The TIR Homologue Lies near Resistance Genes in Staphylococcus aureus, Coupling Modulation of Virulence and Antimicrobial Susceptibility.

abstract：:Since 2003, more than 380 cases of H5N1 influenza virus infection of humans have been reported. Although the resultant disease in these cases was often severe or fatal, transmission of avian influenza viruses between humans is rare. The precise nature of the barrier blocking human-to-human spread is unknown. It is cle...

journal_title：PLoS pathogens

authors： Steel J,Lowen AC,Mubareka S,Palese P

更新日期：2009-01-01 00:00:00

abstract：:Type III secretion systems (T3SS) are nano-syringes used by a wide range of Gram-negative pathogens to promote infection by directly injecting effector proteins into targeted host cells. Translocation of effectors is triggered by host-cell contact and requires assembly of a pore in the host-cell plasma membrane, which...

journal_title：PLoS pathogens

authors： Armentrout EI,Rietsch A

更新日期：2016-03-29 00:00:00

abstract：:Microfold (M) cell host-pathogen interaction studies would benefit from the visual analysis of dynamic cellular and microbial interplays. We adapted a human in vitro M cell model to physiological bacterial infections, expression of fluorescent localization reporters and long-term three-dimensional time-lapse microscop...

journal_title：PLoS pathogens

authors： Rey C,Chang YY,Latour-Lambert P,Varet H,Proux C,Legendre R,Coppée JY,Enninga J

更新日期：2020-04-13 00:00:00

abstract：:Plants possess active defense systems and can protect themselves from pathogenic invasion by secretion of a variety of small antimicrobial or antifungal proteins such as thionins. The antibacterial and antifungal properties of thionins are derived from their ability to induce open pore formation on cell membranes of p...

journal_title：PLoS pathogens

authors： Asano T,Miwa A,Maeda K,Kimura M,Nishiuchi T

更新日期：2013-01-01 00:00:00

abstract：:Altered cell metabolism is inherently connected with pathological conditions including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). KS tumour cells display features of lymphatic endothelial differentiation and in their vast majority are ...

journal_title：PLoS pathogens

authors： Yogev O,Lagos D,Enver T,Boshoff C

更新日期：2014-09-25 00:00:00

abstract：:Increasing evidence suggests important roles for long noncoding RNAs (lncRNAs) as new gene modulators involved in various biological processes. However, the function roles of lncRNAs in lower vertebrates are still unknown. Here, we firstly identify a lncRNA, named MAVS antiviral-related lncRNA (MARL), as a key regulat...

journal_title：PLoS pathogens

authors： Chu Q,Xu T,Zheng W,Chang R,Zhang L

更新日期：2020-07-17 00:00:00

abstract：:The Kaposi's sarcoma-associated herpesvirus (KSHV) genome encodes a G protein-coupled receptor (vGPCR). vGPCR is a ligand-independent, constitutively active signaling molecule that promotes cell growth and proliferation; however, it is not clear how vGPCR is negatively regulated. We report here that the KSHV K7 small ...

journal_title：PLoS pathogens

authors： Feng H,Dong X,Negaard A,Feng P

更新日期：2008-09-19 00:00:00

abstract：:Cellular metal homeostasis is a critical process for all organisms, requiring tight regulation. In the major pathogen Helicobacter pylori, the acquisition of nickel is an essential virulence determinant as this metal is a cofactor for the acid-resistance enzyme, urease. Nickel uptake relies on the NixA permease and th...

journal_title：PLoS pathogens

authors： Denic M,Turlin E,Michel V,Fischer F,Khorasani-Motlagh M,Zamble D,Vinella D,de Reuse H

更新日期：2021-01-14 00:00:00

abstract：:Phagocytosis is an ancient mechanism central to both tissue homeostasis and immune defense. Both the identity of the receptors that mediate bacterial phagocytosis and the nature of the interactions between phagocytosis and other defense mechanisms remain elusive. Here, we report that Croquemort (Crq), a Drosophila mem...

journal_title：PLoS pathogens

authors： Guillou A,Troha K,Wang H,Franc NC,Buchon N

更新日期：2016-10-25 00:00:00

abstract：:Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators...

journal_title：PLoS pathogens

authors： Coussens AK,Wilkinson RJ,Nikolayevskyy V,Elkington PT,Hanifa Y,Islam K,Timms PM,Bothamley GH,Claxton AP,Packe GE,Darmalingam M,Davidson RN,Milburn HJ,Baker LV,Barker RD,Drobniewski FA,Mein CA,Bhaw-Rosun L,Nuamah RA,

