particles is not well understood. To investigate the kinetics of core trafficking, we developed me...

journal_title：PLoS pathogens

authors： Counihan NA,Rawlinson SM,Lindenbach BD

更新日期：2011-10-01 00:00:00

abstract：:Entamoeba histolytica transmembrane kinases (EhTMKs) can be grouped into six distinct families on the basis of motifs and sequences. Analysis of the E. histolytica genome revealed the presence of 35 EhTMKB1 members on the basis of sequence identity (>or=95%). Only six homologs were full length containing an extracellu...

journal_title：PLoS pathogens

authors： Shrimal S,Bhattacharya S,Bhattacharya A

更新日期：2010-06-03 00:00:00

abstract：:The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction. Since dendritic cells (DCs) typically initiate anti-leishmanial immunity, a role for DCs in aberrant LD clearance was inve...

journal_title：PLoS pathogens

authors： Haldar AK,Yadav V,Singhal E,Bisht KK,Singh A,Bhaumik S,Basu R,Sen P,Roy S

更新日期：2010-05-20 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a global public health burden for which no licensed vaccine exists. To aid vaccine development via increased understanding of the protective antibody response to RSV prefusion glycoprotein F (PreF), we performed structural and functional studies using the human neutralizing antibod...

journal_title：PLoS pathogens

authors： Harshbarger W,Tian S,Wahome N,Balsaraf A,Bhattacharya D,Jiang D,Pandey R,Tungare K,Friedrich K,Mehzabeen N,Biancucci M,Chinchilla-Olszar D,Mallett CP,Huang Y,Wang Z,Bottomley MJ,Malito E,Chandramouli S

更新日期：2020-11-02 00:00:00

abstract：:Prions are pathogens formed from abnormal conformers (PrPSc) of the host-encoded cellular prion protein (PrPC). PrPSc conformation to disease phenotype relationships extensively vary among prion strains. In particular, prions exhibit a strain-dependent tropism for lymphoid tissues. Prions can be composed of several su...

journal_title：PLoS pathogens

authors： Béringue V,Tixador P,Andréoletti O,Reine F,Castille J,Laï TL,Le Dur A,Laisné A,Herzog L,Passet B,Rezaei H,Vilotte JL,Laude H

更新日期：2020-07-23 00:00:00

abstract：:EBV transforms B cells in vitro and causes human B-cell lymphomas including classical Hodgkin lymphoma (CHL), Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). The EBV latency protein, EBNA2, transcriptionally activates the promoters of all latent viral protein-coding genes expressed in type III EBV lat...

journal_title：PLoS pathogens

authors： Li C,Romero-Masters JC,Huebner S,Ohashi M,Hayes M,Bristol JA,Nelson SE,Eichelberg MR,Van Sciver N,Ranheim EA,Scott RS,Johannsen EC,Kenney SC

更新日期：2020-06-15 00:00:00