更新日期：2013-01-01 00:00:00

abstract：:The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from the endoplasmic reticulum via subversion of the host cell secretory pathway. rBCV biogenesis requires the expression of the Type IV secretion system (T4SS) VirB, which is thought to translocate effector proteins that mo...

journal_title：PLoS pathogens

authors： Myeni S,Child R,Ng TW,Kupko JJ 3rd,Wehrly TD,Porcella SF,Knodler LA,Celli J

更新日期：2013-01-01 00:00:00

abstract：:The pathogenic fungus Cryptococcus neoformans exhibits morphological changes in cell size during lung infection, producing both typical size 5 to 7 μm cells and large titan cells (> 10 μm and up to 100 μm). We found and optimized in vitro conditions that produce titan cells in order to identify the ancestry of titan c...

journal_title：PLoS pathogens

authors： Hommel B,Mukaremera L,Cordero RJB,Coelho C,Desjardins CA,Sturny-Leclère A,Janbon G,Perfect JR,Fraser JA,Casadevall A,Cuomo CA,Dromer F,Nielsen K,Alanio A

更新日期：2018-05-18 00:00:00

abstract：:Herpesviruses encode a characteristic serine protease with a unique fold and an active site that comprises the unusual triad Ser-His-His. The protease is essential for viral replication and as such constitutes a promising drug target. In solution, a dynamic equilibrium exists between an inactive monomeric and an activ...

journal_title：PLoS pathogens

authors： Zühlsdorf M,Werten S,Klupp BG,Palm GJ,Mettenleiter TC,Hinrichs W

更新日期：2015-07-10 00:00:00

abstract：:Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains of specific host proteins, such as Nedd4 and ITCH, to facilitate...

journal_title：PLoS pathogens

authors： Liang J,Sagum CA,Bedford MT,Sidhu SS,Sudol M,Han Z,Harty RN

更新日期：2017-01-11 00:00:00

abstract：:Community acquired-methicillin resistant Staphylococcus aureus (CA-MRSA) is a socially problematic pathogen that infects healthy individuals, causing severe disease. CA-MRSA is more virulent than hospital associated-MRSA (HA-MRSA). The underlying mechanism for the high virulence of CA-MRSA is not known. The transcript...

journal_title：PLoS pathogens

authors： Kaito C,Saito Y,Ikuo M,Omae Y,Mao H,Nagano G,Fujiyuki T,Numata S,Han X,Obata K,Hasegawa S,Yamaguchi H,Inokuchi K,Ito T,Hiramatsu K,Sekimizu K

更新日期：2013-01-01 00:00:00

abstract：:Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobino...

journal_title：PLoS pathogens

authors： Taylor SM,Cerami C,Fairhurst RM

更新日期：2013-01-01 00:00:00

abstract：:Prions are unorthodox infectious agents that replicate by templating misfolded conformations of a host-encoded glycoprotein, collectively termed PrPSc. Prion diseases are invariably fatal and currently incurable, but oral drugs that can prolong incubation times in prion-infected mice have been developed. Here, we test...

journal_title：PLoS pathogens

authors： Burke CM,Mark KMK,Kun J,Beauchemin KS,Supattapone S

更新日期：2020-05-18 00:00:00

abstract：:In HPV-related cancers, the "high-risk" human papillomaviruses (HPVs) are frequently found integrated into the cellular genome. The integrated subgenomic HPV fragments express viral oncoproteins and carry an origin of DNA replication that is capable of initiating bidirectional DNA re-replication in the presence of HPV...

journal_title：PLoS pathogens

authors： Kadaja M,Isok-Paas H,Laos T,Ustav E,Ustav M

更新日期：2009-04-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a leading cause of liver disease worldwide. The HCV RNA genome is translated into a single polyprotein. Most of the cleavage sites in the non-structural (NS) polyprotein region are processed by the NS3/NS4A serine protease. The vital NS2-NS3 cleavage is catalyzed by the NS2 autopro...

journal_title：PLoS pathogens

authors： Isken O,Langerwisch U,Jirasko V,Rehders D,Redecke L,Ramanathan H,Lindenbach BD,Bartenschlager R,Tautz N

更新日期：2015-03-16 00:00:00

abstract：:The porcine reproductive and respiratory syndrome virus (PRRSV) is a major threat to swine health worldwide and is considered the most significant viral disease in the swine industry today. In past years, studies on the entry of the virus into its host cell have led to the identification of a number of essential virus...

journal_title：PLoS pathogens

authors： Van Breedam W,Van Gorp H,Zhang JQ,Crocker PR,Delputte PL,Nauwynck HJ

更新日期：2010-01-15 00:00:00

abstract：:Deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) induce a persistent infection that remains generally asymptomatic but can also lead to leukemia or lymphoma. These viruses replicate by infecting new lymphocytes (i.e. the infectious cycle) or via clonal expansion of t...

journal_title：PLoS pathogens

authors： Gillet NA,Gutiérrez G,Rodriguez SM,de Brogniez A,Renotte N,Alvarez I,Trono K,Willems L

更新日期：2013-01-01 00:00:00

abstract：:Plant microRNAs (miRNA) guide cleavage of target mRNAs by DICER-like proteins, thereby reducing mRNA abundance. Native precursor miRNAs can be redesigned to target RNAs of interest, and one application of such artificial microRNA (amiRNA) technology is to generate plants resistant to pathogenic viruses. Transgenic Ara...

journal_title：PLoS pathogens

authors： Lin SS,Wu HW,Elena SF,Chen KC,Niu QW,Yeh SD,Chen CC,Chua NH

更新日期：2009-02-01 00:00:00

abstract：:Rapid reprogramming of the macrophage activation phenotype is considered important in the defense against consecutive infection with diverse infectious agents. However, in the setting of persistent, chronic infection the functional importance of macrophage-intrinsic adaptation to changing environments vs. recruitment ...

journal_title：PLoS pathogens

authors： Rückerl D,Campbell SM,Duncan S,Sutherland TE,Jenkins SJ,Hewitson JP,Barr TA,Jackson-Jones LH,Maizels RM,Allen JE

更新日期：2017-03-23 00:00:00

abstract：:Plants have evolved pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and effector-triggered immunity (ETI) to protect themselves from infection by diverse pathogens. Avirulence (Avr) effectors that trigger plant ETI as a result of recognition by plant resistance (R) gene products have been identif...

journal_title：PLoS pathogens

authors： Dong S,Yin W,Kong G,Yang X,Qutob D,Chen Q,Kale SD,Sui Y,Zhang Z,Dou D,Zheng X,Gijzen M,Tyler BM,Wang Y

更新日期：2011-11-01 00:00:00

abstract：:Viruses have evolved several strategies to modify cellular processes and evade the immune response in order to successfully infect, replicate, and persist in the host. By utilizing in-silico testing of a transmembrane sequence library derived from virus protein sequences, we have pin-pointed a nine amino-acid motif sh...

journal_title：PLoS pathogens

authors： Cohen T,Cohen SJ,Antonovsky N,Cohen IR,Shai Y

更新日期：2010-09-02 00:00:00

abstract：:RIG-I-Like Receptors (RLRs) sense cytosolic viral RNA to transiently activate type I IFN production. Here, we report that a type I IFN inducible DExD/H helicase, DDX24, exerts a negative-regulatory effect on RLR function. Expression of DDX24 specifically suppressed RLR activity, while DDX24 loss, which caused embryoni...

journal_title：PLoS pathogens

authors： Ma Z,Moore R,Xu X,Barber GN

更新日期：2013-10-01 00:00:00

abstract：:Human defensins are at the forefront of the host responses to HIV and other pathogens in mucosal tissues. However, their ability to inactivate HIV in the bloodstream has been questioned due to the antagonistic effect of serum. In this study, we have examined the effect of sub-inhibitory concentrations of human α-defen...

journal_title：PLoS pathogens

authors： Demirkhanyan L,Marin M,Lu W,Melikyan GB

更新日期：2013-01-01 00:00:00

abstract：:Modified vaccinia virus Ankara (MVA) is an approved smallpox vaccine and a promising vaccine vector for other pathogens as well as for cancer therapeutics with more than 200 current or completed clinical trials. MVA was derived by passaging the parental Ankara vaccine virus hundreds of times in chick embryo fibroblast...

journal_title：PLoS pathogens

authors： Peng C,Wyatt LS,Glushakow-Smith SG,Lal-Nag M,Weisberg AS,Moss B

更新日期：2020-08-31 00:00:00

abstract：:After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding interaction between TRIM5...

journal_title：PLoS pathogens

authors： Ohkura S,Goldstone DC,Yap MW,Holden-Dye K,Taylor IA,Stoye JP

更新日期：2011-03-01 00:00:00

abstract：:The bactericidal function of macrophages against pneumococci is enhanced by their apoptotic demise, which is controlled by the anti-apoptotic protein Mcl-1. Here, we show that lysosomal membrane permeabilization (LMP) and cytosolic translocation of activated cathepsin D occur prior to activation of a mitochondrial pat...

journal_title：PLoS pathogens

authors： Bewley MA,Marriott HM,Tulone C,Francis SE,Mitchell TJ,Read RC,Chain B,Kroemer G,Whyte MK,Dockrell DH

更新日期：2011-01-27 00:00:00